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Triamterene

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https://www.readbyqxmd.com/read/30098233/triamterene-grafted-g-c3n4-with-electronic-potential-redistribution-for-efficient-photocatalytic-hydrogen-evolution
#1
Wei-De Zhang, Miao Sun, Kui Li, Yu-Xian Yu
In this study, we report a photocatalyst with distorted skeleton, which was synthesized by grafting triamterene onto graphitic carbon nitride (g-C3N4) frameworks. Pteridine ring of triamterene-based nitrogen-enriched organic structure, functions as trapped electron sites due to its inductive effect. Benzene ring in triamterene plays an important role on even dispersion of electrons by conjugative effect. Intramolecular electronic potential redistribution caused by synergistic effect between pteridine ring and benzene ring of triamterene promotes separation and migration of photo-induced charge carriers...
August 11, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/30043689/in-vitro-cytotoxicity-and-dna-hsa-interaction-study-of-triamterene-using-molecular-modelling-and-multi-spectroscopic-methods
#2
Neda Hosseinpour Moghadam, Sadegh Salehzadeh, Hamid Tanzadehpanah, Massoud Saidijam, Jamshid Karimi, Sadegh Khazalpour
The anticancer activity of triamterene on HCT116 and CT26 colon cancer cells lines was investigated. Furthermore, the mechanism of interaction between triamterene and calf thymus DNA (ct-DNA) and also human serum albumin (HSA) was conducted using multi-spectroscopic and molecular docking techniques. In vitro cytotoxicity of triamterene against HCT116 and CT26 cells showed promising anticancer effects with IC50 values of 31.30 and 24.45 μM, respectively. Competitive studies of the triamterene with NR (Neutral Red) and MB (Methylene Blue) as intercalator probes showed that triamterene can be replaced by these probes...
July 25, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29989004/raman-spectroscopy-for-the-diagnosis-of-intratubular-triamterene-crystallization
#3
C John Sperati, Chi Zhang, Marco Delsante, Rajib Gupta, Serena Bagnasco, Ishan Barman
No abstract text is available yet for this article.
July 2018: KI Reports
https://www.readbyqxmd.com/read/29792170/liddle-s-like-syndrome-associated-with-nephrotic-syndrome-secondary-to-membranous-nephropathy-the-first-case-report
#4
Eriko Yamaguchi, Kazuhiro Yoshikawa, Izaya Nakaya, Karen Kato, Yoshikazu Miyasato, Terumasa Nakagawa, Yutaka Kakizoe, Masashi Mukoyama, Jun Soma
BACKGROUND: Liddle's syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome present with early onset of hypertension, hypokalemia, metabolic alkalosis, hyporeninemia and hypoaldosteronism, and a potassium-sparing diuretics (triamterene or amiloride) can drastically improves the disease condition. Although elderly patients having these characteristics were considered to have Liddle's syndrome or Liddle's-like syndrome, no previous report has indicated that Liddle's-like syndrome could be caused by nephrotic syndrome of primary glomerular disease, which is characterized by urinary excretion of > 3 g of protein/day plus edema and hypoalbuminemia, or has explained how the activity function of ENaC could be affected in the setting of high proteinuria...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29779929/prescription-medication-use-and-antinuclear-antibodies-in-the-united-states-1999-2004
#5
Gregg E Dinse, Christine G Parks, Helen C S Meier, Caroll A Co, Edward K L Chan, Todd A Jusko, James Yeh, Frederick W Miller
BACKGROUND: Clinical reports link specific medications with the development of antinuclear antibodies (ANA), but population-based evidence is limited. OBJECTIVE: The present study investigated associations between prescription medication use and ANA in a representative sample of the adult noninstitutionalized US population, first focusing on medications previously related to ANA and then considering all medications reported in the National Health and Nutrition Examination Survey (NHANES)...
