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Masato Ishikawa, Takenobu Ohashi, Toshiyuki Yamamoto
No abstract text is available yet for this article.
July 2018: Indian Journal of Dermatology
Daniel P Friedmann, Vineet Mishra, Trevor Batty
This case report highlights a unique variant of seborrheic dermatitis (SD) in a 30-year-old African-American woman with progressive facial papules. Four weeks of uninterrupted mild potency topical corticosteroid therapy produced marked improvement of signs and symptoms of biopsy-confirmed SD. SD mimicking cutaneous sarcoidosis is a unique treatment-responsive variant of SD that may be more likely to be encountered in African-American patients.
July 2018: Journal of Clinical and Aesthetic Dermatology
Fahad Alsaif, Fares Abdulmajed Alkhayal, Rawan Aldahash, Ahmed Alhumaidi
The Leser-Trélat sign is a rare sign of some malignant tumors and is characterized by the sudden appearance of seborrheic keratosis in association with an underlying malignancy. We describe a 60-year-old Saudi man with mycosis fungoides (MF) who developed numerous, rapidly growing, seborrheic keratoses on his face and back. To the best of our knowledge, this is the first reported case of MF with the Leser-Trélat sign from Saudi Arabia.
May 2018: Case Reports in Oncology
Tyler Werbel, Philip R Cohen
INTRODUCTION: 5-Fluorouracil is a fluoropyrimidine antineoplastic medication that is used to topically treat actinic keratoses. Although local adverse effects to the drug are common and anticipated, distant skin reactions are rare and unexpected. In this case report, we describe a patient who developed seborrheic dermatitis-like eruption at a distant site after topical application of 5-fluorouracil to his arms. CASE REPORT: A 63-year-old man with actinic keratoses on his arms developed a facial seborrheic dermatitis-like reaction after topically applying 5-fluorouracil 5% cream twice daily to actinic keratoses on his forearms for 7 days...
July 26, 2018: Dermatology and Therapy
E Lenczowski, E Tung-Hahn, J Higareda, C McCormick, T Markoff, M Arffa, E Poon, K Lee, M Alam
Objective: Although dermatologists strive to provide patient education on sun protection and skin cancer, approximately 90% of Americans have limited health literacy skills. Little has been written about the means to best teach all levels of learners to recognize common benign and malignant skin lesions. Earlier work found that with advancing age, adults were less able to identify concerning lesions, thus underscoring the need for accessible education. Methods: We showed subjects a brief video (7th grade level) about common cutaneous growths, reducing the risk of skin cancer, and the importance of early detection...
June 2018: International Journal of Women's Dermatology
Javiera Hansen S, Patricia Lacourt R
INTRODUCTION: Cushing's syndrome (CS) is an endocrine disease by to glucocorticoids excess, depen dent or independent of adrenocorticotropic hormone (ACTH). The main cause is iatrogenic due to excessive use of glucocorticoids. OBJECTIVE: To show the association between prolonged use of topical corticosteroids and the development of CS. CLINICAL CASE: An infant treated with topical corticosteroids due to seborrheic dermatitis. Due to long-term unsupervised use, he develops Cushing's syndrome characterized by obesity and compromised growth rate...
June 2018: Revista Chilena de Pediatría
Raphaël André, Emmanuel Laffitte, Marem Abosaleh, Bégonia Cortès, Laurence Toutous-Trellu, Gürkan Kaya
Sign of Leser-Trélat is a rare paraneoplastic cutaneous manifestation, characterized by the sudden appearance and rapid increase in size and number of seborrheic keratoses, accompanied by pruritus. Edmund Leser and Ulysse Trélat described this sign in 1890. Since their first description, their conclusions have been considered controversial and some authors assert the absence of a causal link. It seems to be frequently associated with solid tumors and in particular gastrointestinal cancer. Here, we describe a new case associated with a cutaneous T-cell lymphoma and a partial response to extracorporeal photopheresis...
April 2018: Dermatopathology (Basel, Switzerland)
Pooja H Rambhia, Kord Honda, Joshua Arbesman
Immune checkpoint inhibitors targeting the programmed cell death (PD)-1 receptor have dramatically changed the landscape of metastatic melanoma treatment. Nevertheless, these immuno-modulatory agents have associated side effects, including dermatologic manifestations. To this end, we report a patient with metastatic melanoma that was treated with PD-1 inhibitor, and subsequently developed inflammation of existing seborrheic keratosis lesions and new verrucous keratoses, a cutaneous side effect that has not been previously reported to our knowledge...
