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https://www.readbyqxmd.com/read/30314288/kappa-opioid-receptor-agonist-mesyl-sal-b-attenuates-behavioral-sensitization-to-cocaine-with-fewer-aversive-side-effects-than-salvinorin-a-in-rodents
#1
Bronwyn M Kivell, Kelly F Paton, Nitin Kumar, Aashish S Morani, Aimee Culverhouse, Amy Shepherd, Susan A Welsh, Andrew Biggerstaff, Rachel S Crowley, Thomas E Prisinzano
The acute activation of kappa opioid receptors (KOPr) produces antinociceptive and anti-cocaine effects, however, their side-effects have limited further clinical development. Mesyl Sal B is a potent and selective KOPr analogue of Salvinorin A (Sal A), a psychoactive natural product isolated from the plant Salvia divinorum . We assessed the antinociceptive, anti-cocaine, and side-effects of Mesyl Sal B. The anti-cocaine effects are evaluated in cocaine-induced hyperactivity and behavioral sensitization to cocaine in male Sprague Dawley rats...
October 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30312741/effects-and-mechanisms-of-danshen-shanzha-herb-pair-for-atherosclerosis-treatment-using-network-pharmacology-and-experimental-pharmacology
#2
Jianyong Zhang, Rixin Liang, Lan Wang, Bin Yang
ETHNOPHARMACOLOGICAL RELEVANCE: The danshen (the root of Salvia miltiorrhiza Bge.)-shanzha (the fruit of Crataegus pinnatifida Bge. var. major N.E.Br.) (DS) herb combination is a commonly used traditional Chinese medicine with cardiovascular disease (CVD) treatment potential. MATERIALS AND METHODS: In this study, we investigated the anti-atherosclerotic effects and mechanisms of DS by the integration of network pharmacology and polypharmacology. Eight main components were selected for target fishing by PharmMapper...
October 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30306652/radix-salviae-miltiorrhizae-improves-bone-microstructure-and-strength-through-wnt-%C3%AE-catenin-and-osteoprotegerin-receptor-activator-for-nuclear-factor-%C3%AE%C2%BAb-ligand-cathepsin-k-signaling-in-ovariectomized-rats
#3
Haixia Liu, Ruyuan Zhu, Lili Wang, Chenyue Liu, Rufeng Ma, Bowen Qi, Beibei Chen, Lin Li, Yubo Guo, Shepo Shi, Qiangqiang Jia, Jianzhao Niu, Dandan Zhao, Fangfang Mo, Sihua Gao, Dongwei Zhang
Although radix Salviae miltiorrhizae (RSM) is reported to exhibit the antiosteoporotic effect in preclinical study, the underlying mechanism is unclear. To this end, ovariectomized (OVX) rats were employed with administration of RSM (5 g/kg) for 14 weeks. The disturbed serum levels of alkaline phosphatase (ALP), osteoprotegerin (OPG), tartrate-resistant acid phosphatase, and receptor activator of nuclear factor-κB ligand (RANKL) in OVX rats were improved by RSM treatment. Furthermore, supplement of RSM to OVX rats resulted in an increase in femoral bone mineral density and bone strength as well as an improvement in bone microstructures...
October 11, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30287195/rosmarinus-officinalis-essential-oil-a-review-of-its-phytochemistry-anti-inflammatory-activity-and-mechanisms-of-action-involved
#4
REVIEW
Raphaelle Sousa Borges, Brenda Lorena Sánchez Ortiz, Arlindo César Matias Pereira, Hady Keita, José Carlos Tavares Carvalho
ETHNOPHARMACOLOGICAL RELEVANCE: Plant species Rosmarinus officinalis L. (Lamiaceae; Synonyms: Salvia rosmarinus Schleid. and Rosmarinus angustifolius Mill.) is a herb widely used worldwide. In local and traditional medicine, its used for inflammation-related diseases. Currently, studies report anti-inflammatory activity in its essential oil (EORO). However, to better understand EORO's anti-inflammatory activity its necessary to understand its phytochemistry and the signaling pathways affected by it...
October 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30268748/flow-behavior-viscoelastic-textural-and-foaming-characterization-of-whipped-cream-influence-of-lallemantia-royleana-seed-salvia-macrosiphon-seed-and-carrageenan-gums
#5
Reza Farahmandfar, Maryam Asnaashari, Afsaneh Taheri, Tandis Khosravi Rad
The effects of sage (Salvia macrosiphon) seed gum (SSG), balangu (Lallemantia royleana) seed gum (BSG) and carrageenan gum were examined on the foaming qualities (foam stability, foam capacity and overrun), viscoelastic properties (frequency sweep test and extrusion test) and flow properties of thickened cream as a function of gum concentration. The flow behavior of the cream samples was fitted to the Herschel-Bulkley model (R2  > 0.95). All samples demonstrated a gel structure with higher G' (storage modulus) values than the G″ (loss modulus) values...
