keyword
https://read.qxmd.com/read/38650121/tanshinone%C3%A2-iia-suppresses-ferroptosis-to-attenuate-renal-podocyte-injury-in-diabetic-nephropathy-through-the-embryonic-lethal-abnormal-visual-like-protein%C3%A2-1-and-acyl-coenzyme%C3%A2-a-synthetase-long-chain-family-member%C3%A2-4-signaling-pathway
#1
JOURNAL ARTICLE
Shuai Zhu, Zhiqiang Kang, Fengjiao Zhang
AIMS/INTRODUCTION: Tanshinone IIA (TIIA) is one of the main components of the root of the red-rooted Salvia miltiorrhiza Bunge. However, the molecular mechanisms underlying TIIA-mediated protective effects in diabetic nephropathy (DN) are still unclear. MATERIALS AND METHODS: High glucose (HG)-induced mouse podocyte cell line (MPC5) cells were used as the in vitro model of DN and treated with TIIA. Cell viability, proliferation and apoptosis were detected using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide, 5-ethynyl-2'-deoxyuridine and flow cytometry assays...
April 22, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38648242/risankizumab-as-a-therapeutic-approach-for-recalcitrant-pyoderma-gangrenosum
#2
JOURNAL ARTICLE
Alessandra Michelucci, Flavia Manzo Margiotta, Giammarco Granieri, Giorgia Salvia, Cristian Fidanzi, Matteo Bevilacqua, Salvatore Panduri, Marco Romanelli, Valentina Dini
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis that is challenging to diagnose and treat. Clinicians frequently use fast-acting corticosteroids, which are subsequently combined with slower-acting immunosuppressants to progressively taper the corticosteroid dosage. Current research is focused on the use of monoclonal antibodies (mAbs) directed against target molecules involved in the pathogenesis of PG. However, available data on their efficacy are based on sporadic case reports and clinical experiences, so the authors aimed to evaluate the efficacy of risankizumab, an anti-interleukin-23 mAb, in the management of two complex PG cases...
May 1, 2024: Advances in Skin & Wound Care
https://read.qxmd.com/read/38641076/salvia-miltiorrhiza-suppresses-cardiomyocyte-ferroptosis-after-myocardial-infarction-by-activating-nrf2-signaling
#3
JOURNAL ARTICLE
Yu-Ting Wu, Guo-Yong Zhang, Lei Li, Bin Liu, Ru-Yu Wang, Rong-Qiang Song, Yue Hua, Yi-Ming Bi, Xin Han, Feng Zhang, Dong Wang, Ling-Peng Xie, Ying-Chun Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Ferroptosis, a recently identified non-apoptotic form of cell death reliant on iron, is distinguished by an escalation in lipid reactive oxygen species (ROS) that are iron-dependent. This phenomenon has a strong correlation with irregularities in iron metabolism and lipid peroxidation. Salvia miltiorrhiza Bunge (DS), a medicinal herb frequently utilized in China, is highly esteemed for its therapeutic effectiveness in enhancing blood circulation and ameliorating blood stasis, particularly during the treatment of cardiovascular diseases (CVDs)...
April 17, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38640337/role-and-molecular-mechanism-of-salvia-miltiorrhiza-associated-with-chemical-compounds-in-the-treatment-of-diabetes-mellitus-and-its-complications-a-review
#4
JOURNAL ARTICLE
Jiajie Li, Jinxing Liu, Weibing Shi, Jinchen Guo
Diabetes mellitus (DM) is one of the most prevalent diseases worldwide, greatly impacting patients' quality of life. This article reviews the progress in Salvia miltiorrhiza, an ancient Chinese plant, for the treatment of DM and its associated complications. Extensive studies have been conducted on the chemical composition and pharmacological effects of S miltiorrhiza, including its anti-inflammatory and antioxidant activities. It has demonstrated potential in preventing and treating diabetes and its consequences by improving peripheral nerve function and increasing retinal thickness in diabetic individuals...
April 19, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38636259/salvia-miltiorrhiza-polysaccharide-mitigates-afb1-induced-liver-injury-in-rabbits
#5
JOURNAL ARTICLE
Lu Zhang, Ying Liu, Qiongyi Zhang, Weiyu Yao, Zenghui Zhao, Xiao Wang, Yongzhan Bao, Wanyu Shi
Aflatoxin B1 (AFB1) is one of the common dietary contaminants worldwide, which can harm the liver of humans and animals. Salvia miltiorrhiza polysaccharide (SMP) is a natural plant-derived polysaccharide with numerous pharmacological activities, including hepatoprotective properties. The purpose of this study is to explore the intervention effect of SMP on AFB1-induced liver injury and its underlying mechanisms in rabbits. The rabbits were administered AFB1 (25 μg/kg/feed) and or treatment with SMP (300, 600, 900 mg/kg/feed) for 42 days...
