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Karen Herbst

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https://www.readbyqxmd.com/read/29764856/-tp53-stk11-and-egfr-mutations-predict-tumor-immune-profile-and-the-response-to-anti-pd-1-in-lung-adenocarcinoma
#1
Jérôme Biton, Audrey Mansuet-Lupo, Nicolas Pécuchet, Marco Alifano, Hanane Ouakrim, Jennifer Arrondeau, Pascaline Boudou-Rouquette, François Goldwasser, Karen Leroy, Jeremy Goc, Marie Wislez, Claire Germain, Pierre Laurent-Puig, Marie-Caroline Dieu-Nosjean, Isabelle Cremer, Ronald Herbst, Hélène Blons, Diane Damotte
Purpose: By unlocking antitumor immunity, antibodies targeting programmed cell death 1 (PD-1) exhibit impressive clinical results in non-small cell lung cancer, underlining the strong interactions between tumor and immune cells. However, factors that can robustly predict long-lasting responses are still needed. Experimental Design: We performed in-depth immune profiling of lung adenocarcinoma using an integrative analysis based on immunohistochemistry, flow-cytometry, and transcriptomic data. Tumor mutational status was investigated using next-generation sequencing...
May 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29522416/lipedema-friend-and-foe
#2
REVIEW
Yanira Sanchez-De la Torre, Rita Wadeea, Victoria Rosas, Karen L Herbst
Background Lipedema is a chronic disorder presenting in women during puberty or other times of hormonal change such as childbirth or menopause, characterized by symmetric enlargement of nodular, painful subcutaneous adipose tissue (fat) in the limbs, sparing the hands, feet and trunk. Healthcare providers underdiagnose or misdiagnose lipedema as obesity or lymphedema. Materials and methods The benefits (friend) and negative aspects (foe) of lipedema were collected from published literature, discussions with women with lipedema, and institutional review board approved evaluation of medical charts of 46 women with lipedema...
March 9, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29324785/phylogenetic-diversity-antimicrobial-susceptibility-and-virulence-gene-profiles-of-brachyspira-hyodysenteriae-isolates-from-pigs-in-germany
#3
Jessica Joerling, Stefanie A Barth, Karen Schlez, Hermann Willems, Werner Herbst, Christa Ewers
Swine dysentery (SD) is an economically important diarrheal disease in pigs caused by different strongly hemolytic Brachyspira (B.) species, such as B. hyodysenteriae, B. suanatina and B. hampsonii. Possible associations of epidemiologic data, such as multilocus sequence types (STs) to virulence gene profiles and antimicrobial susceptibility are rather scarce, particularly for B. hyodysenteriae isolates from Germany. In this study, B. hyodysenteriae (n = 116) isolated from diarrheic pigs between 1990 and 2016 in Germany were investigated for their STs, susceptibility to the major drugs used for treatment of SD (tiamulin and valnemulin) and genes that were previously linked with virulence and encode for hemolysins (tlyA, tlyB, tlyC, hlyA, BHWA1_RS02885, BHWA1_RS09085, BHWA1_RS04705, and BHWA1_RS02195), outer membrane proteins (OMPs) (bhlp16, bhlp17...
2018: PloS One
https://www.readbyqxmd.com/read/29206478/lactate-is-oxidized-outside-of-the-mitochondrial-matrix-in-rodent-brain
#4
Eric A F Herbst, Mitchell A J George, Karen Brebner, Graham P Holloway, Daniel A Kane
The nature and existence of mitochondrial lactate oxidation is debated in the literature. Obscuring the issue are disparate findings in isolated mitochondria, as well as relatively low rates of lactate oxidation observed in permeabilized muscle fibres. However, respiration with lactate has yet to be directly assessed in brain tissue with the mitochondrial reticulum intact. To determine if lactate is oxidized in the matrix of brain mitochondria, oxygen consumption was measured in saponin-permeabilized mouse brain cortex samples, and rat prefrontal cortex and hippocampus (dorsal) subregions...
May 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29169877/cetuximab-plus-carboplatin-and-paclitaxel-with-or-without-bevacizumab-versus-carboplatin-and-paclitaxel-with-or-without-bevacizumab-in-advanced-nsclc-swog-s0819-a-randomised-phase-3-study
#5
Roy S Herbst, Mary W Redman, Edward S Kim, Thomas J Semrad, Lyudmila Bazhenova, Gregory Masters, Kurt Oettel, Perry Guaglianone, Christopher Reynolds, Anand Karnad, Susanne M Arnold, Marileila Varella-Garcia, James Moon, Philip C Mack, Charles D Blanke, Fred R Hirsch, Karen Kelly, David R Gandara
BACKGROUND: EGFR antibodies have shown promise in patients with advanced non-small-cell lung cancer (NSCLC), particularly with squamous cell histology. We hypothesised that EGFR copy number by fluorescence in-situ hybridisation (FISH) can identify patients most likely to benefit from these drugs combined with chemotherapy and we aimed to explore the activity of cetuximab with chemotherapy in patients with advanced NSCLC who are EGFR FISH-positive. METHODS: We did this open-label, phase 3 study (SWOG S0819) at 277 sites in the USA and Mexico...
