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https://www.readbyqxmd.com/read/30115565/transmembrane-mucin-muc13-distinguishes-intraductal-papillary-mucinous-neoplasms-from-non-mucinous-cysts-and-is-associated-with-high-risk-lesions
#1
Zachary E Stiles, Sheema Khan, Kurt T Patton, Meena Jaggi, Stephen W Behrman, Subhash C Chauhan
BACKGROUND: Intraductal papillary mucinous neoplasms (IPMN) are currently managed based on imaging characteristics and cyst fluid sampling. This study was designed to determine if MUC13, a glycoprotein aberrantly overexpressed in pancreatic adenocarcinoma, might aid in distinguishing high-risk lesions (high grade dysplasia/invasive disease) from low-grade lesions. METHODS: MUC13 immunohistochemical staining was performed on surgically resected formalin-fixed tissue specimens from 49 IPMNs and 23 non-mucinous cysts...
August 13, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30113486/novel-surgical-treatment-of-abdominal-aortic-aneurysm-complicated-with-primary-aorto-colonic-fistula-a-case-report
#2
Maoxun Huang, Hulin Piao, Yong Wang, Weitie Wang, Shibo Wei, Chulong Xie, Kexiang Liu
RATIONALE: Primary aorto-colonic fistula is a rare complication of an abdominal aortic aneurysm. Without surgical treatment, the associated mortality rate is 100%. Even if patients receive timely surgical treatment, they may still die of complications such as infection. PATIENT CONCERNS: A 65-year-old male patient was transferred to our hospital because of massive hematochezia and abdominal pain. DIAGNOSES: Aortic computed tomography angiography demonstrated abdominal aortic aneurysm complicated with aorto-enteric fistula...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30110565/epigenetic-modification-of-intestinal-smooth-muscle-cell-phenotype-during-proliferation
#3
Quinn A Bonafiglia, Sandra R Lourenssen, David J Hurlbut, Michael G Blennerhassett
Inflammation causes proliferation of intestinal smooth muscle cells (ISMC), which contributes to a thickened intestinal wall, and also to stricture formation in Crohn's disease. Proliferation of ISMC both in vitro and in vivo caused decreased expression of marker proteins, but the underlying cause is unclear. Since epigenetic change is important in other systems, we examined this in cell lines from rat colon at either low passage or after extended growth, using immunocytochemistry, immunoblotting and qPCR to evaluate phenotype...
August 15, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/30107703/-the-application-of-intestinal-stomas-in-mesenteric-ischemia
#4
S L Sun, W W Ding, B C Liu, X X Fan, X J Wu, J S Li
Objective: To evaluate the application of intestinal stomas in mesenteric ischemia (MI) according to the concept of damage control surgery. Methods: Clinical data of 59 MI patients received intestinal stomas at Jinling Hospital, Nanjing University School of Medicine from January 2010 to June 2017 were analyzed retrospectively. There were 41 male and 18 female patients aging of (51±14) years (ranging from 20 to 86 years). All the patients were divided to two groups according to the degree of bowel ischemia: acute MI group (AMI, bowel necrosis, n =43) and chronic MI group (CMI, bowel stricture, n =16)...
