Sean N Avedissian, Johid R Malik, Anthony T Podany, Michael Neely, Nathaniel J Rhodes, Kimberly K Scarsi, Marc H Scheetz, Michael J Duryee, Ukamaka O Modebelu, Timothy M Mykris, Lee C Winchester, Siddappa N Byrareddy, Courtney V Fletcher
Three years after SARS-CoV-2 emerged as a global infectious threat, the virus has become endemic. The neurological complications such as depression, anxiety, and other CNS complications after COVID-19 disease are increasing. The brain, and CSF have been shown as viral reservoirs for SARS-CoV-2, yielding a potential hypothesis for CNS effects. Thus, we investigated the CNS pharmacology of orally dosed nirmatrelvir/ritonavir (NMR/RTV). Using both an in vitro and an in vivo rodent model, we investigated CNS penetration and potential pharmacodynamic activity of NMR...
May 10, 2024: Scientific Reports