keyword
MENU ▼
Read by QxMD icon Read
search

NKp44

keyword
https://www.readbyqxmd.com/read/30514329/mutated-von-hippel-lindau-renal-cell-carcinoma-rcc-promotes-patients-specific-natural-killer-nk-cytotoxicity
#1
Anna Maria Trotta, Sara Santagata, Serena Zanotta, Crescenzo D'Alterio, Maria Napolitano, Giuseppina Rea, Rosa Camerlingo, Fabio Esposito, Elvira Lamantia, Annamaria Anniciello, Giovanni Botti, Nicola Longo, Gerardo Botti, Sandro Pignata, Sisto Perdonà, Stefania Scala
BACKGROUND: Previous evidence demonstrated that restoration of wild type VHL in human renal cancer cells decreased in vitro NK susceptibility. To investigate on the role of tumoral VHL status versus NK capability in renal cancer patients, 51 RCC patients were characterized for VHL mutational status and NK function. METHODS: VHL mutational status was determined by direct DNA sequencing on tumor tissue. NK cytotoxicity was measured against specific target cells K562, VHL-wild type (CAKI-1) and VHL-mutated (A498) human renal cancer cells through externalization of CD107a and IFN-γ production...
December 4, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30504420/cd62l-is-a-functional-and-phenotypic-marker-for-circulating-innate-lymphoid-cell-precursors
#2
Yotam E Bar-Ephraim, Jasper J Koning, Estefany Burniol Ruiz, Tanja Konijn, Vera P Mourits, Kim A Lakeman, Louis Boon, Marijn Bögels, J Peter van Maanen, Joke M M Den Haan, Marjolein van Egmond, Gerd Bouma, Rogier M Reijmers, Reina E Mebius
Innate lymphoid cells (ILCs) guard epithelial tissue integrity during homeostasis, but can be potent immune effector cells during inflammation. Precursors to all ILC subsets (ILC precursors [ILCP]) have been identified in human peripheral blood (PB). We found that during homeostasis, ILCP in PB of mouse and human expressed homing receptors for secondary lymphoid organs, mainly CD62L. These ILCP entered mouse lymph nodes in a CD62L-dependent way and relied on S1P receptors for their exit. Importantly, CD62L expression was absent on human ILCs expressing NKp44 in tonsils and PB of Crohn disease patients, and relatively fewer CD62L+ ILCP were present in PB of Crohn disease patients...
November 30, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30496425/distinct-alterations-in-the-composition-of-mucosal-innate-lymphoid-cells-in-newly-diagnosed-and-established-crohn-s-disease-and-ulcerative-colitis
#3
Marianne Forkel, Sophie van Tol, Charlotte Höög, Jakob Michaëlsson, Sven Almer, Jenny Mjösberg
Background and Aims: Innate lymphoid cells [ILC] have been suggested to play a role in inflammatory bowel disease [IBD]. Here, we investigated the ILC compartment in intestinal biopsies and blood from distinct patient groups with Crohn's disease [CD] and ulcerative colitis [UC], either newly diagnosed or with disease established for at least 1 year. This approach allowed us to simultaneously investigate temporal, disease-specific, and tissue-specific changes in ILC composition in IBD...
November 29, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/30451213/role-of-natural-killer-t-nkt-cells-in-type-ii-diabetes-induced-vascular-injuries
#4
Xiaohong Lv, Yun Gao, Tantan Dong, Libo Yang
BACKGROUND This study investigated the distribution and features of natural killer T (NKT) cells in the peripheral blood of diabetic patients, and their regulatory roles on vascular endothelial cells. MATERIAL AND METHODS Peripheral lymphocytes were isolated from diabetic patients. NKT cell distribution, proportion, and surface and intracellular markers were detected with flow cytometry. Peripheral blood-derived NKT cells were isolated and co-cultured with human umbilical vein endothelial cells (HUVECs). Proliferation and migration of HUVECs were assessed with the CCK-8 assay and the Transwell chamber assay...
November 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30373848/innate-lymphoid-cells-have-decreased-hla-dr-expression-but-retain-their-responsiveness-to-tlr-ligands-during-sepsis
#5
David Cruz-Zárate, Graciela Libier Cabrera-Rivera, Bibiana Patricia Ruiz-Sánchez, Jeanet Serafín-López, Rommel Chacón-Salinas, Constantino López-Macías, Armando Isibasi, Humberto Gallegos-Pérez, Marco Antonio León-Gutiérrez, Eduardo Ferat-Osorio, Lourdes Arriaga-Pizano, Iris Estrada-García, Isabel Wong-Baeza
Sepsis, one of the leading causes of death in intensive care units, is caused by a dysregulated host response to infection that leads to life-threatening organ dysfunction. The proinflammatory and anti-inflammatory responses activated by the infecting microorganism become systemic, and the sustained anti-inflammatory response induces a state of immunosuppression that is characterized by decreased expression of HLA-DR on monocytes, T cell apoptosis, and reduced production of TNF-α by monocytes and macrophages in response to TLR ligands...