June 29, 2018: Melanoma Research
M Augustin, N Kirsten, A Körber, D Wilsmann-Theis, G Itschert, P Staubach-Renz, J-T Maul, N Zander
BACKGROUND: Dry skin is a frequent and multifaceted condition which can be associated with skin irritation, itch, patient discomfort and manifest skin disease. In spite of being frequent, little is known about the epidemiology of dry skin in the population. OBJECTIVE: To determine the prevalence of dry skin in the German adult population. METHODS: Data of 48 630 employed persons were assessed on a cross-sectional level in whole-body examinations by experienced dermatologists during company-based skin screenings conducted in 343 German companies...
June 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Kira Kravets, Olga Vasylenko, Zhanna Dranyk, Olga Bogomolets
BACKGROUND: Among all malignancies in Ukraine in 2016, the group of non-melanoma skin cancers headed the list in men and made up 21.6%. This group was second in women and made up 17.6%. The diagnostics of skin tumors are becoming increasingly relevant. METHODS: The store-and-forward (SAF) method was used. The study included patients that were remotely diagnosed with melanocytic nevi, seborrheic keratoses, skin cancer, and skin melanoma. Patients signed up for remote diagnostics, were examined in person by dermatologists, and had tumors excised with a subsequent histological examination...
June 2018: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
Mariana Cruz-Manzano, Cristina N Brau-Javier, Sheila Valentín-Nogueras, Luz D Figueroa-Guzmán
OBJECTIVE: To characterize and analyze the inpatient and emergency pediatric dermatology consults in our academic hospital center. METHODS: We reviewed 485 consultations that were done by the University of Puerto Rico Department of Dermatology from July 2007 to June 2012. The date, patient age and gender, consulting service, presumptive diagnosis, final diagnosis, and diagnostic procedures performed were documented for each consult. RESULTS: The patients' ages ranged from newborn to 18 years; the 13 to 18 years age group was the most common (29%)...
June 2018: Puerto Rico Health Sciences Journal
Mohammed A Al-Masni, Mugahed A Al-Antari, Mun-Taek Choi, Seung-Moo Han, Tae-Seong Kim
BACKGROUND AND OBJECTIVE: Automatic segmentation of skin lesions in dermoscopy images is still a challenging task due to the large shape variations and indistinct boundaries of the lesions. Accurate segmentation of skin lesions is a key prerequisite step for any computer-aided diagnostic system to recognize skin melanoma. METHODS: In this paper, we propose a novel segmentation methodology via full resolution convolutional networks (FrCN). The proposed FrCN method directly learns the full resolution features of each individual pixel of the input data without the need for pre- or post-processing operations such as artifact removal, low contrast adjustment, or further enhancement of the segmented skin lesion boundaries...
August 2018: Computer Methods and Programs in Biomedicine
Raimunda Sâmia Nogueira Brilhante, Maria Gleiciane da Rocha, Glaucia Morgana de Melo Guedes, Jonathas Sales de Oliveira, Géssica Dos Santos Araújo, Jaime David Acosta España, Jamille Alencar Sales, Lara de Aguiar, Manoel de Araújo Neto Paiva, Rossana de Aguiar Cordeiro, Waldemiro de Aquino Pereira-Neto, Adriana de Queiroz Pinheiro, José Júlio Costa Sidrim, Débora de Souza Collares Maia Castelo-Branco, Marcos Fábio Gadelha Rocha
The yeast Malassezia pachydermatis is a component of the microbiota of dogs and cats, however it can cause otitis and seborrheic dermatitis in these animals. The objective of this study was to determine the antifungal susceptibility, and evaluate virulence and pathogenicity of 25 M. pachydermatis strains from animals. Susceptibility to ketoconazole, fluconazole, itraconazole, voriconazole, terbinafine, and amphotericin B was evaluated by broth microdilution assay. In addition, biofilm-forming ability, protease, phospholipase, hemolysin and melanin production and adhesion to epithelial cells by this yeast species were assessed...
July 2018: Veterinary Microbiology
T Niemeyer-van der Kolk, H E C van der Wall, C Balmforth, M B A Van Doorn, R Rissmann
AIMS: To explore the potential of the skin microbiome as biomarker in six dermatological conditions: atopic dermatitis (AD), acne vulgaris (AV), psoriasis vulgaris (PV), hidradenitis suppurativa (HS), seborrhoeic dermatitis/pityriasis capitis (SD/PC) and ulcus cruris (UC). METHODS: A systematic literature review was conducted according to the PRISMA guidelines. Two investigators independently reviewed the included studies and ranked the suitability microbiome implementation for early phase clinical studies in an adapted GRADE method...
