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Mitochondria Cancer

Kuan-Fu Liao, Tsung-Lang Chiu, Sung-Ying Huang, Teng-Fu Hsieh, Shu-Fang Chang, Jhen-Wei Ruan, Shee-Ping Chen, Cheng-Yoong Pang, Sheng-Chun Chiu
BACKGROUND/AIMS: Radix Angelica Sinensis (danggui in Chinese) is widely used in traditional chinese medicine (TCM). N-butylidenephthalide (BP), a bioactive compound in danggui, is a potential antitumor agent for various cancer types. However, its clinical effect and mechanism in the treatment of gastric cancer remain undetermined. METHODS: The in vivo protective effect of danggui in patients with gastric cancer were validated using data from Taiwan's National Health Insurance Research Database (NHIRD)...
August 16, 2018: Cellular Physiology and Biochemistry
Yongfeng Tian, Hua Zhang, Yanmei Qin, Dong Li, Yang Liu, Hao Wang, Li Gan
As a major cause for the inefficiency of cancer chemotherapy, multidrug resistance (MDR) has become a major barrier to cancer treatment. Mitochondrion-orientated transportation of smart liposomes has been developed as a promising strategy to deliver anticancer drugs directly to tumor sites and actively target the mitochondria, so that drugs can interfere with mitochondrial function and facilitate cell apoptosis, overcoming MDR. Herein, we report a novel dual-functional paclitaxel (PTX) liposome system possessing both CD44 targeting and mitochondrial targeting properties to enhance drug accumulation in mitochondria and trigger apoptosis of drug-resistant cancer cells...
August 16, 2018: Drug Development and Industrial Pharmacy
Sangiliyandi Gurunathan, Min-Hee Kang, Jin-Hoi Kim
Although many treatment strategies have been reported for lung disease, the mechanism of combination therapy using silver nanoparticles (AgNPs) and histone deacetylases inhibitors (HDACi) remains unclear. Therefore, innovative treatment strategies are essential for addressing the therapeutic challenges of this highly aggressive lung cancer. AgNPs and HDACi seem to be the best candidates for anticancer therapy because of their anti-proliferative effect in a variety of cancer cells. First, we synthesized AgNPs using wogonin as a reducing and stabilizing agent, following which the synthesized AgNPs were characterized by various analytical techniques...
August 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Heng Zhou, Yu Liu, Chao Wang, Limei Liu, Huan Wang, Yaqian Zhang, Cong Long, Xiaoping Sun
BACKGROUND: Epstein-Barr virus (EBV) is widely found in nasopharyngeal carcinoma (NPC) tissue and associated with poor prognosis of patients. EBV nuclear antigen 1 (EBNA1) is expressed in all NPC tumors and plays multiple biological roles in both virus and host cells. Triptolide is a natural product extracted from Tripterygium and shows anti-cancer activities. The goal of this work was to illustrate the anti-cancer effect of triptolide and elucidate a novel anti-apoptotic mechanism of EBNA1 in NPC cells encountered with triptolide...
August 15, 2018: Journal of Experimental & Clinical Cancer Research: CR
Li-Juan He, Jin-Sheng Li, Xia Chen, Han-Tao Zhang, Xiao-Guang Zhu, Xiao-di Zhang, Su-Hua Xie, Hai-Ou Gu
To study the effect of serum containing Xihuang pill on the proliferation of human breast cancer cell lines MDA-MB-435 and MCF-7 and the gene and protein expressions of Bcl-2, Bax, TP53, in order to explore the effect and mechanism of Xihuang pill in resisting breast cancer. The serum of the rats was prepared by the method of MTT assay. The expressions of Bcl-2 and Bax were detected by RT-PCR. The serum levels of Bcl-2 and Bax and the mRNA expression of TP53 were detected by immunofluorescence. The rats with serum containing Xihuang pill could inhibit the proliferation of MDA-MB-435 cells and MCF-7 cells ( P <0...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Juan Manuel Vazquez, Michael Sulak, Sravanthi Chigurupati, Vincent J Lynch
Large-bodied organisms have more cells that can potentially turn cancerous than small-bodied organisms, imposing an increased risk of developing cancer. This expectation predicts a positive correlation between body size and cancer risk; however, there is no correlation between body size and cancer risk across species ("Peto's paradox"). Here, we show that elephants and their extinct relatives (proboscideans) may have resolved Peto's paradox in part through refunctionalizing a leukemia inhibitory factor pseudogene (LIF6) with pro-apoptotic functions...
