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Tongyu C Wikramanayake, Penelope Hirt, Maram Almastadi, Hunter Mitchell, Marjana Tomic-Canic, Laura Romero, Denisse Garcia, Natasa Strbo
Seborrheic Dermatitis (SD) is a common inflammatory skin disorder, but its molecular pathogenesis remains elusive. Previously, we have established the Mpzl3 knockout (-/-) mice as a model for SD. In this study, we focused on early phases of skin inflammation and determined the cytokine profiles and identified immune cell types in the lesional skin in the Mpzl3 -/- mice. Using flow cytometry, we detected significant increase of CD45+ leukocytes, CD3+ T lymphocytes and especially γδ T cells but not αβ T cells in the lesional skin compared to control...
October 11, 2018: Experimental Dermatology
Lindsey West, Matthew Carlson, Luke Wallis, Heather W Goff
BACKGROUND: The sign of Leser-Trelát is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses. CASE: A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Her symptoms were concerning for a paraneoplastic eruption; workup revealed an elevated CA 125 level and an ovarian mass on abdominal computed tomography scan...
October 5, 2018: Obstetrics and Gynecology
Anna Kołodziejczak, Angelika Wieczorek, Helena Rotsztejn
OBJECTIVE: The aim of this study was to assess objectively the effects of the combination of corundum microdermabrasion and cavitation peeling in the therapy of seborrheic skin with visible symptoms of acne punctata. MATERIAL AND METHODS: The study involved a group of nine women. A series of six treatments with the combination of microdermabrasion and cavitation peeling were performed within facial skin at 10-14 days intervals. Corneometric measurements examining skin hydration level and sebumetric measurements analyzing skin sebum level were made before the series of treatments and after second, fourth and sixth procedure in five facial areas...
October 9, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Thomas George Olsen, B Hunter Jackson, Theresa Ann Feeser, Michael N Kent, John C Moad, Smita Krishnamurthy, Denise D Lunsford, Rajath E Soans
Background: Artificial intelligence is advancing at an accelerated pace into clinical applications, providing opportunities for increased efficiency, improved accuracy, and cost savings through computer-aided diagnostics. Dermatopathology, with emphasis on pattern recognition, offers a unique opportunity for testing deep learning algorithms. Aims: This study aims to determine the accuracy of deep learning algorithms to diagnose three common dermatopathology diagnoses...
2018: Journal of Pathology Informatics
Bruno Gualtieri, Salvatore Panduri, Andrea Chiricozzi, Marco Romanelli
No abstract text is available yet for this article.
September 20, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Bareqa Salah, Mohamad Mahseeri, Zaid Al-Ali, Ata Gaith, Tareq Aldwan, Baeth Al-Rawashdeh
INTRODUCTION: Seborrheic keratosis is one of the most common benign epidermal cutaneous lesions encountered by dermatologists and plastic surgeons in their daily practice. PRESENTATION OF THE CASE: A 66-year-old man was presented with a large verrucous mass on the sacrum and perianal area of 10 years duration. After the diagnosis of SK was confirmed, a complete excision of the lesion was done with coverage of the defect with a partial thikness skin graft, with a good outcome...
September 12, 2018: International Journal of Surgery Case Reports
Stephanie Kao, Alexi Kiss, Tatiana Efimova, Adam J Friedman
Seborrheic keratosis (SK) is the most common skin tumor seen by dermatologists in everyday practice. Although the lesions are mostly benign, many patients still elect to have asymptomatic SK removed. The historical standards of treatment are cryosurgery and electrocautery, two surgical options that are effective at lesion removal but have high rates of postoperative adverse events such as treatment-site scarring and pigmentary alterations. The cosmetic outcomes of SK treatment modalities are of keen interest to dermatologists, as the American population becomes increasingly more diverse...