June 7, 2018: British Journal of Clinical Pharmacology
Hermann Kneitz, Stefanie Fetzer, Matthias Goebeler, Eva-Bettina Bröcker
BACKGROUND AND OBJECTIVES: The histological differential diagnosis between benign trichogenic skin tumors and basal cell carcinoma may be challenging. We therefore set out to investigate whether expression of CD10, a cell surface protein with neutral endopeptidase activity, might be a suitable marker for the histological differential diagnosis of trichogenic skin tumors. PATIENTS AND METHODS: We immunohistochemically analyzed 119 cases of benign trichogenic skin tumors and basal cell carcinoma...
June 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Leslie S Baumann, Andrew Blauvelt, Zoe D Draelos, Steven E Kempers, Mary P Lupo, Joel Schlessinger, Stacy R Smith, David C Wilson, Mark Bradshaw, Esther Estes, Stuart D Shanler
BACKGROUND: Approved topical treatments for seborrheic keratoses (SKs) are an unmet need. OBJECTIVE: To evaluate the safety/efficacy of 40% hydrogen peroxide topical solution (HP40) versus vehicle (VEH) for the treatment of SKs (A-101-SEBK). METHODS: 937 patients with 4 SKs (≥1 lesion each on face and trunk/extremity) were randomized 1:1 to HP40 or VEH. At each visit, SKs were graded using the Physician's Lesion Assessment (PLA) scale (0:Clear; 1:Near-Clear; 2:≤1mm thick, and 3:>1mm thick)...
June 1, 2018: Journal of the American Academy of Dermatology
Vijay Zawar, Snehal Daga, Manoj Pawar, Shrikant Kumavat
Pigmented transverse nasal band (PTNB) is an interesting morphological entity mainly of cosmetic concern. It is believed to be related to a defect in the development of the nasal cartilages and bones from childhood to adolescence. Some patients may have genetic predisposition. It is asymptomatic in nature and may be associated with certain dermatological conditions such as seborrheic diathesis, dermatosis papulosa nigra, ichthyosis, atopic dermatitis, acne vulgaris, psoriasis, and seborrheic melanosis.
May 28, 2018: Journal of Cosmetic Dermatology
Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Sanjay Chhibber, Om Prakash Katare
BACKGROUND: Topical infections, involving a number of diseases such as impetigo, eczema, pustular acne, psoriasis and infected seborrheic dermatitis are one among the many challenges to health which stand out for their profound impact on human species. The treatment of topical infections has always been a difficult proposition because of the lack of efficacy of existing anti-infectives, longer period of treatment and yet incomplete recovery. The increasing emergence of antibiotic resistant bacterial strains like Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa undermine the need of development of new delivery systems to enhance the therapeutic efficacy of existing topical anti-infectives...
May 28, 2018: Recent Patents on Anti-infective Drug Discovery
Kevin J Mills, Michael K Robinson, Joseph D Sherrill, Daniel J Schnell, Jun Xu
Triggers of skin disease pathogenesis vary, but events associated with the elicitation of a lesion share many features in common. Our objective was to examine gene expression patterns in skin disease to develop a molecular signature of disruption of cutaneous homeostasis. Gene expression data from common inflammatory skin diseases (e.g., psoriasis, atopic dermatitis, seborrheic dermatitis and acne), and a novel statistical algorithm were used to define a unifying molecular signature referred to as the "Unhealthy Skin Signature" (USS)...
May 28, 2018: Experimental Dermatology
A Guo, J Chen, C Yang, Y Ding, Q Zeng, L Tan
BACKGROUND: Seborrheic keratosis (SK) is one of the most common skin tumors seen by dermatologists. It should be differentiated with many diseases, especially skin tumors. Reflectance confocal microscopy (RCM) has been applied for evaluation of SK. There are a few studies that describe the RCM of SK. The aim of the study was to find the challenge of diagnosing seborrheic keratosis by reflectance confocal microscopy. METHODS: A total of 390 patients with a clinical suspicious diagnosis of seborrheic keratosis were enrolled in this study, and lesions from each patient were imaged with RCM...
May 24, 2018: Skin Research and Technology
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