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https://www.readbyqxmd.com/read/30340592/anaemia-and-malaria
#1
REVIEW
Nicholas J White
Malaria is a major cause of anaemia in tropical areas. Malaria infection causes haemolysis of infected and uninfected erythrocytes and bone marrow dyserythropoiesis which compromises rapid recovery from anaemia. In areas of high malaria transmission malaria nearly all infants and young children, and many older children and adults have a reduced haemoglobin concentration as a result. In these areas severe life-threatening malarial anaemia requiring blood transfusion in young children is a major cause of hospital admission, particularly during the rainy season months when malaria transmission is highest...
October 19, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30328088/recovery-of-urinary-function-after-robotic-assisted-laparoscopic-prostatectomy-versus-radical-perineal-prostatectomy-for-early-stage-prostate-cancer
#2
S Mohammad Jafri, Laura N Nguyen, Larry T Sirls
INTRODUCTION: Robotic-assisted laparoscopic prostatectomy (RALP) has largely replaced open radical prostatectomy in many centers. Radical perineal prostatectomy (RPP) is another less invasive approach that has not been widely adopted. RPP offers excellent exposure of the urinary sphincter and bladder neck that may provide good urinary function outcomes. We evaluate urinary function after RALP and RPP. METHODS: Retrospective review of a prospective radical prostatectomy database was performed...
October 16, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30327702/closed-looped-stimulation-cardiac-pacing-for-recurrent-vasovagal-syncope-a-systematic-review-and-meta-analysis
#3
Pattara Rattanawong, Tanawan Riangwiwat, Pakawat Chongsathidkiet, Wasawat Vutthikraivit, Nath Limpruttidham, Narut Prasitlumkum, Napatt Kanjanahattakij, Chanavuth Kanitsoraphan
Background: Vasovagal syncope (VVS) is defined by transient loss of consciousness with spontaneous rapid recovery. Recently, a closed-loop stimulation pacing system (CLS) has shown superior effectiveness to conventional pacing in refractory VVS. However, systematic review and meta-analysis has not been performed. We assessed the impact of CLS implantation and reduction in recurrent VVS events by a systematic review and a meta-analysis. Methods: We comprehensively searched the databases of MEDLINE and EMBASE from inception to September 2017...
October 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/30311893/thoracoscopy-assisted-minimally-surgery-nuss-procedure-for-pectus-excavatum-vs-novel-modified-nuss-procedure-a-single-center-retrospective-study
#4
Lifei Meng, Mingsong Wang
OBJECTIVE: The purpose of this article is to evaluate the efficacy of thoracoscopy assisted minimally surgery (NUSS procedure) for pectus excavatum and novel modified NUSS procedure by comparing the data of patients of pectus excavatum who had undergone novel modified NUSS Procedure or NUSS procedure. METHODS: A retrospective study was performed, involving 132 cases of patients with pectus excavatum collected from Shanghai Jiaotong University School of Medicine Xinhua Hospital cardio-thoracic surgery between Jan...
September 27, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/30305950/echocardiography-guidance-of-atrial-septal-defect-closure
#5
REVIEW
Bushra S Rana
Transcatheter procedures offer less invasive approaches allowing rapid recovery and earlier hospital discharge. A number of international guidelines have defined the role of echocardiography spanning diagnosis, detailed anatomical assessment, device sizing and selection, peri-procedure guidance and post device surveillance. This review discusses the role of echocardiography in transcatheter atrial septal defect (ASD) closure. It describes a systematic approach to assessment including the crucial role of three dimensional echo and provides the reader with key information required during device sizing and procedure guidance...
