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https://www.readbyqxmd.com/read/30102527/biotin-modified-plga-nanoparticles-with-improved-antiproliferative-activity-of-15-16-dihydrotanshinone-i-in-human-cervical-cancer-cells
#1
Jingjing Luo, Xiaofeng Meng, Jianyu Su, Hang Ma, Wen Wang, Liming Fang, Huade Zheng, Yexia Qin, Tianfeng Chen
15,16-dihydrotanshinone I (DI), a natural compound isolated from a traditional Asian functional food Salvia Miltiorrhiza Bunge, is known for its anticancer activity. However, the poor solubility of DI limits its desirable anticancer application. Herein, poly lactic-co-glycolic acid (PLGA) was functionalized with polyethylene glycol (PEG) and biotin to form co-polymers PEG-PLGA (PPA) and biotin-PEG-PLGA (BPA). DI was encapsulated in co-polymers PPA and BPA to obtain DI-PPA-NPs and DI-BPA-NPs, respectively. The particle size and its distribution, encapsulation efficiency, and in vitro releasing capacity of DI-BPA-NPs were characterized by biophysical methods...
August 13, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/30095430/effects-of-surface-sterilisation-with-green-synthesised-silver-nanoparticles-on-lamiaceae-seeds
#2
Pınar Nartop
Nanoparticles have been used in many areas of biotechnology. In this study, an alternative surface sterilisation method was established for plant tissue cultures. Silver nanoparticles synthesised via green synthesis were used for the surface sterilisation of Lamiaceae seeds ( Salvia farinecae, Ocimum basilicum - Large Leaf Italian, Thymus vulgaris, Ocimum basilicum var. purpurascens). Water extracts of dried Alkanna tinctorum rhizomes and Syzygium aromaticum flowers were utilised in the bioreduction of silver ions...
August 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30094960/cryptotanshinone-suppresses-cell-proliferation-and-glucose-metabolism-via-stat3-sirt3-signaling-pathway-in-ovarian-cancer-cells
#3
Yufei Yang, Yue Cao, Lihua Chen, Fei Liu, Zihao Qi, Xi Cheng, Ziliang Wang
Ovarian cancer is the most malignant gynecologic cancer among women worldwide. Cryptotanshinone (CT), isolated from Salvia miltiorrhiza Bunge, has been identified as a potential therapeutic agent in treating several malignant tumors, but the molecular mechanism of CT in ovarian cancer still remains illustrated. Here, we sought to elucidate the regulatory function of CT on cell glucose metabolism in ovarian cancer. The treatment of CT on ovarian cancer cells effectively inhibited glucose uptake and lactate production in ovarian cancer cells...
August 9, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30087294/volatile-terpenes-and-brain-function-investigation-of-the-cognitive-and-mood-effects-of-mentha-%C3%A3-piperita-l-essential-oil-with-in-vitro-properties-relevant-to-central-nervous-system-function
#4
David Kennedy, Edward Okello, Paul Chazot, Melanie-Jayne Howes, Samuel Ohiomokhare, Philippa Jackson, Crystal Haskell-Ramsay, Julie Khan, Joanne Forster, Emma Wightman
Extracts of several members of the monoterpene-rich Lamiaceae sub-family Nepetoideae, including those from the Salvia (sage), Melissa ( Lemon balm ) and Rosmarinus (rosemary) genera, evince cognitive and mood effects in humans that are potentially related to their effects on cholinergic and GABAergic neurotransmission. To date, despite promising in vitro properties, the cognitive and mood effects of the closely related Mentha spicata (spearmint) and Mentha piperita (peppermint) remain unexplored. This study therefore assessed the human cognitive/mood effects of the M...
August 7, 2018: Nutrients
https://www.readbyqxmd.com/read/30084970/separation-and-determination-of-selected-polyphenols-from-medicinal-plants
#5
Judyta Hejniak, Irena Baranowska, Sandra Stencel, Sylwia Bajkacz
A study of the simultaneous separation and determination of selected polyphenols (rutin, narirutin, naringin, hesperidin, neohesperidin, quercetin, naringenin, kaempferol and hesperetin) with reported effects in the treatment of depression and cardiac and neurodegenerative diseases was performed. An RP-ultrahigh-performance liquid chromatography (UHPLC)-ultraviolet method for analyte separation and determination was successfully developed and validated for a ZORBAX Eclipse Plus C18 RRHD analytical column. Separation was carried out in gradient elution mode with acetonitrile and water modified with 0...
