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https://www.readbyqxmd.com/read/30551549/potential-mechanisms-underlying-the-protective-effects-of-salvianic-acid-a-against-atherosclerosis-in-vivo-and-vitro
#1
Qiongtao Song, Yuanyuan Zhang, Xue Han, Ying Zhang, Xuan Zhang, Yonggang Gao, Jianping Zhang, Li Chu, Senming Zhao
Salvianic acid A (SAA) is an active water-soluble constituent derived from Salvia miltiorrhiza Bge that is used extensively in the treatment of angiocardiopathy in China. However, few reports have investigated the therapeutic effect and the underlying mechanisms of SAA on atherosclerosis (AS). This study examines the protective mechanisms of SAA on AS in vivo and in vitro. SAA treatment (3 and 10 mg/kg/d) prevented the progression of atherosclerotic lesions and decreased 58.2% and 72.8% of the lipid deposition in the aorta of high fat-diet-induced AS rat...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30551430/danshen-can-interact-with-intestinal-bacteria-from-normal-and-chronic-renal-failure-rats
#2
Hongdie Cai, Shulan Su, Yonghui Li, Zhenhua Zhu, Jianming Guo, Yue Zhu, Sheng Guo, Dawei Qian, Jinao Duan
Danshen (Salviae Miltiorrhizae Radix et Rhizoma, SMR) has been used as a traditional Chinese medicine in clinic for treatment of coronary heart diseases. Previous works have shown that the chronic renal failure (CRF) is closely related to changes of intestinal bacteria. The aim is to explore the interaction between active components of SMR and intestinal bacteria from normal and CRF rats. The changes of intestinal bacteria were evaluated among normal rats, CRF model rats and SMR-treated rats via 16S rRNA gene sequencing technology...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30544925/four-new-depsides-isolated-from-salvia-miltiorrhiza-and-their-significant-nerve-protective-activities
#3
Qinghao Jin, Xinyi Hu, Yanping Deng, Jinjun Hou, Min Lei, Hongjian Ji, Jing Zhou, Hua Qu, Wanying Wu, Dean Guo
By investigating of the roots of Salvia miltiorrhiza , which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides ( 1 ⁻ 4 ) that were previously undescribed, along with eight known ones ( 5 ⁻ 12 ). Their structure characteristics were assessed by HR-ESIMS, CD, NMR (¹H, 13 C, HSQC, HMBC) data analyses. These four newly isolated compounds ( 1 ⁻ 4 ), as well as the other eight compounds ( 5 ⁻ 12 ), show extraordinary protective effects on hydrogen peroxide-induced apoptosis in HS-SY5Y cells...
December 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30544912/heterologous-expression-of-salvia-miltiorrhiza-microrna408-enhances-tolerance-to-salt-stress-in-nicotiana-benthamiana
#4
Xiaorong Guo, Junfeng Niu, Xiaoyan Cao
MicroRNAs (miRNAs) are a class of endogenous small RNAs that regulate the expression of target genes post-transcriptionally; they are known to play major roles in development and responses to abiotic stress. MicroRNA408 (miR408) is a conserved small RNA in plants; it was reported that miR408 genes were involved in abiotic stress in Arabidopsis . However, miR408 in Salvia miltiorrhiza has been rarely investigated. In this study, we cloned Sm-MIR408 , the miR408 precursor sequence, and its promoter sequence from S...
December 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30542590/branched-bbb-shuttle-peptides-chemoselective-modification-of-proteins-to-enhance-blood-brain-barrier-transport
#5
Cristina Díaz-Perlas, Benjamí Oller-Salvia, Macarena Sánchez-Navarro, Meritxell Teixidó, Ernest Giralt
The blood-brain barrier (BBB) hampers the delivery of therapeutic proteins into the brain. BBB-shuttle peptides have been conjugated to therapeutic payloads to increase the permeability of these molecules. However, most BBB-shuttles have several limitations, such as a lack of resistance to proteases and low effectiveness in transporting large biomolecules. We have previously reported on the THRre peptide as a protease-resistant BBB-shuttle that is able to increase the transport of fluorophores and quantum dots in vivo ...