September 26, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30258193/hgk-sestrin-2-signaling-mediated-autophagy-contributes-to-antitumor-efficacy-of-tanshinone-iia-in-human-osteosarcoma-cells
#6
Jia-Hau Yen, Sheng-Teng Huang, Hung-Sen Huang, Yi-Chin Fong, Yi-Ying Wu, Jen-Huai Chiang, Yuan-Chih Su
Tanshinone IIA (TIIA) is a diterpenoid naphthoquinone isolated from the herb Salvia miltiorrhiza with antitumor effects manifested at multiple levels that are mechanistically obscure. In our previous studies, we illustrated that TIIA treatment triggered apoptosis in human osteosarcoma 143B cells both in vitro and in vivo, accompanied with mitochondrial dysfunction. Importantly, the overall survival rate of patients with osteosarcoma who were randomly recruited to S. miltiorrhiza treatment was significantly higher than those without...
September 26, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/30257337/salvianolic-acid-b-renders-glioma-cells-more-sensitive-to-radiation-via-fis-1-mediated-mitochondrial-dysfunction
#7
Wei Chen, Ning Wang, Rui-Chun Li, Gao-Feng Xu, Gang Bao, Hai-Tao Jiang, Mao-De Wang
Glioma remains the leading cause of brain tumor-related death worldwide, and radiation is a standard adjuvant therapy with proven efficacy. Salvianolic acid B (SalB), a bioactive compound isolated from Radix Salviae, has been shown to exert anti-cancer effects in many cancer cell lines, including glioma. This study aimed to investigate whether SalB could affect response to radiation in human glioma cells. We found that SalB decreased cell viability of U87 cells in a-dose-dependent manner. A subthreshold dose of SalB at 0...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30255492/anti-apoptotic-effects-and-mechanisms-of-salvianolic-acid-a-on-cardiomyocytes-in-ischemia-reperfusion-injury
#8
REVIEW
Wei Qian, Zilong Wang, Tongda Xu, Dongye Li
Prompt myocardial reperfusion during acute myocardial infarction by fibrinolytic therapy, percutaneous coronary intervention, or coronary artery bypass grafting limits the affected area and improves prognosis. However, reperfusion itself can cause cardiomyocyte damage and decrease treatment efficacy. No treatments that effectively prevent myocardial ischemia/reperfusion (I/R) injury are currently available, and are therefore the focus of ongoing research. Salvianolic acid A (SAA), the active ingredient of the traditional Chinese herbal remedy Salvia miltiorrhiza, has anti-thrombotic activity, anti-inflammatory, and anti-cancer activity; regulates blood lipids and provides hepatic and neural protection...
September 26, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/30233688/therapeutic-effects-of-salvia-miltiorrhiza-injection-combined-with-telmisartan-in-patients-with-diabetic-nephropathy-by-influencing-collagen-iv-and-fibronectin-a-case-control-study
#9
Jie-Ming Nie, Hai-Feng Li
Involvement of collagen IV (ColIV) and fibronectin (FN) in the occurrence and development of diabetic nephropathy (DN) and the effects of telmisartan and Salvia miltiorrhiza injection in the treatment of the patients were investigated. Two hundred and fifty-eight patients with stage IV DN were selected as the case group, and another 110 normal healthy subjects were incorporated as the control group. Involved patients were subdivided into different groups according to different treatment therapies; patients in the telmisartan group (T group) were given oral telmisartan; patients in the Salvia miltiorrhiza injection + telmisartan (S + T group) were administered with Salvia miltiorrhiza injection combined with telmisartan treatment, and there was a group of patients who received no intervention as the placebo group...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30230238/design-of-multi-drug-combinations-for-poly-pharmacological-effects-using-composition-activity-relationship-modeling-and-multi-objective-optimization-approach-application-in-traditional-chinese-medicine
#10
Bo Fan, Yunfei Li, Bi Yong, Ling Tong, Dongxiang Li, Yi Wang
In recent years, multi-component therapies are increasingly utilized to treat complex diseases such as cancer, diabetes, and other chronic complex diseases. Here, we proposed the protocol for rational design of drug combination with poly-pharmacological effects by integration of design of experiments (DOE), computational modeling and multiple-objective optimization algorithm. Here we introduce a common workflow for modeling quantitative relationship of chemical composition and multiple activities of drug combinations...
