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J M Colijn, A I den Hollander, A Demirkan, A Cougnard-Grégoire, T Verzijden, E Kersten, M A Meester, B M J Merle, G Papageorgiou, S Ahmad, M T Mulder, M A Costa, P Benlian, G Bertelsen, A Bron, B Claes, C Creuzot-Garcher, M G Erke, S Fauser, P J Foster, C J Hammond, H W Hense, C B Hoyng, A P Khawaja, J Korobelnik, S Piermarocchi, T Segato, R Silva, E H Souied, K M Williams, C M van Duijn, C Delcourt, C C W Klaver
PURPOSE: Genetic and epidemiologic studies have shown that lipid genes and High Density Lipoproteins (HDL) are implicated in age-related macular degeneration (AMD). We studied circulating lipid levels in relation to AMD in a large European dataset, and investigated whether this relationship is driven by certain sub fractions. DESIGN: (Pooled) analysis of cross-sectional data. PARTICIPANTS: 30,953 individuals aged 50+ participating in the E3 consortium; and 1530 individuals from the Rotterdam Study with lipid sub fraction data...
October 10, 2018: Ophthalmology
Helen Triantafyllidi, Dimitris Benas, Stefanos Vlachos, Dimitris Vlastos, George Pavlidis, Antonios Schoinas, Mary Varoudi, Dionysia Birmpa, Paraskevi Moutsatsou, John Lekakis, Ignatios Ikonomidis
Endothelial dysfunction indicates target organ damage in hypertensive patients. The integrity of endothelial glycocalyx (EG) plays a vital role in vascular permeability, inflammation and elasticity, and finally to cardiovascular disease. The authors aimed to investigate the role of increased HDL cholesterol (HDL-C) levels, which usually are considered protective against cardiovascular disease, in EG integrity in older hypertensive patients. The authors studied 120 treated hypertensive patients older than 50 years were divided regarding HDL-C tertiles in group HDLH (HDL-C ≥ 71 mg/dL, upper HDL-C tertile) and group HDLL (HDL-C < 71 mg/dL, two lower HDL-C tertiles)...
October 13, 2018: Journal of Clinical Hypertension
Katarzyna Szczeklik, Tomasz Mach, Dorota Cibor, Danuta Owczarek, Jacek Sapa, Monika Papież, Jolanta Pytko-Polończyk, Wirginia Krzyściak
Diagnostics of Crohn's disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD. The CD activity index was based on the current classification. Plasma PON-1 was measured in 47 patients with CD, and in 23 control volunteers. Using quantitative variables such as receiver operating characteristics (ROC) (area under the curve (AUC)), the diagnostic utility of PON-1 in differentiating the severity of CD was assessed...
October 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Damodara Gowda, Hitha Harshitha, Amrit M Mirajkar
The aim of this study was to investigate the relationship between serum ferritin level and antioxidative status and metabolic dysregulation in young adult obese population. This cross-sectional study included three hundred subjects of either sex, grouped as obese and non-obese subjects. The Body Mass Index (BMI), serum ferritin, Iron, Total Iron Binding Capacity (TIBC), Fasting Blood Glucose (FBS), Total cholesterol (TC), High-Density Lipoprotein Cholesterol (HDL-C), Low-Density Lipoprotein Cholesterol (LDL-C), Triglyceride (TG), Glutathione (GSH), superoxide dismutase (SOD) activity and vitamin-C level was estimated...
October 12, 2018: Canadian Journal of Physiology and Pharmacology
Petter Bjornstad, Sunita K Singh, Janet K Snell-Bergeon, Julie A Lovshin, Yuliya Lytvyn, Leif E Lovblom, Marian J Rewers, Genevieve Boulet, Vesta Lai, Josephine Tse, Leslie Cham, Andrej Orszag, Alanna Weisman, Hillary A Keenan, Michael H Brent, Narinder Paul, Vera Bril, Bruce A Perkins, David Z I Cherney
OBJECTIVE: Our aim was to define the relationships between plasma biomarkers of kidney injury and intrarenal hemodynamic function (glomerular filtration rate [GFR], effective renal plasma flow [ERPF], renal vascular resistance [RVR]) in adults with type 1 diabetes (T1D). METHODS: The study sample consisted of patients with longstanding T1D (≥50 years duration); 44 Diabetic Kidney Disease (DKD) resistors (eGFR >60mL/min/1.73m2 and <30mg/day urine albumin excretion) and 22 with DKD, in addition to 73 controls...
October 12, 2018: Diabetes, Obesity & Metabolism
Rucha Saoji, Rajat Subra Das, Meena Desai, Achhelal Pasi, Geetanjali Sachdeva, Tapan Kumar Das, M Ikram Khatkhatay
This study investigated association between lipids and homocysteine (Hcy) with bone mineral density (BMD) in young women as opposed to previous studies on elderly women. HDL, triglyceride, and Hcy are significantly associated with BMD in young women and tobacco and alcohol consumption have no effect on this association. PURPOSE: The present study investigates whether the association of serum lipids and homocysteine (Hcy) with bone mineral density (BMD) reported mostly in elderly population can be generalized to young or premenopausal women, consequently suggesting screening of young women with low BMD for dyslipidemia or any cardiovascular events and vice versa...