October 29, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30350355/brief-report-innate-lymphoid-cells-and-t-cells-contribute-to-the-il-17a-signature-detected-in-the-synovial-fluid-of-patients-with-juvenile-idiopathic-arthritis
#6
Elizabeth C Rosser, Hannah Lom, David Bending, Chantal L Duurland, Mona Bajaj-Elliott, Lucy R Wedderburn
OBJECTIVE: Evidence suggests that aberrant function of innate lymphoid cells (ILC), whose functional and transcriptional profile overlap with T helper (Th) cell subsets, contribute to immune-mediated pathologies. To date, analysis of Juvenile Idiopathic Arthritis (JIA) immune-pathology has concentrated on the contribution of CD4+ T-cells; we have previously identified an expansion of Th17 cells within the synovial fluid (SF) of JIA patients. Here, we extend this analysis to investigate a role for ILC and other IL-17 producing T-cell subsets...
October 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/30260078/il-22-and-gm-csf-expressing-but-not-il-17a-expressing-group-3-innate-lymphoid-cells-are-expanded-in-the-inflamed-spondyloarthritis-joint
#7
Iris C J Blijdorp, Silvia Menegatti, Leonike J J Van Mens, Marleen G H van de Sand, Sijia Chen, Hulda S Hreggvidsdottir, Troy Noordenbos, Talia E Latuhihin, Jochem H Bernink, Hergen Spits, Lars Rogge, Dominique L P Baeten, Nataliya G Yeremenko
OBJECTIVE: Clinical trials of the anti-IL-17A antibody secukinumab demonstrated a crucial role of the IL-17A cytokine in the pathogenesis of spondyloarthritis (SpA), however its cellular source in this condition remains controversial. Group 3 innate lymphoid cells (ILC3s) have been recently identified in a number of different tissues as potent producers of proinflamatory cytokines, including IL-17A and IL-22. In this study we set out to characterize the presence and composition of ILCs and investigate whether these cells are an important source of IL-17A in the synovial tissue of patients with SpA...
September 27, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/30254632/immune-phenotyping-and-transcriptomic-profiling-of-peripheral-blood-mononuclear-cells-from-patients-with-breast-cancer-identification-of-a-3-gene-signature-which-predicts-relapse-of-triple-negative-breast-cancer
#8
Gemma A Foulds, Jayakumar Vadakekolathu, Tarek M A Abdel-Fatah, Divya Nagarajan, Stephen Reeder, Catherine Johnson, Simon Hood, Paul M Moseley, Stephen Y T Chan, A Graham Pockley, Sergio Rutella, Stephanie E B McArdle
Background: Interactions between the immune system and tumors are highly reciprocal in nature, leading to speculation that tumor recurrence or therapeutic resistance could be influenced or predicted by immune events that manifest locally, but can be detected systemically. Methods: Multi-parameter flow cytometry was used to examine the percentage and phenotype of natural killer (NK) cells, myeloid-derived suppressor cells (MDSCs), monocyte subsets and regulatory T (Treg) cells in the peripheral blood of of 85 patients with breast cancer (50 of whom were assessed before and after one cycle of anthracycline-based chemotherapy), and 23 controls...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30228939/nidogen-1-is-a-novel-extracellular-ligand-for-the-nkp44-activating-receptor
#9
Silvia Gaggero, Maurizio Bruschi, Andrea Petretto, Monica Parodi, Genny Del Zotto, Chiara Lavarello, Carola Prato, Laura Santucci, Alessandra Barbuto, Cristina Bottino, Giovanni Candiano, Alessandro Moretta, Massimo Vitale, Lorenzo Moretta, Claudia Cantoni
The release of soluble ligands of activating Natural Killer (NK) cell receptors may represent a regulatory mechanism of NK cell function both in physiologic and in pathologic conditions. Here, we identified the extracellular matrix protein Nidogen-1 (NID1) as a ligand of NKp44, an important activating receptor expressed by activated NK cells. When released as soluble molecule, NID1 regulates NK cell function by modulating NKp44-induced IFN-γ production or cytotoxicity. In particular, it also modulates IFN-γ production induced by Platelet-Derived Growth Factor (PDGF)-DD following NKp44 engagement...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/30176163/corrigendum-haemagglutinin-neuraminidase-from-hpiv3-mediates-human-nk-regulation-of-t-cell-proliferation-via-nkp44-and-nkp46
#10
Samantha McQuaid, Sinead Loughran, Patrick Power, Paula Maguire, Dermot Walls, Maria Grazia Cusi, Claes Orvell, Patricia Johnson
No abstract text is available yet for this article.
