keyword
https://read.qxmd.com/read/22068352/antibodies-to-mutated-citrullinated-vimentin-in-patients-with-chronic-hepatitis-c-virus-genotype-iv-infection-related-arthropathy
#21
JOURNAL ARTICLE
M Zehairy, E Soliman, A Daghaidy
One of the extra-hepatic manifestations of hepatitis C virus (HCV) infection is polyarthritis that mimics rheumatoid arthritis (RA). Anti-mutated citrullinated vimentin (MCV) was recently introduced in the diagnostic workup of RA, but its exact role in HCV infection and its related arthropathy is still unclear. The aim of the study is to determine the prevalence of anti-MCV antibodies in HCV-infected patients with or without articular involvement, and to investigate whether anti-MCV antibodies have an additional role to anticyclic citrullinated peptide (CCP) antibodies and rheumatoid factor (RF) in differentiating patients with RA from patients with HCV-related arthropathy...
November 2012: Rheumatology International
https://read.qxmd.com/read/21532235/rheumatoid-arthritis-following-a-treatment-with-ifn-alpha-ribavirin-against-hcv-infection
#22
JOURNAL ARTICLE
Yasumori Izumi, Atsumasa Komori, Yuki Yasunaga, Satoru Hashimoto, Taiichiro Miyashita, Seigo Abiru, Hiroshi Yatsuhashi, Hiromi Ishibashi, Kiyoshi Migita
We report a 48-year-old man who developed rheumatoid arthritis (RA) after a successful treatment with peg-IFN-alpha plus ribavirin for chronic hepatitis C virus (HCV) infection. He had a history of smoking and a single copy of the HLA-DRB1 shared epitope (SE). In a retrospective analysis, he exhibited the anti-CCP antibodies before the start of IFN plus ribavirin treatment. However, the titers of anti-CCP antibodies and BAFF levels were elevated by the IFN plus ribavirin therapy. These observations suggest that IFN plus ribavirin therapy may work as a "trigger" for RA in genetically and environmentally predisposed individuals by affecting the cytokine network...
2011: Internal Medicine
https://read.qxmd.com/read/20686805/antibodies-against-cyclic-citrullinated-peptides-in-infectious-diseases-a-systematic-review
#23
REVIEW
Isabella Lima, Mittermayer Santiago
Rheumatoid arthritis (RA) is a disease characterized by symmetrical polyarthritis of the large and small joints, and in the majority of patients, there is a presence of the rheumatoid factor and erosions in the X-ray of the joints. More recently, the presence of anti-cyclic citrullinated peptide antibodies (anti-CCP) in this disease has been described, with diagnostic and prognostic value. Nevertheless, these antibodies have also been described in infectious diseases. The aim of the present study was to make a systematic review of the presence of antibodies against citrullinated peptides in infectious diseases...
December 2010: Clinical Rheumatology
https://read.qxmd.com/read/20012964/the-diagnostic-utilities-of-anti-agalactosyl-igg-antibodies-anti-cyclic-citrullinated-peptide-antibodies-and-rheumatoid-factors-in-rheumatoid-arthritis
#24
JOURNAL ARTICLE
Hee Jung Ryu, Fujio Takeuchi, Shoji Kuwata, Yoon Jun Kim, Eun Young Lee, Eun Bong Lee, Yeong Wook Song
The purpose of this study was to investigate the diagnostic utilities of anti-agalactosyl IgG antibody (CARF), anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor (RF) in rheumatoid arthritis (RA), non-RA rheumatic diseases, and chronic viral hepatitis. The authors determined serum levels of CARF and anti-CCP2 by ELISA and IgM-RF by a immunonephelometric method in 834 controls and in 397 patients with the following conditions: RA (100), non-RA rheumatic diseases [systemic lupus erythematosus (SLE) 30, primary Sjogren's syndrome 18, systemic sclerosis 30, inflammatory myositis 19], chronic viral hepatitis B and C (HBV 100, HCV 100)...
March 2011: Rheumatology International
https://read.qxmd.com/read/19882340/anti-cyclic-citrullinated-peptide-antibodies-as-a-discriminating-marker-between-rheumatoid-arthritis-and-chronic-hepatitis-c-related-polyarthropathy
#25
JOURNAL ARTICLE
Wafaa M Ezzat, Hala M Raslan, Azza A Aly, Nahed A Emara, Manal M El Menyawi, Amr Edrees
Articular involvement is a frequent extrahepatic manifestation of hepatitis C virus (HCV) infection. The distinction between HCV-related polyarthropathy and true RA may be very difficult, especially with recent onset RA before articular damage and erosions develop. The objective of the study is to assess the diagnostic utility of anti-CCP antibodies and compare it with that of rheumatoid factor (RF) in distinguishing between rheumatoid arthritis (RA) and HCV-related polyarthropathy. Anti-cyclic citrullinated peptide (CCP) antibodies and RF were determined in the sera of 30 patients with RA and 22 patients with HCV-related polyarthropathy...
