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https://www.readbyqxmd.com/read/30076412/tumor-penetrating-peptides-inhibiting-myc-as-a-potent-targeted-therapeutic-strategy-for-triple-negative-breast-cancers
#1
Edina Wang, Anabel Sorolla, Paula T Cunningham, Heique M Bogdawa, Samuel Beck, Emily Golden, Robert E Dewhurst, Laura Florez, Mark N Cruickshank, Katrin Hoffmann, Richard M Hopkins, Jonghwan Kim, Andrew J Woo, Paul M Watt, Pilar Blancafort
Overexpression of MYC oncogene is highly prevalent in many malignancies such as aggressive triple-negative breast cancers (TNBCs) and it is associated with very poor outcome. Despite decades of research, attempts to effectively inhibit MYC, particularly with small molecules, still remain challenging due to the featureless nature of its protein structure. Herein, we describe the engineering of the dominant-negative MYC peptide (OmoMYC) linked to a functional penetrating 'Phylomer' peptide (FPPa) as a therapeutic strategy to inhibit MYC in TNBC...
August 3, 2018: Oncogene
https://www.readbyqxmd.com/read/29895235/reliability-and-validity-of-frontal-plane-kinematics-of-the-trunk-and-lower-extremity-measured-with-two-dimensional-cameras-during-athletic-tasks-a-systematic-review-with-meta-analysis
#2
Thiago Jambo Alves Lopes, Deisi Ferrari, Joshua Ioannidis, Milena Simic, Fábio Mícolis de Azevedo, Evangelos Pappas
Study Design Systematic review with meta-analysis. Background Two-dimensional (2D) analysis is commonly used to quantify frontal plane kinematics of the trunk and lower extremity; however, there are conflicting results regarding the reliability and validity of these measurements. Objective To synthesize the current literature to determine if 2D analysis is a reliable and valid method of measuring frontal plane kinematics of the trunk and lower extremity during squatting, landing and cutting tasks. Methods MEDLINE, CINAHL, EMBASE, Scopus and SportDISCUS databases were searched from inception until March 2017...
June 12, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29366914/the-effects-of-a-four-week-jump-training-program-on-frontal-plane-projection-angle-in-female-gymnasts
#3
A Colclough, A G Munro, L C Herrington, J J McMahon, P Comfort
OBJECTIVES: To investigate the effects of a four week jump training program on frontal plane projection angle (FPPA) in young female gymnasts. DESIGN: Intervention study, consisting of a four week jump training program performed for 15 min as part of a warm-up, three days per week for four weeks. SETTING: Gymnastics training center. PARTICIPANTS: Fourteen youth female gymnasts (age: 13.5 ± 2.14 years, height: 1.54 ± 0...
March 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29091512/knee-frontal-plane-projection-angle-a-comparison-study-between-drop-vertical-jump-and-step-down-tests-with-young-volleyball-athletes
#4
Gabriel Andrade Paz, Marianna de Freitas Maia, Haroldo Gualter Santana, Humberto Miranda, Vicente Lima, John D Willson
STUDY DESIGN: Observational study. CONTEXT: Altered frontal plane knee mechanics during dynamic tasks have been often associated with lower extremity injuries. Strategies to decrease these risk factors and improve knee joint stability are often applied in rehabilitation and training environments. OBJECTIVE: The purpose of this study was to compare knee joint frontal plane projection angles (FPPA) via two dimensional (2D) video analysis during drop vertical jump (DVJ) and step-down test (SDT) tasks in the preferred and non-preferred limbs of young male and female volleyball players...
November 1, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28437781/the-reliability-and-criterion-validity-of-2d-video-assessment-of-single-leg-squat-and-hop-landing
#5
Lee Herrington, Faisal Alenezi, Msaad Alzhrani, Hasan Alrayani, Richard Jones
The objective was to assess the intra-tester, within and between day reliability of measurement of hip adduction (HADD) and frontal plane projection angles (FPPA) during single leg squat (SLS) and single leg landing (SLL) using 2D video and the validity of these measurements against those found during 3D motion capture. 15 healthy subjects had their SLS and SLL assessed using 3D motion capture and video analysis. Inter-tester reliability for both SLS and SLL when measuring FPPA and HADD show excellent correlations (ICC2,1 0...