September 2018: Journal of General Virology
https://www.readbyqxmd.com/read/30175783/globo-a-binds-to-the-recombinant-natural-cytotoxicity-receptor-nkp44
#11
Kenichiro Ito, Ryo Shiraishi, Koji Higai
Natural killer (NK) cells play an important role in tumor immunity and infection control. The natural cytotoxicity receptors (NCRs) NKp46, NKp44 and NKp30 are involved in the control of the activation of NK cells. Few reports have investigated the ligands of NCRs. We previously reported the NCRs binding affinity to heparin and glycosaminoglycans. We also showed that multimeric sialyl Lewis X-expressing transferrin, secreted by human hepatoma HepG2 cells, binds to NKp46 and NKp44, but not to NKp30. In this study, we investigated the binding between NCRs and glycolipids...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30140269/prostaglandin-e2-secreted-by-thyroid-cancer-cells-contributes-to-immune-escape-through-the-suppression-of-natural-killer-nk-cell-cytotoxicity-and-nk-cell-differentiation
#12
Arum Park, Yunhee Lee, Mi Sun Kim, Young Ju Kang, Young-Jun Park, Haiyoung Jung, Tae-Don Kim, Hee Gu Lee, Inpyo Choi, Suk Ran Yoon
Natural killer (NK) cells play important roles in immune surveillance. However, the tumor microenvironment suppresses NK cell function and allows cancer cells to evade immune detection. In this study, we investigated whether the thyroid cancer cell microenvironment has this effect on NK cells. We found that prostaglandin (PG) E2 produced by thyroid cancer cells suppressed the cytolytic activity of NK cells by inhibiting the expression of the natural cytotoxicity receptors NKp44 and NKp30 and the death receptor tumor necrosis factor-related apoptosis-inducing ligand...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30086799/a-possible-new-pathway-in-natural-killer-cell-activation-also-reveals-the-difficulty-in-determining-human-nk-cell-function-in-cancer
#13
Robert J Canter, William J Murphy
Immunotherapy is rapidly becoming the fourth arm of cancer treatment, and breakthrough successes have been observed in multiple malignancies. However, despite the potential for impressive anti-tumor effects, on average, only 25% of patients respond, and barriers clearly remain. Hence, uncovering innovative ways to apply immunotherapy and overcome immune resistance remains an unmet need in immuno-oncology. Natural killer (NK) cells are an attractive candidate for extending the promise of immunotherapy, although success to date has been largely limited to hematological cancers...
August 7, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/30055825/altered-distribution-and-function-of-splenic-innate-lymphoid-cells-in-adult-chronic-immune-thrombocytopenia
#14
Sylvain Audia, Thomas Moulinet, Marion Ciudad-Bonté, Maxime Samson, Olivier Facy, Pablo Ortega-Deballon, Philippe Saas, Bernard Bonnotte
Innate lymphoid cells (ILCs) have been characterized as innate immune cells capable to modulate the immune response in the mucosae. Human ILCs have been rarely described in secondary lymphoid organs except in tonsils. Moreover, their function and phenotype in human secondary lymphoid organs during autoimmune diseases have never been studied. We took advantage of splenectomy as a treatment of immune thrombocytopenia (ITP) to describe and compare splenic ILC from 18 ITP patients to 11 controls. We first confirmed that ILC3 represented the most abundant ILC subset in human non-inflamed spleens, accounting for 90% of total ILC, and that they were mostly constituted of NKp44- cells...
September 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/30008723/-in-vitro-exposure-to-prostratin-but-not-bryostatin-1-improves-natural-killer-cell-functions-including-killing-of-cd4-t-cells-harboring-reactivated-human-immunodeficiency-virus
#15
Maria Giovanna Desimio, Erica Giuliani, Angelo Salvatore Ferraro, Gaspare Adorno, Margherita Doria
In the attempt of purging the HIV-1 reservoir through the "shock-and-kill" strategy, it is important to select latency-reversing agents (LRAs) devoid of deleterious effects on the antiviral function of immune effector cells. Here, we investigated two LRAs with PKC agonist activity, prostratin (PRO) and bryostatin-1 (BRY), for their impact on the function of natural killer (NK) cells, the major effectors of innate immunity whose potential in HIV-1 eradication has emerged in recent clinical trials. Using NK cells of healthy donors, we found that exposure to either PRO or BRY potently activated NK cells, resulting in upmodulation of NKG2D and NKp44 activating receptors and matrix metalloprotease-mediated shedding of CD16 receptor...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29897565/effector-%C3%AE-%C3%AE-t-cells-in-human-renal-fibrosis-and-chronic-kidney-disease
#16
Becker Meng-Po Law, Ray Wilkinson, Xiangju Wang, Katrina Kildey, Mae Lindner, Kenneth Beagley, Helen Healy, Andrew J Kassianos
Background: γδ T cells are effector lymphocytes recognized as key players during chronic inflammatory processes. Mouse studies suggest a pathological role for γδ T cells in models of kidney disease. Here we evaluated γδ T cells in human native kidneys with tubulointerstitial fibrosis, the pathological hallmark of chronic kidney disease. Methods: γδ T cells were extracted from human kidney tissue and enumerated and phenotyped by multicolour flow cytometry...
