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https://www.readbyqxmd.com/read/30021652/the-dynamic-changes-in-the-number-of-uterine-natural-killer-cells-are-specific-to-the-eutopic-but-not-to-the-ectopic-endometrium-in-women-and-in-a-baboon-model-of-endometriosis
#1
Josephine A Drury, Kirstin L Parkin, Lucy Coyne, Emma Giuliani, Asgerally T Fazleabas, Dharani K Hapangama
BACKGROUND: Endometriosis is a common condition associated with growth of endometrial-like tissue beyond the uterine cavity. Previous reports have suggested a role for uNK cells in the pathogenesis of endometriosis postulating that survival and accumulation of menstrual endometrial tissue in the peritoneal cavity may relate to a reduction in the cytotoxic activity of peripheral blood NK cells. We aimed to assess the differences in percentage of uNK cells and their phenotypical characterization in eutopic and ectopic endometrial samples from women with and without endometriosis and baboons with induced endometriosis...
July 18, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/30013549/the-ebola-glycoprotein-modulates-the-function-of-natural-killer-cells
#2
Avishay Edri, Avishai Shemesh, Muhammed Iraqi, Omri Matalon, Michael Brusilovsky, Uzi Hadad, Olga Radinsky, Orly Gershoni-Yahalom, John M Dye, Ofer Mandelboim, Mira Barda-Saad, Leslie Lobel, Angel Porgador
The Ebola virus (EBOV) uses evasion mechanisms that directly interfere with host T-cell antiviral responses. By steric shielding of human leukocyte antigen class-1, the Ebola glycoprotein (GP) blocks interaction with T-cell receptors (TCRs), thus rendering T cells unable to attack virus-infected cells. It is likely that this mechanism could promote increased natural killer (NK) cell activity against GP-expressing cells by preventing the engagement of NK inhibitory receptors; however, we found that primary human NK cells were less reactive to GP-expressing HEK293T cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29895693/distinct-human-circulating-nkp30-fc%C3%AE%C2%B5ri%C3%AE-cd8-t-cell-population-exhibiting-high-natural-killer-like-antitumor-potential
#3
Margareta P Correia, Ana Stojanovic, Katharina Bauer, Dilafruz Juraeva, Lars-Oliver Tykocinski, Hanns-Martin Lorenz, Benedikt Brors, Adelheid Cerwenka
CD8+ T cells are considered prototypical cells of adaptive immunity. Here, we uncovered a distinct CD8+ T cell population expressing the activating natural killer (NK) receptor NKp30 in the peripheral blood of healthy individuals. We revealed that IL-15 could de novo induce NKp30 expression in a population of CD8+ T cells and drive their differentiation toward a broad innate transcriptional landscape. The adaptor FcεRIγ was concomitantly induced and was shown to be crucial to enable NKp30 cell-surface expression and function in CD8+ T cells...
June 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29888839/cd56-bright-natural-killer-cells-induce-hbsag-reduction-via-cytolysis-and-cccdna-decay-in-long-term-entecavir-treated-patients-switching-to-peginterferon-alfa-2a
#4
A Shi, X Zhang, F Xiao, L Zhu, W Yan, M Han, X Luo, T Chen, Q Ning
HBV surface antigen (HBsAg) reduction is well observed in chronic hepatitis B (CHB) patients treated with pegylated interferon alpha-2a (PegIFNα). However, the mechanism of HBsAg suppression has not been fully elucidated. Twenty-seven of 55 entecavir-treated CHB e antigen positive patients were switched to PegIFNα treatment (Group A) whereas 28 patients continued entecavir treatment (Group B). The percentage or absolute number of CD56bright /CD56dim NK cells, expression of receptors and cytokines were evaluated by flow cytometry for 48 weeks and correlated with treatment efficacy...