August 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29767498/reagentless-detection-of-low-molecular-weight-triamterene-using-self-doped-tio-2-nanotubes
#6
Felipe F Hudari, Guilherme G Bessegato, Flávio C Bedatty Fernandes, Maria V B Zanoni, Paulo R Bueno
TiO2 nanotube electrodes were self-doped by electrochemical cathodic polarization, potentially converting Ti4+ into Ti3+ , and thereby increasing both the normalized conductance and capacitance of the electrodes. One-hundred (from 19.2 ± 0.1 μF cm-2 to 1.9 ± 0.1 mF cm-2 for SD-TNT) and two-fold (from ∼6.2 to ∼14.4 mS cm-2 ) concomitant increases in capacitance and conductance, respectively, were achieved in self-doped TiO2 nanotubes; this was compared with the results for their undoped counterparts. The increases in the capacitance and conductance indicate that the Ti3+ states enhance the density of the electronic states; this is attributed to an existing relationship between the conductance and capacitance for nanoscale structures built on macroscopic electrodes...
June 19, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29755747/structural-studies-of-crystalline-forms-of-triamterene-with-carboxylic-acid-gras-and-api-molecules
#7
Abida Rehman, Amit Delori, David S Hughes, William Jones
Pharmaceutical salt solvates (dimethyl sulfoxide, DMSO) of the drug triamterene with the coformers acetic, succinic, adipic, pimelic, azelaic and nicotinic acid and ibuprofen are prepared by liquid-assisted grinding and solvent-evaporative crystallization. The modified Δp K a rule as proposed by Cruz-Cabeza [(2012 ▸). CrystEngComm , 14 , 6362-6365] is in close agreement with the results of this study. All adducts were characterized by X-ray diffraction and thermal analytical techniques, including single-crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry and thermal gravimetric analysis...
May 1, 2018: IUCrJ
https://www.readbyqxmd.com/read/29534496/liddle-syndrome-review-of-the-literature-and-description-of-a-new-case
#8
REVIEW
Martina Tetti, Silvia Monticone, Jacopo Burrello, Patrizia Matarazzo, Franco Veglio, Barbara Pasini, Xavier Jeunemaitre, Paolo Mulatero
Liddle syndrome is an inherited form of low-renin hypertension, transmitted with an autosomal dominant pattern. The molecular basis of Liddle syndrome resides in germline mutations of the SCNN1A , SCNN1B and SCNN1G genes, encoding the α, β, and γ-subunits of the epithelial Na⁺ channel (ENaC), respectively. To date, 31 different causative mutations have been reported in 72 families from four continents. The majority of the substitutions cause an increased expression of the channel at the distal nephron apical membrane, with subsequent enhanced renal sodium reabsorption...
March 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29447674/green-modified-micellar-liquid-chromatography-for-isocratic-isolation-of-some-cardiovascular-drugs-with-different-polarities-through-experimental-design-approach
#9
Amir M Ramezani, Ghodratollah Absalan, Raheleh Ahmadi
Bilayer pseudo-stationary phase micellar liquid chromatography (MLC) was developed for simultaneous isocratic isolation of hydrochlorothiazide, as a basic-polar (hydrophilic) cardiovascular drug, as well as triamterene and losartan potassium, as acidic-nonpolar (hydrophobic) cardiovascular drugs. Utilizing a deep eutectic solvent (DES), as a novel green mobile phase additive in combination with acetonitrile (ACN) and acetic acid (ACA), drastically improved the chromatographic behavior of the drugs. Concentration of sodium dodecyl sulphate (SDS), as well as volume percentages of ACN, DES, and ACA were optimized by using a central composite design...
