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JOURNAL ARTICLE
Joel W Neal, Katherine Minichiello, Ryan Brennick, Richard S P Huang, Matthew C Hiemenz, Cornel Amler, Jyoti Patel, Roy Herbst, Karen L Reckamp, Hossein Borghaei, Louise Highleyman, Mary W Redman, Lincoln W Pasquina, David E Kozono
For cancer clinical trials that require central confirmation of tumor genomic profiling, exhaustion of tissue from standard-of-care testing may prevent enrollment. For Lung-MAP, a master protocol that requires results from a defined centralized clinical trial assay to assign patients to a therapeutic substudy, we developed a process to repurpose existing commercial vendor raw genomic data for eligibility: genomic data reanalysis (GDR). Molecular results for substudy assignment were successfully generated for 369 of the first 374 patients (98...
April 10, 2024: Oncologist
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JOURNAL ARTICLE
David Sinan Koca, Vladimir Kolpakov, Jana Ihlow, Maximilian von Laffert, Katharina Erb-Eigner, Hermann Herbst, Karen Kriese, Leonille Schweizer, Eckart Bertelmann
The orbital manifestation of a solitary fibrous tumor (SFT) is exceptionally rare and poses specific challenges in diagnosis and treatment. Its rather exceptional behavior among all SFTs comprises a high tendency towards local recurrence, but it rarely culminates in metastatic disease. This raises the question of prognostic factors in orbital SFTs (oSFTs). Telomerase reverse transcriptase ( TERT )-promoter mutations have previously been linked to an unfavorable prognosis in SFTs of other locations. We analyzed the prevalence of TERT promoter mutations of SFTs in the orbital compartment...
February 10, 2024: Current Issues in Molecular Biology
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JOURNAL ARTICLE
Hayley S Clements, Emmanuel Do Linh San, Gareth Hempson, Birthe Linden, Bryan Maritz, Ara Monadjem, Chevonne Reynolds, Frances Siebert, Nicola Stevens, Reinette Biggs, Alta De Vos, Ryan Blanchard, Matthew Child, Karen J Esler, Maike Hamann, Ty Loft, Belinda Reyers, Odirilwe Selomane, Andrew L Skowno, Tshegofatso Tshoke, Diarrassouba Abdoulaye, Thierry Aebischer, Jesús Aguirre-Gutiérrez, Graham J Alexander, Abdullahi H Ali, David G Allan, Esther E Amoako, Samuel Angedakin, Edward Aruna, Nico L Avenant, Gabriel Badjedjea, Adama Bakayoko, Abraham Bamba-Kaya, Michael F Bates, Paul J J Bates, Steven R Belmain, Emily Bennitt, James Bradley, Chris A Brewster, Michael B Brown, Michelle Brown, Josef Bryja, Thomas M Butynski, Filipe Carvalho, Alan Channing, Colin A Chapman, Callan Cohen, Marina Cords, Jennifer D Cramer, Nadine Cronk, Pamela M K Cunneyworth, Fredrik Dalerum, Emmanuel Danquah, Harriet T Davies-Mostert, Andrew D de Blocq, Yvonne A De Jong, Terrence C Demos, Christiane Denys, Chabi A M S Djagoun, Thomas M Doherty-Bone, Marine Drouilly, Johan T du Toit, David A Ehlers Smith, Yvette C Ehlers Smith, Seth J Eiseb, Peter J Fashing, Adam W Ferguson, José M Fernández-García, Manfred Finckh, Claude Fischer, Edson