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Xiaohong Wang, Na Shi, Huanling Shi, Hong Ye, Ning Li, Peng Sun, Dongfang Bai, Haipeng Yuan
BACKGROUND This study investigated the correlations between acute cerebral hemorrhage complicated with stress ulcer bleeding and corresponding indexes, including the Acute Physiology and Chronic Health Evaluation (APACHE) II score, vascular endothelin-1 (ET-1), tumor necrosis factor-alpha (TNF-α), and blood lipid factors. MATERIAL AND METHODS A total of 53 patients with acute cerebral hemorrhage complicated with stress ulcer bleeding were selected as the observation group and 50 patients with simple acute cerebral hemorrhage were selected as the control group...
December 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Zhi Luo, Lijun Pu, Irfan Muhammad, Yun Chen, Xiaoqian Sun
BACKGROUND: Several meta-analyses have demonstrated that the rs662 polymorphism in Paraoxonase 1 gene (PON1) gene is associated with coronary heart disease (CHD). However, it is still uncertain whether this polymorphism is associated with the plasma levels of oxidized low-density lipoprotein (Ox-LDL) and lipids. This meta-analysis is aimed to clarify the relationships between the rs662 polymorphism and plasma levels of Ox-LDL and lipids. METHODS: By searching in PubMed, Google Scholar, Web of Science, Cochrane Library, Wanfang, VIP and CNKI databases, 5 studies (1369 subjects) and 85 studies (46,740 subjects) were respectively identified for Ox-LDL association analysis and lipid association analysis...
December 13, 2018: Lipids in Health and Disease
You Zhou, Mingcai Zhao, Zheyan Pu, Guoqiang Xu, Xiangkun Li
The average age of hyperuricemia patients has gradually decreased, but young patients with primary hyperuricemia often do not exhibit clinical symptoms and have not received sufficient attention. However, a lack of symptoms with primary hyperuricemia does not mean that high serum uric acid (UA) levels cannot lead to pathological effects, such as oxidative stress and inflammation, and the specific damage is still unclear. We aimed to determine the relationship between oxidative stress and inflammation to explore the possible role of pathological damage in asymptomatic young patients with primary hyperuricemia...
December 2018: Medicine (Baltimore)
Marek M Nagiec, Jeremy R Duvall, Adam P Skepner, Eleanor A Howe, Jessica Bastien, Eamon Comer, Jean-Charles Marie, Stephen E Johnston, Joseph Negri, Michelle Eichhorn, Julien Vantourout, Clary Clish, Kiran Musunuru, Michael Foley, Jose R Perez, Michelle A J Palmer
Increased expression of the Tribbles pseudokinase 1 gene ( TRIB1 ) is associated with lower plasma levels of LDL cholesterol and triglycerides, higher levels of HDL cholesterol and decreased risk of coronary artery disease and myocardial infarction. We identified a class of tricyclic glycal core-based compounds that upregulate TRIB1 expression in human HepG2 cells and phenocopy the effects of genetic TRIB1 overexpression as they inhibit expression of triglyceride synthesis genes and ApoB secretion in cells...
November 1, 2018: MedChemComm
Beatriz Hemo, Danit R Shahar, Dikla Geva, Anthony D Heymann
OBJECTIVES: Disease registry for diabetes care encourages transparency and benchmarking of quality of care (QoC) measurements for all service providers and seems to improve diabetes care. This study evaluate changes over time in QoC measurement performance in a large diabetes registry among newly diagnosed diabetics and it association with mortality. METHODS: Retrospective cohort study of patients in a large health maintenance organization diabetes registry from years 2000 to 2013...
2018: PloS One
Arman Qamar, Robert P Giugliano, Anthony C Keech, Julia F Kuder, Sabina A Murphy, Christopher E Kurtz, Scott M Wasserman, Peter S Sever, Terje R Pedersen, Marc S Sabatine
Importance: Little is known about the heterogeneity in low-density lipoprotein cholesterol levels (LDL-C) lowering with proprotein convertase subtilisin kexin 9 (PCSK9) inhibitor medications. Objective: To evaluate the interindividual variability in LDL-C reduction with the PCSK9 inhibitor drug evolocumab. Design, Setting, and Participants: We examined the percentage change in LDL-C levels from baseline in the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER) trial, a placebo-controlled randomized clinical trial of the PCSK9 inhibitor evolocumab in patients with stable atherosclerotic cardiovascular disease who were taking statin medications...
December 12, 2018: JAMA Cardiology
Maire F Osborn, Andrew H Coles, Annabelle Biscans, Reka A Haraszti, Loic Roux, Sarah Davis, Socheata Ly, Dimas Echeverria, Matthew R Hassler, Bruno M D C Godinho, Mehran Nikan, Anastasia Khvorova
Efficient delivery of therapeutic RNA beyond the liver is the fundamental obstacle preventing its clinical utility. Lipid conjugation increases plasma half-life and enhances tissue accumulation and cellular uptake of small interfering RNAs (siRNAs). However, the mechanism relating lipid hydrophobicity, structure, and siRNA pharmacokinetics is unclear. Here, using a diverse panel of biologically occurring lipids, we show that lipid conjugation directly modulates siRNA hydrophobicity. When administered in vivo, highly hydrophobic lipid-siRNAs preferentially and spontaneously associate with circulating low-density lipoprotein (LDL), while less lipophilic lipid-siRNAs bind to high-density lipoprotein (HDL)...
