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Tdcs, Depression

Nya Mehnwolo Boayue, Gábor Csifcsák, Oula Puonti, Axel Thielscher, Matthias Mittner
During the past decade, it became clear that the effects of non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are substantially influenced by variations in individual head and brain anatomy. In addition to structural variations in the healthy, several psychiatric disorders are characterized by anatomical alterations that are likely to further constrain the intracerebral effects of NIBS. Here, we present high-resolution realistic head models derived from structural magnetic resonance imaging data of 19 healthy adults and 19 patients diagnosed with major depressive disorder (MDD)...
2018: F1000Research
Anne Sauvaget, Agathe Tostivint, François Etcheverrigaray, Anne Pichot, Cécile Dert, Solène Schirr-Bonnais, Johann Clouet, Olivier Sellal, Nicolas Mauduit, Christophe Leux, Clémence Cabelguen, Samuel Bulteau, Valéry-Pierre Riche
OBJECTIVES: Due to its ease of use, tolerance, and cost of acquisition, transcranial direct current stimulation (tDCS) could constitute a credible therapeutic option for non-resistant depression in primary care, when combined with drug management. This indication has yet to receive official recognition in France. The objective of this study is to evaluate the production cost of tDCS for the treatment of depression in hospitals, under realistic conditions. METHODS: The methodology adopted is based on cost accounting and was validated by a multidisciplinary working group...
November 27, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Hikmat Hadoush, Alham Al-Sharman, Hanan Khalil, Saleem A Banihani, Muhammed Al-Jarrah
BACKGROUND Sleep dysfunctions impose a large burden on quality of life for patients with Parkinson's disease (PD). Several studies on PD reported potential therapeutic effects of transcranial direct current stimulation (tDCS) on motor and non-motor functions, but not related to sleep quality. Therefore, the present study examined sleep quality, depression perception, and quality of life changes after bilateral anodal tDCS in patients with PD. MATERIAL AND METHODS Twenty-one patients (n=21) with PD underwent 10 sessions (20 min each, 5 per week) of bilateral anodal tDCS stimulation applied simultaneously over the left and right prefrontal and motor areas...
November 19, 2018: Medical Science Monitor Basic Research
Sang Hoon Lee, Jooyeon Jamie Im, Jin Kyoung Oh, Eun Kyoung Choi, Sujung Yoon, Marom Bikson, In-Uk Song, Hyeonseok Jeong, Yong-An Chung
AIM: Excessive use of online games can have negative influences on mental health and daily functioning. Although the effects of transcranial direct current stimulation (tDCS) have been investigated for the treatment of addiction, it has not been evaluated for excessive online game use. This study aimed to investigate the feasibility and tolerability of tDCS over the dorsolateral prefrontal cortex (DLPFC) in online gamers. METHODS: A total of 15 online gamers received 12 active tDCS sessions over the DLPFC (anodal left/cathodal right, 2 mA for 30 min, 3 times per week for 4 weeks)...
November 12, 2018: Journal of Behavioral Addictions
Mark Corbett, Emily South, Melissa Harden, Sam Eldabe, Erlick Pereira, Imad Sedki, Neil Hall, Nerys Woolacott
BACKGROUND: Although many treatments exist for phantom limb pain (PLP), the evidence supporting them is limited and there are no guidelines for PLP management. Brain and spinal cord neurostimulation therapies are targeted at patients with chronic PLP but have yet to be systematically reviewed. OBJECTIVE: To determine which types of brain and spinal stimulation therapy appear to be the best for treating chronic PLP. DESIGN: Systematic reviews of effectiveness and epidemiology studies, and a survey of NHS practice...
November 2018: Health Technology Assessment: HTA
Yeganeh Shahsavar, Majid Ghoshuni, Ali Talaei
The main goal of this study was to assess the changes in brain activities of patients with severe depression by applying transcranial direct current stimulation (tDCS) using event related potentials (ERPs). Seven patients (four males, with the mean age 34.85 ± 4.25) were asked to fill out Beck's depression questionnaires. EEG signals of subjects were recorded during Stroop test. This test entailed 360 stimulations, which included 120 congruent, 120 incongruent, and 120 neutral stimulations lasting for 12 min...