Gandiwa, Philippe Gaubert, Jerome Y Gaugris, Dalton J Gibbs, Jason S Gilchrist, Jose M Gil-Sánchez, Anthony N Githitho, Peter S Goodman, Laurent Granjon, J Paul Grobler, Bonginkosi C Gumbi, Vaclav Gvozdik, James Harvey, Morgan Hauptfleisch, Firas Hayder, Emmanuel M Hema, Marna Herbst, Mariano Houngbédji, Brian J Huntley, Rainer Hutterer, Samuel T Ivande, Kate Jackson, Gregory F M Jongsma, Javier Juste, Blaise Kadjo, Prince K Kaleme, Edwin Kamugisha, Beth A Kaplin, Humphrey N Kato, Christian Kiffner, Duncan M Kimuyu, Robert M Kityo, N'goran G Kouamé, Marcel Kouete T, Aliza le Roux, Alan T K Lee, Mervyn C Lötter, Anne Mette Lykke, Duncan N MacFadyen, Gacheru P Macharia, Zimkitha J K Madikiza, Themb'alilahlwa A M Mahlaba, David Mallon, Mnqobi L Mamba, Claude Mande, Rob A Marchant, Robin A Maritz, Wanda Markotter, Trevor McIntyre, John Measey, Addisu Mekonnen, Paulina Meller, Haemish I Melville, Kevin Z Mganga, Michael G L Mills, Liaan Minnie, Alain Didier Missoup, Abubakr Mohammad, Nancy N Moinde, Bakwo Fils E Moise, Pedro Monterroso, Jennifer F Moore, Simon Musila, Sedjro Gilles A Nago, Maganizo W Namoto, Fatimata Niang, Violaine Nicolas, Jerry B Nkenku, Evans E Nkrumah, Gonwouo L Nono, Mulavwa M Norbert, Katarzyna Nowak, Benneth C Obitte, Arnold D Okoni-Williams, Jonathan Onongo, M Justin O'Riain, Samuel T Osinubi, Daniel M Parker, Francesca Parrini, Mike J S Peel, Johannes Penner, Darren W Pietersen, Andrew J Plumptre, Damian W Ponsonby, Stefan Porembski, R John Power, Frans G T Radloff, Ramugondo V Rambau, Tharmalingam Ramesh, Leigh R Richards, Mark-Oliver Rödel, Dominic P Rollinson, Francesco Rovero, Mostafa A Saleh, Ute Schmiedel, M Corrie Schoeman, Paul Scholte, Thomas L Serfass, Julie Teresa Shapiro, Sidney Shema, Stefan J Siebert, Jasper A Slingsby, Alexander Sliwa, Hanneline A Smit-Robinson, Etotepe A Sogbohossou, Michael J Somers, Stephen Spawls, Jarryd P Streicher, Lourens Swanepoel, Iroro Tanshi, Peter J Taylor, William A Taylor, Mariska Te Beest, Paul T Telfer, Dave I Thompson, Elie Tobi, Krystal A Tolley, Andrew A Turner, Wayne Twine, Victor Van Cakenberghe, Frederik Van de Perre, Helga van der Merwe, Chris J G van Niekerk, Pieter C V van Wyk, Jan A Venter, Luke Verburgt, Geraldine Veron, Susanne Vetter, Maria S Vorontsova, Thomas C Wagner, Paul W Webala, Natalie Weber, Sina M Weier, Paula A White, Melissa A Whitecross, Benjamin J Wigley, Frank J Willems, Christiaan W Winterbach, Galena M Woodhouse
Sub-Saharan Africa is under-represented in global biodiversity datasets, particularly regarding the impact of land use on species' population abundances. Drawing on recent advances in expert elicitation to ensure data consistency, 200 experts were convened using a modified-Delphi process to estimate 'intactness scores': the remaining proportion of an 'intact' reference population of a species group in a particular land use, on a scale from 0 (no remaining individuals) to 1 (same abundance as the reference) and, in rare cases, to 2 (populations that thrive in human-modified landscapes)...