April 17, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38635813/wastewater-based-epidemiology-as-a-surveillance-tool-during-the-current-covid-19-pandemic-on-a-college-campus-east-carolina-university-and-its-accuracy-in-predicting-sars-cov-2-outbreaks-in-dormitories
#6
JOURNAL ARTICLE
Avian White, Guy Iverson, LaNika Wright, John T Fallon, Kimberly P Briley, Changhong Yin, Weihua Huang, Charles Humphrey
The COVID-19 outbreak led governmental officials to close many businesses and schools, including colleges and universities. Thus, the ability to resume normal campus operation required adoption of safety measures to monitor and respond to COVID-19. The objective of this study was to determine the efficacy of wastewater-based epidemiology as a surveillance method in monitoring COVID-19 on a college campus. The use of wastewater monitoring as part of a surveillance program to control COVID-19 outbreaks at East Carolina University was evaluated...
2024: PloS One
https://read.qxmd.com/read/38635350/hemisynthesis-and-cytotoxic-evaluation-of-manoyl-oxide-analogs-from-sclareol-effect-of-two-tertiary-hydroxyls-heck-coupling-on-cytotoxicity
#7
JOURNAL ARTICLE
Ifshana Gani, Zahidul Islam Sofi, Gursimar Kaur, Anindya Goswami, Khursheed Ahmad Bhat
Sclareol, a bioactive diterpene alcohol isolated from Salvia sclarea , was subjected to structural modification and cytotoxic evaluation. Boron-Heck-coupled analogs of manoyl oxide were prepared from sclareol in a two-step reaction scheme. In the first step manoyl oxide was prepared from sclareol using cerium (IV) ammonium nitrate. Further the structural modification of manoyl oxide via Palladium (II) catalysed Boron-Heck coupling reaction produced a new series of compounds. All the synthesised compounds were screened for in vitro cytotoxic evaluation against four cancer cell lines HCT-116, MCF-7, MDA-MB231and MDA-MB468...
April 18, 2024: Natural Product Research
https://read.qxmd.com/read/38633614/-salvia-miltiorrhiza-ameliorates-endometritis-in-dairy-cows-by-relieving-inflammation-energy-deficiency-and-blood-stasis
#8
JOURNAL ARTICLE
Shiyang Tian, Tianyi Liu, Jingwei Jiang, Xiting Zhao, Yunpeng Fan, Weimin Zhang, Wuren Ma, Tingting Guo, Weiling Wang, Yingqiu Liu
Introduction: According to traditional Chinese veterinary medicine, endometritis is caused by a combination of Qi deficiency, blood stasis, and external evil invasion. Salvia miltiorrhiza is a traditional Chinese medicine that counteracts blood stasis and has additional demonstrated effects in boosting energy and restraining inflammation. Salvia miltiorrhiza has been employed in many traditional Chinese prescriptions that have proven effective in healing clinical dairy cow endometritis. Methods: the in vivo effect of Salvia miltiorrhiza in treating endometritis was evaluated in dairy cows...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38621967/-effects-of-organic-fertilizer-from-traditional-chinese-medicine-residues-on-growth-and-soil-microbial-community-of-salvia-miltiorrhiza-by-metagenomic-technique
#9
JOURNAL ARTICLE
Zi-Han Wang, Sha Liu, Guang Yang, Zu-Yu Lu, Rong-Qing Zhu, Ying Li, Ye Shen, Li-Ping Kang, Mei-Lan Chen
Soil microbiome is a key evaluation index of soil health. Previous studies have shown that organic fertilizer from traditional Chinese medicine(TCM)residues can improve the yield and quality of cultivated traditional Chinese medicinal materials. However, there are few reports on the effects of organic fertilizer from TCM residues on soil microbiome. Therefore, on the basis of evaluating the effects of organic fertilizer from TCM residues on the yield and quality of cultivated Salvia miltiorrhiza, the metagenomic sequencing technique was used to study the effects of organic fertilizer from TCM residues on rhizosphere microbiome community and function of cultivated S...
March 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38621886/-network-meta-analysis-of-chinese-patent-medicine-in-treatment-of-heart-failure-with-preserved-ejection-fraction
#10
JOURNAL ARTICLE
Jing Tian, Bai-Rong Xu, Zuo-Ying Xing, Bo-Yong Qiu, Chun-Ying Si, Ming-Jun Zhu, Yong-Xia Wang
This study systematically evaluated the efficacy and safety of different Chinese patent medicines combined with conventional western medicine in the treatment of heart failure with preserved ejection fraction(HFpEF) and ranked for the drug selection. Randomized controlled trial(RCT) on Chinese patent medicines in treatment of HFpEF were obtained from the CNKI, Wanfang, VIP, SinoMed, PubMed, Cochrane Library, EMbase, Web of Science, and other databases from the inception to October 9, 2022. The included RCT was quantitatively analyzed using gemtc and rjags packages of R software for the network Meta-analysis...