September 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30301085/urban-coral-reefs-degradation-and-resilience-of-hard-coral-assemblages-in-coastal-cities-of-east-and-southeast-asia
#6
Eliza C Heery, Bert W Hoeksema, Nicola K Browne, James D Reimer, Put O Ang, Danwei Huang, Daniel A Friess, Loke Ming Chou, Lynette H L Loke, Poonam Saksena-Taylor, Nadia Alsagoff, Thamasak Yeemin, Makamas Sutthacheep, Si Tuan Vo, Arthur R Bos, Girley S Gumanao, Muhammad Ali Syed Hussein, Zarinah Waheed, David J W Lane, Ofri Johan, Andreas Kunzmann, Jamaluddin Jompa, Suharsono, Daisuke Taira, Andrew G Bauman, Peter A Todd
Given predicted increases in urbanization in tropical and subtropical regions, understanding the processes shaping urban coral reefs may be essential for anticipating future conservation challenges. We used a case study approach to identify unifying patterns of urban coral reefs and clarify the effects of urbanization on hard coral assemblages. Data were compiled from 11 cities throughout East and Southeast Asia, with particular focus on Singapore, Jakarta, Hong Kong, and Naha (Okinawa). Our review highlights several key characteristics of urban coral reefs, including "reef compression" (a decline in bathymetric range with increasing turbidity and decreasing water clarity over time and relative to shore), dominance by domed coral growth forms and low reef complexity, variable city-specific inshore-offshore gradients, early declines in coral cover with recent fluctuating periods of acute impacts and rapid recovery, and colonization of urban infrastructure by hard corals...
October 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/30292951/direct-recovery-of-malate-dehydrogenase-from-highly-turbid-yeast-cell-homogenate-using-dye-ligand-affinity-chromatography-in-stirred-fluidized-bed
#7
Kuei-Hsiang Chen, Sze-Ying Lee, Pau-Loke Show, Shih-Cheng Hong, Yu-Kaung Chang
Dye-ligand affinity chromatography in a stirred fluidized bed has been developed for the rapid recovery of malate dehydrogenase (MDH) from highly turbid baker's yeast cell homogenate in a single step. The most suitable dye, namely Reactive Orange 4, in its optimal immobilized concentration of 8.78 mg/mL was immobilized onto high-density STREAMLINE matrix. To further examine optimal adsorption and elution conditions, the enzyme recovery operation was carried out using unclarified cell homogenates in stirred fluidized bed system...
October 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/30291931/a-review-on-injectable-chitosan-beta-glycerophosphate-hydrogels-for-bone-tissue-regeneration
#8
REVIEW
Sekaran Saravanan, Selvaraj Vimalraj, Palanisamy Thanikaivelan, Sivanantham Banudevi, Geetha Manivasagam
Tissue engineering (TE) is a promising approach for repairing diseased and damaged bone tissue. Injectable hydrogel based strategies offer a wide range of applications in rapid recovery of bone defects by acting as filler materials and depots for delivering various bioactive molecules and averting the need for surgical intervention. Chitosan (CS), a natural polysaccharide, forms a thermosensitive injectable hydrogel through the addition of beta-glycerophosphate (β-GP). This hybrid hydrogel possesses numerous advantages namely mimicking native extracellular matrix (ECM) and providing an amenable microenvironment for cell growth...
October 4, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30289796/robotic-assisted-medial-unicompartmental-knee-arthroplasty-options-and-outcomes
#9
Jess H Lonner, Mitchell R Klement
Medial unicompartmental knee arthroplasty (UKA) has several benefits over total knee arthroplasty for the surgical treatment of isolated medial compartmental arthritis in the knee, including reduced surgical risk and postoperative morbidity, rapid recovery, more normal kinematics, greater patient satisfaction, and shorter hospitalization. Nonetheless, there is substantial concern about the higher revision rates and lower survivorship in UKA compared to those in total knee arthroplasty. Robotic assistance has been advanced to improve the precision of bone preparation, component alignment, and quantified ligament balance in UKA, with the ultimate goal of improving kinematics and implant survivorship...
October 4, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/30284518/arterial-blood-sampling-in-male-cd-1-and-c57bl-6j-mice-with-1-isoflurane-is-similar-to-awake-mice
#10
Ashley M Loeven, Candace N Receno, Caitlin M Cunningham, Lara R DeRuisseau
Isoflurane (ISO) is a commonly used anesthetic that offers rapid recovery for laboratory animal research. Initial studies indicated no difference in PaCO2 or pH between conscious (NO ISO) and 1% ISO exposed CD-1 mice. Our laboratory investigated if arterial blood sampling with 1% ISO is a suitable alternative to NO ISO sampling for monitoring ventilation in a commonly studied mouse strain. We hypothesized similar blood chemistry, breathing patterns and cardiovascular responses with NO ISO and 1% ISO. C57BL/6J mice underwent unrestrained barometric plethysmography to quantify the pattern of breathing...