February 12, 2024: Scientific Data
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JOURNAL ARTICLE
Edwin Roger Parra, Jiexin Zhang, Dzifa Yawa Duose, Edgar Gonzalez-Kozlova, Mary W Redman, Hong Chen, Ganiraju C Manyam, Gayatri Kumar, Jianhua Zhang, Xingzhi Song, Rossana Lazcano, Mario L Marques-Piubelli, Caddie Laberiano-Fernandez, Frank Rojas, Baili Zhang, Len Taing, Aashna Jhaveri, Jacob Geisberg, Jennifer Altreuter, Franziska Michor, James Provencher, Joyce Yu, Ethan Cerami, Radim Moravec, Kasthuri Kannan, Rajyalakshmi Luthra, Gheath Alatrash, Hsin-Hui Huang, Hui Xie, Manishkumar Patel, Kai Nie, Jocelyn Harris, Kimberly Argueta, James Lindsay, Roshni Biswas, Stephen Van Nostrand, Seunghee Kim-Schulze, Jhanelle E Gray, Roy Herbst, Ignacio I Wistuba, Scott Gettinger, Karen Kelly, Lyudmila Bazhenova, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Cara Haymaker
BACKGROUND: Identifying molecular and immune features to guide immune checkpoint inhibitor (ICI)-based regimens remains an unmet clinical need. METHODS: Tissue and longitudinal blood specimens from phase III trial S1400I in metastatic lung squamous cell carcinoma (SqNSCLC) patients treated with nivolumab monotherapy (nivo) or nivolumab plus ipilimumab (nivo+ipi) were subjected to multi-omics analyses including multiplex immunofluorescence (mIF), nCounter PanCancer Immune Profiling Panel, whole-exome sequencing, and Olink...
January 26, 2024: Clinical Cancer Research
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JOURNAL ARTICLE
Elsie T Nguyen, Karen Ordovas, Phil Herbst, Rebecca Kozor, Ming-Yen Ng, Luigi Natale, Robin Nijveldt, Rodrigo Salgado, Felipe Sanchez, Dipan Shah, Jadranka Stojanovska, Anne Marie Valente, Mark Westwood, Sven Plein
This position statement guides cardiovascular magnetic resonance (CMR) imaging program directors and learners on the key competencies required for Level II and III CMR practitioners, whether trainees come from a radiology or cardiology background. This document is built upon existing curricula and was created and vetted by an international panel of cardiologists and radiologists on behalf of the Society for Cardiovascular Magnetic Resonance (SCMR).
December 22, 2023: Journal of Cardiovascular Magnetic Resonance
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JOURNAL ARTICLE
Thomas Wright, Megan Babula, Jaime Schwartz, Corbin Wright, Noah Danesh, Karen Herbst
BACKGROUND: Lipedema is a chronic inflammatory subcutaneous adipose-rich connective tissue disease affecting millions of women worldwide. Disproportionate fat accumulation on the extremities characterized by heaviness, tenderness, and swelling can affect function, mobility, and quality of life. Treatments include conservative measures and lipedema reduction surgery (LRS). Here, we report lipedema comorbidities and surgical techniques, outcomes measures, and complications after LRS. METHODS: This is a single outpatient clinic retrospective chart review case series of comorbidities and complications in 189 women with lipedema...
November 2023: Plastic and Reconstructive Surgery. Global Open
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JOURNAL ARTICLE
Aaron W Aday, Paula Mc Donahue, Maria Garza, Vanessa N Crain, Niral J Patel, John A Beasley, Karen L Herbst, Joshua A Beckman, Shannon L Taylor, Michael Pridmore, Sheau-Chiann Chen, Manus J Donahue, Rachelle Crescenzi
BACKGROUND: National survey data exploring the patient experience with lipedema are lacking. METHODS: We conducted national surveys from 2016 to 2022 of women with lipedema as well as female controls. Surveys collected information on symptomatology, pain, and therapies. We performed logistic regression comparing symptoms among those with lipedema versus controls adjusting for age and BMI. RESULTS: A total of 707 women with lipedema and 216 controls completed the surveys...
October 16, 2023: Vascular Medicine
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JOURNAL ARTICLE
Sara Al-Ghadban, Samantha G Walczak, Spencer U Isern, Elizabeth C Martin, Karen L Herbst, Bruce A Bunnell
Lipedema is a connective tissue disorder characterized by increased dilated blood vessels (angiogenesis), inflammation, and fibrosis of the subcutaneous adipose tissue. This project aims to gain insights into the angiogenic processes in lipedema using human umbilical vein endothelial cells (HUVECs) as an in vitro model. HUVECs were cultured in conditioned media (CM) collected from healthy (non-lipedema, AQH) and lipedema adipocytes (AQL). The impacts on the expression levels of multiple endothelial and angiogenic markers [CD31, von Willebrand Factor (vWF), angiopoietin 2 (ANG2), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMPs), NOTCH and its ligands] in HUVECs were investigated...