February 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38621425/tanshinone-iia-acts-as-a-regulator-of-lipogenesis-to-overcome-osimertinib-acquired-resistance-in-lung-cancer
#11
JOURNAL ARTICLE
Lin Cao, Zhiyan Qin, Ting Yu, Xupeng Bai, Shiqin Jiang, Daifei Wang, Fangqing Ning, Min Huang, Jing Jin
Osimertinib is a novel epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), acting as the first-line medicine for advanced EGFR-mutated NSCLC. Recently, the acquired resistance to osimertinib brings great challenges to the advanced treatment. Therefore, it is in urgent need to find effective strategy to overcome osimertinib acquired resistance. Here, we demonstrated that SREBP pathway-driven lipogenesis was a key mediator to promote osimertinib acquired resistance, and firstly found Tanshinone IIA (Tan IIA), a natural pharmacologically active constituent isolated from Salvia miltiorrhiza, could overcome osimertinib-acquired resistance in vitro and in vivo via inhibiting SREBP pathway-mediated lipid lipogenesis by using LC-MS based cellular lipidomics analysis, quantitative real-time PCR (qRT-PCR) analysis, western blotting analysis, flow cytometry, small interfering RNAs transfection, and membrane fluidity assay et al...
April 13, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38616000/traditional-chinese-medicine-injections-with-activating-blood-circulation-equivalent-effect-of-anticoagulation-or-antiplatelet-for-acute-myocardial-infarction-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#12
REVIEW
Xue-Yan Sun, Jia-Ping Chen, Ju-Ju Shang, Hong-Xu Liu, Xiang Li, Yan Lou, Hui-Wen Zhou
BACKGROUND: Traditional Chinese medicine injection for Activating Blood Circulation (TCMi-ABC), which exhibits comparable anticoagulant and antiplatelet effects, is commonly used as an adjuvant treatment for acute myocardial infarction (AMI) in China. OBJECTIVE: The aim of this study was to conduct a meta-analysis to assess the efficacy and safety of TCMi-ABC in combination with conventional western medicine in reducing mortality associated with AMI. METHODS: We conducted a comprehensive search of PubMed, Cochrane Library, EMBASE, Web of Science, CBM, WanFang Data, and CNKI databases...
April 12, 2024: Complementary Therapies in Medicine
https://read.qxmd.com/read/38613276/amplitude-analysis-of-the-b-0-%C3%A2-k-0-%C3%AE-%C3%AE-decay
#13
JOURNAL ARTICLE
R Aaij, A S W Abdelmotteleb, C Abellan Beteta, F Abudinén, T Ackernley, B Adeva, M Adinolfi, P Adlarson, C Agapopoulou, C A Aidala, Z Ajaltouni, S Akar, K Akiba, P Albicocco, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, Z Aliouche, P Alvarez Cartelle, R Amalric, S Amato, J L Amey, Y Amhis, L An, L Anderlini, M Andersson, A Andreianov, P Andreola, M Andreotti, D Andreou, A Anelli, D Ao, F Archilli, M Argenton, S Arguedas Cuendis, A Artamonov, M Artuso, E Aslanides, M Atzeni, B Audurier, D Bacher, I Bachiller Perea, S Bachmann, M Bachmayer, J J Back, A Bailly-Reyre, P Baladron Rodriguez, V Balagura, W Baldini, J Baptista de Souza Leite, M Barbetti, I R Barbosa, R J Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, J M Basels, G Bassi, B Batsukh, A Battig, A Bay, A Beck, M Becker, F Bedeschi, I B Bediaga, A Beiter, S Belin, V Bellee, K Belous, I Belov, I Belyaev, G Benane, G Bencivenni, E Ben-Haim, A Berezhnoy, R Bernet, S Bernet Andres, H C Bernstein, C Bertella, A Bertolin, C Betancourt, F Betti, J Bex, Ia Bezshyiko, J Bhom, M S Bieker, N V Biesuz, P Billoir, A Biolchini, M Birch, F C R Bishop, A Bitadze, A Bizzeti, M P Blago, T