November 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/30541057/effect-of-salvia-miltiorrhiza-injection-in-patients-with-autologous-fat-grafting-to-the-breast-a-preliminary-comparative-study
#6
Danning Zheng, Maoqun Li, Jia Zhou, Jian Wang, Weiwei Bian, Kotaro Yoshimura, Li Yu
Background: Salvia miltiorrhiza (SM) is a herb used in Chinese medicine formulations for promoting blood circulation and minimizing vascular stasis. It has been successfully utilized in treating cardiovascular diseases, such as atherosclerosis, thromboembolism, and angina. Objective: To study the effect of SM injections in autologous fat grafting to the breast. Methods: Fifteen women who elected to undergo breast augmentation with autologous fat grafting were included in this study...
December 12, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/30540782/mediterranean-herb-extracts-inhibit-microbial-growth-of-representative-oral-microorganisms-and-biofilm-formation-of-streptococcus-mutans
#7
Joachim Hickl, Aikaterini Argyropoulou, Maria Eleni Sakavitsi, Maria Halabalaki, Ali Al-Ahmad, Elmar Hellwig, Nektarios Aligiannis, Alexios Leandros Skaltsounis, Annette Wittmer, Kirstin Vach, Lamprini Karygianni
In light of the growing antibiotic resistance, the usage of plant-derived antimicrobial agents could serve as an effective alternative treatment against oral infections. The aim of this study was to investigate the antimicrobial and antibiofilm activity of Mediterranean herb extracts against representative oral microorganisms. The extraction procedures and the analysis of the obtained extracts were performed under established experimental conditions. The minimum inhibitory (MIC) and bactericidal (MBC) concentrations of the methanol extracts of Cistus creticus ssp...
2018: PloS One
https://www.readbyqxmd.com/read/30537633/anti-allergic-effects-of-salvianolic-acid-a-and-tanshinone-iia-from-salvia-miltiorrhiza-determined-using-in-vivo-and-in-vitro-experiments
#8
Jae-Yeong Heo, Dong-Soon Im
Salvia miltiorrhiza root has been used in Asian traditional medicine for the treatment of cardiovascular diseases, asthma, and other conditions. Salvianolic acid B from S. miltiorrhiza extracts has been shown to improve airway hyperresponsiveness. We investigated the effects of salvianolic acid A, tanshinone I, and tanshinone IIA from S. miltiorrhiza in allergic asthma by using rat RBL-2H3 mast cells and female Balb/c mice. Antigen-induced degranulation was assessed by measuring β-hexosaminidase activity in vitro...
December 8, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30535483/salvianolic-acid-b-an-antioxidant-derived-from-salvia-militarize-protects-mice-against-%C3%AE-%C3%A2-radiation%C3%A2-induced-damage-through-nrf2-bach1
#9
Ruifang Zhou, Haishan Long, Bei Zhang, Zhizhao Lao, Quanyu Zheng, Tiancheng Wang, Yongxin Zhang, Qingguang Wu, Xiaoping Lai, Geng Li, Lizhu Lin
Salvianolic acid B (SB) is an antioxidant derived from Salvia militarize, and is one of the most widely used herbs in traditional Chinese medicine. SB is a potent antioxidant that has been well documented as a scavenger of oxygen free radicals, and has been used for the prevention and treatment of atherosclerosis‑associated disorders. To explore its potential therapeutic effects in treating radiation damage, in this study, mice were treated with SB at different doses of 5, 12.5 and 20 mg/kg, subsequent to receiving γ‑irradiation...
December 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30532017/antithrombotic-effects-and-related-mechanisms-of-salvia-deserta-schang-root-etoac-extracts
#10
Rena Kasimu, Xinling Wang, Xiaomei Wang, Junping Hu, Xiaoqing Wang, Yuming Mu
Salvia deserta Schang (SDS) belongs to the same family as Salvia miltiorrhiza bunge, one of the antithrombotic Chinese herbal medicines. In our study, EtOAc root extracts were analyzed for their effects on adenosine diphosphate (ADP)-induced platelet aggregation in rabbits and FeCl3 -induced rat common carotid artery thrombosis as well as on rat blood plasma concentrations of thromboxane B2 (TXB2 ), 6-keto-prostaglandin F1 alpha (6-keto-PGF1α ), antithrombin-III (AT-III), protein C (PC), plasminogen (PLG), plasminogen activator inhibitor (PAI-1), von Willebrand factor (vWF) and tissue-type plasminogen activator (t-PA)...