December 8, 2018: Nucleic Acids Research
R Aller, D Primo, O Izaola, D A de Luis
BACKGROUND: The role of CB2R gene variants on weight loss after a dietary intervention has been investigated in few studies. OBJECTIVE: We evaluate the effect of this genetic variant (rs3123554) of CB2R gene on cardiovascular risk factors and weight loss secondary to high monounsaturated fat vs a high polyunsaturated fat hypocaloric diets. DESIGN: A Caucasian population of 362 obese patients was enrolled. Patients were randomly allocated during 3 months to one of two diets (Diet P high polyunsaturated (PUFAs) fat hypocaloric diet vs, Diet M high monounsaturated (MUFAs) fat hypocaloric diet)...
November 30, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Eeva Sliz, Johannes Kettunen, Michael V Holmes, Clare Oliver Williams, Charles Boachie, Qin Wang, Minna Männikkö, Sylvain Sebert, Robin Walters, Kuang Lin, Iona Y Millwood, Robert Clarke, Liming Li, Naomi Rankin, Paul Welsh, Christian Delles, J Wouter Jukema, Stella Trompet, Ian Ford, Markus Perola, Veikko Salomaa, Marjo-Riitta Järvelin, Zhengming Chen, Debbie A Lawlor, Mika Ala-Korpela, John Danesh, George Davey Smith, Naveed Sattar, Adam Butterworth, Peter Würtz
Background: Both statins and PCSK9 inhibitors lower blood low-density lipoprotein cholesterol (LDL-C) levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these two lipid-lowering therapies, we performed detailed lipid and metabolite profiling of a large randomized statin trial and compared the results with the effects of genetic inhibition of PCSK9, acting as a naturally occurring trial. Methods: 228 circulating metabolic measures were quantified by nuclear magnetic resonance spectroscopy, including lipoprotein subclass concentrations and their lipid composition, fatty acids, and amino acids, for 5,359 individuals (2,659 on treatment) in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial at 6-months post-randomization...
November 27, 2018: Circulation
Monica Verdoia, Patrizia Pergolini, Matteo Nardin, Roberta Rolla, Lucia Barbieri, Paolo Marino, Alessandro Carriero, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: ADP-antagonists such as prasugrel have reduced but yet not overcome the phenomenon of high-on treatment platelet reactivity (HRPR), that has been shown to increase the rate of major cardiovascular events after an acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI). However, the exact prevalence and the principal determinants of suboptimal platelet inhibition in patients treated with dual antiplatelet therapy (DAPT) with prasugrel have not been completely clarified and were therefore the aim of the present study...
December 3, 2018: Journal of Cardiology
A Sicras-Mainar, L Sánchez-Álvarez, R Navarro-Artieda, J Darbà
BACKGROUND: High blood lipoprotein concentrations are one of the major risk factors for cardiovascular diseases. Drug therapy is the base of treatment; statins in particular. Both brand-name and generic presentations are available for statin therapy of high cholesterol levels. Factors that may influence their use in routine medical practice include, among others, patient persistence and adherence to treatment as prescribed by physicians. The aim of this retrospective analysis was to provide real-world evidence of treatment persistence and adherence and their consequences on economic and patient outcomes of generic versus brand-name statins routinely used to treat high cholesterol levels in Spain...
December 6, 2018: Lipids in Health and Disease
Caroline C Gasparin, Neiva Leite, Luciane V Tureck, Ricardo L R Souza, Gerusa E Milano-Gai, Larissa R Silva, Wendell A Lopes, Lupe Furtado-Alle
Genes can influence lipid profile and anthropometric variables related to obesity. The present study aimed to verify if variants of the APOE, APOB, ADIPOQ, HSD11β1, and PLIN4 genes are associated with lipid levels or anthropometric variables in a sample comprised of 393 Euro-Brazilian children and adolescents. DNA was genotyped by TaqMan allelic discrimination assay. The ε4 and ε2 alleles of the APOE gene were associated respectively with lower high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels (p=0...
November 23, 2018: Genetics and Molecular Biology
Gamze Aslan, Veli Polat, Evin Bozcali, Selçuk Opan, Nurcan Çetin, Dilek Ural
OBJECTIVES: Coronary microvascular dysfunction plays a major role in the pathogenesis of microvascular angina (MVA). Along with endothelial dysfunction, microvascular atherosclerosis and inflammation seem to contribute to the development of coronary microvascular dysfunction. Serum soluble ST2 (sST2) and serum soluble CD40 ligand (sCD40L) are two biomarkers associated with inflammation and atherosclerosis. The aim of this study was to investigate the role of these biomarkers in the pathogenesis of MVA and determine their possible association with coronary microvascular dysfunction...