Blake, F Blanc, J E Blank, S Blusk, D Bobulska, V Bocharnikov, J A Boelhauve, O Boente Garcia, T Boettcher, A Bohare, A Boldyrev, C S Bolognani, R Bolzonella, N Bondar, F Borgato, S Borghi, M Borsato, J T Borsuk, S A Bouchiba, T J V Bowcock, A Boyer, C Bozzi, M J Bradley, S Braun, A Brea Rodriguez, N Breer, J Brodzicka, A Brossa Gonzalo, J Brown, D Brundu, A Buonaura, L Buonincontri, A T Burke, C Burr, A Bursche, A Butkevich, J S Butter, J Buytaert, W Byczynski, S Cadeddu, H Cai, R Calabrese, L Calefice, S Cali, M Calvi, M Calvo Gomez, J Cambon Bouzas, P Campana, D H Campora Perez, A F Campoverde Quezada, S Capelli, L Capriotti, R Caravaca-Mora, A Carbone, L Carcedo Salgado, R Cardinale, A Cardini, P Carniti, L Carus, A Casais Vidal, R Caspary, G Casse, J Castro Godinez, M Cattaneo, G Cavallero, V Cavallini, S Celani, J Cerasoli, D Cervenkov, S Cesare, A J Chadwick, I Chahrour, M Charles, Ph Charpentier, C A Chavez Barajas, M Chefdeville, C Chen, S Chen, A Chernov, S Chernyshenko, V Chobanova, S Cholak, M Chrzaszcz, A Chubykin, V Chulikov, P Ciambrone, M F Cicala, X Cid Vidal, G Ciezarek, P Cifra, P E L Clarke, M Clemencic, H V Cliff, J Closier, J L Cobbledick, C Cocha Toapaxi, V Coco, J Cogan, E Cogneras, L Cojocariu, P Collins, T Colombo, A Comerma-Montells, L Congedo, A Contu, N Cooke, I Corredoira, A Correia, G Corti, J J Cottee Meldrum, B Couturier, D C Craik, M Cruz Torres, R Currie, C L Da Silva, S Dadabaev, L Dai, X Dai, E Dall'Occo, J Dalseno, C D'Ambrosio, J Daniel, A Danilina, P d'Argent, A Davidson, J E Davies, A Davis, O De Aguiar Francisco, C De Angelis, J de Boer, K De Bruyn, S De Capua, M De Cian, U De Freitas Carneiro Da Graca, E De Lucia, J M De Miranda, L De Paula, M De Serio, D De Simone, P De Simone, F De Vellis, J A de Vries, F Debernardis, D Decamp, V Dedu, L Del Buono, B Delaney, H-P Dembinski, J Deng, V Denysenko, O Deschamps, F Dettori, B Dey, P Di Nezza, I Diachkov, S Didenko, S Ding, V Dobishuk, A D Docheva, A Dolmatov, C Dong, A M Donohoe, F Dordei, A C Dos Reis, L Douglas, A G Downes, W Duan, P Duda, M W Dudek, L Dufour, V Duk, P Durante, M M Duras, J M Durham, A Dziurda, A Dzyuba, S Easo, E Eckstein, U Egede, A Egorychev, V Egorychev, C Eirea Orro, S Eisenhardt, E Ejopu, S Ek-In, L Eklund, M Elashri, J Ellbracht, S Ely, A Ene, E Epple, S Escher, J Eschle, S Esen, T Evans, F Fabiano, L N Falcao, Y Fan, B Fang, L Fantini, M Faria, K Farmer, D Fazzini, L Felkowski, M Feng, M Feo, M Fernandez Gomez, A D Fernez, F Ferrari, F Ferreira Rodrigues, S Ferreres Sole, M Ferrillo, M Ferro-Luzzi, S Filippov, R A Fini, M Fiorini, M Firlej, K M Fischer, D S Fitzgerald, C Fitzpatrick, T Fiutowski, F Fleuret, M Fontana, F Fontanelli, L F Foreman, R Forty, D Foulds-Holt, M Franco Sevilla, M Frank, E Franzoso, G Frau, C Frei, D A Friday, L Frontini, J Fu, Q Fuehring, Y Fujii, T Fulghesu, E Gabriel, G Galati, M D Galati, A Gallas Torreira, D Galli, S Gambetta, M Gandelman, P Gandini, H Gao, R Gao, Y Gao, Y Gao, Y Gao, M Garau, L M Garcia Martin, P Garcia Moreno, J García Pardiñas, B Garcia Plana, K G Garg, L Garrido, C Gaspar, R E Geertsema, L L Gerken, E Gersabeck, M Gersabeck, T Gershon, Z Ghorbanimoghaddam, L Giambastiani, F I Giasemis, V Gibson, H K Giemza, A L Gilman, M Giovannetti, A Gioventù, P Gironella Gironell, C Giugliano, M A Giza, E L Gkougkousis, F C Glaser, V V Gligorov, C Göbel, E Golobardes, D Golubkov, A Golutvin, A Gomes, S Gomez Fernandez, F Goncalves Abrantes, M Goncerz, G Gong, J A Gooding, I V Gorelov, C Gotti, J P Grabowski, L A Granado Cardoso, E