January 2018: Lancet Oncology
https://www.readbyqxmd.com/read/28930626/pilot-study-whole-body-manual-subcutaneous-adipose-tissue-sat-therapy-improved-pain-and-sat-structure-in-women-with-lipedema
#6
Karen L Herbst, Christopher Ussery, Alyna Eekema
Background Lipedema is a common painful subcutaneous adipose tissue (SAT) disorder in women affecting the limbs. SAT therapy is a manual therapy to improve soft tissue quality. Objective Determine if SAT therapy improves pain and structure of lipedema SAT. Design Single arm prospective pilot study. Setting Academic medical center. Patients Seven women, 46 ± 5 years, weight 90 ± 19 kg, with lipedema. Intervention Twelve 90-min SAT therapy sessions over 4 weeks. Outcomes Dual X-ray absorptiometry (DXA) scans, SAT ultrasound (Vevo 2100), leg volumetrics, skin caliper assessment, tissue exam, weight, resting metabolic rate, pain assessment, lower extremity functional scale (LEFS) and body shape questionnaire (BSQ) at baseline and end of study...
September 20, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27757353/lipedema-a-relatively-common-disease-with-extremely-common-misconceptions
#7
Donald W Buck, Karen L Herbst
Lipedema, or adiposis dolorosa, is a common adipose tissue disorder that is believed to affect nearly 11% of adult women worldwide. It is characterized most commonly by disproportionate adipocyte hypertrophy of the lower extremities, significant tenderness to palpation, and a failure to respond to extreme weight loss modalities. Women with lipedema report a rapid growth of the lipedema subcutaneous adipose tissue in the setting of stress, surgery, and/or hormonal changes. Women with later stages of lipedema have a classic "column leg" appearance, with masses of nodular fat, easy bruising, and pain...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27229180/the-international-association-for-the-study-of-lung-cancer-consensus-statement-on-optimizing-management-of-egfr-mutation-positive-non-small-cell-lung-cancer-status-in-2016
#8
REVIEW
Daniel S W Tan, Sue S Yom, Ming S Tsao, Harvey I Pass, Karen Kelly, Nir Peled, Rex C Yung, Ignacio I Wistuba, Yasushi Yatabe, Michael Unger, Philip C Mack, Murry W Wynes, Tetsuya Mitsudomi, Walter Weder, David Yankelevitz, Roy S Herbst, David R Gandara, David P Carbone, Paul A Bunn, Tony S K Mok, Fred R Hirsch
Mutations in the epidermal growth factor receptor gene (EGFR) represent one of the most frequent "actionable" alterations in non-small cell lung cancer (NSCLC). Typified by high response rates to targeted therapies, EGFR tyrosine kinase inhibitors (TKIs) are now established first-line treatment options and have transformed the treatment paradigm for NSCLC. With the recent breakthrough designation and approval of the third-generation EGFR TKI osimertinib, available systemic and local treatment options have expanded, requiring new clinical algorithms that take into account individual patient molecular and clinical profiles...
July 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27052032/right-test-wrong-patient-biomarkers-and-value
#9
Catherine S Forster, Karen E Jerardi, Lori Herbst, Patrick W Brady
No abstract text is available yet for this article.
May 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/25769412/differences-in-weight-loss-between-persons-on-standard-balanced-vs-nutrigenetic-diets-in-a-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Karen A Frankwich, Jeremy Egnatios, Mandy L Kenyon, Thomas R Rutledge, Patricia S Liao, Samir Gupta, Karen L Herbst, Amir Zarrinpar
BACKGROUND & AIMS: Many companies provide genetic tests for obesity-related polymorphisms (nutrigenetics) and make dietary recommendations for weight loss that are based on the results. We performed a randomized controlled trial to determine whether more participants who followed a nutrigenetic-guided diet lost ≥5% of their body weight than participants on a standard balanced diet for 8 and 24 weeks. METHODS: We performed a prospective study of 51 obese or overweight U...