November 28, 2018: Microvascular Research
Jidong Sung, Soo Jin Cho, Kyong Pyo Hong
BACKGROUND: There is a well-established relationship between cardiorespiratory fitness (CRF) and arterial stiffness. However, it is unclear whether this relationship differs significantly between hypertensive and non-hypertensive patients. METHODS: Adults without a history of ischemic heart disease or stroke and normal exercise test results who underwent health screening were included. Cardiopulmonary function test was performed using the Bruce protocol. Peak oxygen consumption (VO2peak) was measured...
November 30, 2018: Clinical and Experimental Hypertension: CHE
Lawrence A Leiter, Hwee Teoh, David Kallend, R Scott Wright, Ulf Landmesser, Peter L J Wijngaard, John J P Kastelein, Kausik K Ray
OBJECTIVE: To evaluate the efficacy and safety of inclisiran by diabetes status. RESEARCH DESIGN AND METHODS: ORION-1 (, NCT02597127) randomized 501 subjects with atherosclerotic cardiovascular disease (ASCVD) or ASCVD risk equivalents and high LDL cholesterol (LDL-C), despite maximally tolerated LDL-C-lowering therapies, to one or two doses of placebo or inclisiran. Levels of lipids and proprotein convertase subtilisin/kexin type 9 (PCSK9) at baseline and day 180 were compared...
November 28, 2018: Diabetes Care
Agnieszka Dettlaff-Pokora, Elzbieta Sucajtys-Szulc, Tomasz Sledzinski
Studies designed to examine effects of fat mass reduction (including lipodystrophy and lipectomy) on human serum total and LDL-cholesterol concentrations are inconsistent. The purpose of this study was to examine effect of partial lipectomy in rats (as an experimental model of fat mass reduction in humans) on (1) circulating total cholesterol, LDL-cholesterol + VLDL-cholesterol and HDL-cholesterol concentrations, and (2) factors which may affect serum cholesterol concentrations such as: (a) liver LDL-receptor level, (b) expression of liver PCSK9 and (c) circulating PCSK9 concentration...
November 27, 2018: Molecular and Cellular Biochemistry
Semih Tangal, Asim Ozayar, Kemal Ener, Mehmet Ilker Gokçe, Ahmet Hakan Haliloglu
PURPOSE: The mean platelet volume (MPV) has important role in the pathophysiology of vascular diseases as a marker of the platelet activity. To investigate the association between mean platelet volume and erectile dysfunction (ED) and to search whether this marker can be used for diagnosis of ED. MATERIALS AND METHODS: Of the 312 patients with ED of various degrees, 122 patients without ED (IIEF-5>21) were included in this prospective study. Severity of ED was determined according to IIEF-5 questionnaire...
November 24, 2018: Revista Internacional de Andrología
Run Du, Rui Yan Zhang, Lin Lu, Ying Shen, Li Jin Pu, Zheng Bin Zhu, Qi Zhang, Jian Hu, Zhen Kun Yang, Feng Hua Ding, Jian Sheng Zhang, Wei Feng Shen
BACKGROUND: Negative coronary artery remodeling is frequent in patients with diabetes, but its mechanism remains unclear. We here evaluated the association of serum levels of glycated albumin (GA) and endogenous secretory receptor for advanced glycation end products (esRAGE) with coronary artery remodeling in type 2 diabetic patients. METHODS: Serum levels of GA and esRAGE were measured and intravascular ultrasound was performed in 136 consecutive diabetic patients with 143 coronary intermediate lesions...
November 27, 2018: Cardiovascular Diabetology
Carolina Nylén, Leonidas S Lundell, Julie Massart, Juleen R Zierath, Erik Näslund
Diet intervention in obese adults is the first strategy to induce weight loss and to improve insulin sensitivity. We hypothesized that improvements in insulin sensitivity after weight loss from a short-term dietary intervention tracks with alterations in expression of metabolic genes and abundance of specific lipid species. Eight obese, insulin resistant, non-diabetic adults were recruited to participate in a three-week low calorie diet intervention cohort study (1,000 kcal/day). Fasting blood samples and vastus lateralis skeletal muscle biopsies were obtained before and after the dietary intervention...
November 27, 2018: American Journal of Physiology. Endocrinology and Metabolism
B Almeida-Pititto, I T Silva, A C Goulart, M I H Fonseca, M S Bittencourt, R D Santos, M Blaha, S Jones, P P Toth, K Kulakarni, P A Lotufo, I M Bensenor, S R G Ferreira
Background: Neck circumference (NC) is associated with traditional cardiovascular risk factors (CVRF), but its usefulness to identify earlier atherogenic risk has been scarcely examined. Associations of NC with non-traditional CVRF were investigated in participants at low-to-moderate risk from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: 807 individuals (35-54 years) without obesity, diabetes or cardiovascular disease was stratified into quartiles of NC (cut-off for men: 36...
2018: Diabetology & Metabolic Syndrome
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