July 31, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/30072891/salvianolic-acid-b-improves-mitochondrial-function-in-3t3-l1-adipocytes-through-a-pathway-involving-ppar%C3%AE-coactivator-1%C3%AE-pgc-1%C3%AE
#6
Yanyun Pan, Wenjing Zhao, Dandan Zhao, Chaoyang Wang, Na Yu, Tian An, Fangfang Mo, Jiaxian Liu, Jianan Miao, Bohan Lv, Yujie Gu, Sihua Gao, Guangjian Jiang
Purpose: Mitochondrial dysfunction in adipose tissue has emerged as key to the development of obesity and diabetes. Salvianolic acid B (SalB) is a water-soluble ingredient derived from Salvia miltiorrhiza that has been shown to possess potential anti-obese and anti-diabetic activities. However, the cellular mechanism of SalB on mitochondrial function with respect to these metabolic disorders has not been elucidated. Therefore, we aim to investigate the effects of SalB on mitochondrial function in 3T3-L1 adipocytes and analyze the underlying molecular mechanism...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30061833/salvia-miltiorrhiza-ameliorates-liver-fibrosis-by-activating-hepatic-natural-killer-cells-in-vivo-and-in-vitro
#7
Yuan Peng, Tao Yang, Kai Huang, Li Shen, Yanyan Tao, Chenghai Liu
Natural killer (NK) cells are known for their ability to kill activated hepatic stellate cells (HSCs), which has been confirmed both in patients and animal models. But the killing function is depressed in period of advanced liver injury. Salvia Miltiorrhiza (SM), a Chinese herbal medicine for invigorating blood circulation and eliminating stasis, is widely used to treat liver fibrosis in clinic. Nevertheless, the immunological mechanism remains unclearly. Here, we put forward the hypothesis that the anti-fibrotic effect of SM is concerned with boosting the activation of hepatic NK cells...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30056541/carbon-tetrachloride-induced-hepato-renal-toxicity-in-experimental-mice-antioxidant-potential-of-egyptian-salvia-officinalis-l-essential-oil
#8
Maha A Fahmy, Kawthar A Diab, Negm S Abdel-Samie, Enayat A Omara, Zeinab M Hassan
The present research designed to assess the protective role of Salvia officinalis essential oil (SO) against carbon tetrachloride (CCl4 )-induced liver and kidney damage in mice. This is evidenced by estimation of antiradical scavenging activity of SO using DPPH assay, biochemical markers, histological investigation of liver and kidney sections, and comet assay. Mice were given CCl4 (1.2 mL/kg for 24 h or 0.8 mL/kg for 2 weeks, 3 times/week) and with or without SO (0.1, 0.2, and 0.4 mL/kg, for 2 week, 5 times/week)...
July 28, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30050659/therapeutic-potential-of-salviae-miltiorrhizae-radix-et-rhizoma-against-human-diseases-based-on-activation-of-nrf2-mediated-antioxidant-defense-system-bioactive-constituents-and-mechanism-of-action
#9
REVIEW
Guo-Hui Li, Yan-Ru Li, Ping Jiao, Yu Zhao, Hui-Xin Hu, Hong-Xiang Lou, Tao Shen
Oxidative stress plays a central role in the pathogenesis of many human diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating the intracellular antioxidant response and is an emerging target for the prevention and therapy of oxidative stress-related diseases. Salviae Miltiorrhizae Radix et Rhizoma (SMRR) is a traditional Chinese medicine (TCM) and is commonly used for the therapy of cardiac cerebral diseases. Cumulative evidences indicated that the extract of SMRR and its constituents, represented by lipophilic diterpenoid quinones and hydrophilic phenolic acids, were capable of activating Nrf2 and inhibiting oxidative stress...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30050654/tanshinone-iia-pretreatment-protects-h9c2-cells-against-anoxia-reoxygenation-injury-involvement-of-the-translocation-of-bcl-2-to-mitochondria-mediated-by-14-3-3-%C3%AE
#10
Zeyu Zhang, Huan He, Yang Qiao, Jiyi Huang, Zelong Wu, Ping Xu, Dong Yin, Ming He
Tanshinone IIA is an important component that is isolated from danshen ( Salvia miltiorrhiza ), which is known to be beneficial for cardiovascular health. In this study, we determined the effects of Tanshinone IIA and its underlying mechanisms of action in an anoxia/reoxygenation (A/R) cell line model. Prior to inducing A/R injury, rat cardiomyocyte-derived cell line H9c2 was stimulated with 8  μ M of Tanshinone IIA for 48 hours. When compared with the A/R group, the Tanshinone IIA treatment significantly increased cell viability and decreased lactate dehydrogenase activity...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30036889/cryptotanshinone-from-salvia-miltiorrhiza-roots-reduces-cytokeratin-ck1-10-expression-in-keratinocytes-by-activation-of-peptidyl-prolyl-cis-trans-isomerase-fkbp1a
#11
Stefan Esch, Simone König, Bertan Bopp, Joachim Jose, Simone Brandt, Andreas Hensel
Cryptotanshinone (CTS) (1 µM) from the roots of Salvia miltiorrhiza exerts a strong influence on the terminal differentiation of human keratinocytes (HaCaT cell line, primary natural human keratinocytes) and downregulates the expression of differentiation-specific cytokeratins CK1 and CK10 on protein and gene level. Other differentiation specific proteins as involucrin, filaggrin, loricrin, and transglutaminase were not affected to a higher extent. CTS (1 µM) did not influence the cell viability and the proliferation of keratinocytes...