December 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30530290/salvianolic-acid-b-attenuates-experimental-skin-fibrosis-of-systemic-sclerosis
#11
Qingmei Liu, Jiaying Lu, Jinran Lin, Yulong Tang, Weilin Pu, Xiangguang Shi, Shuai Jiang, Jing Liu, Yanyun Ma, Yuan Li, Jinhua Xu, Li Jin, Jiucun Wang, Wenyu Wu
Systemic sclerosis (SSc) is a connective tissue disease characterized mainly by fibrosis of skin and internal organs. Our previous study has shown that salvianolic acid B (SAB), a bioactive component extracted from Salvia miltiorrhiza (SM), was one of the essential ingredients in the traditional Chinese medicine Yiqihuoxue formula, which has been used to treat SSc-related dermal and pulmonary fibrosis. The aim of the present study was to evaluate the effect of SAB on skin fibrosis and explore its underlying anti-fibrotic mechanism...
December 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30513773/-salvia-elegans-salvia-greggii-and-salvia-officinalis-decoctions-antioxidant-activities-and-inhibition-of-carbohydrate-and-lipid-metabolic-enzymes
#12
Olívia R Pereira, Marcelo D Catarino, Andrea F Afonso, Artur M S Silva, Susana M Cardoso
Salvia elegans Vahl., Salvia greggii A. Gray, and Salvia officinalis L. decoctions were investigated for their health-benefit properties, in particular with respect to antioxidant activity and inhibitory ability towards key enzymes with impact in diabetes and obesity (α-glucosidase, α-amylase and pancreatic lipase). Additionally, the phenolic profiles of the three decoctions were determined and correlated with the beneficial properties. The S. elegans decoction was the most promising in regard to the antioxidant effects, namely in the scavenging capacity of the free radicals DPPH• , NO• and O₂•⁻ , and the ability to reduce Fe3+ , as well as the most effective inhibitor of α-glucosidase (EC50 = 36...
December 1, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30506914/cryptotanshinone-inhibits-rankl-induced-osteoclastogenesis-by-regulating-erk-and-nf-%C3%AE%C2%BAb-signaling-pathways
#13
Weizhuo Wang, Mengdi Huang, Yigeng Hui, Puwei Yuan, Xiong Guo, Kunzheng Wang
Osteoporosis (OS) is one of the most common healthy problems characterized by low bone mass. Osteoclast, the primary bone-resorbing cell, is responsible for destructive bone diseases including osteoporosis (OS). Cryptotanshinone (CTS), an active component extracted from the root of Salvia miltiorrhiza bunge, has been shown to prevent the destruction of cartilage and the thickening of subchondral bone in mice osteoarthritis models. However, its molecular mechanism in osteoclastogenesis needs to be determined...
December 2, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30505967/palliative-therapy-in-pancreatic-cancer-interventional-treatment-with-radiofrequency-ablation-irreversible-electroporation
#14
REVIEW
Salvatore Paiella, Matteo De Pastena, Mirko D'Onofrio, Stefano Francesco Crinò, Teresa Lucia Pan, Riccardo De Robertis, Giovanni Elio, Enrico Martone, Claudio Bassi, Roberto Salvia
Pancreatic cancer (PC) is a solid tumor with still a dismal prognosis. Diagnosis is usually late, when the disease is metastatic or locally advanced (LAPC). Only 20% of PC are amenable to surgery at the time of diagnosis and the vast majority of them, despite radically resected will unavoidably recur. The treatment of LAPC is a challenge. Current guidelines suggest to adopt systemic therapies upfront, based on multi-drugs chemotherapy regimens. However, the vast majority of patients will never experience conversion to surgical exploration and radical resection...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30505336/-salvia-hispanica-l-chia-seeds-oil-extracts-reduce-lipid-accumulation-and-produce-stress-resistance-in-caenorhabditis-elegans
#15
Cristiane Freitas Rodrigues, Willian Salgueiro, Matheus Bianchini, Juliana Cristina Veit, Robson Luiz Puntel, Tatiana Emanuelli, Cristiane Casagrande Dernadin, Daiana Silva Ávila
Background: Salvia hispanica seeds have been commonly used by people that seek healthy habits through natural foods to reduce cholesterol and triacylglycerides levels, however, the evidences that support this assumption are still scarce in literature. Here, we aimed to evaluate the lipid lowering effects of chia by using Caenorhabditis elegans as animal model, a nematode that has proven its usefulness for lipid metabolism studies. Methods: We prepared hexane (HE) and Bligh-Dyer (BDE) extracts, evaluated and compared their safety, antioxidant potential and their lipid-lowering activity in the worms...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/30503790/the-attenuation-of-hiv-1-tat-induced-neurotoxicity-by-salvianic-acid-a-and-danshen-granule
#16
Dengke Bao, Jingkai Wang, Junqi Liu, Hongliang Liu
The neurotoxicity of HIV-1 Tat protein contributes significantly to the pathogenesis of HAND, and hence the attractive therapeutic strategies focusing on Tat-induced neurotoxicity are warranted. Salvia miltiorrhiza have been known to antioxidant property and neuroprotective effects. The Danshen granule is the pharmaceutical dosage forms of Salvia miltiorrhiza and Salvianic acid A is an essential chemical constituent of Salvia miltiorrhiza. However, the protective effects of Salvianic acid A and Danshen granule on Tat-induced neurotoxicity remain unknown...
