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Aging Meta-analysis

Ryan Sun, Zhaoxi Wang, Birgit Claus Henn, Li Su, Quan Lu, Xihong Lin, Robert O Wright, David C Bellinger, Molly Kile, Maitreyi Mazumdar, Martha Maria Tellez-Rojo, Lourdes Schnaas, David C Christiani
It is believed that genetic factors play a large role in the development of many cognitive and neurological processes; however, epidemiological evidence for the genetic basis of childhood neurodevelopment is very limited. Identification of the genetic polymorphisms associated with early-stage neurodevelopment will help elucidate biological mechanisms involved in neuro-behavior and provide a better understanding of the developing brain. To search for such variants, we performed a genome-wide association study (GWAS) for infant mental and motor ability at two years of age with mothers and children recruited from cohorts in Bangladesh and Mexico...
August 17, 2018: Molecular Psychiatry
Rustam Al-Shahi Salman, Joseph Frantzias, Robert J Lee, Patrick D Lyden, Thomas W K Battey, Alison M Ayres, Joshua N Goldstein, Stephan A Mayer, Thorsten Steiner, Xia Wang, Hisatomi Arima, Hitoshi Hasegawa, Makoto Oishi, Daniel A Godoy, Luca Masotti, Dar Dowlatshahi, David Rodriguez-Luna, Carlos A Molina, Dong-Kyu Jang, Antonio Davalos, José Castillo, Xiaoying Yao, Jan Claassen, Bastian Volbers, Seiji Kazui, Yasushi Okada, Shigeru Fujimoto, Kazunori Toyoda, Qi Li, Jane Khoury, Pilar Delgado, José Álvarez Sabín, Mar Hernández-Guillamon, Luis Prats-Sánchez, Chunyan Cai, Mahesh P Kate, Rebecca McCourt, Chitra Venkatasubramanian, Michael N Diringer, Yukio Ikeda, Hans Worthmann, Wendy C Ziai, Christopher D d'Esterre, Richard I Aviv, Peter Raab, Yasuo Murai, Allyson R Zazulia, Kenneth S Butcher, Seyed Mohammad Seyedsaadat, James C Grotta, Joan Martí-Fàbregas, Joan Montaner, Joseph Broderick, Haruko Yamamoto, Dimitre Staykov, E Sander Connolly, Magdy Selim, Rogelio Leira, Byung Hoo Moon, Andrew M Demchuk, Mario Di Napoli, Yukihiko Fujii, Craig S Anderson, Jonathan Rosand
BACKGROUND: Intracerebral haemorrhage growth is associated with poor clinical outcome and is a therapeutic target for improving outcome. We aimed to determine the absolute risk and predictors of intracerebral haemorrhage growth, develop and validate prediction models, and evaluate the added value of CT angiography. METHODS: In a systematic review of OVID MEDLINE-with additional hand-searching of relevant studies' bibliographies- from Jan 1, 1970, to Dec 31, 2015, we identified observational cohorts and randomised trials with repeat scanning protocols that included at least ten patients with acute intracerebral haemorrhage...
August 14, 2018: Lancet Neurology
Christopher A Pickett, Todd C Villines, Jon R Resar, Edward A Hulten
BACKGROUND: Up to half the patients with cryptogenic stroke under the age of 55 years have been found to have a PFO. Observational studies have demonstrated a benefit from closure of PFO and several RCTs have shown a trend toward benefit. The cost and clinical effectiveness of PFO closure is unclear. METHODS AND RESULTS: We searched for RCTs of PFO closure in patients with cryptogenic stroke and performed a detailed cost analysis and meta-analysis of treatment outcomes based on the results of the meta-analysis...
July 21, 2018: International Journal of Cardiology
Tracy L Leong, Paula M Loveland, Alexandra Gorelik, Louis Irving, Daniel P Steinfort
BACKGROUND: Performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for staging the radiologically normal mediastinum has been reported with inconsistent findings. We assessed the sensitivity of systematic staging using EBUS-TBNA for detection of radiologically occult mediastinal metastases in cN0/N1 lung cancer. METHODS: Studies evaluating EBUS-TBNA for systematic mediastinal staging in cN0/N1 lung cancer were identified by systematic review...
August 16, 2018: Journal of Bronchology & Interventional Pulmonology
Brianna Adamson, Nicole Letourneau, Catherine Lebel
BACKGROUND: Maternal anxiety disorders are common during pregnancy and postpartum, and are associated with increased behaviour problems and risk of mental health difficulties in children. Understanding alterations in brain structure and function associated with maternal anxiety may help elucidate potential mechanisms via which high maternal anxiety could affect children. METHODS: We conducted a systematic review of extant research studying the associations between prenatal anxiety and children's brain structure and function, as assessed through neuroimaging...