September 19, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/30228801/the-effect-of-short-toothed-and-dalmatian-sage-extracts-on-platelet-aggregation
#11
Andrea Antolić, Željan Maleš, Maja Tomičić, Mirza Bojić
Sage ( Salvia sp.) is a genus of a native Mediterranean plant used for aromatization of foods. In this study, total polyphenolic profile, antioxidant properties and antiplatelet effect of short-toothed sage ( Salvia brachyodon Vandas) are analyzed and compared to most commonly used Salvia species ( S. officinalis , Dalmatian sage). Content of total flavonoids was 0.08-0.23% and of phenolic acids 0.47-3.04%. Antioxidant DPPH assay showed higher antioxidant capacity of S. brachyodon (29-36 mg/mL of gallic acid equivalents) than of S...
June 2018: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/30226574/cardioprotective-effects-and-underlying-mechanism-of-radix-salvia-miltiorrhiza-and-lignum-dalbergia-odorifera-in-a-pig-chronic-myocardial-ischemia-model
#12
Rui Lin, Jialin Duan, Fei Mu, Haixu Bian, Meina Zhao, Min Zhou, Yao Li, Aidong Wen, Yong Yang, Miaomiao Xi
Traditional Chinese medicines, including Radix Salvia miltiorrhiza (SM) and Lignum Dalbergia odorifera (DO) extracts, have historically been used to treat myocardial ischemia and other cardiovascular diseases. The volatile oil of DO (DOO) is one of the main components of DO. The aim of the present study was to assess the cardioprotective effects and possible underlying mechanisms of SM‑DOO in pigs with ameroid constriction‑induced chronic myocardial ischemia. An ameroid constrictor was placed around the left anterior descending coronary artery of pigs to induce chronic myocardial ischemia...
November 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30226540/tanshinone-iia-can-inhibit-miapaca%C3%A2-2-human-pancreatic-cancer-cells-by-dual-blockade-of-the-ras-raf-mek-erk-and-pi3k-akt-mtor-pathways
#13
Chin-Cheng Su
Tanshinone IIA (Tan‑IIA; C19H18O3) is derived from Danshen (the roots of Salvia miltiorrhiza), and has been reported to possess anti‑inflammatory and antioxidant activities. Tan‑IIA can inhibit BxPC‑3 human pancreatic cancer cells in vitro through inducing endoplasmic reticulum stress and apoptosis via mitochondrial pathways. However, the efficacy and molecular mechanisms of Tan‑IIA in human pancreatic cancer have not yet been elucidated. The transmembrane tyrosine kinases, including insulin‑like growth factor 1 receptor (IGF1R), vascular endothelial growth factor receptor (VEGFR) or epidermal growth factor receptor (EGFR) have been implicated in the survival and metastasis of cancer...
November 2018: Oncology Reports
https://www.readbyqxmd.com/read/30223150/bioactive-seco-abietane-rearranged-diterpenoids-from-the-aerial-parts-of-salvia-prionitis
#14
Lingnan Li, Miaomiao Zhou, Guimin Xue, Wenli Wang, Xuwei Zhou, Xiaobing Wang, Lingyi Kong, Jianguang Luo
Five previously undescribed 4,5-seco-abietane rearrange diterpenoids (1-5, Prionidipene A-E) were isolated from the aerial parts of Salvia prionitis, along with thirteen known seco-abietane diterpenoids (6-18). The structures of 1-5 were elucidated mainly based on analysis of NMR and MS data. The absolute configurations of 1-3 were determined by evaluation of experimental and calculated electronic circular dichroism (ECD) spectra. Putative biosynthetic pathways toward the formation of 1 and 2 are proposed. The nitric oxide (NO) production inhibitory effects of all isolates in lipopolysaccharide (LPS)-induced in RAW 264...