June 20, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29310290/adsorptive-stripping-voltammetry-for-simultaneous-determination-of-hydrochlorothiazide-and-triamterene-in-hemodialysis-samples-using-a-multi-walled-carbon-nanotube-modified-glassy-carbon-electrode
#10
Felipe Fantinato Hudari, João Carlos Souza, Maria Valnice Boldrin Zanoni
Hemodialysis is the most commonly used method for the treatment of chronic kidney disease. In this procedure, some patients use diuretics to control weight gain and blood pressure. In this work, a voltammetric sensor based on a glassy carbon electrode modified with carbon nanotubes (GCE/MWCNT) is described for the simultaneous determination of the diuretics hydrochlorothiazide (HCT) and triamterene (TRT). The oxidation of the diuretics on the GCE/MWCNT surface was observed at 1.01 and 1.17V for HCT and TRT, respectively, allowing simultaneous determination, which was not possible with the unmodified glassy carbon electrode...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29098333/synthesis-of-multirecognition-magnetic-molecularly-imprinted-polymer-by-atom-transfer-radical-polymerization-and-its-application-in-magnetic-solid-phase-extraction
#11
Xiang-Jin Kong, Chao Zheng, Yao-Han Lan, Shuai-Shuai Chi, Qian Dong, Hao-Long Liu, Chao Peng, Lin-Yi Dong, Liang Xu, Xian-Hua Wang
In this work, we reported an effective method for the synthesis of a multirecognition magnetic molecularly imprinted polymer (MMIP) with atom transfer radical polymerization (ATRP), using 2,4-diamino-6-methyl-1,3,5-triazine as pseudo-template. The resulting MMIP was characterized in detail by Fourier transform-infrared (FT-IR) spectra, scanning electron microscopy (SEM), thermogravimetic analysis (TGA), and vibrating sample magnetometry (VSM). These results indicated the successful synthesis of MMIP with sufficient thermal stability and magnetic properties...
January 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29086856/using-crystallography-topology-and-graph-set-analysis-for-the-description-of-the-hydrogen-bond-network-of-triamterene-a-rational-approach-to-solid-form-selection
#12
David S Hughes, Amit Delori, Abida Rehman, William Jones
This study has demonstrated the use of crystallography, topology and graph set analysis in the description and classification of the complex hydrogen bonded network of triamterene. The aim is to give a brief overview of the methodology used to discuss the crystal structure of triamterene with a view to extending the study to include the solvates, cocrystals and salts of this compound. Graphical abstract One of the structurally significant dimers (supramolecular synthons) of triamterene identified by this study...
July 13, 2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28881290/glycyrrhizic-acid-increases-glucagon-like-peptide-1-secretion-via-tgr5-activation-in-type-1-like-diabetic-rats
#13
Lin-Yu Wang, Kai Chun Cheng, Yingxiao Li, Chiang-Shan Niu, Juei-Tang Cheng, Ho-Shan Niu
Glycyrrhizic acid (GA) is belonged to triterpenoid saponin that is contained in the root of licorice and is known to affect metabolic regulation. Recently, glucagon like peptide-1 (GLP-1) has widely been applied in diabetes therapeutics. However, the role of GLP-1 in GA-induced anti-diabetic effects is still unknown. Therefore, we are interested in understanding the association of GLP-1 with GA-induced effects. In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), GA increased the level of plasma GLP-1, which was blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-coupled receptor 5 (TGR5)...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28588673/modulatory-effects-of-hydrochlorothiazide-and-triamterene-on-resistant-hypertension-patients
#14
Haibin Gong, Yun Li, Cheng Zheng, Tian-Tian Du, Bing-Quan Luo, Min Pang
The present study explored the modulatory potential of hydrochlorothiazide and triamterene on resistant hypertension patients. The mechanistic information for resistant hypertension was explored by studying the pressure-natriuresis curves between the salt sensitive population and non-salt sensitive population. A cohort of 23 patients with non-hypertension (NH) (13 males and 10 females; aged from 23 to 62 years), 26 patients with controlled hypertension (CH) (14 males and 12 females; aged from 19 to 72 years) and 23 patients with resistant hypertension (RH) (13 males and 10 females; aged from 19 to 76 years) were selected...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28482565/photoresponsive-hollow-molecularly-imprinted-polymer-for-trace-triamterene-in-biological-samples
#15