June 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28323136/self-reported-knee-pain-and-disability-among-healthy-individuals-reference-data-and-factors-associated-with-the-knee-injury-and-osteoarthritis-outcome-score-koos-and-koos-child
#6
J N Baldwin, M J McKay, M Simic, C E Hiller, N Moloney, E J Nightingale, J Burns
OBJECTIVE: To develop normative reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS) and KOOS-Child, as well as investigate socio-demographic, psychological and physical factors associated with knee pain and disability among healthy adults. METHOD: The KOOS or KOOS-Child (each containing five subscales) was administered to participants aged 8-101 years within the 1000 Norms Project, an observational study of 1000 self-reported healthy individuals...
August 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28095108/the-relationship-between-2-dimensional-knee-valgus-angles-during-single-leg-squat-single-leg-land-and-drop-jump-screening-tests
#7
Allan Munro, Lee Herrington, Paul Comfort
CONTEXT: Injuries to the anterior cruciate ligament (ACL) and patellofemoral joint (PFJ) are a significant problem in female athletes. A number of screening tasks have been used in the literature to identify those at greatest risk of injury. To date, no study has examined the relationship in 2-dimensional (2D) knee valgus between common screening tasks to determine whether individuals exhibit similar movement patterns across tasks. OBJECTIVE: To establish whether frontal-plane projection angle (FPPA) during the single-leg squat (SLS), single-leg land (SLL), and drop jump (DJ) are related...
January 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27104054/kinematic-analysis-of-knee-valgus-during-drop-vertical-jump-and-forward-step-up-in-young-basketball-players
#8
Gabriel Andrade Paz, Marianna de Freitas Maia, Déborah Farias, Haroldo Santana, Humberto Miranda, Vicente Lima, Lee Herrington
PURPOSE/BACKGROUND: Lower limb asymmetry between dominant and nondominant limbs is often associated with injuries. However, there is a lack of evidence about frontal plane projection angle (FPPA) of the knee joint (knee valgus) during drop vertical jump (DVJ) and forward step-up tasks (FSUP) in young basketball players. Therefore, the purpose of this study was to assess the FPPA (i.e., dynamic knee valgus) via 2D video analysis during DVJ and FSUP tasks in the dominant and nondominant limbs of young male basketball players...
April 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27069887/q-angle-in-patellofemoral-pain-relationship-with-dynamic-knee-valgus-hip-abductor-torque-pain-and-function
#9
Gabriel Peixoto Leão Almeida, Ana Paula de Moura Campos Carvalho E Silva, Fábio Jorge Renovato França, Maurício Oliveira Magalhães, Thomaz Nogueira Burke, Amélia Pasqual Marques
OBJECTIVE: To investigate the relationship between the q-angle and anterior knee pain severity, functional capacity, dynamic knee valgus and hip abductor torque in women with patellofemoral pain syndrome (PFPS). METHODS: This study included 22 women with PFPS. The q-angle was assessed using goniometry: the participants were positioned in dorsal decubitus with the knee and hip extended, and the hip and foot in neutral rotation. Anterior knee pain severity was assessed using a visual analog scale, and functional capacity was assessed using the anterior knee pain scale...
March 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/26816531/the-relationship-of-foot-and-ankle-mobility-to-the-frontal-plane-projection-angle-in-asymptomatic-adults
#10
Narelle Wyndow, Amy De Jong, Krystal Rial, Kylie Tucker, Natalie Collins, Bill Vicenzino, Trevor Russell, Kay Crossley
BACKGROUND: The frontal plane projection angle (FPPA) is frequently used as a measure of dynamic knee valgus during functional tasks, such as the single leg squat. Increased dynamic knee valgus is observed in people with knee pathologies including patellofemoral pain and anterior cruciate injury. As the foot is the primary interface with the support surface, foot and ankle mobility may affect the FPPA. This study investigated the relationship between foot and ankle mobility and the FPPA in asymptomatic adults...