April 20, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29875773/nkp44-derived-peptide-binds-proliferating-cell-nuclear-antigen-and-mediates-tumor-cell-death
#17
Avishai Shemesh, Kiran Kundu, Refael Peleg, Rami Yossef, Irena Kaplanov, Susmita Ghosh, Yana Khrapunsky, Orly Gershoni-Yahalom, Tatiana Rabinski, Adelheid Cerwenka, Roee Atlas, Angel Porgador
Proliferating cell nuclear antigen (PCNA) is considered as a hub protein and is a key regulator of DNA replication, repair, cell cycle control, and apoptosis. PCNA is overexpressed in many cancer types, and PCNA overexpression is correlated with cancer virulence. Membrane-associated PCNA is a ligand for the NKp44 (NCR2) innate immune receptor. The purpose of this study was to characterize the PCNA-binding site within NKp44. We have identified NKp44-derived linear peptide (pep8), which can specifically interact with PCNA and partly block the NKp44-PCNA interaction...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29740448/working-in-nk-mode-natural-killer-group-2-member-d-and-natural-cytotoxicity-receptors-in-stress-surveillance-by-%C3%AE-%C3%AE-t-cells
#18
REVIEW
Bruno Silva-Santos, Jessica Strid
Natural killer cell receptors (NKRs) are germline-encoded transmembrane proteins that regulate the activation and homeostasis of NK cells as well as other lymphocytes. For γδ T cells, NKRs play critical roles in discriminating stressed (transformed or infected) cells from their healthy counterparts, as proposed in the "lymphoid stress-surveillance" theory. Whereas the main physiologic role is seemingly fulfilled by natural killer group 2 member D, constitutively expressed by γδ T cells, enhancement of their therapeutic potential may rely on natural cytotoxicity receptors (NCRs), like NKp30 or NKp44, that can be induced selectively on human Vδ1+ T cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29683419/haemagglutinin-neuraminidase-from-hpiv3-mediates-human-nk-regulation-of-t-cell-proliferation-via-nkp44-and-nkp46
#19
Samantha McQuaid, Sinead Loughran, Patrick Power, Paula Maguire, Dermot Walls, Maria Grazia Cusi, Claes Orvell, Patricia Johnson
HPIV3 is a respiratory virus causing airway diseases, including pneumonia, croup, and bronchiolitis, during infancy and childhood. Currently there is no effective vaccine or anti-viral therapy for this virus. Studies have suggested that poor T cell proliferation following HPIV3 infection is responsible for impaired immunological memory associated with this virus. We have previously demonstrated that NK cells mediate regulation of T cell proliferation during HPIV3 infection. Here we add to these studies by demonstrating that the regulation of T cell proliferation during HPIV3 infection is mediated via NK receptors NKp44 and NKp46 and involves the surface glycoprotein haemagglutinin-neuraminidase but not the fusion protein of the virus...
June 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29650045/characterization-of-the-interaction-between-human-decidua-parietalis-mesenchymal-stem-stromal-cells-and-natural-killer-cells
#20
M H Abumaree, E Bahattab, A Alsadoun, A Al Dosaimani, F M Abomaray, T Khatlani, B Kalionis, M F El-Muzaini, A O Alawad, A S AlAskar
BACKGROUND: Human decidua parietalis mesenchymal stem/multipotent stromal cells (DPMSCs) have unique phenotypic and functional properties that make them promising candidates for cell-based therapy. Here, we investigated DPMSC interaction with natural killer (NK) cells, and the effects of this interaction on NK cell phenotypic characteristics and functional activities. METHODS: DPMSCs isolated from the decidua parietalis of human fetal membranes were cultured with interleukin (IL)-2-activated and IL-2-unactivated NK cells isolated from healthy human peripheral blood...
April 12, 2018: Stem Cell Research & Therapy
keyword
keyword
166957
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"