October 10, 2018: Archives of Osteoporosis
Edward K Duran, Nancy R Cook, Paul M Ridker
No abstract text is available yet for this article.
October 9, 2018: JAMA: the Journal of the American Medical Association
Chang Li, Jia Wei Chen, Zhu Hui Liu, Ying Shen, Feng Hua Ding, Gang Gu, Jun Liu, Jia Pei Qiu, Jie Gao, Rui Yan Zhang, Wei Feng Shen, Xiao Qun Wang, Lin Lu
BACKGROUND AND AIMS: Increased transcytosis of low-density lipoprotein (LDL) across the endothelium and oxidation of LDL deposited within the subendothelial space are crucial early events in atherogenesis. C1q/TNF-related protein (CTRP) 5 is a novel secreted glycoprotein and its biological functions are largely undefined. METHODS: Expression of CTRP5 was analyzed in sera and atherosclerotic plaques of patients with coronary artery disease (CAD). The role of CTRP5 in atherogenesis was investigated in vitro and in vivo...
September 28, 2018: Atherosclerosis
Cassandra Sparkes, Robert Gibson, Andrew Sinclair, Paul L Else, Barbara J Meyer
Omega-3 long chain polyunsaturated fatty acid ( n -3 LCPUFA) supplementation has been shown to improve plasma lipid profiles in men and post-menopausal women, however, data for pre-menopausal women are lacking. The benefits of intakes less than 1 g/day have not been well studied, and dose⁻response data is limited. The aim of this study was to determine the effect of low doses of docosahexaenoic acid (DHA)-rich tuna oil on plasma triglyceride (TG) lowering in pre-menopausal women, and investigate if low dose DHA-rich tuna oil supplementation would increase the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle sizes...
October 8, 2018: Nutrients
Michel Farnier, G Kees Hovingh, Gisle Langslet, Robert Dufour, Marie T Baccara-Dinet, Chantal Din-Bell, Garen Manvelian, John R Guyton
BACKGROUND AND AIMS: ODYSSEY OLE (open-label extension; NCT01954394) included patients diagnosed with heterozygous familial hypercholesterolemia (HeFH), receiving maximally tolerated statins, who had completed one of four Phase 3 double-blind parent studies (all 18 months' duration), with the aim to assess longer-term safety and efficacy of alirocumab. METHODS: Patients received starting dose alirocumab 75 mg every 2 weeks (Q2W; patients from FH I, FH II, and LONG TERM) or alirocumab 150 mg Q2W (patients from HIGH FH)...
September 1, 2018: Atherosclerosis
Peter Willeit, Paul M Ridker, Paul J Nestel, John Simes, Andrew M Tonkin, Terje R Pedersen, Gregory G Schwartz, Anders G Olsson, Helen M Colhoun, Florian Kronenberg, Christiane Drechsler, Christoph Wanner, Samia Mora, Anastasia Lesogor, Sotirios Tsimikas
BACKGROUND: Elevated lipoprotein(a) is a genetic risk factor for cardiovascular disease in general population studies. However, its contribution to risk for cardiovascular events in patients with established cardiovascular disease or on statin therapy is uncertain. METHODS: Patient-level data from seven randomised, placebo-controlled, statin outcomes trials were collated and harmonised to calculate hazard ratios (HRs) for cardiovascular events, defined as fatal or non-fatal coronary heart disease, stroke, or revascularisation procedures...
October 4, 2018: Lancet
M Cheurfa, H H Abdallah, R Allem, A Noui, C M N Picot-Allain, F Mahomoodally
Aqueous and ethanol extracts prepared from leaves of Olea europaea L. were evaluated for in vitro antioxidant and in vivo hypocholesterolemic effect. The result of administration of O. europaea leaf extracts on serum total cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) in hypercholesterolaemic mice was evaluated. In addition, rutin and luteolin, reported to occur naturally in O. europaea leaves, were docked against HMG-CoA reductase, the rate-limiting enzyme in cholesterol metabolism...
October 4, 2018: Food and Chemical Toxicology
Eiji Kutoh, Asuka Wada, Jyunka Hayashi
OBJECTIVES: The aim of this study is to investigate the effects of sitagliptin on the regulation of FFA and other metabolic parameters in drug-naïve subjects with T2DM. SUBJECTS AND METHODS: This is a prospective, non-randomized, observational study. Drug naïve subjects with T2DM received 25-50 mg/day sitagliptin monotherapy (n=64). At 3 months, FFA and other metabolic parameters were compared with those at baseline. FFA was measured by colorimetry with enzymatic reactions...
