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https://www.readbyqxmd.com/read/30551159/elagolix-for-endometriosis-all-that-glitters-is-not-gold
#1
Paolo Vercellini, Paola Viganò, Giussy Barbara, Laura Buggio, Edgardo Somigliana
Elagolix, an orally active non-peptidic GnRH antagonist, has been approved by the Food and Drug Administration for the management of moderate to severe pain associated with endometriosis. As the degree of ovarian suppression obtained with elagolix is dose-dependent, pain relief may be achieved by modulating the level of hypo-oestrogenism while limiting side effects. Elagolix may thus be considered a novelty in terms of its endocrine and pharmacological properties but not for its impact on the pathogenic mechanisms of endometriosis, as the target of this new drug is, yet again, alteration of the hormonal milieu...
December 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/30550884/proteomic-analyses-reveal-lower-expression-of-tex40-and-atp6v0a2-proteins-related-to-calcium-ion-entry-and-acrosomal-acidification-in-asthenozoospermic-males
#2
Ashima Sinha, Virendra Singh, Sarman Singh, Savita Yadav
AIMS: Idiopathic nature of male infertility disorder needs to be investigated by different horizons of molecular biology for its treatment and to device male contraceptive. Further, it can also aid in advancement of assisted reproductive technology (ART), as nowadays the failure and disquiets of ART are consistent. Herein, we have attempted to find out proteins responsible for male infertility by comparing proteome profile of sperms collected from normal control and asthenozoospermic (AS) males...
December 11, 2018: Life Sciences
https://www.readbyqxmd.com/read/30548397/contraceptive-use-among-women-with-prediabetes-and-diabetes-in-a-us-national-sample
#3
Laura E Britton, Jon M Hussey, Diane C Berry, Jamie L Crandell, Jada L Brooks, Amy G Bryant
INTRODUCTION: Although elevated blood glucose is associated with adverse maternal and fetal health outcomes, evidence suggests that women with diabetes may not be receiving comprehensive reproductive health care, including family planning and preconception care. Using a population-based sample, we evaluated the relationship between contraceptive use and biomarker-identified diabetes. METHODS: This cross-sectional study used data from 5548 women in the nationally representative National Longitudinal Study of Adolescent to Adult Health (Add Health) from 2007 to 2009...
December 12, 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/30544261/dietary-intake-of-nutrients-involved-in-folate-mediated-one-carbon-metabolism-and-risk-for-endometrial-cancer
#4
Jana Lu, Britton Trabert, Linda M Liao, Ruth M Pfeiffer, Kara A Michels
Background: Studies disagree as to whether intakes of folate-mediated one-carbon metabolism nutrients are associated with endometrial cancer. Methods: Using data from the large, prospective NIH-AARP Diet and Health Study, we used Cox proportional hazards models to evaluate endometrial cancer risk associated with calorie-adjusted dietary intake of several B vitamins and methionine. All models accounted for age, race, body mass index (BMI), smoking, oral-contraceptive use, menopausal hormone therapy use and caloric intake...
December 13, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/30531683/epidemiology-and-risk-factors-of-menopause-syndrome-among-uyghur-han-and-kazak-women-in-xinjiang-china
#5
Xinlian Liu, Xi Fu, Rong Du, Zhifang Chen, Jialin Sun, Yan Ding
BACKGROUND This study analyzed the epidemiology and the risk factors of menopause syndrome (MPS) among Uyghur, Han, and Kazak women in Xinjiang. MATERIAL AND METHODS This was a cross-sectional study. The stratified-cluster random-sampling method was used. A total of 3382 women aged 40 to 60 years of age were included from Urumqi City, Kashgar City, Altay City, Ili Kazakh Autonomous Prefecture, Künes County, Mongolkure County, Tekes County,Talede town, Alemale Township, and Ulugchat County (Kashgar Prefecture) in Xinjiang Province...