Graugés, E Graverini, L Grazette, G Graziani, A T Grecu, L M Greeven, N A Grieser, L Grillo, S Gromov, C Gu, M Guarise, M Guittiere, V Guliaeva, P A Günther, A-K Guseinov, E Gushchin, Y Guz, T Gys, T Hadavizadeh, C Hadjivasiliou, G Haefeli, C Haen, J Haimberger, M Hajheidari, T Halewood-Leagas, M M Halvorsen, P M Hamilton, J Hammerich, Q Han, X Han, S Hansmann-Menzemer, L Hao, N Harnew, T Harrison, M Hartmann, C Hasse, J He, K Heijhoff, F Hemmer, C Henderson, R D L Henderson, A M Hennequin, K Hennessy, L Henry, J Herd, P Herrero Gascon, J Heuel, A Hicheur, D Hill, S E Hollitt, J Horswill, R Hou, Y Hou, N Howarth, J Hu, J Hu, W Hu, X Hu, W Huang, W Hulsbergen, R J Hunter, M Hushchyn, D Hutchcroft, M Idzik, D Ilin, P Ilten, A Inglessi, A Iniukhin, A Ishteev, K Ivshin, R Jacobsson, H Jage, S J Jaimes Elles, S Jakobsen, E Jans, B K Jashal, A Jawahery, V Jevtic, E Jiang, X Jiang, Y Jiang, Y J Jiang, M John, D Johnson, C R Jones, T P Jones, S Joshi, B Jost, N Jurik, I Juszczak, D Kaminaris, S Kandybei, Y Kang, M Karacson, D Karpenkov, M Karpov, A M Kauniskangas, J W Kautz, F Keizer, D M Keller, M Kenzie, T Ketel, B Khanji, A Kharisova, S Kholodenko, G Khreich, T Kirn, V S Kirsebom, O Kitouni, S Klaver, N Kleijne, K Klimaszewski, M R Kmiec, S Koliiev, L Kolk, A Konoplyannikov, P Kopciewicz, P Koppenburg, M Korolev, I Kostiuk, O Kot, S Kotriakhova, A Kozachuk, P Kravchenko, L Kravchuk, M Kreps, S Kretzschmar, P Krokovny, W Krupa, W Krzemien, J Kubat, S Kubis, W Kucewicz, M Kucharczyk, V Kudryavtsev, E Kulikova, A Kupsc, B K Kutsenko, D Lacarrere, A Lai, A Lampis, D Lancierini, C Landesa Gomez, J J Lane, R Lane, C Langenbruch, J Langer, O Lantwin, T Latham, F Lazzari, C Lazzeroni, R Le Gac, S H Lee, R Lefèvre, A Leflat, S Legotin, M Lehuraux, O Leroy, T Lesiak, B Leverington, A Li, H Li, K Li, L Li, P Li, P-R Li, S Li, T Li, T Li, Y Li, Y Li, Z Li, Z Lian, X Liang, C Lin, T Lin, R Lindner, V Lisovskyi, R Litvinov, G Liu, H Liu, K Liu, Q Liu, S Liu, Y Liu, Y Liu, Y L Liu, A Lobo Salvia, A Loi, J Lomba Castro, T Long, J H Lopes, A Lopez Huertas, S López Soliño, G H Lovell, C Lucarelli, D Lucchesi, S Luchuk, M Lucio Martinez, V Lukashenko, Y Luo, A Lupato, E Luppi, K Lynch, X-R Lyu, G M Ma, R Ma, S Maccolini, F Machefert, F Maciuc, I Mackay, L R Madhan Mohan, M M Madurai, A Maevskiy, D Magdalinski, D Maisuzenko, M W Majewski, J J Malczewski, S Malde, B Malecki, L Malentacca, A Malinin, T Maltsev, G Manca, G Mancinelli, C Mancuso, R Manera Escalero, D Manuzzi, D Marangotto, J F Marchand, R Marchevski, U Marconi, S Mariani, C Marin Benito, J Marks, A M Marshall, P J Marshall, G Martelli, G Martellotti, L Martinazzoli, M Martinelli, D Martinez Santos, F Martinez Vidal, A Massafferri, M Materok, R Matev, A Mathad, V Matiunin, C Matteuzzi, K R Mattioli, A Mauri, E Maurice, J Mauricio, P Mayencourt, M Mazurek, M McCann, L Mcconnell, T H McGrath, N T McHugh, A McNab, R McNulty, B Meadows, G Meier, D Melnychuk, M Merk, A Merli, L Meyer Garcia, D Miao, H Miao, M Mikhasenko, D A Milanes, A Minotti, E Minucci, T Miralles, S E Mitchell, B Mitreska, D S Mitzel, A Modak, A Mödden, R A Mohammed, R D Moise, S Mokhnenko, T Mombächer, M Monk, I A Monroy, S Monteil, A Morcillo Gomez, G Morello, M J Morello, M P Morgenthaler, J Moron, A B Morris, A G Morris, R Mountain, H Mu, Z M Mu, E Muhammad, F Muheim, M Mulder, K Müller, F Muñoz-Rojas, R Murta, P Naik, T Nakada, R Nandakumar, T Nanut, I Nasteva, M Needham, N Neri, S Neubert, N Neufeld, P Neustroev, R Newcombe, J Nicolini, D Nicotra, E M Niel, N Nikitin, P Nogga, N