September 2015: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/25044620/an-abnormal-lymphatic-phenotype-is-associated-with-subcutaneous-adipose-tissue-deposits-in-dercum-s-disease
#11
John C Rasmussen, Karen L Herbst, Melissa B Aldrich, Chinmay D Darne, I-Chih Tan, Banghe Zhu, Renie Guilliod, Caroline E Fife, Erik A Maus, Eva M Sevick-Muraca
OBJECTIVE: Investigational, near-infrared fluorescence (NIRF) lymphatic imaging was used to assess lymphatic architecture and contractile function in participants diagnosed with Dercum's disease, a rare, poorly understood disorder characterized by painful lipomas in subcutaneous adipose tissues. METHODS: After informed consent and as part of an FDA-approved feasibility study to evaluate lymphatics in diseases in which their contribution has been implicated, three women diagnosed with Dercum's disease and four control subjects were imaged...
October 2014: Obesity
https://www.readbyqxmd.com/read/24485426/heat-related-deaths-in-adelaide-south-australia-review-of-the-literature-and-case-findings-an-australian-perspective
#12
Jonathon Herbst, Kerryn Mason, Roger W Byard, John D Gilbert, Cheryl Charlwood, Karen J Heath, Carl Winskog, Neil E I Langlois
Heat waves are not uncommon in Australia, but the event of 2009 was particularly severe and ranks third of the 21 recorded heat wave events in south-eastern Australia in terms of the resulting mortality and morbidity. This is a review of Coronial autopsy findings in South Australia (which has an area of nearly 1 million square kilometres with a population of 1.6 million that predominantly resides within the region of the capital: Adelaide) during the period of the 2009 heat wave. Fifty-four post-mortem examinations were performed on cases in which exposure to high ambient temperature was regarded as having caused or significantly contributed to the death...
February 2014: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/24344872/testosterone-with-dutasteride-but-not-anastrazole-improves-insulin-sensitivity-in-young-obese-men-a-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Patricia S Juang, Susan Peng, Kambiz Allehmazedeh, Ansal Shah, Andrea D Coviello, Karen L Herbst
INTRODUCTION: Testosterone (T) administration to men increases T, estradiol (E2), dihydrotestosterone (DHT), and fat-free mass (FFM), and decreases fat mass (FM) but does not consistently improve insulin sensitivity (IS). AIM: The aim of this study was to examine the effects of T administration in obese, nondiabetic men on body composition and IS, and to determine if inhibition (i) of metabolism of T to E2 with anastrazole or to DHT with dutasteride alters these effects...
February 2014: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/24189513/phase-ii-trial-of-carboplatin-paclitaxel-cetuximab-and-bevacizumab-followed-by-cetuximab-and-bevacizumab-in-advanced-nonsquamous-non-small-cell-lung-cancer-swog-s0536
#14
Edward S Kim, James Moon, Roy S Herbst, Mary W Redman, Shaker R Dakhil, Mario R Velasco, Fred R Hirsch, Philip C Mack, Karen Kelly, John V Heymach, David R Gandara
INTRODUCTION: Cetuximab and bevacizumab have each been demonstrated to prolong survival when added to chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC). However, the potential benefit of combining cetuximab and bevacizumab together with a platinum-based doublet had not been explored. We designed this phase II trial to evaluate the safety, tolerability, and efficacy of the combination of carboplatin, paclitaxel, cetuximab, and bevacizumab in chemotherapy-naive patients with advanced, nonsquamous NSCLC...
December 2013: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/23910839/multiple-bee-stings-peritumoral-mast-cell-degranulation-and-anaphylaxis-is-there-a-relationship
#15
Jonathon Herbst, Karen Heath, Robert Heddle, John D Gilbert, Roger W Byard
A case of a 58-year-old with fatal anaphylaxis due to multiple bee stings is reported. Supportive evidence for anaphylaxis included post-mortem serum tests, which demonstrated a markedly elevated tryptase level and increased sensitivity to bees on radioallergosorbent test (RAST). At autopsy a previously undiagnosed esophageal adenocarcinoma involving the gastroesophageal (GE) junction was also identified. Histology of the tumor demonstrated significant numbers of mast cells, many of which were degranulating...
August 2013: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/23528749/developing-a-patient-centered-ishaped-handoff-with-patient-family-and-parent-advisory-councils
#16
Mary Ann Friesen, Anna Herbst, Jeanine Warisse Turner, Karen Gabel Speroni, James Robinson
Our hospital system used Lean strategies to develop a new process for the change-of-shift bedside handoff titled ISHAPED (I = Introduce, S = Story, H = History, A = Assessment, P = Plan, E = Error Prevention, and D = Dialogue). Several teams collaborated with a Parent Advisory Council and a Patient/Family Advisory Council to design a study to explore patient perceptions of the handoff. The findings from the study along with recommendations from the councils were used to develop education modules on implementing patient-centered handoffs...