July 23, 2018: Planta Medica
https://www.readbyqxmd.com/read/30030474/coactivation-of-mep-biosynthetic-genes-and-accumulation-of-abietane-diterpenes-in-salvia-sclarea-by-heterologous-expression-of-wrky-and-myc2-transcription-factors
#12
Mariaevelina Alfieri, Maria Carmela Vaccaro, Elisa Cappetta, Alfredo Ambrosone, Nunziatina De Tommasi, Antonietta Leone
Plant abietane diterpenoids (e.g. aethiopinone, 1- oxoaethiopinone, salvipisone and ferruginol), synthesized in the roots of several Salvia spp, have antibacterial, antifungal, sedative and anti-proliferative properties. Recently we have reported that content of these compounds in S. sclarea hairy roots is strongly depending on transcriptional regulation of genes belonging to the plastidial MEP-dependent terpenoid pathway, from which they mostly derive. To boost the synthesis of this interesting class of compounds, heterologous AtWRKY18, AtWRKY40, and AtMYC2 TFs were overexpressed in S...
July 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30029467/long-term-dietary-intake-of-chia-seed-is-associated-with-increased-bone-mineral-content-and-improved-hepatic-and-intestinal-morphology-in-sprague-dawley-rats
#13
Evelyn M Montes Chañi, Sandaly O S Pacheco, Gustavo A Martínez, Maykon R Freitas, Joaquin G Ivona, Javier A Ivona, Winston J Craig, Fabio J Pacheco
Chia seeds ( Salvia hispanica ) provide an unusually high content of α-linolenic acid with several potential health benefits, but few studies have examined the long-term intake of n -3 fatty acid-rich plant foods such as chia. In this work, we investigated some of the effects of a diet containing 10% chia seeds versus a conventional isocaloric diet for 10 and 13 months on body measurements, musculoskeletal system, the liver, and the intestines of 20 male Sprague-Dawley rats assigned into two groups. The n -6/ n -3 ratios for the control and chia diets were 7...
July 19, 2018: Nutrients
https://www.readbyqxmd.com/read/30021339/tanshinones-from-salvia-miltiorrhiza-bunge-revert-chemotherapy-induced-neuropathic-pain-and-reduce-glioblastoma-cells-malignancy
#14
Lorenzo Di Cesare Mannelli, Marialuisa Piccolo, Francesco Maione, Maria Grazia Ferraro, Carlo Irace, Vincenzo De Feo, Carla Ghelardini, Nicola Mascolo
Medicinal plants and herbal extracts from traditional Chinese medicine are used increasingly commonly worldwide for their benefits to health and quality of life as dietary supplements or as ingredients in functional foods. Among them, Salvia miltiorrhiza Bunge (a natural strong remedy for the treatment of a variety of conditions) is traditionally used for centuries in Asian countries as antioxidant, anticancer, and anti-inflammatory agent. In this context, several evidences support the hypothesis that some tanshinones (in particular tanshinone IIA and cryptotanshinone) extracted from the roots (Danshen) of Salvia miltiorrhiza exert neuroprotective and analgesic activities...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30018746/circular-rna-cpg-island-hypermethylation-associated-silencing-in-human-cancer
#15
Humberto J Ferreira, Veronica Davalos, Manuel Castro de Moura, Marta Soler, Montserrat Perez-Salvia, Alberto Bueno-Costa, Fernando Setien, Sebastian Moran, Alberto Villanueva, Manel Esteller
Noncoding RNAs (ncRNAs), such as microRNAs and long noncoding RNAs (lncRNAs), participate in cellular transformation. Work done in the last decade has also demonstrated that ncRNAs with growth-inhibitory functions can undergo promoter CpG island hypermethylation-associated silencing in tumorigenesis. Herein, we wondered whether circular RNAs (circRNAs), a type of RNA transcripts lacking 5'-3' ends and forming closed loops that are gaining relevance in cancer biology, are also a target of epigenetic inactivation in tumors...