September 1, 2018: Journal of Drugs in Dermatology: JDD
Daniel Flood, Amanda Lezanski-Gujda, Nathanial R Miletta
Pemphigus foliaceus (PF) is an autoimmune dermatologic disease that typically presents with painful, superficial blisters that evolve into scaling erosions in a seborrheic distribution. This case study intends to demonstrate that due to the relative scarcity of the disease and its distribution on the body, PF can easily be misdiagnosed. We present a 43-year-old African American male that presented to the dermatology clinic with an 18-month history of non-pruritic, violaceous, scaling patches and plaques most prominent on the malar cheeks, upper chest and upper back...
September 12, 2018: Military Medicine
Heidi Oi-Yee Li, Sophia Colantonio, Nordau Kanigsberg
Darier's disease, an autosomal dominant genodermatosis, arises from a mutation in the ATP2A2 gene that codes for sarco/endoplasmic reticulum Ca2+ -ATPase in the endoplasmic reticulum and is characterized by greasy keratotic papules commonly found in seborrheic regions. Conventional treatments, including topical corticosteroids, antibiotics, antifungals and retinoids, often have limited efficacy. The present article reports the novel use of oral magnesium chloride supplementation (300 mg daily) in the treatment of Darier disease...
2018: SAGE Open Medical Case Reports
N Brankov, R Z Conic, N Atanaskova-Mesinkovska, M Piliang, W F Bergfeld
Background: Lichen planopilaris (LPP) is a rare, cicatricial, lymphocyte-mediated alopecia that is thought to have an autoimmune pathogenesis and possibly related to other autoimmune diseases. However, data are limited and studies that examine comorbid conditions are lacking. Objectives: We sought to determine the prevalence of systemic comorbid conditions, nutritional deficiencies, psychological problems, and skin cancers in patients with LPP. Methods: We identified 334 patients with LPP who were seen in the Department of Dermatology at the Cleveland Clinic Foundation between 2000 and 2016...
September 2018: International Journal of Women's Dermatology
Anne George, Banavasi Shanmukha Girisha, Satish Rao
Background: Cutaneous disorders are frequently seen in psychiatric patients. This may be attributed to the common ectodermal origin of skin and neurons. There is a paucity of data on cutaneous comorbidity in primary psychiatric disorders. Aims: The aim of this study is to determine the pattern of cutaneous manifestations in patients with primary psychiatric disorders. Settings and Design: This was a hospital-based observational study. Subjects and Methods: A total of 210 patients suffering from various psychiatric disorders along with associated skin disease were recruited...
April 2018: Indian Journal of Psychiatry
Nikolai Klebanov, Nicole Gunasekera, William M Lin, Elena B Hawryluk, David M Miller, Bobby Y Reddy, Mitalee P Christman, Derek Beaulieu, Suvithan Rajadurai, Lyn M Duncan, Arthur J Sober, Hensin Tsao
BACKGROUND: Melanoma can mimic other cutaneous lesions, but the full spectrum and prevalence of these morphological variants remain largely unknown. OBJECTIVE: To classify non-acral cutaneous melanomas into distinct morphological "clusters" and characterize clusters' clinicopathological features. METHODS: All pathological melanoma diagnoses (2011-2016) were reviewed for routine pre-biopsy digital photographs (n=400). Six dermatologists independently assigned lesions into one of 14 diagnostic classes based on morphology...
August 27, 2018: Journal of the American Academy of Dermatology
Karmveer Singh, Emanuela Camera, Linda Krug, Abhijit Basu, Rajeev Kumar Pandey, Saira Munir, Meinhard Wlaschek, Stefan Kochanek, Marina Schorpp-Kistner, Mauro Picardo, Peter Angel, Catherin Niemann, Pallab Maity, Karin Scharffetter-Kochanek
Transcription factors ensure skin homeostasis via tight regulation of distinct resident stem cells. Here we report that JunB, a member of the AP-1 transcription factor family, regulates epidermal stem cells and sebaceous glands through balancing proliferation and differentiation of progenitors and by suppressing lineage infidelity. JunB deficiency in basal progenitors results in a dermatitis-like syndrome resembling seborrheic dermatitis harboring structurally and functionally impaired sebaceous glands with a globally altered lipid profile...