December 2018: Australasian Physical & Engineering Sciences in Medicine
Daniel L Kenney-Jung, Caren J Blacker, Deniz Doruk Camsari, Jonathan C Lee, Charles P Lewis
Transcranial direct current stimulation (tDCS) involves the application of weak electric current to the scalp. tDCS may influence brain functioning through effects on cortical excitability, neural plasticity, and learning. Evidence in adults suggests promising therapeutic applications for depression, and the adverse effect profile is generally mild. Early research indicates complex interactions between tDCS and concurrent cognitive and motor tasks. Further investigation is warranted to understand how tDCS impacts processes relevant to psychiatric conditions...
January 2019: Child and Adolescent Psychiatric Clinics of North America
Ahmet Zihni Soyata, Serkan Aksu, Adam J Woods, Pınar İşçen, Kardelen Türkü Saçar, Sacit Karamürsel
Decision making and cognitive flexibility are two components of cognitive control that play a critical role in the emergence, persistence, and relapse of gambling disorder. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been reported to enhance decision making and cognitive flexibility in healthy volunteers and individuals with addictive disorders. In this triple-blind randomized sham-controlled parallel study, we aimed to determine whether tDCS over DLPFC would modulate decision making and cognitive flexibility in individuals with gambling disorder...
October 26, 2018: European Archives of Psychiatry and Clinical Neuroscience
Tifei Yuan, Ali Yadollahpour, Julio Salgado-Ramírez, Daniel Robles-Camarillo, Rocío Ortega-Palacios
BACKGROUND: Tinnitus is the perception of sound in the absence of any external acoustic stimulation. Transcranial direct current stimulation (tDCS) has shown promising though heterogeneous therapeutic outcomes for tinnitus. The present study aims to review the recent advances in applications of tDCS for tinnitus treatment. In addition, the clinical efficacy and main mechanisms of action of tDCS on suppressing tinnitus are discussed. METHODS: The study was performed in accordance with the PRISMA guidelines...
October 25, 2018: BMC Neuroscience
Timothy Y Mariano, Frederick W Burgess, Marguerite Bowker, Jason Kirschner, Mascha Van't Wout-Frank, Richard N Jones, Christopher W Halladay, Michael Stein, Benjamin D Greenberg
Background and Objective: Chronic low back pain (CLBP) is highly prevalent, with a substantial psychosocial burden. Pain has both sensory and affective components. The latter component is a significant driver of disability and psychiatric comorbidity but is often inadequately treated. Previously we reported that noninvasive transcranial direct current stimulation (tDCS) may modulate pain-associated affective distress. Here we tested whether 10 daily tDCS sessions aimed to inhibit the left dorsal anterior cingulate cortex (dACC), a region strongly implicated in the affective component of pain, would produce selective reduction in pain-related symptoms...
October 24, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Maria Ironside, Michael Browning, Tahereh L Ansari, Christopher J Harvey, Mama N Sekyi-Djan, Sonia J Bishop, Catherine J Harmer, Jacinta O'Shea
Importance: Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) is under clinical investigation as a treatment for major depressive disorder. However, the mechanisms of action are unclear, and there is a lack of neuroimaging evidence, particularly among individuals with affective dysfunction. Furthermore, there is no direct causal evidence among humans that the prefrontal-amygdala circuit functions as described in animal models (ie, that increasing activity in prefrontal cortical control regions inhibits amygdala response to threat)...
October 17, 2018: JAMA Psychiatry
Andre R Brunoni, Bernardo Sampaio-Junior, Adriano H Moffa, Luana V Aparício, Pedro Gordon, Izio Klein, Rosa M Rios, Lais B Razza, Colleen Loo, Frank Padberg, Leandro Valiengo
OBJECTIVE: Noninvasive brain stimulation (NIBS) techniques, such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), are increasingly being used to treat mental disorders, particularly major depression. The aim of this comprehensive review is to summarize the main advances, limitations, and perspectives of the field. METHODS: We searched PubMed and other databases from inception to July 2017 for articles, particularly systematic reviews and meta-analyses, evaluating the use of NIBS in psychiatric disorders...
October 11, 2018: Revista Brasileira de Psiquiatria
Aakash V Sathappan, Bruce M Luber, Sarah H Lisanby
Pharmacotherapy, psychotherapy, and non-invasive brain stimulation (NIBS)1 each show efficacy in the treatment of psychiatric disorders; however, more efficacious interventions are needed as reflected by an overall unmet need in mental health care. While each modality has typically been studied and developed as a monotherapy, in practice they are typically used in combination. Research has begun to emerge studying the potential synergistic actions of multi-modal, combination therapies. For example, NIBS combined with rehabilitation strategies have demonstrated some success for speech and motor rehabilitation in stroke patients...