2016: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/26406201/relationship-between-frontal-plane-projection-angle-of-the-knee-and-hip-and-trunk-strength-in-women-with-and-without-patellofemoral-pain
#11
Gabriel Peixoto Leão Almeida, Ana Paula de Moura Campos Carvalho E Silva, Fábio Jorge Renovato França, Maurício Oliveira Magalhães, Thomaz Nogueira Burke, Amélia Pasqual Marques
BACKGROUND: It is theorized that increased dynamic knee valgus relates to decreased hip posterolateral muscle strength. OBJECTIVE: The aim here was to assess the relationship between the frontal plane projection angle (FPPA) of the knee and hip and trunk muscle strength in women with and without patellofemoral pain (PFP). METHODS: The sample comprised 43 women: Patellofemoral Pain Group (PPG, n = 22) and Control Group (CG, n = 21). Muscle strength for hip abduction, extension, external rotation and lateral core were measured using a handheld dynamometer...
April 27, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/26118529/does-anterior-knee-pain-severity-and-function-relate-to-the-frontal-plane-projection-angle-and-trunk-and-hip-strength-in-women-with-patellofemoral-pain
#12
Gabriel Peixoto Leão Almeida, Ana Paula de Moura Campos Carvalho E Silva, Fábio Jorge Renovato França, Maurício Oliveira Magalhães, Thomaz Nogueira Burke, Amélia Pasqual Marques
The aim of the present study was to determine the relationship between knee pain severity and function with the frontal plane projection angle (FPPA) and trunk and hip peak torque (PT) in women with patellofemoral pain (PFPS). Twenty-two women with PFPS were assessed. Knee pain severity (KPS) was assessed with an 11-point visual analog scale and function with an Anterior Knee Pain Scale. The FPPA was recorded with a digital camera. PT of extensors, abductors, and the lateral rotators of hip and lateral core stability were measured with a handheld dynamometer...
July 2015: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/25920339/a-preliminary-study-into-the-effect-of-jumping-landing-training-and-strength-training-on-frontal-plane-projection-angle
#13
COMPARATIVE STUDY
Lee Herrington, Allan Munro, Paul Comfort
The presence of increased knee valgus angles during functional tasks has been associated with a range of knee pathologies. A number of different exercise interventions have been undertaken to improve knee alignment during functional tasks. The most successful of these interventions are multi-modal incorporating both strength and jump-landing training. Little research has been undertaken to compare these elements individually to assess if success is due to an individual element or the training as a whole. The study assessed the between group effects of strength training or jump-landing training alone on knee valgus alignment during a number of functional tasks, using a cohort specific treatment superiority design...
October 2015: Manual Therapy
https://www.readbyqxmd.com/read/25658442/two-and-three-dimensional-relationships-between-knee-and-hip-kinematic-motion-analysis-single-leg-drop-jump-landings
#14
COMPARATIVE STUDY
Bryan Sorenson, Thomas W Kernozek, John David Willson, Robert Ragan, Jordan Hove
CONTEXT: Hip- and knee-joint kinematics during drop landings are relevant to lower-extremity injury mechanisms. In clinical research the "gold standard" for joint kinematic assessment is 3-dimensional (3D) motion analysis. However, 2-dimensional (2D) kinematic analysis is an objective and feasible alternative. OBJECTIVE: To quantify the relationship between 2D and 3D hip and knee kinematics in single-leg drop landings and test for a set of 3D hip and knee kinematics that best predicts 2D kinematic measures during single-leg drop landings Design: Descriptive, comparative laboratory study...
November 2015: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/25366084/observational-ratings-of-frontal-plane-knee-position-are-related-to-the-frontal-plane-projection-angle-but-not-the-knee-abduction-angle-during-a-step-down-task
#15
Debi Jones, Susan M Tillman, Kari Tofte, Ryan L Mizner, Scott Greenberg, Michael W Moser, Terese L Chmielewski
STUDY DESIGN: Laboratory study, cross-sectional. OBJECTIVES: To determine if the magnitude of frontal plane knee angle, as determined with a 3-D motion-capture system (knee abduction angle [KAA]) or digital video (frontal plane projection angle [FPPA]), varies among groups of individuals with different frontal plane knee position, as determined by observational ratings. BACKGROUND: Performing functional tasks with the knee positioned medial to the foot may increase the risk for knee injury...