December 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30531578/reproductive-health-care-in-catholic-facilities-a-scoping-review
#6
Nichole B Thorne, Taylor K Soderborg, Jacqueline J Glover, Lilian Hoffecker, Maryam Guiahi
OBJECTIVE: Given the rise in Catholic ownership of U.S. health care facilities, we aimed to examine reproductive health care provision and patient outcomes. We performed a scoping review, which maps the literature and considers inclusion of studies that are not specifically quantitative. DATA SOURCES: We searched five databases (MEDLINE, EMBASE, Web of Science and Cochrane Library, ClinialTrials.gov) from inception through August 2018 using terms related to reproductive health care and religion...
December 4, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30508411/women-s-reproductive-history-and-pre-clinical-peripheral-arterial-disease-in-late-life-the-san-diego-population-study
#7
Yamnia I Cortés, Nisha Parikh, Matthew A Allison, Michael H Criqui, Natalie Suder, Emma Barinas-Mitchell, Christina L Wassel
OBJECTIVE: Reproductive events have been linked with increased cardiovascular risk in women, but whether they are associated with pre-clinical peripheral arterial disease (PAD) has been understudied. We evaluated associations between reproductive factors and later-life ankle-brachial index (ABI), femoral artery intima-media thickness (fIMT), and femoral plaques. METHODS: Cross-sectional analysis of 707 multiethnic women who participated in a follow-up exam of the San Diego Population Study in 2007-2011...
December 1, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/30481275/reproductive-factors-exogenous-hormone-use-and-risk-of-b-cell-non-hodgkin-lymphoma-in-a-cohort-of-women-from-the-european-prospective-investigation-into-cancer-and-nutrition
#8
Laura Costas, Leila Lujan-Barroso, Yolanda Benavente, Naomi E Allen, Pilar Amiano, Eva Ardanaz, Caroline Besson, Heiner Boeing, Bas Bueno-de-Mesquita, Iris Cervenka, R Enée T Fortner, Agnès Fournier, Marc Gunter, Sophia Harlid, José María Huerta, Mats Jerkeman, Karin Jirström, Rudolf Kaaks, Anna Karakatsani, Kay-Tee Khaw, Anastasia Kotanidou, Eiliv Lund, Giovanna Masala, Amalia Mattiello, Beatrice Melin, Virginia Menéndez, Neil Murphy, Alexandra Nieters, Kim Overvad, Elio Riboli, Carlotta Sacerdote, Maria-Jose Sánchez, Julie A Schmidt, Sabina Sieri, Anne Tjønneland, Antonia Trichopoulou, Rosario Tumino, Roel Vermeulen, Elisabete Weiderpass, Silvia de Sanjosé, Antonio Agudo, Delphine Casabonne
The role of hormonal factors in lymphoid neoplasms etiology remains unclear. Previous studies have yielded conflicting results, been underpowered to assess many lymphoma subtypes, or lacked detailed information on relevant exposures. Within the European Prospective Investigation into Cancer and Nutrition cohort, we analyzed comprehensive data collected at baseline (1992-2000) on reproductive factors and exogenous hormone use among 343,458 women, including 1,427 incident B-cell non-Hodgkin lymphomas (NHL) and its major subtypes identified after a mean follow-up of 14 years (through 2015)...
November 27, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/30473102/-state-of-play-of-teenage-pregnancies
#9
Marjolaine Prieto, Laelia Benoit, Marie-Rose Moro, Rahmeth Radjack
Teenage pregnancy represents a global risk. In France, in 2016, 1.14% of pregnancies concerned 15-17 year olds. Rare in our societies, they are socially condemned. A medical-psychological-sociological literature review shows that, beyond the contraceptive failure or the accidental nature evoked, it is essential to spot high risk situations and focus on the meaning behind these teenage pregnancies.