October 4, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/30283302/the-effects-of-chronic-stress-on-migraine-relevant-phenotypes-in-male-mice
#11
Dan Kaufmann, K C Brennan
Migraine is a disabling neurological disorder affecting 12% of the world's population. Stress is a major reported trigger and exacerbator of migraine. We evaluated the effects of two chronic stress paradigms on migraine relevant phenotypes in male C57Bl/6 mice. Methods: Fifty six mice were used in a 14 day social defeat stress (SDS) and twenty three mice were used in a 40 day chronic variable stress (CVS) paradigm. Anxiety measures were evaluated using the open field and elevated plus maze (EPM) tests. Migraine relevant phenotypes were evaluated using the nitroglycerin (NTG) and cortical spreading depression (CSD) models...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/30283177/a-study-comparing-propofol-auto-coinduction-and-standard-propofol-induction-in-patients-undergoing-general-anesthesia-without-midazolam-pretreatment-a-prospective-randomized-control-trial
#12
Unnikrishnan Prathapadas, Maya Gomathiamma, Appavoo Arulvelan, Karen Ruby Lionel, Ajay Prasad Hrishi
Background: Propofol has emerged as an induction agent of choice over the past two decades due to its quick, smooth induction and rapid recovery. The main concern for an anesthesiologist is the hemodynamic instability caused by the standard induction dose of propofol (2-3 mg/kg). Aim: We aim to study the efficacy of propofol auto-coinduction technique in comparison to the standard propofol induction technique in terms of the total induction dose requirement of propofol, the incidence of hemodynamic side effects and pain on injection, and the incidence of fentanyl-induced cough (FIC) in the absence of a synergistic agent like midazolam...
July 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/30277141/bio-polymer-substrates-in-buccal-drug-delivery-current-status-and-future-trend
#13
Bo Sun, Weijun Wang, Zhibin He, Min Zhang, Fangong Kong, Mohini Sain
BACKGROUND: This paper provides a critical review of biopolymer-based substrates, especially the cellulose derivatives, for their application in buccal drug delivery. Drug delivery to the buccal mucous has the benefits of immobile muscle, abundant vascularization and rapid recovery, but not all the drugs can be administered through the buccal mucosa (e. g., macromolecular drugs), due to the low bioavailability caused by their large molecular size. This shortfall inspired the rapid development of drug-compounding technologies and the corresponding usage of biopolymer substrates...
October 1, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/30271541/reduced-representation-sequencing-detects-only-subtle-regional-structure-in-a-heavily-exploited-and-rapidly-recolonizing-marine-mammal-species
#14
Nicolas Dussex, Helen R Taylor, Willam R Stovall, Kim Rutherford, Ken G Dodds, Shannon M Clarke, Neil J Gemmell
Next-generation reduced representation sequencing (RRS) approaches show great potential for resolving the structure of wild populations. However, the population structure of species that have shown rapid demographic recovery following severe population bottlenecks may still prove difficult to resolve due to high gene flow between subpopulations. Here, we tested the effectiveness of the RRS method Genotyping-By-Sequencing (GBS) for describing the population structure of the New Zealand fur seal (NZFS, Arctocephalus forsteri ), a species that was heavily exploited by the 19th century commercial sealing industry and has since rapidly recolonized most of its former range from a few isolated colonies...
September 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/30266987/gls-409-an-antagonist-of-both-p2y-1-and-p2y-12-potently-inhibits-canine-coronary-artery-thrombosis-and-reversibly-inhibits-human-platelet-activation
#15
Elena Smolensky Koganov, Alan D Michelson, Ivan B Yanachkov, Milka I Yanachkova, George E Wright, Karin Przyklenk, Andrew L Frelinger
Dual antiplatelet therapy with aspirin and an adenosine diphosphate (ADP) P2Y12 receptor antagonist reduces ischemic events in patients with acute coronary syndrome. Previous evidence from our group, obtained in a preclinical model of recurrent platelet-mediated thrombosis, demonstrated that GLS-409, a diadenosine tetraphosphate derivative that inhibits both P2Y1 and P2Y12 ADP receptors, may be a novel and promising antiplatelet drug candidate. However, the salutary antiplatelet effects of GLS-409 were accompanied by a trend toward an unfavorable increase in bleeding...