August 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/30105286/toll-like-receptor-mediated-intestinal-inflammatory-imbalance-in-the-pathogenesis-of-necrotizing-enterocolitis
#5
REVIEW
David J Hackam, Chhinder P Sodhi
Necrotizing enterocolitis (NEC) remains the leading cause of death from gastrointestinal disease in premature infants and attacks the most fragile patients at a time when they appear to be the most stable. Despite significant advances in our overall care of the premature infant, NEC mortality remains stubbornly high. There is no specific treatment for NEC beyond broad-spectrum antibiotics and intestinal resection, and current efforts have focused on preventive strategies. Over the past decade, we have proposed a unifying hypothesis to explain the pathogenesis of NEC in premature infants that suggests that NEC develops in response to an imbalance between exaggerated proinflammatory signaling in the mucosa of the premature gut leading to mucosal injury, which is not countered effectively by endogenous repair processes, and in the setting of impaired mesenteric perfusion leads to intestinal ischemia and disease development...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30100725/identifying-a-subpopulation-with-higher-likelihoods-of-early-response-to-treatment-in-a-heterogeneous-rare-disease-a-post-hoc-study-of-response-to-teduglutide-for-short-bowel-syndrome
#6
Kristina S Chen, Jipan Xie, Wenxi Tang, Jing Zhao, Palle B Jeppesen, James E Signorovitch
Purpose: Teduglutide, a glucagon-like peptide-2 analog, has demonstrated efficacy in reducing parenteral support (PS) among patients with short bowel syndrome with intestinal failure (SBS-IF). This study aims to identify a subpopulation of SBS-IF patients for whom teduglutide has an especially pronounced effect. Patients and methods: Data were from a 24-week, Phase III trial (Study of Teduglutide Effectiveness in Parenteral Nutrition-Dependent SBS Subjects; NCT00798967) that randomized SBS-IF patients with PS dependency to receive teduglutide (n=43) or placebo (n=43)...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/30097824/trametinib-for-progressive-pediatric-low-grade-gliomas
#7
Maria Kondyli, Valérie Larouche, Christine Saint-Martin, Benjamin Ellezam, Lauranne Pouliot, Daniel Sinnett, Geneviève Legault, Louis Crevier, Alex Weil, Jean-Pierre Farmer, Nada Jabado, Sébastien Perreault
INTRODUCTION: Pediatric pilocytic astrocytomas (PAs) are low grade gliomas and the most common brain tumors in children. They often represent a therapeutic challenge when incompletely resected as they can recur and progress despite the use of several lines of chemotherapeutic agents or even radiation therapy. Genetic alterations leading to activation of the mitogen-activated-protein-kinase pathway are a hallmark of this disease and offer an interesting therapeutic alternative through the use of targeted inhibitors...
August 10, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/30094706/-palliative-therapy-concepts-for-pancreatic-carcinoma
#8
M Brunner, R Grützmann, G F Weber
The majority of patients with ductal pancreatic adenocarcinoma are already in a locally advanced or metastatic stage at the time of diagnosis and require palliative therapy. Interventional and operative measures are available for the restoration of biliary outflow in bile duct obstruction and the continuity of the upper intestinal lumen in duodenal or gastric outlet obstruction. In the presence of tumor-related pain, pain therapy according to the World Health Organization (WHO) scheme or a truncus coeliacus blockade, in cachexia a nutritional therapy and in thromboembolic events an anticoagulant therapy are used...
August 9, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/30094245/critical-appraisal-of-guidelines-for-screening-and-surveillance-of-barrett-s-esophagus
#9
REVIEW
Spyridon Michopoulos
Esophageal adenocarcinoma (EAC) arising on Barrett esophagus (BE) has become the most frequent type of esophageal malignancy in the Western world. BE is a frequent condition but progression to EAC is rare. Scientific societies publish guidelines in order to improve patients' care. However, there are fields where evidence is lacking or there are many controversies. We aimed to spotlight the most important changes, as well as the points of controversy in the recently published guidelines for BE. For most, a length ≥1 cm of a salmon-pink mucosa extending above the eso-gastric junction is required in order to define BE, accompanied with the presence of intestinal metaplasia (IM) at histology...
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094153/isolated-colonic-metastasis-two-years-after-resection-of-stage-ia-primary-adenocarcinoma-of-the-lung-a-case-report
#10
Stylianos Vittorakis, Georgia Giannakopoulou, Konstantinos Konstantinides, Anna Daskalaki, Konstantinos Samitas
Colonic metastasis from lung cancer is rare, generally asymptomatic and usually develop at advanced cancer stages. Here, we report a case with a resected stage IA lung adenocarcinoma in a 51yo male patient that presented two years later with mild abdominal pain due to intestinal obstruction caused by a metastatic colon tumor. The patient underwent colonoscopy followed by surgical resection and the pathologic report was adenocarcinoma which was the same as that from a lung nodule that was excised two years earlier...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/30093993/-no-visible-lesions-an-unusual-case-of-intestinal-metaplasia-of-the-bladder
#11
Mithun Kailavasan, Ricky Ellis, Sophie O'Dowd, Benedict Sherwood, Alvaro Bazo
Intestinal metaplasia (IM) of the bladder is an extremely rare benign condition. The clinical features are similar to other bladder tumours. Its pathogenesis is unclear and its role as a precursor of adenocarcinoma has long been debated. Transurethral resection is the main form of treatment for IM. We report the case of a 49-year-old gentleman who presented with visible haematuria. He was submitted to multiple cystoscopies which showed no macroscopic irregularities. Radiological (CT urogram and multiparametric MRI) imaging revealed abnormalities within the bladder neck, suspicious of a neoplastic lesion...