June 26, 2018: Oncotarget
https://www.readbyqxmd.com/read/30015919/tanshinone-iia-attenuates-paraquat%C3%A2-induced-acute-lung-injury-by-modulating-angiotensin%C3%A2-converting-enzyme-2-angiotensin%C3%A2-1%C3%A2-7-in-rats
#16
Yanxia Wang, Huajie Wu, Wen Niu, Jian Chen, Manlin Liu, Xin Sun, Zhichao Li
Tanshinone IIA (TIIA) is an active compound that can be isolated from the Chinese herb, Salvia miltiorrhizae Bunge, also known as danshen. Previous studies have demonstrated that TIIA can effectively attenuate bleomycin‑induced pulmonary fibrosis in rats. However, it has not been determined whether TIIA can attenuate paraquat (PQ)‑induced acute lung injury (ALI). In the present study, the protective effects exhibited by TIIA on PQ‑induced ALI, as well as its underlying mechanisms, were investigated using Sprague‑Dawley (SD) rats...
September 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30012386/herbal-medicine-for-hemorrhage-related-hydrocephalus-a-systematic-review-of-randomised-controlled-trials
#17
REVIEW
Bongki Park, Seung Cheol Hong, Song Won Park, Chan-Sol Yi, You-Kyung Ha, Dong-Jun Choi
BACKGROUND & OBJECTIVE: Hemorrhage related hydrocephalus is a common complication intraventricular hemorrhage, subarachnoid hemorrhage, intracranial hemorrhage and traumatic brain injury. It increases morbidity and disability. The aim of this review is to assess the efficacy of herbal medicine for hemorrhage related hydrocephalus. METHODS: We searched randomized controlled trials (RCTs) investigating herbal medicine through 13 electronic databases. Extracting and assessing the data were performed independently by two authors...
August 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/30006095/o-067-effect-of-heavy-and-light-smartphone-use-on-whole-spine-curvature-profile-and-cervical-mobility-in-young-adults
#18
P Salvia, R Cohen, O D'Halluin, S Van Sint Jan, V Feipel, B Beyer
No abstract text is available yet for this article.
June 22, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30003065/anti-proliferative-effect-of-15-16-dihydrotanshinone-i-through-cell-cycle-arrest-and-the-regulation-of-amp-activated-protein-kinase-akt-mtor-and-mitogen-activated-protein-kinase-signaling-pathway-in-human-hepatocellular-carcinoma-cells
#19
Ji-Young Hong, So Hyun Park, Hyen Joo Park, Sang Kook Lee
Background: 15,16-dihydrotanshinone I (DHTS) is a natural abietane diterpenoid that is mainly found in the roots of Salvia miltiorrhiza Bunge (Labiatae). DHTS exhibits a potential anti-proliferative effect in various human cancer cells. However, the mechanisms of action of DHTS as an anti-cancer agent have not been fully elucidated. Therefore, the present study investigated the anti-cancer effect of DHTS in terms of cell cycle regulation and the regulation of the AMP-activated protein kinase (AMPK)/Akt/mTOR signaling pathway in SK-HEP-1 human hepatocellular carcinoma cells...
June 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/30001730/tanshinone-iia-promotes-the-differentiation-of-bone-marrow-mesenchymal-stem-cells-into-neuronal-like-cells-in-a-spinal-cord-injury-model
#20
Xue-Mei Zhang, Jiao Ma, Yang Sun, Bing-Qian Yu, Zhuo-Min Jiao, Duo Wang, Mei-Yu Yu, Jin-Yue Li, Jin Fu
BACKGROUND: Spinal cord injury (SCI) is one of the most severe central nervous system injuries. Currently, transplanting bone marrow mesenchymal stem cells (BMSCs) is considered a therapeutic option for SCI. Tanshinone IIA (TIIA) is one of the extracts obtained from Salvia miltiorrhiza Bunge, which has been shown to have some protective effects against SCI. The present research was aimed to explore whether TIIA would influence the fate of transplanted BMSCs in a rat model of SCI, especially with regard to their differentiation into neuronal cells...
July 13, 2018: Journal of Translational Medicine
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