January 2011: Rheumatology International
https://read.qxmd.com/read/19774484/constriction-infection
#26
JOURNAL ARTICLE
J A Purvis, M Roberts, M T Harbinson
Chronic constrictive pericarditis (CCP) is a clinical syndrome caused by compression of the heart due to a thickened or rigid pericardium. In the affluent West, the majority of cases of CCP are neither tuberculous nor calcific. In an American cohort undergoing pericardectomy for the condition, only 27% had calcification and under 10% had TB [1]. As a result, pericardial calcification (PC) as a marker of CCP has become neglected. We present a 48-year-old male admitted with atrial flutter, acute chest infection and signs of right heart congestion...
January 2010: International Journal of Cardiovascular Imaging
https://read.qxmd.com/read/19575546/clinical-significance-of-anti-cyclic-citrullinated-peptide-antibodies-in-egyptian-patients-with-chronic-hepatitis-c-virus-genotype-iv-infection
#27
JOURNAL ARTICLE
Iman H Bassyouni, Yasser Ezzat, Sherif Hamdy, Roba M Talaat
BACKGROUND: Symmetric polyarthritis associated with hepatitis C virus (HCV) infection frequently displays a clinical picture like rheumatoid arthritis (RA). Antibodies to cyclic citrullinated peptide (CCP) have high specificity for the diagnosis of RA. This study examined the frequency and clinical significance of anti-CCP antibodies in patients with chronic HCV infection, with and without manifestations of joint involvement, compared to RA patients. METHODS: Serum anti-CCP antibodies and rheumatoid factor (RF) were evaluated in 30 patients with RA and 47 patients with chronic HCV infection...
2009: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/19547976/the-positivity-of-rheumatoid-factor-and-anti-cyclic-citrullinated-peptide-antibody-in-nonarthritic-patients-with-chronic-hepatitis-c-infection
#28
JOURNAL ARTICLE
E Orge, A Cefle, Ayten Yazici, N Gürel-Polat, S Hulagu
Chronic hepatitis C virus (HCV) has extrahepatic autoimmune properties and a variety of autoantibodies were found in patients with HCV. Patients with HCV infection may have rheumatic symptoms and signs, and 50-70% of the cases may contain rheumatoid factor (RF). The increased prevalence of RF in patients with HCV infection diminishes the diagnostic specificity of serum RF for rheumatoid arthritis (RA) in patients with HCV. Therefore, the presence of RF mostly does not help in distinguishing between RA and HCV-associated rheumatic symptoms...
February 2010: Rheumatology International
https://read.qxmd.com/read/19531755/is-screening-for-hepatitis-b-and-hepatitis-c-useful-in-patients-with-recent-onset-polyarthritis-the-espoir-cohort-study
#29
JOURNAL ARTICLE
Xavier Guennoc, Valérie Narbonne, Sandrine Jousse-Joulin, Valerie Devauchelle-Pensec, Maxime Dougados, Jean Pierre Daurès, Alain Saraux
OBJECTIVE: To evaluate the seroprevalence of hepatitis B (HBV) and C (HCV) in patients living in France with recent-onset polyarthritis suggesting rheumatoid arthritis. METHODS: The 813 patients in the ESPOIR cohort were screened for anti-HCV antibodies and HBs antigen. RESULTS: Seroprevalence was 0.86% for HCV (n = 7) and 0.12% for HBV (n = 1). HCV-related arthritis was diagnosed in 4 (0.5%) patients; no patient had HBV-related arthritis...
July 2009: Journal of Rheumatology
https://read.qxmd.com/read/19286846/anti-cyclic-citrullinated-peptide-antibodies-distinguish-hepatitis-b-virus-hbv-associated-arthropathy-from-concomitant-rheumatoid-arthritis-in-patients-with-chronic-hbv-infection
#30
JOURNAL ARTICLE
Mi-Kyoung Lim, Dong-Hyuk Sheen, Yun Jung Lee, You Ri Mun, Mira Park, Seung-Cheol Shim
OBJECTIVE: To determine whether anti-cyclic citrullinated peptide (anti-CCP) antibodies, which are a highly specific test for rheumatoid arthritis (RA), could differentiate between hepatitis B virus (HBV)-associated arthropathy and concomitant RA in Korean patients with chronic HBV infection. METHODS: We investigated 240 patients with HBV infection. Anti-CCP antibodies were measured by ELISA and rheumatoid factor (RF) by the latex fixation test. Patient records were reviewed, and a standard form was used to record all demographic, clinical, and laboratory characteristics...