S Nolte, C Normand, J Novoa Fernandez, G Nowak, C Nunez, H N Nur, A Oblakowska-Mucha, V Obraztsov, T Oeser, S Okamura, R Oldeman, F Oliva, M Olocco, C J G Onderwater, R H O'Neil, J M Otalora Goicochea, T Ovsiannikova, P Owen, A Oyanguren, O Ozcelik, K O Padeken, B Pagare, P R Pais, T Pajero, A Palano, M Palutan, G Panshin, L Paolucci, A Papanestis, M Pappagallo, L L Pappalardo, C Pappenheimer, C Parkes, B Passalacqua, G Passaleva, D Passaro, A Pastore, M Patel, J Patoc, C Patrignani, C J Pawley, A Pellegrino, M Pepe Altarelli, S Perazzini, D Pereima, A Pereiro Castro, P Perret, A Perro, K Petridis, A Petrolini, S Petrucci, H Pham, L Pica, M Piccini, B Pietrzyk, G Pietrzyk, D Pinci, F Pisani, M Pizzichemi, V Placinta, M Plo Casasus, F Polci, M Poli Lener, A Poluektov, N Polukhina, I Polyakov, E Polycarpo, S Ponce, D Popov, S Poslavskii, K Prasanth, C Prouve, V Pugatch, V Puill, G Punzi, H R Qi, W Qian, N Qin, S Qu, R Quagliani, R I Rabadan Trejo, B Rachwal, J H Rademacker, M Rama, M Ramírez García, M Ramos Pernas, M S Rangel, F Ratnikov, G Raven, M Rebollo De Miguel, F Redi, J Reich, F Reiss, Z Ren, P K Resmi, R Ribatti, G R Ricart, D Riccardi, S Ricciardi, K Richardson, M Richardson-Slipper, K Rinnert, P Robbe, G Robertson, E Rodrigues, E Rodriguez Fernandez, J A Rodriguez Lopez, E Rodriguez Rodriguez, A Rogovskiy, D L Rolf, A Rollings, P Roloff, V Romanovskiy, M Romero Lamas, A Romero Vidal, G Romolini, F Ronchetti, M Rotondo, S R Roy, M S Rudolph, T Ruf, M Ruiz Diaz, R A Ruiz Fernandez, J Ruiz Vidal, A Ryzhikov, J Ryzka, J J Saborido Silva, R Sadek, N Sagidova, N Sahoo, B Saitta, M Salomoni, C Sanchez Gras, I Sanderswood, R Santacesaria, C Santamarina Rios, M Santimaria, L Santoro, E Santovetti, A Saputi, D Saranin, G Sarpis, M Sarpis, A Sarti, C Satriano, A Satta, M Saur, D Savrina, H Sazak, L G Scantlebury Smead, A Scarabotto, S Schael, S Scherl, A M Schertz, M Schiller, H Schindler, M Schmelling, B Schmidt, S Schmitt, H Schmitz, O Schneider, A Schopper, N Schulte, S Schulte, M H Schune, R Schwemmer, G Schwering, B Sciascia, A Sciuccati, S Sellam, A Semennikov, M Senghi Soares, A Sergi, N Serra, L Sestini, A Seuthe, Y Shang, D M Shangase, M Shapkin, I Shchemerov, L Shchutska, T Shears, L Shekhtman, Z Shen, S Sheng, V Shevchenko, B Shi, E B Shields, Y Shimizu, E Shmanin, R Shorkin, J D Shupperd, R Silva Coutinho, G Simi, S Simone, N Skidmore, R Skuza, T Skwarnicki, M W Slater, J C Smallwood, E Smith, K Smith, M Smith, A Snoch, L Soares Lavra, M D Sokoloff, F J P Soler, A Solomin, A Solovev, I Solovyev, R Song, Y Song, Y Song, Y S Song, F L Souza De Almeida, B Souza De Paula, E Spadaro Norella, E Spedicato, J G Speer, E Spiridenkov, P Spradlin, V Sriskaran, F Stagni, M Stahl, S Stahl, S Stanislaus, E N Stein, O Steinkamp, O Stenyakin, H Stevens, D Strekalina, Y Su, F Suljik, J Sun, L Sun, Y Sun, P N Swallow, K Swientek, F Swystun, A Szabelski, T Szumlak, M Szymanski, Y Tan, S Taneja, M D Tat, A Terentev, F Terzuoli, F Teubert, E Thomas, D J D Thompson, H Tilquin, V Tisserand, S T'Jampens, M Tobin, L Tomassetti, G Tonani, X Tong, D Torres Machado, L Toscano, D Y Tou, C Trippl, G Tuci, N Tuning, L H Uecker, A Ukleja, D J Unverzagt, E Ursov, A Usachov, A Ustyuzhanin, U Uwer, V Vagnoni, A Valassi, G Valenti, N Valls Canudas, H Van Hecke, E van Herwijnen, C B Van Hulse, R Van Laak, M van Veghel, R Vazquez Gomez, P Vazquez Regueiro, C Vázquez Sierra, S Vecchi, J J Velthuis, M Veltri, A Venkateswaran, M Vesterinen, D Vieira, M Vieites Diaz, X Vilasis-Cardona, E Vilella Figueras, A