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2D Analysis

Sam Orde, Michel Slama, Nicola Stanley, Stephen Huang, Anthony Mclean
BACKGROUND: Transthoracic 3D cardiac analysis is enticing in its potential simplicity and wealth of data available. It has been suggested to be accurate vs magnetic resonance imaging in relatively stable patients, but feasibility and agreement with conventional echocardiographic assessment of stroke volume (SV) have not been thoroughly assessed in critically ill patients, who are traditionally harder to image. The objectives of this study were to compare 3D transthoracic volumetric analysis vs Doppler assessment of SV (which is suggested to be accurate in the critically ill) and Simpson's biplane assessment in a cohort typical of the intensive care unit (ICU), where accurate assessment is important: mechanically ventilated patients with a significant ventilation/perfusion (V/Q) mismatch...
August 19, 2018: Critical Care: the Official Journal of the Critical Care Forum
Marcelo Zanchetta do Nascimento, Alessandro Santana Martins, Thaína Aparecida Azevedo Tosta, Leandro Alves Neves
Mantle cell lymphoma, follicular lymphoma and chronic lymphocytic leukemia are the principle subtypes of the non-Hodgkin lymphomas. The diversity of clinical presentations and the histopathological features have made diagnosis of such lymphomas a complex task for specialists. Computer aided diagnosis systems employ computational vision and image processing techniques, which contribute toward the detection, diagnosis and prognosis of digitised images of histological samples. Studies aimed at improving the understanding of morphological and non-morphological features for classification of lymphoma remain a challenge in this area...
September 2018: Computer Methods and Programs in Biomedicine
Martin Bartoš, Tomáš Suchý, René Foltán
BACKGROUND: Collagen-based scaffolds provide a promising option for the treatment of bone defects. One of the key parameters of such scaffolds consists of porosity, including pore size. However, to date, no agreement has been found with respect to the methodology for pore size evaluation. Since the determination of the exact pore size value is not possible, the comparison of the various methods applied is complicated. Hence, this study focuses on the comparison of two widely-used methods for the characterization of porosity-scanning electron microscopy (SEM) and micro-computed tomography (micro-CT)...
August 17, 2018: Biomedical Engineering Online
Ken C L Wong, Tanveer Syeda-Mahmood, Mehdi Moradi
Deep learning has shown promising results in medical image analysis, however, the lack of very large annotated datasets confines its full potential. Although transfer learning with ImageNet pre-trained classification models can alleviate the problem, constrained image sizes and model complexities can lead to unnecessary increase in computational cost and decrease in performance. As many common morphological features are usually shared by different classification tasks of an organ, it is greatly beneficial if we can extract such features to improve classification with limited samples...
August 4, 2018: Medical Image Analysis
Chunhui Han, Yulin Peng, Yifei Wang, Xiaokui Huo, Baojing Zhang, Dawei Li, Aijing Leng, Houli Zhang, Xiaochi Ma, Chao Wang
Euphoroids A-C (1-3), three new ent-abietane-type diterpenoids, together with ten known analogues (4-13) were obtained from the roots of Euphorbia ebracteolata. The structures of these compounds were determined by extensive spectroscopic data analysis, including UV, HRESIMS, 1D-, and 2D-NMR data. The inhibitory effects of compounds 1-13 on human cancer cells were determined using the MTT assay. The results revealed that new compounds 2 and 3 showed moderate cytotoxic activities against human cancer cell lines...
August 2, 2018: Bioorganic Chemistry
Jennifer H Shepherd, Daniel Howard, Amie K Waller, Holly Rebecca Foster, Annett Muller, Thomas Moreau, Amanda L Evans, Meera Arumugam, Guénaëlle Bouët Chalon, Eleonora Vriend, Natalia Davidenko, Cedric Ghevaert, Serena M Best, Ruth E Cameron
Platelet transfusions are a key treatment option for a range of life threatening conditions including cancer, chemotherapy and surgery. Efficient ex vivo systems to generate donor independent platelets in clinically relevant numbers could provide a useful substitute. Large quantities of megakaryocytes (MKs) can be produced from human pluripotent stem cells, but in 2D culture the ratio of platelets harvested from MK cells has been limited and restricts production rate. The development of biomaterial cell supports that replicate vital hematopoietic micro-environment cues are one strategy that may increase in vitro platelet production rates from iPS derived Megakaryocyte cells...