June 11, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29780393/immunomodulatory-drugs-exert-anti-leukemia-effects-in-acute-myeloid-leukemia-by-direct-and-immunostimulatory-activities
#5
Aude Le Roy, Thomas Prébet, Rémy Castellano, Armelle Goubard, Florence Riccardi, Cyril Fauriat, Samuel Granjeaud, Audrey Benyamine, Céline Castanier, Florence Orlanducci, Amira Ben Amara, Frédéric Pont, Jean-Jacques Fournié, Yves Collette, Jean-Louis Mege, Norbert Vey, Daniel Olive
Immunomodulatory drugs (IMiDs) are anticancer drugs with immunomodulatory, anti-angiogenesis, anti-proliferative, and pro-apoptotic properties. IMiDs are currently used for the treatment of multiple myeloma, myelodysplastic syndrome, and B-cell lymphoma; however, little is known about efficacy in acute myeloid leukemia (AML). We proposed in this study to investigate the relevance of IMiDs therapy for AML treatment. We evaluated the effect of IMiDs on primary AML blasts ( n  = 24), and the impact in natural killer (NK) cell-mediated immunosurveillance of AML...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29764843/poorly-cytotoxic-terminally-differentiated-cd56-neg-cd16-pos-nk-cells-accumulate-in-kenyan-children-with-burkitt-lymphomas
#6
Catherine S Forconi, Cormac P Cosgrove, Pryia Saikumar-Lakshmi, Christina E Nixon, Joslyn Foley, John Michael Ong'echa, Juliana A Otieno, Galit Alter, Christian Münz, Ann M Moormann
Natural killer (NK) cells are critical for restricting viral infections and mediating tumor immunosurveillance. Epstein-Barr virus (EBV) and Plasmodium falciparum malaria are known risk factors for endemic Burkitt lymphoma (eBL), the most common childhood cancer in equatorial Africa. To date, the composition and function of NK cells have not been evaluated in eBL etiology or pathogenesis. Therefore, using multiparameter flow cytometry and in vitro killing assays, we compared NK cells from healthy children and children diagnosed with eBL in Kenya...
May 22, 2018: Blood Advances
https://www.readbyqxmd.com/read/29755462/comparison-of-phenotypic-and-functional-characteristics-between-canine-non-b-non-t-natural-killer-lymphocytes-and-cd3-cd5-dim-cd21-cytotoxic-large-granular-lymphocytes
#7
Soo-Hyeon Lee, Dong-Jun Shin, Yoseop Kim, Cheol-Jung Kim, Je-Jung Lee, Mee Sun Yoon, Tung Nguyen Thanh Uong, Dohyeon Yu, Ji-Youn Jung, Duck Cho, Bock-Gie Jung, Sang-Ki Kim, Guk-Hyun Suh
Natural killer (NK) cells play a pivotal role in the immune response against infections and malignant transformation, and adopted transfer of NK cells is thought to be a promising therapeutic approach for cancer patients. Previous reports describing the phenotypic features of canine NK cells have produced inconsistent results. Canine NK cells are still defined as non-B and non-T (CD3- CD21- ) large granular lymphocytes. However, a few reports have demonstrated that canine NK cells share the phenotypic characteristics of T lymphocytes, and that CD3+ CD5dim CD21- lymphocytes are putative canine NK cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29752261/nk-cell-editing-mediates-epithelial-to-mesenchymal-transition-via-phenotypic-and-proteomic-changes-in-melanoma-cell-lines
#8
Leticía Huergo-Zapico, Monica Parodi, Claudia Cantoni, Chiara Lavarello, Juan L Fernández-Martínez, Andrea Petretto, Enrique J DeAndrés-Galiana, Mirna Balsamo, Alejandro López-Soto, Gabriella Pietra, Mattia Bugatti, Enrico Munari, Marcella Marconi, Maria Cristina Mingari, William Vermi, Lorenzo Moretta, Segundo González, Massimo Vitale
Tumor cell plasticity is a major obstacle for the cure of malignancies as it makes tumor cells highly adaptable to microenvironmental changes, enables their phenotype switching among different forms, and favors the generation of prometastatic tumor cell subsets. Phenotype switching toward more aggressive forms involves different functional, phenotypic, and morphologic changes, which are often related to the process known as epithelial-mesenchymal transition (EMT). In this study, we report natural killer (NK) cells may increase the malignancy of melanoma cells by inducing changes relevant to EMT and, more broadly, to phenotype switching from proliferative to invasive forms...