September 1, 2023: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Riha Vaidya, Joseph M Unger, Lu Qian, Katherine Minichiello, Roy S Herbst, David R Gandara, Joel W Neal, Ticiana A Leal, Jyoti D Patel, Konstantin H Dragnev, Saiama N Waqar, Martin J Edelman, Ellen V Sigal, Stacey J Adam, Shakun Malik, Charles D Blanke, Michael L LeBlanc, Karen Kelly, Jhanelle E Gray, Mary W Redman
PURPOSE: Lung Cancer Master Protocol (Lung-MAP), a public-private partnership, established infrastructure for conducting a biomarker-driven master protocol in molecularly targeted therapies. We compared characteristics of patients enrolled in Lung-MAP with those of patients in advanced non-small-cell lung cancer (NSCLC) trials to examine if master protocols improve trial access. METHODS: We examined patients enrolled in Lung-MAP (2014-2020) according to sociodemographic characteristics...
September 2023: JCO Precision Oncology
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JOURNAL ARTICLE
Reinhard Dummer, Pippa Corrie, Ralf Gutzmer, Tarek M Meniawy, Michele Del Vecchio, Céleste Lebbé, Michele Guida, Caroline Dutriaux, Brigitte Dreno, Nicolas Meyer, Pier Francesco Ferrucci, Stéphane Dalle, Muhammad Adnan Khattak, Jean-Jacques Grob, Karen Briscoe, James Larkin, Sandrine Mansard, Thierry Lesimple, Massimo Guidoboni, Silvia Sabatini, Erika Richtig, Rudolf Herbst, Maurice Lobo, Margarita Askelson, Paolo A Ascierto, Michele Maio
PURPOSE: To address the paucity of data in patients with historically poor outcomes, we conducted the single-arm phase IIIb CheckMate 401 study to evaluate the safety and efficacy of nivolumab plus ipilimumab followed by nivolumab monotherapy in clinically diverse patient populations with advanced melanoma. METHODS: Treatment-naive patients with unresectable stage III-IV melanoma received nivolumab 1 mg/kg plus ipilimumab 3 mg/kg once every 3 weeks (four doses) followed by nivolumab 3 mg/kg (240 mg following a protocol amendment) once every 2 weeks for ≤24 months...
August 10, 2023: Journal of Clinical Oncology
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JOURNAL ARTICLE
Joseph M Unger, Lu Qian, Mary W Redman, Susan S Tavernier, Lori Minasian, Ellen V Sigal, Vassiliki A Papadimitrakopoulou, Michael LeBlanc, Charles S Cleeland, Samuel A Dzingle, Thomas J Summers, Herta Chao, Sheshadri Madhusudhana, Liza Villaruz, Jeffrey Crawford, Jhanelle E Gray, Karen L Kelly, David R Gandara, Lyudmila Bazhenova, Roy S Herbst, Scott N Gettinger, Carol M Moinpour
BACKGROUND: An important issue for patients with cancer treated with novel therapeutics is how they weigh the effects of treatment on survival and quality-of-life (QOL). We compared QOL in patients enrolled to SWOG-1400I, a substudy of the LungMAP biomarker-driven master protocol. METHODS: SWOG S1400I was a randomized phase III trial comparing nivolumab/ipilimumab vs nivolumab for treatment of immunotherapy-naïve disease in advanced squamous cell lung cancer...
January 10, 2023: Journal of the National Cancer Institute
#12
REVIEW
Catherine Baxley, Brian Borsari, Jill V Reavis, Jennifer K Manuel, Ellen Herbst, William Becker, David Pennington, Steven L Batki, Karen Seal
BACKGROUND: Craving is a distressing symptom of opioid use disorder (OUD) that can be alleviated with medications for OUD (MOUD). Buprenorphine is an effective MOUD that may suppress craving; however, treatment discontinuation and resumed opioid use is common during the early phases of treatment. More information on the craving response through the high-risk period of initiating buprenorphine may provide meaningful information on how to better target craving, which in turn may enhance outcomes...