Cheng-Bin Gong, Yu-Bo Wei, Lan-Tao Liu, An-Xun Zheng, Yue-Hong Yang, Cheuk-Fai Chow, Qian Tang
This paper reports a photoresponsive hollow molecularly imprinted polymer for the determination of trace triamterene in biological sample. The photoresponsive hollow molecularly imprinted polymer was prepared on sacrificial silica microspheres via surface imprinting technique through atom transfer radical polymerization using a novel water-soluble azobenzene derivative, 4-[(4-methacryloyloxy)phenylazo]-3,5-dimethyl benzenesulfonic acid, as the functional monomer, and the sacrificial silica core was subsequently removed using HF etching method with 1...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28435224/investigation-of-triamterene-as-an-inhibitor-of-the-tgr5-receptor-identification-in-cells-and-animals
#16
Yingxiao Li, Kai Chun Cheng, Chiang-Shan Niu, Shih-Hsiang Lo, Juei-Tang Cheng, Ho-Shan Niu
BACKGROUND: G-protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) has been shown to participate in glucose homeostasis. In animal models, a TGR5 agonist increases incretin secretion to reduce hyperglycemia. Many agonists have been developed for clinical use. However, the effects of TGR5 blockade have not been studied extensively, with the exception of studies using TGR5 knockout mice. Therefore, we investigated the potential effect of triamterene on TGR5. METHODS: We transfected the TGR5 gene into cultured Chinese hamster ovary cells (CHO-K1 cells) to express TGR5...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28406849/current-management-practices-in-m%C3%A3-ni%C3%A3-re-s-disease
#17
Joseph W Clyde, Benjamin S Oberman, Huseyin Isildak
OBJECTIVE: To evaluate current trends in managing Ménière's disease (MD) by both general otolaryngologists and otologists/neurotologists and discuss treatment modalities. STUDY DESIGN: Cross-sectional study. SETTING: Survey of physicians. SUBJECTS AND METHODS: An electronic questionnaire was disseminated to all members of American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS). RESULTS: Eight hundred and sixty members replied for a response rate of 14...
July 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/27913567/drug-repositioning-screens-identify-triamterene-as-a-selective-drug-for-the-treatment-of-dna-mismatch-repair-deficient-cells
#18
Delphine Guillotin, Philip Austin, Rumena Begum, Marta O Freitas, Ashirwad Merve, Tim Brend, Susan Short, Silvia Marino, Sarah A Martin
Purpose: The DNA mismatch repair (MMR) pathway is required for the maintenance of genome stability. Unsurprisingly, mutations in MMR genes occur in a wide range of different cancers. Studies thus far have largely focused on specific tumor types or MMR mutations; however, it is becoming increasingly clear that a therapy targeting MMR deficiency in general would be clinically very beneficial. Experimental Design: Based on a drug-repositioning approach, we screened a large panel of cell lines with various MMR deficiencies from a range of different tumor types with a compound drug library of previously approved drugs...
June 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27896928/liddle-syndrome-clinical-and-genetic-profiles
#19
Yunying Cui, Anli Tong, Jun Jiang, Fen Wang, Chunyan Li
Liddle syndrome is a rare autosomal dominant monogenic form of hypertension. The authors analyzed clinical and genetic features of 12 cases of Liddle syndrome, the largest sample size ever reported. Clinical data were studied retrospectively. The exon 13 of the β and γ subunits of the epithelial sodium channel were amplified and sequenced in the peripheral blood leukocytes of the patients. The onset age of the 12 patients was 15.5±3.3 years. Their blood pressures were poorly controlled, and serum potassium levels in most patients were <3...
May 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/27814935/diuretic-resistance
#20
REVIEW
Ewout J Hoorn, David H Ellison
Diuretic resistance is defined as a failure to achieve the therapeutically desired reduction in edema despite a full dose of diuretic. The causes of diuretic resistance include poor adherence to drug therapy or dietary sodium restriction, pharmacokinetic issues, and compensatory increases in sodium reabsorption in nephron sites that are not blocked by the diuretic. To illustrate the pathophysiology and management of diuretic resistance, we describe a patient with nephrotic syndrome. This patient presented with generalized pitting edema and weight gain despite the use of oral loop diuretics...
January 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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