Martin E Baumdick, Annika Niehrs, Frauke Degenhardt, Maria Schwerk, Ole Hinrichs, Ana Jordan-Paiz, Benedetta Padoan, Lucy H M Wegner, Sebastian Schloer, Britta F Zecher, Jakob Malsy, Vinita R Joshi, Christin Illig, Jennifer Schröder-Schwarz, Kimberly J Möller, Maureen Martin, Yuko Yuki, Mikki Ozawa, Jürgen Sauter, Alexander H Schmidt, Daniel Perez, Anastasios D Giannou, Mary Carrington, Randall S Davis, Udo Schumacher, Guido Sauter, Samuel Huber, Victor G Puelles, Nathaniel Melling, Andre Franke, Marcus Altfeld, Madeleine J Bunders
BACKGROUND AND AIMS: Ulcerative colitis (UC) is characterized by severe inflammation and destruction of the intestinal epithelium, and associated with risk single nucleotide polymorphism in HLA class II. Given the recently discovered interactions between subsets of HLA-DP molecules and the activating natural killer (NK) cell receptor NKp44, genetic associations of UC and HLA-DP haplotypes and their functional implications were investigated. METHODS: HLA-DP haplotype and UC risk association analyses were performed (UC: N= 13,927; control: N= 26,764)...
July 14, 2023: Gastroenterology