August 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/30093986/intraductal-papillary-mucinous-neoplasm-originating-from-a-heterotopic-pancreas-within-the-jejunum-a-case-report
#12
Eiji Noda, Kenji Kuroda, Tomohisa Sera, Takuya Mori, Haruhito Kinoshita, Tsuyoshi Hasegawa, Hitoshi Teraoka, Takaaki Chikugo
We report a case of intraductal papillary mucinous neoplasm arising within the heterotopic pancreatic tissue which was found incidentally in the jejunum during surgery for bowel obstruction. A 54-year-old female patient was admitted to our hospital due to sudden abdominal pain. In preoperative findings, we diagnosed bowel obstruction and performed surgery. Intra-operative findings showed adhesive intestinal obstruction, we performed synechiotomy for adhesion release. During surgery, when searching the small intestine, we coincidentally found a tumor in the jejunum and partial resected the jejunum...
August 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/30090038/immunohistochemical-differentiation-between-chronic-enteropathy-associated-with-slco2a1-gene-and-other-inflammatory-bowel-diseases
#13
Satoko Yamaguchi, Shunichi Yanai, Shotaro Nakamura, Keisuke Kawasaki, Makoto Eizuka, Noriyuki Uesugi, Tamotsu Sugai, Junji Umeno, Motohiro Esaki, Takayuki Matsumoto
Background/Aims: We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene ( SLCO2A1 ) as causative variants of chronic enteropathy associated with SLCO2A1 (CEAS). The aim of this study was to evaluate SLCO2A1 protein expression in the intestinal tissues of patients with CEAS, intestinal Behçet's disease (BD), simple ulcer (SU), and Crohn's disease (CD). Methods: Immunohistochemical staining using a polyclonal anti-SLCO2A1 antibody was performed on the resected intestinal specimens from 13 cases of CD, 9 cases of intestinal BD/SU, and 3 cases of CEAS...
July 2018: Intestinal Research
https://www.readbyqxmd.com/read/30090001/upfront-surgery-of-small-intestinal-neuroendocrine-tumors-time-to-reconsider
#14
EDITORIAL
Kosmas Daskalakis, Apostolos V Tsolakis
Small intestinal neuroendocrine tumors (SI-NETs) may demonstrate a widely variable clinical behavior but usually it is indolent. In cases with localized disease, locoregional resective surgery (LRS) is generally indicated with a curative intent. LRS of SI-NETs is also the recommended treatment when symptoms are present, regardless of the disease stage. Concerning asymptomatic patients with distant metastases, prophylactic LRS has been traditionally suggested to avoid possible future complications. Even the current European Neuroendocrine Tumor Society guidelines emphasize a possible effect of LRS in Stage IV SI-NETs with unresectable liver metastases...
August 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30082555/cervical-esophago-gastric-anastomosis-using-linear-cutter-stapler-in-esophageal-cancer
#15
Parth Kanaiyalal Patel, Mishal Shah, Sanjeev Patni, Shashikant Saini
BACKGROUND: Anastomosis in gastrointestinal (GI) surgery is a commonly performed procedure. Irrelevant various methods of intestinal anastomosis were followed - recent advance is the use of a stapler as a device for GI anastomosis. Due to the use of staplers, technical failures are a rarity, anastomosis is more consistent and can be used at difficult locations. MATERIALS AND METHODS: : Between 2008 and August 2016, 75 patients with esophagus or gastroesophageal junction carcinoma underwent curative intent resection either via a right posterolateral thoracotomy (TTE) or transhiatal esophagectomy or video-assisted thoracoscopic surgery with linear stapler anastomosis...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30081320/multiple-mesenteric-desmoid-tumors-after-gastrectomy-for-gastric-cancer-a-case-report-and-literature-review
#16
Ryusei Yamamoto, Yasuji Mokuno, Hideo Matsubara, Hirokazu Kaneko, Shinsuke Iyomasa
INTRODUCTION: Many patients with desmoids have an antecedent trauma, particularly surgical intervention for familial adenomatous polyposis. However, cases of mesenteric desmoid after gastrectomy are extremely rare. We present a case of multiple mesenteric desmoids after total gastrectomy for gastric cancer. PRESENTATION OF CASE: A 70-year-old man had undergone a total gastrectomy for early stage gastric cancer. He had no other relevant medical history or family history...