August 8, 2018: Biomaterials
J Parrish, K S Lim, K Baer, G J Hooper, T B F Woodfield
Traditional 2D monolayer cell cultures and submillimeter 3D tissue construct cultures used widely in tissue engineering are limited in their ability to extrapolate experimental data to predict in vivo responses due to their simplistic organization and lack of stimuli. The rise of biofabrication and bioreactor technologies has sought to address this through the development of techniques to spatially organize components of a tissue construct, and devices to supply these tissue constructs with an increasingly in vivo-like environment...
August 17, 2018: Lab on a Chip
Rakesh Sinha, Latika Chawla, Shweta Raje, Gayatri Rao
STUDY OBJECTIVE: To evaluate the outcomes of total laparoscopic hysterectomy using 3D vision in comparison with 2D vision in women with large uteri (≥500g). DESIGN: Retrospective analytical study Design Classification: Canadian Task Force II-1 Setting: Tertiary referral center for advanced gynecological surgery. PATIENTS: Five hundred forty six women who underwent total laparoscopic hysterectomy over a period of 13 years were studied: 301 under 2D vision and 245 under 3D vision...
August 14, 2018: Surgical Technology International
Marcin Kozłowski, Chiara Bedon, Dániel Honfi
Glass is largely used in architectural and engineering applications (i.e., buildings and vehicles) as a structural material, especially in the form of laminated glass (LG) sections. To achieve adequate and controlled safety levels in these applications, the well-known temperature-dependent behavior of viscoelastic interlayers for LG sections should be properly accounted for during the design process. Furthermore, the materials' thermomechanical degradation with increases of temperature could severely affect the load-bearing performance of glass assemblies...
August 16, 2018: Materials
Rudi Appels, Kellye Eversole, Catherine Feuillet, Beat Keller, Jane Rogers, Nils Stein, Curtis J Pozniak, Nils Stein, Frédéric Choulet, Assaf Distelfeld, Kellye Eversole, Jesse Poland, Jane Rogers, Gil Ronen, Andrew G Sharpe, Curtis Pozniak, Gil Ronen, Nils Stein, Omer Barad, Kobi Baruch, Frédéric Choulet, Gabriel Keeble-Gagnère, Martin Mascher, Andrew G Sharpe, Gil Ben-Zvi, Ambre-Aurore Josselin, Nils Stein, Martin Mascher, Axel Himmelbach, Frédéric Choulet, Gabriel Keeble-Gagnère, Martin Mascher, Jane Rogers, François Balfourier, Juan Gutierrez-Gonzalez, Matthew Hayden, Ambre-Aurore Josselin, ChuShin Koh, Gary Muehlbauer, Raj K Pasam, Etienne Paux, Curtis J Pozniak, Philippe Rigault, Andrew G Sharpe, Josquin Tibbits, Vijay Tiwari, Frédéric Choulet, Gabriel Keeble-Gagnère, Martin Mascher, Ambre-Aurore Josselin, Jane Rogers, Manuel Spannagl, Frédéric Choulet, Daniel Lang, Heidrun Gundlach, Georg Haberer, Gabriel Keeble-Gagnère, Klaus F X Mayer, Danara Ormanbekova, Etienne Paux, Verena Prade, Hana Šimková, Thomas Wicker, Frédéric Choulet, Manuel Spannagl, David Swarbreck, Hélène Rimbert, Marius Felder, Nicolas Guilhot, Heidrun Gundlach, Georg Haberer, Gemy Kaithakottil, Jens Keilwagen, Daniel Lang, Philippe Leroy, Thomas Lux, Klaus F X Mayer, Sven Twardziok, Luca Venturini, Rudi Appels, Hélène Rimbert, Frédéric Choulet, Angéla Juhász, Gabriel Keeble-Gagnère, Frédéric Choulet, Manuel Spannagl, Daniel Lang, Michael Abrouk, Georg Haberer, Gabriel Keeble-Gagnère, Klaus F X Mayer, Thomas Wicker, Frédéric Choulet, Thomas Wicker, Heidrun Gundlach, Daniel Lang, Manuel Spannagl, Daniel Lang, Manuel Spannagl, Rudi Appels, Iris Fischer, Cristobal Uauy, Philippa Borrill, Ricardo H Ramirez-Gonzalez, Rudi Appels, Dominique Arnaud, Smahane