August 24, 2018: Nature Communications
A Alexoudi, I Alexoudi, S Gatzonis
Sporadic Parkinson's disease (PD) is one of the most common neurodegenerative diseases of the elderly. In the scientific literature, surveys aiming to investigate the potential diagnostic biomarkers for PD have focused on skin and intestinal tissue biopsies, whereas more recent studies have reported an association between PD and skin disorders, such as seborrheic dermatitis and rosacea. In addition, a connection between PD and Crohn's disease has been established. These data suggest the hypothesis of a possible link between the gastrointestinal tract and skin and the development of PD...
August 18, 2018: Revue Neurologique
Martijn G H Sanders, Luba M Pardo, Rebecca S Ginger, Jessica C Kiefte-de Jong, Tamar Nijsten
Current treatments for seborrheic dermatitis only provide a temporary relief. Therefore, identifying modifiable lifestyle factors may help to reduce disease burden. The objective of this study was to determine whether specific dietary patterns or total antioxidant capacity are associated with seborrheic dermatitis. Participants of the Rotterdam Study with a skin examination and a food-frequency questionnaire were included. Total antioxidant capacity was assessed on the basis of ferric reducing antioxidant potential of each food item...
August 18, 2018: Journal of Investigative Dermatology
Balazs Harangi
Skin cancer is a major public health problem with over 123,000 newly diagnosed cases worldwide in every year. Melanoma is the deadliest form of skin cancer, responsible for over 9,000 deaths in the United States each year. Thus, reliable automatic melanoma screening systems would provide a great help for clinicians to detect the malignant skin lesions as early as possible. In the last five years, the efficiency of deep learning-based methods increased dramatically and their performances seem to outperform conventional image processing methods in classification tasks...
August 10, 2018: Journal of Biomedical Informatics
Masato Ishikawa, Takenobu Ohashi, Toshiyuki Yamamoto
No abstract text is available yet for this article.
July 2018: Indian Journal of Dermatology
Daniel P Friedmann, Vineet Mishra, Trevor Batty
This case report highlights a unique variant of seborrheic dermatitis (SD) in a 30-year-old African-American woman with progressive facial papules. Four weeks of uninterrupted mild potency topical corticosteroid therapy produced marked improvement of signs and symptoms of biopsy-confirmed SD. SD mimicking cutaneous sarcoidosis is a unique treatment-responsive variant of SD that may be more likely to be encountered in African-American patients.
July 2018: Journal of Clinical and Aesthetic Dermatology
Fahad Alsaif, Fares Abdulmajed Alkhayal, Rawan Aldahash, Ahmed Alhumaidi
The Leser-Trélat sign is a rare sign of some malignant tumors and is characterized by the sudden appearance of seborrheic keratosis in association with an underlying malignancy. We describe a 60-year-old Saudi man with mycosis fungoides (MF) who developed numerous, rapidly growing, seborrheic keratoses on his face and back. To the best of our knowledge, this is the first reported case of MF with the Leser-Trélat sign from Saudi Arabia.
May 2018: Case Reports in Oncology
Tyler Werbel, Philip R Cohen
INTRODUCTION: 5-Fluorouracil is a fluoropyrimidine antineoplastic medication that is used to topically treat actinic keratoses. Although local adverse effects to the drug are common and anticipated, distant skin reactions are rare and unexpected. In this case report, we describe a patient who developed seborrheic dermatitis-like eruption at a distant site after topical application of 5-fluorouracil to his arms. CASE REPORT: A 63-year-old man with actinic keratoses on his arms developed a facial seborrheic dermatitis-like reaction after topically applying 5-fluorouracil 5% cream twice daily to actinic keratoses on his forearms for 7 days...
September 2018: Dermatology and Therapy
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