July 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29740448/working-in-nk-mode-natural-killer-group-2-member-d-and-natural-cytotoxicity-receptors-in-stress-surveillance-by-%C3%AE-%C3%AE-t-cells
#9
REVIEW
Bruno Silva-Santos, Jessica Strid
Natural killer cell receptors (NKRs) are germline-encoded transmembrane proteins that regulate the activation and homeostasis of NK cells as well as other lymphocytes. For γδ T cells, NKRs play critical roles in discriminating stressed (transformed or infected) cells from their healthy counterparts, as proposed in the "lymphoid stress-surveillance" theory. Whereas the main physiologic role is seemingly fulfilled by natural killer group 2 member D, constitutively expressed by γδ T cells, enhancement of their therapeutic potential may rely on natural cytotoxicity receptors (NCRs), like NKp30 or NKp44, that can be induced selectively on human Vδ1+ T cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29700172/the-early-expansion-of-anergic-nkg2apos-cd56dim-cd16neg-natural-killer-cells-represents-a-therapeutic-target-in-haploidentical-haematopoietic-stem-cell-transplantation
#10
Alessandra Roberto, Clara Di Vito, Elisa Zaghi, Emilia Maria Cristina Mazza, Arianna Capucetti, Michela Calvi, Paolo Tentorio, Veronica Zanon, Barbara Sarina, Jacopo Mariotti, Stefania Bramanti, Elena Tenedini, Enrico Tagliafico, Silvio Bicciato, Armando Santoro, Mario Roederer, Emanuela Marcenaro, Luca Castagna, Enrico Lugli, Domenico Mavilio
Natural Killer cells are the first lymphocyte population to reconstitute early after non myelo-ablative and T cell-replete haploidentical hematopoietic stem cell transplantation with post-transplant infusion of cyclophosphamide. The present study characterizes the transient and predominant expansion starting from the 2nd week after haploidentical hematopoietic stem cell transplantation of a donor-derived unconventional subset of NKp46neg-low/CD56dim/CD16neg natural killer cells expressing remarkable high levels of CD94/NKG2A...
April 26, 2018: Haematologica
https://www.readbyqxmd.com/read/29650045/characterization-of-the-interaction-between-human-decidua-parietalis-mesenchymal-stem-stromal-cells-and-natural-killer-cells
#11
M H Abumaree, E Bahattab, A Alsadoun, A Al Dosaimani, F M Abomaray, T Khatlani, B Kalionis, M F El-Muzaini, A O Alawad, A S AlAskar
BACKGROUND: Human decidua parietalis mesenchymal stem/multipotent stromal cells (DPMSCs) have unique phenotypic and functional properties that make them promising candidates for cell-based therapy. Here, we investigated DPMSC interaction with natural killer (NK) cells, and the effects of this interaction on NK cell phenotypic characteristics and functional activities. METHODS: DPMSCs isolated from the decidua parietalis of human fetal membranes were cultured with interleukin (IL)-2-activated and IL-2-unactivated NK cells isolated from healthy human peripheral blood...
April 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29619416/early-and-late-changes-in-natural-killer-cells-in-response-to-ledipasvir-sofosbuvir-treatment
#12
Lucy Golden-Mason, Rachel H McMahan, Michael S Kriss, Alexandra L Kilgore, Linling Cheng, Rachael J Dran, Amanda Wieland, Hugo R Rosen
Chronic hepatitis C virus (HCV) infection is characterized by dysregulated natural killer (NK) cell responses. NKs play a critical role in achieving sustained responses to interferon (IFN)-α-based therapy. Rapid sustained HCV-RNA clearance is now achieved with direct-acting antivirals (DAAs). Studies of patients receiving first-wave DAAs suggest NK functional restoration. Here, we investigate the effect of mainstream DAA treatment on NKs. We collected a prospective cohort of male HCV genotype 1-infected patients treated with ledipasvir/sofosbuvir (n = 22)...