July 2013: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/23378138/the-2011-2016-transdisciplinary-research-on-energetics-and-cancer-trec-initiative-rationale-and-design
#17
Ruth E Patterson, Graham A Colditz, Frank B Hu, Kathryn H Schmitz, Rexford S Ahima, Ross C Brownson, Kenneth R Carson, Jorge E Chavarro, Lewis A Chodosh, Sarah Gehlert, Jeff Gill, Karen Glanz, Debra Haire-Joshu, Karen Louise Herbst, Christine M Hoehner, Peter S Hovmand, Melinda L Irwin, Linda A Jacobs, Aimee S James, Lee W Jones, Jacqueline Kerr, Adam S Kibel, Irena B King, Jennifer A Ligibel, Jeffrey A Meyerhardt, Loki Natarajan, Marian L Neuhouser, Jerrold M Olefsky, Enola K Proctor, Susan Redline, Cheryl L Rock, Bernard Rosner, David B Sarwer, J Sanford Schwartz, Dorothy D Sears, Howard D Sesso, Meir J Stampfer, S V Subramanian, Elsie M Taveras, Julia Tchou, Beti Thompson, Andrea B Troxel, Marianne Wessling-Resnick, Kathleen Y Wolin, Mark D Thornquist
PURPOSE: Recognition of the complex, multidimensional relationship between excess adiposity and cancer control outcomes has motivated the scientific community to seek new research models and paradigms. METHODS: The National Cancer Institute developed an innovative concept to establish a center grant mechanism in nutrition, energetics, and physical activity, referred to as the Transdisciplinary Research on Energetics and Cancer (TREC) Initiative. This paper gives an overview of the 2011-2016 TREC Collaborative Network and the 15 research projects being conducted at the centers...
April 2013: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/23326516/a-mutation-causes-musk-reduced-sensitivity-to-agrin-and-congenital-myasthenia
#18
Asma Ben Ammar, Payam Soltanzadeh, Stéphanie Bauché, Pascale Richard, Evelyne Goillot, Ruth Herbst, Karen Gaudon, Caroline Huzé, Laurent Schaeffer, Yuji Yamanashi, Osamu Higuchi, Antoine Taly, Jeanine Koenig, Jean-Paul Leroy, Fayçal Hentati, Hossein Najmabadi, Kimia Kahrizi, Manouchehr Ilkhani, Michel Fardeau, Bruno Eymard, Daniel Hantaï
Congenital myasthenic syndromes (CMSs) are a heterogeneous group of genetic disorders affecting neuromuscular transmission. The agrin/muscle-specific kinase (MuSK) pathway is critical for proper development and maintenance of the neuromuscular junction (NMJ). We report here an Iranian patient in whom CMS was diagnosed since he presented with congenital and fluctuating bilateral symmetric ptosis, upward gaze palsy and slowly progressive muscle weakness leading to loss of ambulation. Genetic analysis of the patient revealed a homozygous missense mutation c...
2013: PloS One
https://www.readbyqxmd.com/read/23025537/proof-of-concept-matrix-metalloproteinase-inhibitor-decreases-inflammation-and-improves-muscle-insulin-sensitivity-in-people-with-type-2-diabetes
#19
Karen Frankwich, Courtney Tibble, Moises Torres-Gonzalez, Mariah Bonner, Roy Lefkowitz, Matt Tyndall, Geert W Schmid-Schönbein, Francisco Villarreal, Mike Heller, Karen Herbst
UNLABELLED: HASH(0x4bb27f8) BACKGROUND: Obesity is a state of subclinical inflammation resulting in loss of function of insulin receptors and decreased insulin sensitivity. Inhibition of the inflammatory enzymes, matrix metalloproteinases (MMPs), for 6 months in rodent models restores insulin receptor function and insulin sensitivity. METHODS: This 12-week double-blind, randomized, placebo (PL)-controlled proof-of-concept study was performed to determine if the MMP inhibitor (MMPI), doxycycline, decreased global markers of inflammation and enhanced muscle insulin sensitivity in obese people with type 2 diabetes (DM2)...
October 1, 2012: Journal of Inflammation
https://www.readbyqxmd.com/read/23011461/five-year-changes-in-psychiatric-treatment-status-and-weight-related-comorbidities-following-bariatric-surgery-in-a-veteran-population
#20
Thomas Rutledge, Abby L Braden, Gina Woods, Karen L Herbst, Lisa M Groesz, Michelle Savu
BACKGROUND: Although bariatric surgery is an established treatment for obesity, less is known regarding the long-term effects of surgery on psychiatric function. This paper reports changes in psychiatric treatment status, weight, and weight-related comorbidities over 5 years of follow-up among a population of veterans completing bariatric surgery. METHODS: We assessed 55 veterans undergoing bariatric surgery at a single Veteran Affairs medical center for 5 years post-surgery...
November 2012: Obesity Surgery
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