Chalabi, Boulos Chalhoub, Frédéric Choulet, Aron Cory, Raju Datla, Mark W Davey, Matthew Hayden, John Jacobs, Daniel Lang, Stephen J Robinson, Manuel Spannagl, Burkhard Steuernagel, Josquin Tibbits, Vijay Tiwari, Fred van Ex, Brande B H Wulff, Curtis J Pozniak, Stephen J Robinson, Andrew G Sharpe, Aron Cory, Moussa Benhamed, Etienne Paux, Abdelhafid Bendahmane, Lorenzo Concia, David Latrasse, Jane Rogers, John Jacobs, Michael Alaux, Rudi Appels, Jan Bartoš, Arnaud Bellec, Hélène Berges, Jaroslav Doležel, Catherine Feuillet, Zeev Frenkel, Bikram Gill, Abraham Korol, Thomas Letellier, Odd-Arne Olsen, Hana Šimková, Kuldeep Singh, Miroslav Valárik, Edwin van der Vossen, Sonia Vautrin, Song Weining, Abraham Korol, Zeev Frenkel, Tzion Fahima, Vladimir Glikson, Dina Raats, Jane Rogers, Vijay Tiwari, Bikram Gill, Etienne Paux, Jesse Poland, Jaroslav Doležel, Jarmila Číhalíková, Hana Šimková, Helena Toegelová, Jan Vrána, Pierre Sourdille, Benoit Darrier, Rudi Appels, Manuel Spannagl, Daniel Lang, Iris Fischer, Danara Ormanbekova, Verena Prade, Delfina Barabaschi, Luigi Cattivelli, Pilar Hernandez, Sergio Galvez, Hikmet Budak, Burkhard Steuernagel, Jonathan D G Jones, Kamil Witek, Brande B H Wulff, Guotai Yu, Ian Small, Joanna Melonek, Ruonan Zhou, Angéla Juhász, Tatiana Belova, Rudi Appels, Odd-Arne Olsen, Kostya Kanyuka, Robert King, Kirby Nilsen, Sean Walkowiak, Curtis J Pozniak, Richard Cuthbert, Raju Datla, Ron Knox, Krysta Wiebe, Daoquan Xiang, Antje Rohde, Timothy Golds, Jaroslav Doležel, Jana Čížková, Josquin Tibbits, Hikmet Budak, Bala Ani Akpinar, Sezgi Biyiklioglu, Gary Muehlbauer, Jesse Poland, Liangliang Gao, Juan Gutierrez-Gonzalez, Amidou N'Daiye, Jaroslav Doležel, Hana Šimková, Jarmila Číhalíková, Marie Kubaláková, Jan Šafář, Jan Vrána, Hélène Berges, Arnaud Bellec, Sonia Vautrin, Michael Alaux, Françoise Alfama, Anne-Françoise Adam-Blondon, Raphael Flores, Claire Guerche, Thomas Letellier, Mikaël Loaec, Hadi Quesneville, Curtis J Pozniak, Andrew G Sharpe, Sean Walkowiak, Hikmet Budak, Janet Condie, Jennifer Ens, ChuShin Koh, Ron Maclachlan, Yifang Tan, Thomas Wicker, Frédéric Choulet, Etienne Paux, Adriana Alberti, Jean-Marc Aury, François Balfourier, Valérie Barbe, Arnaud Couloux, Corinne Cruaud, Karine Labadie, Sophie Mangenot, Patrick Wincker, Bikram Gill, Gaganpreet Kaur, Mingcheng Luo, Sunish Sehgal, Kuldeep Singh, Parveen Chhuneja, Om Prakash Gupta, Suruchi Jindal, Parampreet Kaur, Palvi Malik, Priti Sharma, Bharat Yadav, Nagendra K Singh, JitendraP Khurana, Chanderkant Chaudhary, Paramjit Khurana, Vinod Kumar, Ajay Mahato, Saloni Mathur, Amitha Sevanthi, Naveen Sharma, Ram Sewak Tomar, Jane Rogers, John Jacobs, Michael Alaux, Arnaud Bellec, Hélène Berges, Jaroslav Doležel, Catherine Feuillet, Zeev Frenkel, Bikram Gill, Abraham Korol, Edwin van der Vossen, Sonia Vautrin, Bikram Gill, Gaganpreet Kaur, Mingcheng Luo, Sunish Sehgal, Jan Bartoš, Kateřina Holušová, Ondřej Plíhal, Matthew D Clark, Darren Heavens, George Kettleborough, Jon Wright, Miroslav Valárik, Michael Abrouk, Barbora Balcárková, Kateřina Holušová, Yuqin Hu, Mingcheng Luo, Elena Salina, Nikolai Ravin, Konstantin Skryabin, Alexey Beletsky, Vitaly Kadnikov, Andrey Mardanov, Michail Nesterov, Andrey Rakitin, Ekaterina Sergeeva, Hirokazu Handa, Hiroyuki Kanamori, Satoshi Katagiri, Fuminori Kobayashi, Shuhei Nasuda, Tsuyoshi Tanaka, Jianzhong Wu, Rudi Appels, Matthew Hayden, Gabriel Keeble-Gagnère, Philippe Rigault, Josquin Tibbits, Odd-Arne Olsen, Tatiana Belova, Federica Cattonaro, Min Jiumeng, Karl Kugler, Klaus F X Mayer, Matthias Pfeifer, Simen Sandve, Xu Xun, Bujie Zhan, Hana Šimková, Michael