December 2014: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/25070759/relationship-between-hip-and-core-strength-and-frontal-plane-alignment-during-a-single-leg-squat
#16
Laurie Stickler, Margaret Finley, Heather Gulgin
OBJECTIVE: The purpose of this study was to examine the relationship between frontal plane kinematics of the single leg squat and strength of the trunk and hip in females. PARTICIPANTS: Forty healthy females participated in this study. METHODS: An isometric "make" test using a dynamometer was used to assess peak force normalized to body weight for hip abduction, hip extension, hip external rotation, and a sidelying plank test. Two-dimensional software was used to analyze the frontal plane projection angle (FPPA) and pelvic angle during a single leg squat to 60°...
February 2015: Physical Therapy in Sport
https://www.readbyqxmd.com/read/24955621/classification-of-lower-extremity-movement-patterns-based-on-visual-assessment-reliability-and-correlation-with-2-dimensional-video-analysis
#17
Marcie Harris-Hayes, Karen Steger-May, Christine Koh, Nat K Royer, Valentina Graci, Gretchen B Salsich
CONTEXT: Abnormal movement patterns have been implicated in lower extremity injury. Reliable, valid, and easily implemented assessment methods are needed to examine existing musculoskeletal disorders and investigate predictive factors for lower extremity injury. OBJECTIVE: To determine the reliability of experienced and novice testers in making visual assessments of lower extremity movement patterns and to characterize the construct validity of the visual assessments...
May 2014: Journal of Athletic Training
https://www.readbyqxmd.com/read/24950995/the-effect-of-videotape-augmented-feedback-on-drop-jump-landing-strategy-implications-for-anterior-cruciate-ligament-and-patellofemoral-joint-injury-prevention
#18
Allan Munro, Lee Herrington
BACKGROUND: Modification of high-risk movement strategies such as dynamic knee valgus is key to the reduction of anterior cruciate ligament (ACL) and patellofemoral joint (PFJ) injuries. Augmented feedback, which includes video and verbal feedback, could offer a quick, simple and effective alternative to training programs for altering high-risk movement patterns. It is not clear whether feedback can reduce dynamic knee valgus measured using frontal plane projection angle (FPPA). METHODS: Vertical ground reaction force (vGRF), two-dimensional FPPA of the knee, contact time and jump height of 20 recreationally active university students were measured during a drop jump task pre- and post- an augmented feedback intervention...
October 2014: Knee
https://www.readbyqxmd.com/read/24520834/classification-of-lower-extremity-movement-patterns-based-on-visual-assessment-reliability-and-correlation-with-2-dimensional-video-analysis
#19
Marcie Harris-Hayes, Karen Steger-May, Christine Koh, Nat K Royer, Valentina Graci, Gretchen B Salsich
Context : Abnormal movement patterns have been implicated in lower extremity injury. Reliable, valid, and easily implemented assessment methods are needed to examine existing musculoskeletal disorders and investigate predictive factors for lower extremity injury. Objective : To determine the reliability of experienced and novice testers in making visual assessments of lower extremity movement patterns and to characterize the construct validity of the visual assessments. Design : Cross-sectional study. Setting : University athletic department and research laboratory...
February 12, 2014: Journal of Athletic Training
https://www.readbyqxmd.com/read/24380805/knee-valgus-angle-during-single-leg-squat-and-landing-in-patellofemoral-pain-patients-and-controls
#20
Lee Herrington
BACKGROUND: Patellofemoral pain (PFP) is a commonly presenting disorder of the lower limb, frequently effecting young physically active individuals particularly females. The condition has been associated with poor control of limb alignment while undertaking unilateral limb loading tasks. This poor alignment of the limb is believed to alter loading stress within the patellofemoral joint. This study aims to investigate the degree of knee valgus, assessed as 2D frontal plane projection angle (FPPA) during single leg squatting (SLS) and hop landing (SLL) tasks in patients with PFP and compare their performance to controls and the uninjured limb...
March 2014: Knee
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