September 6, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/30217265/metabolic-profiling-of-hypoxia-reoxygenation-injury-in-h9c2-cells-reveals-the-accumulation-of-phytosphingosine-and-the-vital-role-of-dan-shen-in-xin-ke-shu
#15
Lili Sun, Hongmei Jia, Liyan Ma, Meng Yu, Yong Yang, Yang Liu, Hongwu Zhang, Zhongmei Zou
BACKGROUND: Xin-Ke-Shu (XKS), a patent medicine consisting of five commonly used traditional Chinese herbs, is used for the treatment of coronary heart diseases. A previous study showed that XKS has protective effects for ameliorating myocardial ischemia/reperfusion (I/R) injury. PURPOSE: This study was aimed to deeply understand the mechanisms and compatible principle of XKS against hypoxia/reoxygenation (H/R) injury and the contribution of each single herb to the efficacy of XKS...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217003/cryptotanshinone-induces-cell-cycle-arrest-and-apoptosis-of-nsclc-cells-through-the-pi3k-akt-gsk-3%C3%AE-pathway
#16
Sang-A Kim, Ok-Hwa Kang, Dong-Yeul Kwon
Cryptotanshinone (CTT) is a natural product and a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miltiorrhizabunge . Notably, CTT has a variety of anti-cancer actions, including the activation of apoptosis, anti-proliferation, and reduction in angiogenesis. We further investigated the anti-cancer effects of CTT using MTS, LDH, and Annexin V assay, DAPI staining, cell cycle arrest, and Western blot analysis in NSCLC cell lines. NSCLC cells treated with CTT reduced cell growth through PI3K/Akt/GSK3β pathway inhibition, G0/G1 cell cycle arrest, and the activation of apoptosis...
September 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30214513/tanshinone-iia-inhibits-cell-proliferation-and-tumor-growth-by-downregulating-stat3-in-human-gastric-cancer
#17
Yongjun Zhang, Shuguang Guo, Jian Fang, Bojian Peng, Yuan Zhang, Tiansheng Cao
Gastric cancer is the third leading cause of cancer-associated deaths worldwide. Research into the underlying mechanisms of gastric cancer is essential for the development of novel therapeutic agents to improve the prognoses of patients with gastric cancer. Tanshinone IIA (Tan IIA) is the pure extract of Danshen root ( Salvia miltiorrhiza ) and has been report to inhibit the proliferation of gastric cancer cells; however, the intrinsic underlying mechanisms remain unclear. The aim of the present study was to investigate whether Tan IIA has a direct anti-cancer effect in gastric cancer cells and determine the underlying mechanisms responsible...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30213025/tanshinone-iia-attenuates-insulin-like-growth-factor-1-induced-cell-proliferation-in-pc12-cells-through-the-pi3k-akt-and-mek-erk-pathways
#18
Haitao Wang, Xiaoying Su, Jiankang Fang, Xingan Xin, Xia Zhao, Uma Gaur, Qiang Wen, Jiangping Xu, Peter J Little, Wenhua Zheng
The insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) facilitate tumor proliferation and progression. Tanshinone IIA (TSN) is an active diterpene quinone isolated from the roots of the herbal plant Salvia miltiorrhiza . TSN inhibits the proliferation of various types of cancer cells but its role in the IGF-1R-induced proliferation of pheochromocytoma (PC12) cells and the potential mechanisms are largely unknown. This study aims to investigate the anti-proliferative effect of TSN in PC12 cells and its role on IGF-1R signaling transduction...
September 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30210653/polypharmacological-profiles-underlying-the-antitumor-property-of-salvia-miltiorrhiza-root-danshen-interfering-with-nox-dependent-neutrophil-extracellular-traps
#19
Li Tao, Min Xu, Xiaojun Dai, Tengyang Ni, Dan Li, Feng Jin, Haibo Wang, Lide Tao, Bo Pan, James R Woodgett, Yayun Qian, Yanqing Liu
Danshen, the dried root of Salvia miltiorrhiza , one of the most investigated medicinal plants with well-defined phytochemical constituents, has shown prominent clinical outcomes for antioxidant, anti-inflammatory, and anticoagulant activities to attain vascular protection and additional benefits for cancer therapy. More recently, activation of neutrophil and excessive formation of neutrophil extracellular traps (NETs) have been observed in pathological conditions of metastatic cancers; thus, we hypothesized that suppression of NETs could account for an essential cellular event underlying Danshen-mediated reduction of the incidence of metastasis...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30158992/overcoming-p-glycoprotein-mediated-multidrug-resistance-in-colorectal-cancer-potential-reversal-agents-among-herbal-medicines
#20
REVIEW
Gayoung Lee, Jin-Yong Joung, Jung-Hyo Cho, Chang-Gue Son, Namhun Lee
Objectives: Multidrug resistance (MDR) is the major reason for the failure of chemotherapy in colorectal cancer (CRC), and the primary determinant of MDR in CRC patients is active drug efflux owing to overexpression of P-glycoprotein (P-gp) in cancer tissues. Despite research efforts to overcome P-gp-mediated drug efflux, the high toxicity of P-gp inhibitors has been a major obstacle for the clinical use of these agents. The aim of this study was to review the literature for potential P-gp reversal agents among traditional herbal medicines, which offer the advantages of safety and potential synergetic effects in CRC chemotherapy...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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