August 14, 2018: Cell Reports
Jiyong Hu, Chunli Liao, Ruina Mao, Junshuai Zhang, Jin'an Zhao, Zhenzhen Gu
Copper is an essential element and has redox potential, thus copper complexes have been developed rapidly with the hope of curing cancer. To further develop anticancer agents and investigate their anticancer mechanisms, two Cu complexes, [Cu(bpbb)0.5 ·Cl·SCN]·(CH3 OH) ( 1 ) and [Cu2 (bpbb)·Br3 ·(OH)] n ( 2 ), were synthesized and characterized using 4,4'-bis((2-(pyridin-2-yl)-1 H -benzo[ d ]imidazol-1-yl)methyl)biphenyl (bpbb), with associated Cu(ii) salts. Complex 1 is a binuclear structure, whereas 2 is a one-dimensional complex...
February 1, 2018: MedChemComm
Darya A Nedopekina, Rinat R Gubaidullin, Victor N Odinokov, Polina V Maximchik, Boris Zhivotovsky, Yuriy P Bel'skii, Veniamin A Khazanov, Arina V Manuylova, Vladimir Gogvadze, Anna Yu Spivak
A series of new betulinic and ursolic acid conjugates with a lipophilic triphenylphosphonium cation, meant to enhance the bioavailability and mitochondriotropic action of natural triterpenes, have been synthesized. The in vitro experiments on three human cancer cell lines (MCF-7, HCT-116 and TET21N) revealed that all the obtained triphenylphosphonium triterpene acid derivatives not only showed higher cytotoxicity as compared to betulinic acid but were also markedly superior in triggering mitochondria-dependent apoptosis, as assessed using a range of apoptosis markers such as cytochrome c release, stimulation of caspase-3 activity, and cleavage of poly(ADP-ribose) polymerase, which is one of the targets of caspase 3...
October 1, 2017: MedChemComm
Raj K Gopal, Kirsten Kübler, Sarah E Calvo, Paz Polak, Dimitri Livitz, Daniel Rosebrock, Peter M Sadow, Braidie Campbell, Samuel E Donovan, Salma Amin, Benjamin J Gigliotti, Zenon Grabarek, Julian M Hess, Chip Stewart, Lior Z Braunstein, Peter F Arndt, Scott Mordecai, Angela R Shih, Frances Chaves, Tiannan Zhan, Carrie C Lubitz, Jiwoong Kim, A John Iafrate, Lori Wirth, Sareh Parangi, Ignaty Leshchiner, Gilbert H Daniels, Vamsi K Mootha, Dora Dias-Santagata, Gad Getz, David G McFadden
Hürthle cell carcinoma of the thyroid (HCC) is a form of thyroid cancer recalcitrant to radioiodine therapy that exhibits an accumulation of mitochondria. We performed whole-exome sequencing on a cohort of primary, recurrent, and metastatic tumors, and identified recurrent mutations in DAXX, TP53, NRAS, NF1, CDKN1A, ARHGAP35, and the TERT promoter. Parallel analysis of mtDNA revealed recurrent homoplasmic mutations in subunits of complex I of the electron transport chain. Analysis of DNA copy-number alterations uncovered widespread loss of chromosomes culminating in near-haploid chromosomal content in a large fraction of HCC, which was maintained during metastatic spread...
August 13, 2018: Cancer Cell
Maria Mastrangelopoulou, Mantas Grigalavicius, Kristian Berg, Mathilde Menard, Theodossis A Theodossiou
Cercosporin is a naturally occurring perylenequinone. Although other perylenequinones have been extensively studied as photosensitizers in photodynamic therapy of cancer (PDT), cercosporin has been studied in this light only within the remits of phytopathology. Herein we investigated the photocytotoxicity of cercosporin against two glioblastoma multiforme (T98G and U87) and one breast adenocarcinoma (MCF7) human cell lines. Cercosporin was found to be a potent singlet oxygen producer upon 532nm excitation, while its cell loading was similar for MCF7 and U87, but approximately 3-fold higher for T98G cells...