April 2018: Hepatology communications
https://www.readbyqxmd.com/read/29580037/analysis-of-the-expression-of-surface-receptors-on-nk-cells-and-nkg2d-on-immunocytes-in-peripheral-blood-of-patients-with-nasopharyngeal-carcinoma
#13
Yuanji Xu, Rui Zhou, Chuanzhong Huang, Mingwei Zhang, Jieyu Li, Jingfeng Zong, Sufang Qiu, Shaojun Lin, Honglin Chen, Yunbin Ye, Jianji Pan
Background: The aberrant expression of surface receptors on immunocytes may represent potential markers of tumor escape for nasopharyngeal carcinoma (NPC). The aim of this study was to investigate the expression of representative receptors on natural killer (NK) cells and NK group 2, member D (NKG2D) on immunocytes in the peripheral blood of patients with NPC. Methods: Patients (n = 64) with NPC prior to initiation of treatment were defined as the study group. Healthy volunteers (n = 31) served as the control group...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29575692/effect-of-the-in-vivo-application-of-granulocyte-colony-stimulating-factor-on-nk-cells-in-bone-marrow-and-peripheral-blood
#14
Xing-Xing Yu, Ting-Ting Han, Ling-Ling Xu, Ying-Jun Chang, Xiao-Jun Huang, Xiang-Yu Zhao
Granulocyte colony-stimulating factor (G-CSF) has been widely used in the field of allogeneic haematopoietic stem cell transplantation (allo-HSCT) for priming donor stem cells from the bone marrow (BM) to peripheral blood (PB) to collect stem cells more conveniently. Donor-derived natural killer (NK) cells have important antitumour functions and immune regulatory roles post-allo-HSCT. The aim of this study was to evaluate the effect of G-CSF on donors' NK cells in BM and PB. The percentage of NK cells among nuclear cells and lymphocyte was significantly decreased and led to increased ratio of T and NK cells in BM and PB post-G-CSF in vivo application...
June 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29542132/how-do-we-manufacture-clinical-grade-interleukin-15-stimulated-natural-killer-cell-products-for-cancer-treatment
#15
Lucía Fernández, Alejandra Leivas, Jaime Valentín, Adela Escudero, Dolores Corral, Raquel de Paz, Maria Vela, David Bueno, Rebeca Rodríguez, Juan Manuel Torres, Mariana Díaz-Almirón, Eduardo López-Collazo, Joaquin Martinez-Lopez, Antonio Pérez-Martínez
BACKGROUND: Cancer immunotherapy involving natural killer (NK) cells has gained interest. Here we report two methods to obtain interleukin (IL)-15-activated NK cells for clinical use. STUDY DESIGN AND METHODS: IL-15-activated NK cell products were obtained after 1) enrichment from healthy haploidentical donors' peripheral blood mononuclear cells (PBMNCs) collected by nonmobilized apheresis by a two-step magnetic procedure, depletion of CD3+ cells followed by selection of CD56+ cells and ex vivo overnight stimulation with IL-15 (NKIL15); and 2) expansion using the K562-mb15-41BBL cell line (NKAE), from autologous PBMNCs from patients with multiple myeloma or expansion from healthy haploidentical PBMNCs obtained from whole blood using the same previous cell line...
June 2018: Transfusion
https://www.readbyqxmd.com/read/29541698/adcc-mediated-cd56-dim-nk-cell-responses-are-associated-with-early-hbsag-clearance-in-acute-hbv-infection
#16
Wen-Han Yu, Cormac Cosgrove, Christoph T Berger, Patrick C Cheney, Marina Krykbaeva, Arthur Y Kim, Lia Lewis-Ximenez, Georg M Lauer, Galit Alter
Background: Hepatitis B virus (HBV) affects up to 400 million people worldwide and accounts for approximately one million deaths per year from liver pathologies. Current treatment regimens are effective in suppressing viremia but usually have to be taken indefinitely, warranting research into new therapeutic approaches. Acute HBV infection in adults almost universally results in resolution of viremia, with the exception of immunocompromised persons, suggesting that the immune response can functionally cure or even eradicate HBV infection...