March 8, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Marcus Yu Bin Pai, Thais Tavares Terranova, Marcel Simis, Felipe Fregni, Linamara Rizzo Battistella
Neurologic disorders such as stroke and cerebral palsy are leading causes of long-term disability and can lead to severe incapacity and restriction of daily activities due to lower and upper limb impairments. Intensive physical and occupational therapy are still considered main treatments, but new adjunct therapies to standard rehabilitation that may optimize functional outcomes are being studied. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that polarizes underlying brain regions through the application of weak direct currents through electrodes on the scalp, modulating cortical excitability...
September 23, 2018: Journal of Visualized Experiments: JoVE
Giovanni Martinotti, Eleonora Chillemi, Matteo Lupi, Luisa De Risio, Mauro Pettorruso, Massimo Di Giannantonio
INTRODUCTION: Gambling disorder (GD) is a major public health concern with currently no validated and efficacious treatments approved. In this single case study, we report the short- and long-term effect of bilateral transcranial direct current stimulation (tDCS) of dorsolateral prefrontal cortex (DLPFC) on craving and impulse control in a subject with GD. METHODS: The patient is a 26-year-old Caucasian male with an 8-year history of GD as well as alcohol and cocaine misuse...
September 1, 2018: Journal of Behavioral Addictions
Cristina Ottaviani, Francesco Mancini, Samantha Provenzano, Alberto Collazzoni, Francesca D'Olimpio
Previous studies empirically support the existence of a distinctive association between deontological (but not altruistic) guilt and both disgust and obsessive-compulsive (OC) symptoms. Given that the neural substrate underlying deontological guilt comprises brain regions strictly implicated in the emotion of disgust (i.e. the insula), the present study aimed to test the hypothesis that indirect stimulation of the insula via transcranial direct current stimulation (tDCS) would enhance disgust and morality in the deontological domain...
October 2018: Neuropsychologia
Pei-Chun Chao, Chuan-Chia Chang, Hsin-An Chang
Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has been increasingly used to treat bipolar depression. Researchers recently noticed the risk of tDCS-emergent mania/hypomania in depressed patients and started to evaluate this risk by launching a meta-analysis. Here we present a female with bipolar II depression who rapidly developed hypomanic switching during bifrontal tDCS.
September 2018: Psychiatry Investigation
Jessica Grundey, Jerick Barlay, Giorgi Batsikadze, Min-Fang Kuo, Walter Paulus, Michael Nitsche
KEY POINTS: Nicotine (NIC) modulates cognition and memory function by targeting the nicotinic ACh receptor and releasing different transmitter systems postsynaptically. With both NIC-generated mechanisms, calcium influx and calcium permeability can be regulated, which is a key requirement for the induction of long-term potentiation, comprising the physiological basis of learning and memory function. We attempt to unmask the underlying mechanism of nicotinic effects on anodal transcranial direct current stimulation (tDCS)-induced long-term potentiation-like plasticity based on the hypothesis of calcium-dependency...
November 2018: Journal of Physiology
Emma S Welch, Anne Weigand, Julia E Hooker, Noah S Philip, Audrey R Tyrka, Daniel Z Press, Linda L Carpenter
BACKGROUND: Cognitive behavioral therapy (CBT) is effective in the treatment of major depressive disorder (MDD). Transcranial Direct Current Stimulation (tDCS) has demonstrated preliminary antidepressant effects and beneficial effects on cognitive function. OBJECTIVE: We investigated the feasibility and acceptability of using tDCS to enhance the effects of computer-based CBT for treatment of MDD. MATERIALS AND METHODS: In a randomized, double-blind, sham-controlled study, 14 patients with MDD on stable or no pharmacotherapy received active or sham bifrontal tDCS for four weeks with concurrent CBT...
August 28, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Alireza Shahbabaie, Javad Hatami, Ali Farhoudian, Hamed Ekhtiari, Ali Khatibi, Michael A Nitsche
Introduction: Chronic use of most psychoactive drugs may lead to substance dependence and drug addiction. Drug addiction is a chronically relapsing disorder, and current pharmacological and behavioral therapies are not fully efficient. Attentional bias (AB) is hypothesized to have a causal contribution to substance abuse, addiction development and, maintenance. Transcranial direct current stimulation (tDCS) has been of increasing interest in the past few years as a means for modulating neuroplasticity of the human brain...
2018: Frontiers in Pharmacology
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