April 2009: Journal of Rheumatology
https://read.qxmd.com/read/18707027/hepatitis-c-virus-related-arthritis
#31
REVIEW
Carlo Palazzi, Salvatore D'Angelo, Ignazio Olivieri
Although asymptomatic joint involvement and arthralgias are frequent in patients with hepatitis C virus chronic infection (HCV), a true arthritis affects only up to 4% of the subjects. HCV-related arthritis (HCVrA) is usually distinguished in two clinical subsets: a more frequent symmetrical polyarthritis (SP), similar to rheumatoid arthritis but much less serious, and an intermittent mono-oligoarthritis (IMO) that involves medium and large sized joints, mainly the ankle. This latter subset is strictly related to the presence of HCV-induced mixed cryoglobulinemia and its cutaneous manifestations, in particular purpura...
October 2008: Autoimmunity Reviews
https://read.qxmd.com/read/18394318/anti-cyclic-citrullinated-peptide-antibodies-in-patients-affected-by-hcv-related-arthritis
#32
JOURNAL ARTICLE
A Riccio, L Postiglione, P La Dogana, A Spanò, C Marzocchella, G Tarantino
Hepatitis C Virus (HCV) infection can induce immunological disorders with different clinical expressions such as arthritis, Sjogren Syndrome and various forms of vasculitis. Retrospectively, the prevalence of anti-Cyclic Citrullinated peptide antibodies (anti-CCP) in a group of patients affected by HCV-related arthritis with positivity for Rheumatoid Factor (RF) and the eventual correlations with RF and/or Anti-Nuclear Antibodies (ANA) and articular involvement were studied. Thirty patients with arthritis were selected from a population of 380 subjects affected by HCV infection...
January 2008: Journal of Biological Regulators and Homeostatic Agents
https://read.qxmd.com/read/18328158/determination-of-anti-cyclic-citrullinated-peptide-antibodies-in-the-sera-of-patients-with-liver-diseases
#33
JOURNAL ARTICLE
T Koga, K Migita, T Miyashita, Y Maeda, M Nakamura, S Abiru, M Myoji, A Komori, K Yano, H Yatsuhashi, K Eguchi, H Ishibashi
OBJECTIVE: To determine the frequency of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with HCV infection, primary biliary cirrhosis (PBC) and type-I autoimmune hepatitis (AIH) to assess the specificity of anti-CCP antibodies. METHODS: Rheumatoid factor (RF) and anti-CCP antibodies were measured in the sera from patients with HCV infection (n=45), PBC (n=73), AIH (n=55) and rheumatoid arthritis (n=48), and also from the sera of healthy subjects (n=23)...
January 2008: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/18270849/whither-autoimmunity-the-lessons-of-anti-ccp-and-b-cell-depletion
#34
JOURNAL ARTICLE
Yehuda Shoenfeld, M Eric Gershwin
The most difficult component to understand in autoimmune disease has been the issue of causation. In contrast, there have been enormous gains in improved diagnostics as well as improved therapy. Indeed, the use of biologics have changed the profile of numerous autoimmune diseases. In this issue, we discuss two such aspects. Firstly, we place in perspective the use of anti-citrullinated protein antibodies in rheumatoid arthritis. Second, we discuss the increasing use of B cell depletion in the treatment of autoimmunity...
February 2008: Clinical Reviews in Allergy & Immunology
https://read.qxmd.com/read/18078619/comparison-of-anti-agalactosyl-igg-antibodies-rheumatoid-factors-and-anti-cyclic-citrullinated-peptide-antibodies-in-the-differential-diagnosis-of-rheumatoid-arthritis-and-its-mimics
#35
COMPARATIVE STUDY
M-C Lu, S-C Hsieh, N-S Lai, K-J Li, C-H Wu, C-L Yu
OBJECTIVE: Anti-agalactosyl IgG antibodies [anti-Gal(0) IgG] have been regarded as a useful serological marker for rheumatoid arthritis (RA). Our aim was to evaluate the clinical usefulness of anti-Gal(0) IgG in the differential diagnosis of rheumatic disorders that mimic RA compared to rheumatoid factors (RF) and anti-cyclic citrullinated peptide antibodies (anti-CCP). METHODS: Sera were collected from 39 patients with RA, 49 patients with primary Sjögren's syndrome (pSjS), 47 patients with systemic lupus erythematosus (SLE), 65 patients with chronic hepatitis B viral infection (HBV), 68 patients with chronic hepatitis C viral infection (HCV) and 19 normal individuals...