August 14, 2018: Photochemistry and Photobiology
Ping Zhang, Yang Li, Xinyu Tang, Rui Guo, Jiuling Li, Ying Ying Chen, Hua Guo, Jing Su, Liankun Sun, Yanan Liu
Paclitaxel‑based chemotherapy is a promising approach for prostate cancer treatment. However, single‑drug chemotherapy is associated with an increased risk of drug resistance. Therefore, novel combination chemotherapy regimens are a popular topic of research. Zinc participates in the regulation of apoptosis, for example in the form of Zn2+ and via zinc‑dependent enzymes. Zinc can either induce or suppress apoptosis, and its effect depends primarily on its concentration. Previous research has demonstrated that physiological concentrations of zinc can directly induce apoptosis of PC‑3 prostate cancer cells via the mitochondrial pathway...
August 2, 2018: Oncology Reports
Jin Sun Lee, Myung Sun Lee, Eun Young Cha, Phuong Thien Thuong, Ji Young Sul, Jun Beom Park, Young Bok Ko
Ovarian cancer is one of the most common causes of female mortalities from gynecological tumors. An ent‑kaurane diterpenoid compound CRT1 (ent‑18‑acetoxy‑7β‑hydroxy kaur‑15‑oxo‑16‑ene), mainly isolated from the Vietnamese herb Croton tonkinesis has been used in folk medicine in Vietnam for cancer treatment. However, the effect of this compound on human ovarian cancer cells has not yet been reported. The objective of the present study was to determine the effect of CRT1 on the cell viability, apoptosis and metastasis of SKOV3 human ovarian cancer cells using a Cell Counting Kit‑8 assay, flow cytometric analysis of Annexin V‑fluorescein isothiocyanate/propidium iodide staining, western blot analysis, soft agar colony forming assay, wound healing assay and Matrigel invasion assay...
August 9, 2018: Molecular Medicine Reports
Jie Yin, Wenkai Ren, Xingguo Huang, Jinping Deng, Tiejun Li, Yulong Yin
Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer. The de novo biosynthesis of purine depends on six enzymes to catalyze the conversion of phosphoribosylpyrophosphate to inosine 5'-monophosphate. These enzymes cluster around mitochondria and microtubules to form purinosome, which is a multi-enzyme complex involved in de novo purine biosynthesis and purine nucleotides requirement...
2018: Frontiers in Immunology
Meng-Yu Wu, Giuo-Teng Yiang, Pei-Wen Cheng, Pei-Yi Chu, Chia-Jung Li
Hepatocarcinogenesis comprises of multiple, complex steps that occur after liver injury and usually involve several pathways, including telomere dysfunction, cell cycle, WNT/β-catenin signaling, oxidative stress and mitochondria dysfunction, autophagy, apoptosis, and AKT/mTOR signaling. Following liver injury, gene mutations, accumulation of oxidative stress, and local inflammation lead to cell proliferation, differentiation, apoptosis, and necrosis. The persistence of this vicious cycle in turn leads to further gene mutation and dysregulation of pro- and anti-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-10, IL-12, IL-13, IL-18, and transforming growth factor (TGF)-β, resulting in immune escape by means of the NF-κB and inflammasome signaling pathways...
August 13, 2018: Journal of Clinical Medicine
Xiu-Zhen Wang, Zhi Jia, Hui-Hui Yang, Yun-Jun Liu
A new series of dibenzoxanthene derivatives 4a-4d (4a: 1-oxo-5-bromo-11-cyano-13c-methoxy-1,13c-dihydroxyl-dibenzo[a,kl]xanthene, 4b: 1-oxo-5-bromo-11-cyano-13c-ethoxy-1,13c-dihydroxyl-dibenzo[a,kl]xanthene, 4c: 1-oxo-5-bromo-11-cyano-13c-propoxy-1,13c-dihydroxyl-dibenzo[a,kl]xanthene and 4d: 1-oxo-5-bromo-11-cyano-13c-butoxy-1,13c-dihydroxyl-dibenzo[a,kl]xanthene) were synthesized and the molecular mechanisms of anti-cancer activities were investigated. These compounds showed excellent anti-tumor activity against A549, Eca-109, HeLa, HepG2 and SGC-7901 cell lines...