December 17, 2022: Addictive Behaviors
#13
REVIEW
Gabriele Bonetti, Karen L Herbst, Kristjana Dhuli, Aysha Karim Kiani, Serena Michelini, Silvia Michelini, Maria Rachele Ceccarini, Sandro Michelini, Maurizio Ricci, Marina Cestari, Michela Codini, Tommaso Beccari, Francesco Bellinato, Paolo Gisondi, Matteo Bertelli
Lipedema is a chronic disease that mostly manifests in females as the abnormal distribution of subcutaneous adipose connective tissue, usually coupled with bruising, pain, and edema. Lipedema molecular pathophysiology is currently not clear, but several studies suggest that genetics and hormonal imbalance participate in lipedema pathogenesis. Women with lipedema present in some cases with elevated body mass index, and the appearance of obesity in addition to lipedema, where the obesity can cause serious health issues as in lipedema-free individuals with obesity, such as diabetes and cardiovascular disorders...
June 2022: Journal of Preventive Medicine and Hygiene
#14
JOURNAL ARTICLE
Kristjana Dhuli, Gabriele Bonetti, Kyrylo Anpilogov, Karen L Herbst, Stephen Thaddeus Connelly, Francesco Bellinato, Paolo Gisondi, Matteo Bertelli
Differentially expressed genes can serve as drug targets and are used to predict drug response and disease progression. In silico drug analysis based on the expression of these genetic biomarkers allows the detection of putative therapeutic agents, which could be used to reverse a pathological gene expression signature. Indeed, a set of bioinformatics tools can increase the accuracy of drug discovery, helping in biomarker identification. Once a drug target is identified, in vitro cell line models of disease are used to evaluate and validate the therapeutic potential of putative drugs and novel natural molecules...
June 2022: Journal of Preventive Medicine and Hygiene
#15
REVIEW
Aysha Karim Kiani, Derek Pheby, Gary Henehan, Richard Brown, Paul Sieving, Peter Sykora, Robert Marks, Benedetto Falsini, Natale Capodicasa, Stanislav Miertus, Lorenzo Lorusso, Daniele Dondossola, Gianluca Martino Tartaglia, Mahmut Cerkez Ergoren, Munis Dundar, Sandro Michelini, Daniele Malacarne, Gabriele Bonetti, Astrit Dautaj, Kevin Donato, Maria Chiara Medori, Tommaso Beccari, Michele Samaja, Stephen Thaddeus Connelly, Donald Martin, Assunta Morresi, Ariola Bacu, Karen L Herbst, Mykhaylo Kapustin, Liborio Stuppia, Ludovica Lumer, Giampietro Farronato, Matteo Bertelli
Animal experimentation is widely used around the world for the identification of the root causes of various diseases in humans and animals and for exploring treatment options. Among the several animal species, rats, mice and purpose-bred birds comprise almost 90% of the animals that are used for research purpose. However, growing awareness of the sentience of animals and their experience of pain and suffering has led to strong opposition to animal research among many scientists and the general public. In addition, the usefulness of extrapolating animal data to humans has been questioned...
June 2022: Journal of Preventive Medicine and Hygiene
#16
REVIEW
Kristjana Dhuli, Zakira Naureen, Maria Chiara Medori, Francesco Fioretti, Paola Caruso, Marco Alfonso Perrone, Savina Nodari, Paolo Manganotti, Suela Xhufi, Marsida Bushati, Dhurata Bozo, Stephen Thaddeus Connelly, Karen L Herbst, Matteo Bertelli
Physical activity plays a substantial role in maintaining people's good health and mental wellbeing, but that is not all: not only it positively affects the individuals' mental and physical health, but a lack of physical exercise exerts a negative impact also on the overall economy of a nation. In addition, physical inactivity not only increases the risk of non-communicable diseases (NCD), but also contributes significantly to the increased morbidity and mortality in patients suffering from these diseases. On the contrary, physical activity reduces the risk of NCDs - such as cardiovascular diseases, type 2 diabetes, and cancer - in a dose-dependent manner; regular exercise is also associated with many health benefits and delayed mortality...