November 29, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30502766/sodium-tanshinone-iia-sulfonate-attenuates-cardiac-dysfunction-and-improves-survival-of-rats-with-cecal-ligation-and-puncture-induced-sepsis
#17
Zheng-Jie Meng, Chao Wang, Ling-Tong Meng, Bei-Hua Bao, Jin-Hui Wu, Yi-Qiao Hu
Cardiac dysfunction, a common consequence of sepsis, is the major contribution to morbidity and mortality in patients. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of Tanshinone IIA (TA), a main active component of Salvia miltiorrhiza Bunge, which has been widely used in China for the treatment of cardiovascular and cerebral system diseases. In the present study, the effect of STS on sepsis-induced cardiac dysfunction was investigated and its effect on survival rate of rats with sepsis was also evaluated...
November 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30500200/amarisolide-f-an-acylated-diterpenoid-glucoside-and-related-terpenoids-from-salvia-amarissima
#18
Mabel Fragoso-Serrano, Naytzé Ortiz-Pastrana, Norma Luna-Cruz, Rubén A Toscano, Angel G Alpuche-Solís, Alfredo Ortega, Elihú Bautista
Nine terpenoids were isolated from the leaves and flowers of Salvia amarissima, including a new acylated diterpenoid glucoside, amarisolide F (1), a new neo-clerodane diterpenoid, amarissinin D (2), which was isolated as an acetyl derivative (2a), and four known diterpenoids. The structure of amarisolide F (1) was elucidated by NMR and MS data analyses, as well as its methanolysis products 7 and 8, which also constituted new diterpenoids, named amarissinin E and 8- epi-amarissinin E, respectively. The absolute configuration of compound 7 was established by single-crystal X-ray diffraction...
November 30, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/30476177/systemic-insecticide-applications-effects-on-citrus-mealybug-hemiptera-pseudococcidae-populations-under-greenhouse-conditions
#19
Nathan J Herrick, Raymond A Cloyd, Amy L Raudenbush
The citrus mealybug, Planococcus citri (Risso) (Hemiptera: Pseudococcidae), is a major insect pest of greenhouse-grown horticultural crops. Applications of systemic insecticides as drenches to the growing medium are typically used by greenhouse producers to prevent or suppress citrus mealybug populations. A comprehensive study was conducted that included 11 experimental trials designed to assess the effects of growing medium applications of six systemic insecticides (azadirachtin, dinotefuran, flonicamid, imidacloprid, spirotetramat, and thiamethoxam) in preventing the establishment of and suppressing citrus mealybug populations on different plant species...
November 22, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/30466628/potentiation-of-the-anticancer-effect-of-doxorubicinin-drug-resistant-gastric-cancer-cells-by-tanshinone-iia
#20
Zhenyu Xu, Lu Chen, Zhangang Xiao, Yanhong Zhu, Hui Jiang, Yan Jin, Cheng Gu, Yilai Wu, Lin Wang, Wen Zhang, Jian Zuo, Dexi Zhou, Jiajie Luan, Jing Shen
BACKGROUND: Gastric cancer is the fifth commonest cancer and the third cause of cancer-related deaths all over the world. The effectiveness of chemotherapy is still limited by drug resistance in gastric cancer. Tanshinones, abietane diterpenes isolated from the traditional Chinese medicine Danshen (Salvia miltiorrhiza), have exhibited versatile anticancer activities in particular the ability to overcome drug resistance in different cancers. PURPOSE: The current study aimed to explore the capacity of tanshinone IIA, the most abundant tanshinone found in the plant Danshen, to overcome drug resistance of gastric cancer cells to a commonly used anticancer drug doxorubicin...
December 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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