November 2018: Soins. Psychiatrie
https://www.readbyqxmd.com/read/30453124/increased-frequency-of-mind-wandering-in-healthy-women-using-oral-contraceptives
#10
Catherine Raymond, Marie-France Marin's, Robert-Paul Juster, Sarah Leclaire, Olivier Bourdon, Sophia Cayer-Falardeau, Sonia J Lupien
Oral contraceptive (OC) is the most common type of contraceptive method used in industrialized countries. A recent epidemiological study showed that OC use was associated with the onset of depression in young women. Mind wandering, a cognitive process associated with spontaneous thoughts unrelated to the task at-hand, has previously been associated with depressive thinking. Consequently, mind wandering might be a precursor for cognitive vulnerability in individuals who are at-risk for mood disorders. The purpose of this study was to examine the frequency and nature of mind wandering in women using OC in comparison to two control groups: naturally cycling women and men...
November 8, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/30418530/17-%C3%AE-estradiol-and-17%C3%AE-ethinyl-estradiol-exhibit-immunologic-and-epigenetic-regulatory-effects-in-nzb-wf1-female-mice
#11
Rujuan Dai, Michael Edwards, Bettina Heid, S Ansar Ahmed
17α-ethinyl estradiol (EE), a synthetic analog of natural estrogen 17-β estradiol (E2), is extensively used in hormonal contraceptives and estrogen replacement therapy, and has also been found in sewage effluents. Given that E2 is a well-known immunomodulator, surprisingly there has been only limited information on the cellular and molecular immunologic consequences of exposure to EE. To address this fundamental gap, we directly compared the effects of EE with E2 on splenic leukocytes of NZB/WF1 mice during the pre-autoimmune period...
November 9, 2018: Endocrinology
https://www.readbyqxmd.com/read/30416023/-contraception-cngof-guidelines-for-clinical-practice-short-version
#12
N Chabbert-Buffet, H Marret, A Agostini, C Cardinale, N Hamdaoui, D Hassoun, A P Jonville-Bera, M Lambert, T Linet, C Pienkowski, G Plu-Bureau, D Pragout, G Robin, C Rousset Jablonski, M Scheffler, F Vidal, S Vigoureux, B Hédon
The French College of Obstetrics and Gynecology (CNGOF) releases its first global recommendations for clinical practice in contraception, to provide physicians with an updated synthesis of available data as a basis for their practice. The French Health Authority (HAS) methodology was used. Twelve practical issues were selected by the organizing committee and the task force members. The available literature was screened until December 2017, and allowed the release of evidence-based, graded recommendations. This synthesis is issued from 12 developed texts, previously reviewed by experts and physicians from public and private practices, with an experience in the contraceptive field...
November 9, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/30416022/-current-knowledge-on-contraceptive-knowledge-in-france-cngof-contraception-guidelines
#13
S Vigoureux, M Le Guen
OBJECTIVE: To summarize current knowledge on contraceptive coverage in France and worldwide, describe the effectiveness of different types of contraceptives, describe the characteristics of women using contraception, contraceptive failure situations and describe the different medical risks associated with contraceptive methods. METHODS: Consultation of the Medline database and of national or international reports on contraception. RESULTS: Contraceptive coverage in France is high: 97% of women in 2013 use a contraceptive method (among fertile, sexually active women without a desire for pregnancy), with a majority using medical methods (72% using pills and other hormonal contraceptives, intrauterine devices and 25% using natural and traditional barrier methods)...
November 8, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/30404622/effects-of-oral-contraceptives-and-natural-menstrual-cycling-on-environmental-learning
#14
Filippo Bianchini, Paola Verde, Stefano Colangeli, Maddalena Boccia, Felice Strollo, Cecilia Guariglia, Giuseppe Bizzarro, Laura Piccardi
BACKGROUND: Endogenous ovarian hormones as well as exogenous oestradiol and progesterone play an important role in cognitive processing. Specifically, these hormones play a role in different aspects of memory, both in terms of storage capacity and temporal duration of the mnemonic track. These hormones also have various effects on different types of memory (i.e., verbal, visuo-spatial, prospective). This study investigated the effects of hormones on topographic memory, a type of memory specifically needed to recall a pathway and to acquire spatial information about locations, distances, and directions...
