Julian Wenzel, Luzie Badde, Shalaila S Haas, Carolina Bonivento, Tamsyn E Van Rheenen, Linda A Antonucci, Anne Ruef, Nora Penzel, Marlene Rosen, Theresa Lichtenstein, Paris Alexandros Lalousis, Marco Paolini, Alexandra Stainton, Udo Dannlowski, Georg Romer, Paolo Brambilla, Stephen J Wood, Rachel Upthegrove, Stefan Borgwardt, Eva Meisenzahl, Raimo K R Salokangas, Christos Pantelis, Rebekka Lencer, Alessandro Bertolino, Joseph Kambeitz, Nikolaos Koutsouleris, Dominic B Dwyer, Lana Kambeitz-Ilankovic
Cognitively impaired and spared patient subgroups were identified in psychosis and depression, and in clinical high-risk for psychosis (CHR). Studies suggest differences in underlying brain structural and functional characteristics. It is unclear whether cognitive subgroups are transdiagnostic phenomena in early stages of psychotic and affective disorder which can be validated on the neural level. Patients with recent-onset psychosis (ROP; N = 140; female = 54), recent-onset depression (ROD; N = 130; female = 73), CHR (N = 128; female = 61) and healthy controls (HC; N = 270; female = 165) were recruited through the multi-site study PRONIA...
September 22, 2023: Neuropsychopharmacology