2018: Pathogens & Immunity
https://www.readbyqxmd.com/read/29467448/identification-of-the-fungal-ligand-triggering-cytotoxic-prr-mediated-nk-cell-killing-of-cryptococcus-and-candida
#17
Shu Shun Li, Henry Ogbomo, Michael K Mansour, Richard F Xiang, Lian Szabo, Fay Munro, Priyanka Mukherjee, Roy A Mariuzza, Matthias Amrein, Jatin M Vyas, Stephen M Robbins, Christopher H Mody
Natural killer (NK) cells use the activating receptor NKp30 as a microbial pattern-recognition receptor to recognize, activate cytolytic pathways, and directly kill the fungi Cryptococcus neoformans and Candida albicans. However, the fungal pathogen-associated molecular pattern (PAMP) that triggers NKp30-mediated killing remains to be identified. Here we show that β-1,3-glucan, a component of the fungal cell wall, binds to NKp30. We further demonstrate that β-1,3-glucan stimulates granule convergence and polarization, as shown by live cell imaging...
February 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29392336/an-il-15-superagonist-il-15r%C3%AE-fusion-complex-protects-and-rescues-nk-cell-cytotoxic-function-from-tgf-%C3%AE-1-mediated-immunosuppression
#18
Rika Fujii, Caroline Jochems, Sarah R Tritsch, Hing C Wong, Jeffrey Schlom, James W Hodge
Natural killer (NK) cells are innate cytotoxic lymphocytes that play a fundamental role in the immunosurveillance of cancers. NK cells of cancer patients exhibit impaired function mediated by immunosuppressive factors released from the tumor microenvironment (TME), such as transforming growth factor (TGF)-β1. An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor activity in several in vivo studies...
April 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29370095/innovative-clinical-perspectives-for-cik-cells-in-cancer-patients
#19
REVIEW
Martino Introna, Fabio Correnti
Cytokine-induced killer (CIK) cells are T lymphocytes that have acquired, in vitro, following extensive manipulation by Interferon gamma (IFN-γ), OKT3 and Interleukin 2 (IL-2) addition, the expression of several Natural Killer (NK) cell-surface markers. CIK cells have a dual "nature", due to the presence of functional TCR as well as NK molecules, even if the antitumoral activity can be traced back only to the NK-like structures (DNAM-1, NKG2D, NKp30 and CD56). In addition to antineoplastic activity in vitro and in several in-vivo models, CIK cells show very limited, if any, GvHD toxicity as well as a strong intratumoral homing...
January 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29334801/bu-shen-yi-qi-formula-impairs-cytotoxicity-of-nk-cells-by-up-regulating-ido-expression-in-trophoblasts
#20
Shao-Liang Yang, Tian-Tian Niu, Xue-Lian Li, Da-Jin Li, Ming-Qing Li, Hai-Yan Wang
Recurrent spontaneous abortion (RSA) is a common health problem that affects about 5% of fertile women, when it occurs for unknown reasons, it is called unexplained recurrent spontaneous abortion (URSA). Traditional Chinese medicine, such as Bu-Shen-Yi-Qi formula which consists of Dangshen, Tusizi, Baizhu, Baishuo, Duzhong, Sangjisheng, Sugeng, and Tiaohuangqin, has played an invaluable role in the treatment of RSA since ancient times. However, the mechanism of how it takes effect is still not clear. To identify Bu-Shen-Yi-Qi formula could modulate immune condition at maternal-fetal interface via its effect on trophoblasts, HTR-8 of different treatment were co-cultured with peripheral or decidual natural killer (NK) cells, and the receptors such as NKP30 and NKP46 expression on NK cells were measured by flow cytometry (FCM)...
January 15, 2018: Gynecological Endocrinology
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