August 6, 2018: Journal of Photochemistry and Photobiology. B, Biology
Hong Su, Zhou Li, Lissy Lazar, Yasmin Alhamoud, Xin Song, Juan Li, Yafei Wang, Samuel Selorm Fiati Kenston, Muhammad Zubair Lqbal, Aiguo Wu, Zhen Li, Qihang Hua, Min Ding, Jinshun Zhao
Recent studies show that Janus Fe3 O4 -TiO2 nanoparticles (NPs) have potential applications as a multifunctional agent of magnetic resonance imaging (MRI) and photodynamic therapy (PDT) for the diagnosis and therapy of cancer. However, little work has been done on their biological effects. To evaluate the toxicity and underlying molecular mechanisms of Janus Fe3 O4 -TiO2 nanoparticles, an in vitro study using a human liver cell line HL-7702 cells was conducted. For comparison, the Janus Fe3 O4 -TiO2 NPs parent material TiO2 NPs was also evaluated...
August 11, 2018: Environmental Toxicology
Cristina Lorente, Laura Cabeza, Beatriz Clares, Raúl Ortiz, Lyda Halbaut, Ángel V Delgado, Gloria Perazzoli, José Prados, José L Arias, Consolación Melguizo
Magnetoliposomes (MLPs) offer many new possibilities in cancer therapy and diagnosis, including the transport of antitumor drugs, hyperthermia treatment, detection using imaging techniques, and even cell migration. However, high biocompatibility and functionality after cell internalization are essential to their successful application. We synthesized maghemite nanoparticles (γ-Fe2 O3 ) by oxidizing magnetite cores (Fe3 O4 ) and coating them with phosphatidylcholine (PC) liposomes, obtained using the thin film hydration method, to generate MLPs...
July 31, 2018: Colloids and Surfaces. B, Biointerfaces
Lihua Zhou, Yayun Wu, Xiaoqing Meng, Sanpeng Li, Jiali Zhang, Ping Gong, Pengfei Zhang, Tao Jiang, Guanjun Deng, Wenjun Li, Zhihong Sun, Lintao Cai
Phototherapy is a promising treatment method for cancer therapy. However, the various factors have greatly restricted phototherapy development, including the poor accumulation of photosensitizer in tumor, hypoxia in solid tumor tissue and systemic phototoxicity. Herein, a mitochondrial-targeted multifunctional dye-anchored manganese oxide nanoparticle (IR808@MnO NP) is developed for enhancing phototherapy of cancer. In this nanoplatform, IR808 as a small molecule dye acts as a tumor targeting ligand to make IR808@MnO NPs with capacity to actively target tumor cells and relocate finally in the mitochondria...
August 10, 2018: Small
Liqun Chen, Lingjuan Wu, Linyan Zhu, Yiyi Zhao
The nuclear receptor RXRα (retinoid X receptor-α) is a transcription factor that regulates the expression of multiple genes. Its non-genomic function is largely related to its structure, polymeric forms and modification. Previous research revealed that some non-genomic activity of RXRα occurs via formation of heterodimers with Nur77. RXRα-Nur77 heterodimers translocate from the nucleus to the mitochondria in response to certain apoptotic stimuli and this activity correlates with cell apoptosis. More recent studies revealed a significant role for truncated RXRα (tRXRα), which interacts with the p85α subunit of the PI3K/AKT signaling pathway, leading to enhanced activation of AKT and promoting cell growth in vitro and in animals...
2018: Cellular & Molecular Biology Letters
Cristian Ruiz-Moreno, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio
Neuroblastoma (NB) is the most common neoplasm during infancy. Unfortunately, NB is still a lethal cancer. Therefore, innovative curative therapies are immediately required. In this study, we showed the pro-death activity of TPGS in human NB SK-N-SH cancer cells. NB cells were exposed to TPGS (10-80 μM). We report for the first time that TPGS induces cell death by apoptosis in NB cells via a pro-oxidant-mediated signaling pathway. Certainly, H2O2 directly oxidizes DJ-1 cysteine106-thiolate into DJ-1 cysteine106-sulfonate; indirectly activates the transcription factors NF-kappaB, P53 and c-JUN; induces up-regulation of mitochondria regulator proteins BAX/PUMA; provokes loss of mitochondrial membrane potential (m) and activation of CASPASE-3/AIF, leading to nuclear disintegration, demonstrated by cellular and biochemical techniques such as fluorescence microscopy, flow cytometry and Western blot analysis...
August 9, 2018: Chemical Research in Toxicology
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