Abrouk, Jacqueline Batley, Philipp E Bayer, David Edwards, Satomi Hayashi, Helena Toegelová, Zuzana Tulpová, Paul Visendi, Song Weining, Licao Cui, Xianghong Du, Kewei Feng, Xiaojun Nie, Wei Tong, Le Wang, Philippa Borrill, Heidrun Gundlach, Sergio Galvez, Gemy Kaithakottil, Daniel Lang, Thomas Lux, Martin Mascher, Danara Ormanbekova, Verena Prade, Ricardo H Ramirez-Gonzalez, Manuel Spannagl, Nils Stein, Cristobal Uauy, Luca Venturini, Nils Stein, Rudi Appels, Kellye Eversole, Jane Rogers, Philippa Borrill, Luigi Cattivelli, Frédéric Choulet, Pilar Hernandez, Kostya Kanyuka, Daniel Lang, Martin Mascher, Kirby Nilsen, Etienne Paux, Curtis J Pozniak, Ricardo H Ramirez-Gonzalez, Hana Šimková, Ian Small, Manuel Spannagl, David Swarbreck, Cristobal Uauy
An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue- and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development...
August 17, 2018: Science
Guozhu Liu, Baolei Luan, Guiting Liang, Libo Xing, Liang Huang, Changyun Wang, Ying Xu
Capreomycin has good clinical utility to treat multidrug resistant tuberculosis, but it is only used as a second line drug due to its adverse reactions. Literature has demonstrated that the toxicity of capreomycin product is significantly influenced by the impurities in it. Unfortunately, so far, no one impurity in capreomycin has ever been isolated and definitely identified due to its extremely strong basic character and high polarity. An ion-pair method reported in literature can provide separation of capreomycin and its impurities, but it is hard to be used for the preparative purpose...
August 7, 2018: Journal of Chromatography. A
Anupriya Kaur Thind, Thomas Wicker, Thomas Müller, Patrick M Ackermann, Burkhard Steuernagel, Brande B H Wulff, Manuel Spannagl, Sven O Twardziok, Marius Felder, Thomas Lux, Klaus F X Mayer, Beat Keller, Simon G Krattinger
BACKGROUND: Recent improvements in DNA sequencing and genome scaffolding have paved the way to generate high-quality de novo assemblies of pseudomolecules representing complete chromosomes of wheat and its wild relatives. These assemblies form the basis to compare the dynamics of wheat genomes on a megabase scale. RESULTS: Here, we provide a comparative sequence analysis of the 700-megabase chromosome 2D between two bread wheat genotypes-the old landrace Chinese Spring and the elite Swiss spring wheat line 'CH Campala Lr22a'...
August 17, 2018: Genome Biology
Rubab Amin, Jacob B Khurgin, Volker J Sorger
Electro-optic modulators perform a key function for data processing and communication. Rapid growth in data volume and increasing bits per second rates demand increased transmitter and thus modulator performance. Recent years have seen the introduction of new materials and modulator designs to include polaritonic optical modes aimed at achieving advanced performance in terms of speed, energy efficiency, and footprint. Such ad hoc modulator designs, however, leave a universal design for these novel material classes of devices missing...
June 11, 2018: Optics Express
Jacek Jagiello, Mietek Jaroniec
In this work, we develop two-dimensional models based on the non-local density functional theory (2D-NLDFT) for the analysis of pore size distribution (PSD) of oxide materials with cylindrical pores with rough and heterogeneous walls. The existing standard NLDFT models for porous oxides assume the smooth energetically uniform surface of the pore walls. Due to this assumption, the calculated theoretical isotherms show typical layering transitions, which are not consistent with the experimental adsorption isotherms measured on real oxide materials...