July 31, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30081173/revised-endografting-for-a-giant-descending-thoracic-aorta-aneurysm-due-to-synchronous-type-iii-ib-endoleak-causing-dysphagia
#17
George S Georgiadis, Christos Argyriou, Andreas Koutsoumpelis, Fotios Konstantinou, Pelagia Chloropoulou, Ioannis Chrisafis, Vasileios Souftas
PURPOSE: Although surgical resection and graft replacement therapy for thoracic aortic aneurysms has advanced greatly over the last 20 years, significant perioperative morbidity and mortality still occur, particularly in patients considered high risk due to significant coexisting medical illness or previous operations performed for the treatment of intrathoracic disease. CASE REPORT: The case described is that of a patient with a giant (13.8cm) symptomatic descending thoracic aorta (DTA) aneurysm, previously treated endovascularly 15 years ago...
August 3, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30079287/rare-abdominopelvic-actinomycosis-causing-an-intestinal-band-obstruction-and-mimicking-an-ovarian-malignancy
#18
Sakthivel Chinnakkulam Kandhasamy, Byshetty Rajendar, Ashok Kumar Sahoo, Rajesh Nachiappa Ganesh, Mangala Goneppanavar, Vishnu Prasad Nelamangala Ramakrishnaiah
Actinomyces israelii, a commensal of the bronchial and gastrointestinal tracts, is responsible for the majority of actinomycostic infections in humans. Actinomycosis has widely varying clinical presentations ranging from asymptomatic states to infiltrative mass lesions that mimic malignant abdominopelvic disease. Described as one of the most misdiagnosed diseases, actinomycosis poses challenges to accurate preoperative diagnosis. A 67-year-old woman with no significant medical history presented with features of acute intestinal obstruction...
May 31, 2018: Curēus
https://www.readbyqxmd.com/read/30079145/atypical-anastomotic-malignancies-of-small-bowel-after-subtotal-gastrectomy-with-billorth-ii-gastroenterostomy-for-peptic-ulcer-report-of-three-cases-and-review-of-the-literature
#19
Efstathios Kotidis, Orestis Ioannidis, Manousos George Pramateftakis, Konstantinos Christou, Ioannis Kanellos, Konstantinos Tsalis
AIM: To present patients who developed small-bowel malignancy at the level of the gastrointestinal anastomosis decades after a subtotal gastrectomy for ulcer, to review relevant literature, and to attempt to interpret the reasons those cancers developed to these postsurgical non-gastric sights. METHODS: For the current retrospective study and review of literature, the surgical and histopathological records dated from January 1, 1993 to December 31, 2017 of our department were examined, searching for patients who have undergone surgical treatment of small-bowel malignancy to identify those who have undergone subtotal gastrectomy for benign peptic ulcer...
July 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30077833/an-adult-presentation-of-midgut-volvulus-secondary-to-intestinal-malrotation-a-case-report-and-literature-review
#20
William A Butterworth, James W Butterworth
INTRODUCTION: Midgut volvulus secondary to intestinal malrotation is a rare cause of an acute abdomen in adults, with 92 confirmed cases in the literature. Incidence of malrotation is estimated 1 in 6000 live births. 64-80% of malrotation cases present in the first month of life and 90% within the first year. Adult presentation is very rare accounting for only 0.2-0.5% of cases, of which only 15% present with midgut volvulus. PRESENTATION OF CASE: We report a rare case of a 20 year old male with spontaneous midgut volvulus secondary to congenital malrotation of the bowel...
July 11, 2018: International Journal of Surgery Case Reports
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