October 5, 2018: Endocrine Practice
Durdi Qujeq, Abdolkarim Mahrooz, Ahad Alizadeh, Parisa Masoumi, Saleh Annemohammadzadeh, Ruzbeh Boorank
Background: Paraoxonase 1 (PON1) and lipid abnormalities contribute to the development of cardiovascular disease, which is the principal cause of mortality in patients with type 2 diabetes (T2D). Data are not available on the potential association between salt-stimulated activity of PON1 (PON1-salt) and the atherogenic indices in T2D, therefore, we focused on these associations and evaluated whether the functional variants PON1-Q192R and PON1-L55M influence the associations. Methods: Paraoxonase activity (PON1-para), arylesterase activity (PON1-aryl) and salt-stimulated activity (PON1-salt) were measured by spectrophotometric assays...
June 2018: Journal of Diabetes and Metabolic Disorders
Mallikarjunachari V N Uppuladinne, Uddhavesh B Sonavane, Ramesh Ch Deka, Rajendra R Joshi
There is an extensive research carrying out on antisense technology and the molecules entering into clinical trials are increasing rapidly. Phosphorothioate (PS) is a chemical modification in which non-bridged oxygen is replaced with a sulfur, consequently providing resistance against nuclease activity. The 2'-4' conformationaly restricted nucleoside has the structural features of both 2'-O-methoxy ethyl RNA (MOE), which shows good toxicity profile, and locked nucleic acid (LNA), which shows good binding affinity towards the target RNA...
October 4, 2018: Journal of Biomolecular Structure & Dynamics
Ok Sang Lee, Jinlong Zhang, Sun-Hoi Jung, Hyang-Sook Kim, Myung-Koo Lee, Hae-Young Lee
Purpose: Although moderate- to high-intensity statin therapy is increasingly recommended in cardiovascular disease patients, the efficacy and safety in elderly patients have not been proven clearly. Here, we compare the effect of various-intensity statins between elderly and very elderly patients. Methods: 43,870 patients over 65 years old who were treated with statins were screened using electronic medical record data. Results: We evaluated 451 patients in the elderly group aged 65-74 years and 159 patients in the very elderly group over 75 years old...
July 2018: Pulse (Basel, Switzerland)
Zhen Yan, Baosheng Fu, Dan He, Yudi Zhang, Juanjuan Liu, Xiangjian Zhang
This study aimed to study the value of oxidized low-density lipoprotein (OX-LDL) and related ratio in the diagnosis of acute cerebral infarction and the classification of acute cerebral infarction.Of the 129 patients enrolled in this study, 94 patients with acute cerebral infarction were assigned to the case group, and 35 healthy subjects were enrolled as control group (n = 35). And then the case group were divided into large-artery atherosclerosis (LAA) group (n = 61) and small-artery occlusion (SAO) group (n = 33) according to the TOAST classification standard...
September 2018: Medicine (Baltimore)
Constantino Flores-Reséndiz, Alexandra E Soto-Piña, Roxana Valdés-Ramos, Alejandra D Benítez-Arciniega, Patricia Tlatempa-Sotelo, Ana Laura Guadarrama-López, Beatriz E Martínez-Carrillo, Caroline C Pulido-Alvarado
Objective: The objective of this study was to determine whether cardiovascular disease (CVD) risk factors and stress hormones are associated with cognitive performance in Mexican adolescents. Methods: This was a cross-sectional study including 139 Mexican adolescents 10-14 years old. Participants were divided into three categories: 0, 1-2, and ≥3 CVD risk factors. These factors included: high-density lipoprotein-cholesterol (HDL-C) <40 mg/dl; waist circumference (WC) ≥90th percentile for age and sex, systolic or diastolic blood pressure ≥90th percentile for age, sex, and height; and triacylglycerols (TGs) ≥110 mg/dl...
September 28, 2018: Journal of Pediatric Psychology
Olga I Afanasieva, Marat V Ezhov, Oksana A Razova, Marina I Afanasieva, Elena A Utkina, Sergei N Pokrovsky
BACKGROUND AND AIMS: The aim of this study is to investigate the relation between lipoprotein(a) [Lp(a)] and proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations, and their complex, in patients with potential familial hypercholesterolemia (FH), depending on apo(a) phenotype. METHODS: The study included 205 patients with total cholesterol (TC) > 7.5 mmol/L and/or low density lipoprotein cholesterol (LDL-C)>4.9 mmol/L, 32 (15%) patients suffered from ischemic heart disease (IHD), 64 were taking statins...
October 2018: Atherosclerosis
Liam R Brunham, Isabelle Ruel, Etienne Khoury, Robert A Hegele, Patrick Couture, Jean Bergeron, Alexis Baass, Robert Dufour, Gordon A Francis, Lubomira Cermakova, G B John Mancini, James M Brophy, Dianne Brisson, Daniel Gaudet, Jacques Genest
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is under-diagnosed and under-treated in most of the world, including Canada. National registries play a key role in identifying patients with FH, understanding gaps in care, and advancing the science of FH to better treat these patients. METHODS: FH Canada has established a national registry across 19 academic sites acting as "hubs" in Canada to increase awareness and access to standard-of-care therapies...
October 2018: Atherosclerosis
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