Villa, P Vincent, F C Volle, D Vom Bruch, V Vorobyev, N Voropaev, K Vos, G Vouters, C Vrahas, J Walsh, E J Walton, G Wan, C Wang, G Wang, J Wang, J Wang, J Wang, J Wang, M Wang, N W Wang, R Wang, X Wang, X W Wang, Y Wang, Z Wang, Z Wang, Z Wang, J A Ward, N K Watson, D Websdale, Y Wei, B D C Westhenry, D J White, M Whitehead, A R Wiederhold, D Wiedner, G Wilkinson, M K Wilkinson, M Williams, M R J Williams, R Williams, F F Wilson, W Wislicki, M Witek, L Witola, C P Wong, G Wormser, S A Wotton, H Wu, J Wu, Y Wu, K Wyllie, S Xian, Z Xiang, Y Xie, A Xu, J Xu, L Xu, L Xu, M Xu, Z Xu, Z Xu, Z Xu, D Yang, S Yang, X Yang, Y Yang, Z Yang, Z Yang, V Yeroshenko, H Yeung, H Yin, C Y Yu, J Yu, X Yuan, E Zaffaroni, M Zavertyaev, M Zdybal, M Zeng, C Zhang, D Zhang, J Zhang, L Zhang, S Zhang, S Zhang, Y Zhang, Y Zhang, Y Z Zhang, Y Zhao, A Zharkova, A Zhelezov, X Z Zheng, Y Zheng, T Zhou, X Zhou, Y Zhou, V Zhovkovska, L Z Zhu, X Zhu, X Zhu, Z Zhu, V Zhukov, J Zhuo, Q Zou, D Zuliani, G Zunica
An amplitude analysis of the B^{0}→K^{*0}μ^{+}μ^{-} decay is presented using a dataset corresponding to an integrated luminosity of 4.7  fb^{-1} of pp collision data collected with the LHCb experiment. For the first time, the coefficients associated to short-distance physics effects, sensitive to processes beyond the standard model, are extracted directly from the data through a q^{2}-unbinned amplitude analysis, where q^{2} is the μ^{+}μ^{-} invariant mass squared...
March 29, 2024: Physical Review Letters
https://read.qxmd.com/read/38612814/hybrid-materials-obtained-by-immobilization-of-biosynthesized-ag-nanoparticles-with-antioxidant-and-antimicrobial-activity
#14
JOURNAL ARTICLE
Gabriela Petcu, Elena Madalina Ciobanu, Gabriela Paun, Elena Neagu, Adriana Baran, Bogdan Trica, Andreea Neacsu, Irina Atkinson, Razvan Bucuresteanu, Alexandra Badaluta, Lia Mara Ditu, Viorica Parvulescu
Ag nanoparticles (AgNPs) were biosynthesized using sage ( Salvia officinalis L.) extract. The obtained nanoparticles were supported on SBA-15 mesoporous silica (S), before and after immobilization of 10% TiO2 (Degussa-P25, STp; commercial rutile, STr; and silica synthesized from Ti butoxide, STb). The formation of AgNPs was confirmed by X-ray diffraction. The plasmon resonance effect, evidenced by UV-Vis spectra, was preserved after immobilization only for the sample supported on STb. The immobilization and dispersion properties of AgNPs on supports were evidenced by TEM microscopy, energy-dispersive X-rays, dynamic light scattering, photoluminescence and FT-IR spectroscopy...
April 3, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38611836/study-on-the-antitumor-mechanism-of-tanshinone-iia-in-vivo-and-in-vitro-through-the-regulation-of-perk-atf4-hspa5-pathway-mediated-ferroptosis
#15
JOURNAL ARTICLE
Chunxiang Guo, Wei Zhao, Wei Wang, Zheng Yao, Wenhui Chen, Xiaoyi Feng
As a traditional Chinese medicine, Salvia miltiorrhiza Bunge was first recorded in the Shennong Materia Medica Classic and is widely used to treat "the accumulation of symptoms and masses". The main active ingredient of Salvia miltiorrhiza Bunge , Tanshinone IIA (TIIA), has shown anti-inflammatory, antitumor, antifibrosis, antibacterial, and antioxidative activities, etc. In this study, the results showed that TIIA could inhibit the proliferation and migration of HepG2 cells and downregulate glutathione (GSH) and Glutathione Peroxidase 4 (GPX4) levels; besides, TIIA induced the production of Reactive Oxygen Species (ROS), and upregulated the total iron content...