June 2022: Journal of Preventive Medicine and Hygiene
#17
REVIEW
Aysha Karim Kiani, Gabriele Bonetti, Kevin Donato, Jurgen Kaftalli, Karen L Herbst, Liborio Stuppia, Francesco Fioretti, Savina Nodari, Marco Perrone, Pietro Chiurazzi, Francesco Bellinato, Paolo Gisondi, Matteo Bertelli
Every human being possesses an exclusive nutritional blueprint inside their genes. Bioactive food components and nutrients affect the expression of such genes. Nutrigenomics is the science that analyzes gene-nutrient interactions (nutrigenetics), which can lead to the development of personalized nutritional recommendations to maintain optimal health and prevent disease. Genomic diversity among various ethnic groups might affect nutrients bioavailability as well as their metabolism. Nutrigenomics combines different branches of science including nutrition, bioinformatics, genomics, molecular biology, molecular medicine, and epidemiology...
June 2022: Journal of Preventive Medicine and Hygiene
#18
REVIEW
Zakira Naureen, Simone Cristoni, Kevin Donato, Maria Chiara Medori, Michele Samaja, Karen L Herbst, Barbara Aquilanti, Valeria Velluti, Giuseppina Matera, Francesco Fioretti, Amerigo Iaconelli, Marco Alfonso Perrone, Lorenzo DI Giulio, Emanuele Gregorace, Pietro Chiurazzi, Savina Nodari, Stephen Thaddeus Connelly, Matteo Bertelli
Precision nutrition is an emerging branch of nutrition science that aims to use modern omics technologies (genomics, proteomics, and metabolomics) to assess an individual's response to specific foods or dietary patterns and thereby determine the most effective diet or lifestyle interventions to prevent or treat specific diseases. Metabolomics is vital to nearly every aspect of precision nutrition. It can be targeted or untargeted, and it has many applications. Indeed, it can be used to comprehensively characterize the thousands of chemicals in foods, identify food by-products in human biofluids or tissues, characterize nutrient deficiencies or excesses, monitor biochemical responses to dietary interventions, track long- or short-term dietary habits, and guide the development of nutritional therapies...
June 2022: Journal of Preventive Medicine and Hygiene
#19
REVIEW
Aysha Karim Kiani, Maria Chiara Medori, Gabriele Bonetti, Barbara Aquilanti, Valeria Velluti, Giuseppina Matera, Amerigo Iaconelli, Liborio Stuppia, Stephen Thaddeus Connelly, Karen L Herbst, Matteo Bertelli
The Mediterranean diet is the most well-known and researched dietary pattern worldwide. It is characterized by the consumption of a wide variety of foods, such as extra-virgin olive oil (EVOO), legumes, cereals, nuts, fruits, vegetables, dairy products, fish, and wine. Many of these foods provide several phytonutrients, among which polyphenols and vitamins play an important role. Data from several studies have strongly established that nutrition is a key factor in promoting a healthy lifestyle and preventing many chronic diseases...
June 2022: Journal of Preventive Medicine and Hygiene
#20
REVIEW
Aysha Karim Kiani, Zakira Naureen, Derek Pheby, Gary Henehan, Richard Brown, Paul Sieving, Peter Sykora, Robert Marks, Benedetto Falsini, Natale Capodicasa, Stanislav Miertus, Lorenzo Lorusso, Daniele Dondossola, Gianluca Martino Tartaglia, Mahmut Cerkez Ergoren, Munis Dundar, Sandro Michelini, Daniele Malacarne, Gabriele Bonetti, Kevin Donato, Maria Chiara Medori, Tommaso Beccari, Michele Samaja, Stephen Thaddeus Connelly, Donald Martin, Assunta Morresi, Ariola Bacu, Karen L Herbst, Mykhaylo Kapustin, Liborio Stuppia, Ludovica Lumer, Giampietro Farronato, Matteo Bertelli
A clinical research requires a systematic approach with diligent planning, execution and sampling in order to obtain reliable and validated results, as well as an understanding of each research methodology is essential for researchers. Indeed, selecting an inappropriate study type, an error that cannot be corrected after the beginning of a study, results in flawed methodology. The results of clinical research studies enhance the repertoire of knowledge regarding a disease pathogenicity, an existing or newly discovered medication, surgical or diagnostic procedure or medical device...
June 2022: Journal of Preventive Medicine and Hygiene
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