November 7, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/30396606/associations-between-complementary-medicine-utilisation-and-the-use-of-contraceptive-methods-results-of-a-national-cross-sectional-survey
#15
A Steel, J Wardle, J Frawley, J Adams, D Sibbritt, R Lauche
BACKGROUND AND PURPOSE: This study examines the relationship between the use of complementary medicine (CM) interventions or consultations with CM practitioners and women's choice of contraceptive method. MATERIALS AND METHODS: A secondary analysis of a cross-sectional survey of Australian Women aged 34-39 years from the Australian Longitudinal Study on Women's Health (ALSWH) was conducted. Associations between use of CM and contraception were analysed using Chi-squared tests and multivariate logistic regression...
November 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/30389651/insights-from-a-text-messaging-based-sexual-and-reproductive-health-information-program-in-tanzania-m4rh-retrospective-analysis
#16
Patrick S Olsen, Kate F Plourde, Christine Lasway, Eric van Praag
BACKGROUND: Many mobile health (mHealth) interventions have the potential to generate and store vast amounts of system-generated participant interaction data that could provide insight into user engagement, programmatic strengths, and areas that need improvement to maximize efficacy. However, despite the popularity of mHealth interventions, there is little documentation on how to use these data to monitor and improve programming or to evaluate impact. OBJECTIVE: This study aimed to better understand how users of the Mobile for Reproductive Health (m4RH) mHealth intervention engaged with the program in Tanzania from September 2013 to August 2016...
November 1, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/30389545/-natural-family-planning-methods-and-barrier-cngof-contraception-guidelines
#17
D Hassoun
OBJECTIVE: To develop clinical practice recommendations for the use of natural contraception and female and male barrier methods. MATERIALS AND METHODS: A systematic review of English and French literatures related to the safety and effectiveness of natural contraceptive methods based on PubMed, Cochrane Library, practice recommendations issued by international scientific societies and guidelines provided by the World Health Organization (WHO) as well as updates from the Center for Disease Control and Prevention (CDC)...
October 30, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/30381930/time-to-pregnancy-and-associated-factors-among-couples-with-natural-planned-conception-in-addis-ababa-ethiopia
#18
Eyasu Mesfin Kassa, Eskinder Kebede
Waiting time-to-pregnancy (TTP) of couples is closely related to fecundability. Knowledge on TTP helps clinicians to individualize care for sub-fertility/infertility. Published studies on TTP are very limited in African setting. This cross-sectional study assessed TTP and associated factors among couples with natural planned conception in Addis Ababa, Ethiopia. Data was collected interviewing a representative sample of 1150 pregnant women. The mean and median TTPs were 6.4 (±9.4) and 3.0 months respectively...
September 2018: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/30358713/breast-cancer-risk-among-women-under-55-years-of-age-by-joint-effects-of-usage-of-oral-contraceptives-and-hormone-replacement-therapy
#19
Louise A Brinton, Donna R Brogan, Ralph J Coates, Christine A Swanson, Nancy Potischman, Janet L Stanford
OBJECTIVE: To assess effects on breast cancer risk of exposure to both oral contraceptives and menopausal hormones, an increasingly common exposure. DESIGN: A case-control study of breast cancer among women under the age of 55 years in Atlanta, GA involving 1,031 cases and 919 population controls was conducted. RESULTS: Ever use of oral contraceptives was associated with a relative risk of 1.1 (95% 0.9-1.4), whereas the relative risk for hormone replacement therapy was 0...
November 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30342632/client-preferences-for-contraceptive-counseling-asystematic-review
#20
REVIEW
Edith Fox, Arlene Reyna, Nikita M Malcolm, Rachel B Rosmarin, Lauren B Zapata, Brittni N Frederiksen, Susan B Moskosky, Christine Dehlendorf
CONTEXT: Providers can help clients achieve their personal reproductive goals by providing high-quality, client-centered contraceptive counseling. Given the individualized nature of contraceptive decision making, provider attention to clients' preferences for counseling interactions can enhance client centeredness. The objective of this systematic review was to summarize the evidence on what preferences clients have for the contraceptive counseling they receive. EVIDENCE ACQUISITION: This systematic review is part of an update to a prior review series to inform contraceptive counseling in clinical settings...
November 2018: American Journal of Preventive Medicine
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