September 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30261405/a-multimodal-biomarker-for-concussion-identification-prognosis-and-management
#16
Arnaud Jacquin, Saloni Kanakia, Doug Oberly, Leslie S Prichep
BACKGROUND: Prompt, accurate, objective assessment of concussion is crucial, particularly for children/adolescents and young adults. While there is currently no gold standard for the diagnosis of concussion, the importance of multidimensional/multimodal assessments has recently been emphasized. METHODS: Concussed subjects (N = 177), matched controls (N = 187) and healthy volunteers (N = 204) represented a convenience sample of male and female subjects between the ages of 13 and 25 years, enrolled at 29 Colleges and 19 High Schools in the US...
September 15, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/30254131/assessment-of-postoperative-inflammatory-markers-and-pain-in-cats-after-laparoscopy-and-miniceliotomy-ovariectomy
#17
Maria Eduarda Bastos Andrade Moutinho da Conceição, Ricardo Andres Ramirez Uscategui, Paulo Henrique Leal Bertolo, Damazio Campos de Souza, Daniele Dos Santos Rolemberg, Paola Castro de Moraes, Pedro Paulo Maia Teixeira, Luis Gustavo Gosuen Gonçalves Dias
Videosurgery is increasingly used in veterinary medicine. Compared with open surgery, it has been shown to cause minimal pain and promote a more rapid recovery. There are various methods of assessing pain and postoperative inflammation in cats, although their particular behaviours may make these assessments difficult. The aim of this study was to compare levels of postoperative pain and inflammation after laparoscopic ovariectomy with an open minimally invasive technique. Twenty queens were randomly divided into two groups based on the method of haemostasis and surgical technique: (1) laparoscopic ovariectomy using a miniloop (miniloop group (MG)); and (2) minilaparotomy using a Snook hook (control group (CG))...
September 25, 2018: Veterinary Record
https://www.readbyqxmd.com/read/30253999/an-investigation-of-the-effects-of-intratesticular-alfaxalone-and-lidocaine-during-castration-in-piglets
#18
Trina M Hancock, Nigel A Caulkett, Ed A Pajor, Leanna Grenwich
OBJECTIVE: To determine whether intratesticular injection of an alfaxalone-lidocaine combination can induce anesthesia and provide a rapid recovery in piglets undergoing surgical castration. STUDY DESIGN: Randomized experimental study. ANIMALS: A group of 30 male piglets, aged 2-10 days, weighing 1.3-4.6 kg. METHODS: Animals were randomly divided into three equal groups for intratesticular administration of alfaxalone + lidocaine: high dose (group HD; 8 mg kg-1  + 2...
July 31, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/30250750/eplerenone-in-the-treatment-of-central-serous-chorioretinopathy-a-review-of-the-literature
#19
REVIEW
Irini Chatziralli, Aikaterini Vlachodimitropoulou, Chrysoula Daoula, Christina Vrettou, Eleni Galani, George Theodossiadis, Panagiotis Theodossiadis
Purpose: The purpose of this review is to examine the role of eplerenone in the treatment of central serous chorioretinopathy (CSCR). Methods: A comprehensive search of the PubMed database has been conducted regarding eplerenone for CSCR, while studies using spironolactone were excluded. Articles and book chapters cited in the reference lists of articles obtained by this method were reviewed and included when considered appropriate, while the retrieved articles were filtered manually to exclude duplicates...
2018: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/30237968/comparison-between-low-dose-chemotherapy-and-surgery-for-the-treatment-of-extremity-associated-solitary-bone-lesions-in-children-with-langerhans-cell-histiocytosis-in-south-china-a-case-control-study
#20
Hongyi Li, Xianbiao Xie, Junqiang Yin, Jian Tu, Xiaoshuai Wang, Weihai Liu, Jiajun Zhang, Hongbo Li, Changye Zou, Yongqian Wang, Jingnan Shen, Gang Huang
Background: The treatment algorithm for solitary bone lesions of Langerhans cell histiocytosis (SBL-LCH) in children extremities still remains controversial. We conducted a retrospective case-control study to compare the feasibility of low-dose chemotherapy (LDC) and surgery for SBL-LCH in children extremities. Patients and methods: This study compares 43 pediatric patients starting LDC with a surgery control group (n = 44), matched for gender, age, follow-up time, and lesion sites and sizes, treated between 2001 and 2015 at our institution...
September 2018: Journal of Bone Oncology
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