September 2007: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/17876647/usefulness-of-anti-ccp-antibodies-in-patients-with-hepatitis-c-virus-infection-with-or-without-arthritis-rheumatoid-factor-or-cryoglobulinemia
#36
JOURNAL ARTICLE
Feng-Cheng Liu, You-Chen Chao, Tsung-Yun Hou, Hsiang-Cheng Chen, Rong-Yaun Shyu, Tsai-Yuan Hsieh, Chen-Hung Chen, Deh-Ming Chang, Jenn-Haung Lai
The presence of antibodies to cyclic citrullinated peptide (CCP) has high specificity in the diagnosis of rheumatoid arthritis (RA). Hepatitis C virus (HCV) infection may induce extra-hepatic manifestations, such as polyarthritis that mimic RA. The aim of this study was to determine the prevalence of anti-CCP antibodies in HCV-infected patients with or without arthritis, rheumatoid factor (RF), or cryoglobulinemia and to investigate whether anti-CCP antibodies may be helpful in discriminating patients with RA from patients with HCV-associated arthropathy...
April 2008: Clinical Rheumatology
https://read.qxmd.com/read/17136313/absence-of-antibody-to-cyclic-citrullinated-peptide-in-sera-of-non-arthritic-patients-with-chronic-hepatitis-b-virus-infection
#37
JOURNAL ARTICLE
Sang-il Lee, Wan Hee Yoo, Hee Jin Yun, Dal Sik Kim, Hye Soo Lee, Sam Im Choi, Ji An Hur, Yong Gon Cho
The objective of this study was to investigate if antibody to cyclic citrullinated peptide (anti-CCP) is detected in sera of patients with chronic hepatitis B virus (HBV) infection. Serum anti-CCP and IgA, IgG, and IgM rheumatoid factor (RF) isotypes were measured by enzyme-linked immunosorbent assay on 176 non-arthritic patients with HBV infection. IgA RF, IgG RF, and IgM RF were detectable in 29.5, 21, and 18.8% of the tested sera, respectively, with a total seropositivity rate of 42.7%. Marginally elevated anti-CCP was detected in one patient (0...
July 2007: Clinical Rheumatology
https://read.qxmd.com/read/17056293/rheumatologic-manifestations-of-chronic-hepatitis-c-infection
#38
REVIEW
Christian Lormeau, Géraldine Falgarone, Dominique Roulot, Marie-Christophe Boissier
The many rheumatologic manifestations associated with chronic hepatitis C virus (HCV) infection include arthralgia, myalgia, arthritis, vasculitis, and sicca syndrome. Arthralgia is the most common extrahepatic manifestation and may indicate mixed cryoglobulinemia or an adverse reaction to interferon therapy. HCV arthritis unrelated to cryoglobulinemia is far less common but constitutes an independent entity. The picture may mimic rheumatoid arthritis (RA), particularly as rheumatoid factor is present in 50-80% of cases...
December 2006: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/16984940/anti-cyclic-citrullinated-peptide-positivity-in-non-rheumatoid-arthritis-disease-samples-citrulline-dependent-or-not
#39
JOURNAL ARTICLE
A Vannini, K Cheung, M Fusconi, J Stammen-Vogelzangs, J P H Drenth, A C Dall'Aglio, F B Bianchi, L E Bakker-Jonges, W J van Venrooij, G J M Pruijn, A J W Zendman
BACKGROUND: Antibodies directed against citrullinated proteins (eg anti-cyclic citrullinated peptide (CCP)) have excellent diagnostic and good prognostic potential for rheumatoid arthritis. Type 1 autoimmune hepatitis (AIH-1) is a chronic liver disease characterised by a variety of serum autoantibodies. Recently, in a large group of patients with AIH-1 without clear rheumatoid arthritis overlap, a relatively high percentage (9%) of anti-CCP2 positivity was scored. OBJECTIVES: To characterise the citrulline-dependence of the observed anti-CCP2 positivity in AIH-1 sera as well as in other groups of patients without rheumatoid arthritis (mainly rheumatic diseases)...
April 2007: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/16474032/anti-cyclic-citrullinated-peptide-antibodies-in-hepatitis-c-virus-associated-rheumatological-manifestations-and-sjogren-s-syndrome
#40
JOURNAL ARTICLE
D Sène, P Ghillani-Dalbin, N Limal, V Thibault, T van Boekel, J-C Piette, P Cacoub
OBJECTIVE: To investigate the diagnostic reliability of anti-CCP antibodies (anti-CCP Ab) in distinguishing hepatitis C virus (HCV) associated rheumatological manifestations and Sjögren's syndrome from rheumatoid arthritis. METHODS: 147 HCV infected patients (HCV RNA positive) were compared with 64 patients with definite rheumatoid arthritis in a retrospective study. Anti-CCP Ab were detected using the Immunoscan ELISA kit (second generation) and rheumatoid factor (RF) by the FIDIStrade mark Rheuma kit...
March 2006: Annals of the Rheumatic Diseases
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