August 9, 2018: Journal of Colloid and Interface Science
Longhe Xu, Yaobo Liu, Yuhui Sun, Hao Li, Weidong Mi, Yuge Jiang
OBJECTIVE: Chronic neuropathic pain (CNP) is attributed to a lesion or disease of the somatosensory system, may be derived from the peripheral and central system. Recent study revealed that spinal cord stimulation attenuated CNP by inhibiting TLR4/NF-κB signaling pathway. The present study focuses on the potential analgesic effects of TLR4/NF-κB signaling pathway on CNP in a rat model of chronic constriction injury (CCI). METHODS: We successfully established the rat model of CCI by Bennett method, and then inhibited the TLR4/NF-κB signaling pathway in rat models...
August 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hui-I Yu, Hsiu-Chuan Chou, Yi-Ching Su, Li-Hsun Lin, Chieh-Hsiang Lu, Hsiang-Hsun Chuang, Yi-Ting Tsai, En-Chi Liao, Yu-Shan Wei, Yi-Ting Yang, Ying-Ray Lee, Hong-Lin Chan
Evodiamine is a natural product extracted from herbal plants such as Tetradium which has shown to have anti-fat uptake and anti-proliferation properties. However, the effects of evodiamine on the behavior of thyroid cancers are largely unknown. To determine if evodiamine might be useful in the treatment of thyroid cancer and its cytotoxic mechanism, we analyzed the impact of evodiamine treatment on differential protein expression in human thyroid cancer cell line ARO using lysine-labeling two-dimensional difference gel electrophoresis (2D-DIGE) combined with mass spectrometry (MS)...
August 9, 2018: Journal of Pharmaceutical and Biomedical Analysis
Xiaofang Yang, Xing Zheng, Linjie Wu, Xin Cao, Yi Li, Junfeng Niu, Fangang Meng
The occurrence of algae bloom would lead to the release of algae-derived organic matter (AOM) and then alter the abundance and behavior of dissolved organic matter (DOM) in aquatic ecosystems. In this study, the characteristics and photodegradation of AOM, naturally occurring organic matter (NOM) derived from soil and plants and their mixtures were explored to reveal the potential interactions between AOM and NOM in water. Results indicated that the protein-like components from AOM and the humic-like components from SRNOM took place inter-component interactions in the AOM-NOM mixtures...
August 13, 2018: Environmental Pollution
Leice M R de Novais, Cauane C O de Arueira, Luiz F Ferreira, Tereza A N Ribeiro, Paulo T Sousa, Marcos J Jacinto, Mário G de Carvalho, Wagner A S Judice, Larissa O P Jesus, Aline A de Souza, Heron F V Torquato, Edgar J Paredes-Gamero, Virginia C Silva
A new flavone, 4'-hydroxy-6,7-methylenedioxy-3-methoxyflavone 1, and two other nucleosides, ribavirin 2 and adenosine 3, were isolated from the leaves of Dulacia egleri. The nucleosides were identified by spectroscopic techniques (1D, 2D-NMR) while the structure of the flavonoid was established by 1D, 2D-NMR analysis, including HRESIMS data. The results obtained in the biological assays showed that the compound 1 was able to inhibit cathepsins B and L with IC50 of 14.88 ± 0.18 μM and 3.19 ± 0.07 μM, respectively...
August 13, 2018: Fitoterapia
Ashraful Azam, Jungmo Kim, Junyong Park, Travis G Novak, Anand P Tiwari, Sung Ho Song, Bumsoo Kim, Seokwoo Jeon
Two-dimensional (2D) transitional metal oxides (TMOs) are an attractive class of materials due to the combined advantages of high active surface-area, enhanced electrochemical properties, and stability. Among the 2D TMOs, 2D tungsten oxide (WO3 ) nanosheets possess great potential in electrochemical applications, particularly in electrochromic (EC) devices. However, feasible production of 2D WO3 nanosheets is challenging due to the innate 3D crystallographic structure of WO3 . Here we report a novel solution-phase synthesis of 2D WO3 nanosheets through simple oxidation from 2D tungsten disulfide (WS2 ) nanosheets exfoliated from bulk WS2 powder...
August 16, 2018: Nano Letters
Jason S Au, Heikki Yli-Ollila, Maureen J MacDonald
To assess the intra-individual variation in carotid artery longitudinal wall motion (CALM) in healthy adults in order to determine the amount of data required to generate a representative measurement of CALM.
 Approach: We conducted an analysis of 27 healthy men to determine whether calculation of resting individual CALM outcomes is dependent on the number of averaged heart cycles. CALM was assessed at rest, 1-2 cm proximal to the right carotid bifurcation during a breath hold and was segmented into three motion displacements: systolic anterograde CALM, systolic retrograde CALM, and diastolic CALM...
August 16, 2018: Physiological Measurement
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