March 30, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38611827/chemometric-analysis-evidencing-the-variability-in-the-composition-of-essential-oils-in-10-salvia-species-from-different-taxonomic-sections-or-phylogenetic-clades
#16
JOURNAL ARTICLE
Ekaterina-Michaela Tomou, Panagiota Fraskou, Konstantina Dimakopoulou, Eleftherios Dariotis, Nikos Krigas, Helen Skaltsa
Essential oil (EO) of Salvia spp. has been widely used for culinary purposes and in perfumery and cosmetics, as well as having beneficial effects on human health. The present study aimed to investigate the quantitative and qualitative variations in EOs in wild-growing and cultivated pairs of samples from members in four Salvia sections or three clades, namely S. argentea L. (Sect. Aethiopis ; Clade I-C), S. ringens Sm. (Sect. Eusphace ; Clade I-D), S. verticillata L. (Sect. Hemisphace ; Clade I-B), S. amplexicaulis Lam...
March 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38608504/investigating-the-simultaneous-effect-of-chitosan-and-arbuscular-mycorrhizal-fungi-on-growth-phenolic-compounds-pal-enzyme-activity-and-lipid-peroxidation-in-salvia-nemorosa-l
#17
JOURNAL ARTICLE
Marzieh Fotovvat, Farzaneh Najafi, Ramazan Ali Khavari-Nejad, Daryush Talei, Farhad Rejali
Considering the importance of Salvia nemorosa L. in the pharmaceutical and food industries, and also beneficial approaches of arbuscular mycorrhizal fungi (AMF) symbiosis and the use of bioelicitors such as chitosan to improve secondary metabolites, the aim of this study was to evaluate the performance of chitosan on the symbiosis of AMF and the effect of both on the biochemical and phytochemical performance of this plant and finally introduced the best treatment. Two factors were considered for the factorial experiment: AMF with four levels (non-inoculated plants, Funneliformis mosseae, Rhizophagus intraradices and the combination of both), and chitosan with six levels (0, 50, 100, 200, 400 mg L-1 and 1% acetic acid)...
April 9, 2024: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/38594492/antifungal-activity-of-a-trypsin-inhibitor-from-salvia-hispanica-l-chia-seeds-against-fluconazole-resistant-strains-of-candida-spp-and-evaluation-of-its-toxicity-in-vitro
#18
JOURNAL ARTICLE
Francisca Cristiane Nogueira, Adson Ávila de Souza, Nadine Monteiro Salgueiro Araújo, Larissa Alves Lopes de Souza, Rafael Guimarães Gomes Silva, Daniele de Oliveira Bezerra de Sousa, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes Filho, Lívia Gurgel do Amaral Valente Sá, Hélio Vitoriano Nobre Júnior, Hermógenes David de Oliveira
The incidence of Candida species resistant to traditional antifungal drugs is increasing globally. This issue significantly impacts patients' lives and increases healthcare expenses, confirming the need to develop novel therapeutic strategies. Recently, a thermostable trypsin inhibitor named ShTI (11.558 kDa), which has antibacterial effects on Staphylococcus aureus, was isolated from Salvia hispanica L. (chia) seeds. This study aimed to assess the antifungal effect of ShTI against Candida species and its synergism with fluconazole and to evaluate its mode of action...
April 9, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://read.qxmd.com/read/38590834/evaluation-of-hematoprotective-hepatoprotective-and-anti-inflammatory-potentials-of-chia-seed-salvia-hispanica-l-extract-in-rats
#19
JOURNAL ARTICLE
Sabbya Sachi, Mst Prianka Jahan, Purba Islam, Kazi Rafiq, Md Zahorul Islam
This study was conducted to evaluate the effects of chia seed extract on CCl4 -induced hepatotoxicity, hematological profile, and carrageenan-induced inflammation in rats. Water-ethanol-acetone extract of chia seeds at the doses of 200 and 400 mg/kg body weight/day were applied to evaluate the comparative protective roles. Hematological profile and serum biochemical parameters were measured to evaluate the hematoprotective, and hepatoprotective effects of chia seed extract. Paw thickness and motility level were assessed at 0, 1, 3, 5, and 7 h after sub-planter injection of carrageenan to evaluate the anti-inflammatory potential...
June 2024: Veterinary and Animal Science
https://read.qxmd.com/read/38577471/chinese-herbal-medicine-decreases-incidence-of-hepatocellular-carcinoma-in-diabetes-mellitus-patients-with-regular-insulin-management
#20
JOURNAL ARTICLE
Hsiang-Chun Lai, Ju-Chien Cheng, Hei-Tung Yip, Long-Bin Jeng, Sheng-Teng Huang
BACKGROUND: Type 2 diabetes mellitus (DM) is an independent risk factor for hepatocellular carcinoma (HCC), while insulin is a potent mitogen. Identifying a new therapeutic modality for preventing insulin users from developing HCC is a critical goal for researchers. AIM: To investigate whether regular herbal medicine use can decrease HCC risk in DM patients with regular insulin control. METHODS: We used data acquired from the Taiwanese National Health Insurance research database between 2000 and 2017...
March 15, 2024: World Journal of Gastrointestinal Oncology
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