August 8, 2018: Journal of Affective Disorders
Rachel M Walker, Brigid M Gillespie, Lukman Thalib, Niall S Higgins, Jennifer A Whitty
BACKGROUND: Pressure injuries are localised areas of injury to the skin and/or underlying tissues. OBJECTIVES: To assess foam dressings compared to other dressings in healing pressure injuries. DESIGN: Systematic review and meta-analysis DATA SOURCES: The review team searched: the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials; Ovid MEDLINE; Ovid Embase; EBSCO CINAHL Plus and the NHS Economic Evaluation Database...
July 24, 2018: International Journal of Nursing Studies
Andreas Roth, Johannes Beckmann, Klaus Bohndorf, Christian Heiß, Marcus Jäger, Stefan Landgraeber, Uwe Maus, Ulrich Nöth, Klaus M Peters, Christof Rader, Stephan Reppenhagen, Ulrich Smolenski, Ina Kopp, Markus Tingart
The update of the German S3 guideline on atraumatic femoral head necrosis in adults aims to provide an overview of diagnosis and treatment. All clinical studies, systematic reviews, and meta-analyses published in German or English between 01.05.2013 and 30.04.2017 were included. Of 427 studies, 28 were suitable for analysis. Risk factors are corticosteroids, chemotherapy, kidney transplants, hemoglobinopathies, and alcoholism. Differential diagnoses are for example bone marrow edema, insufficiency fracture, and destructive arthropathy...
August 16, 2018: Der Orthopäde
Andrea J Braakhuis, Rohith Nagulan, Vaughan Somerville
Mitochondria are metabolically active organelles that produce significant reactive oxygen species, linked with aging and degenerative diseases. In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alleviate the accumulation of oxidative damage and associated aging. MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process...
2018: Oxidative Medicine and Cellular Longevity
Qingquan Wei, Junling Liu, Qingyu Liu, Chengda Ren, Wenting Cai, Xiuwei Liang, Jing Wen, Jing Yu
The purpose of this meta-analysis was to compare the efficacy and safety of the combination of bevacizumab and photodynamic therapy (PDT) with bevacizumab monotherapy for the treatment of age-related macular degeneration (AMD). Patients with active choroidal neovascularization (CNV) secondary to AMD were included in the present study. The treatment group included patients treated with a combination of bevacizumab and PDT and patients treated with bevacizumab monotherapy. Only randomized controlled trials (RCTs) were included in the analysis...
August 2018: Experimental and Therapeutic Medicine
Sonja Orlovska-Waast, Ole Köhler-Forsberg, Sophie Wiben Brix, Merete Nordentoft, Daniel Kondziella, Jesper Krogh, Michael Eriksen Benros
Infections and inflammatory processes have been associated with the development of schizophrenia and affective disorders; however, no study has yet systematically reviewed all available studies on cerebrospinal fluid (CSF) immune alterations. We aimed to systematically review the CSF immunological findings in schizophrenia spectrum and affective disorders. We identified all studies investigating CSF inflammatory markers in persons with schizophrenia or affective disorders published prior to March 23, 2017 searching PubMed, CENTRAL, EMBASE, Psychinfo, and LILACS...
August 16, 2018: Molecular Psychiatry
Qi Zhao, Micheline S Z S Coelho, Shanshan Li, Paulo H N Saldiva, Kejia Hu, Michael J Abramson, Rachel R Huxley, Yuming Guo
BACKGROUND: Extreme temperature events are known to be adversely associated with a range of health outcomes, but little is known about the effect of less extreme, but more frequent fluctuation in temperature. We examined the spatiotemporal and demographic variation in the effect of temperature variability (TV) on nationwide hospitalizations in Brazil during 2000-2015. METHODS: Data on daily hospitalizations and weather variables were collected from 1814 cities, comprising 78...
August 13, 2018: Environment International
Daisy M Wopereis, Robert S Du Puy, Diana van Heemst, John P Walsh, Alexandra Bremner, Stephan J L Bakker, Douglas C Bauer, Anne R Cappola, Graziano Ceresini, Jean Degryse, Robin P F Dullaart, Martin Feller, Luigi Ferrucci, Carmen Floriani, Oscar H Franco, Massimo Iacoviello, Georgio Iervasi, Misa Imaizumi, J Wouter Jukema, Kay-Tee Khaw, Robert N Luben, Sabrina Molinaro, Matthias Nauck, Kushang V Patel, Robin P Peeters, Bruce M Psaty, Salman Razvi, Roger K Schindhelm, Natasja M van Schoor, David J Stott, Bert Vaes, Mark P J Vanderpump, Henry Völzke, Rudi G J Westendorp, Nicolas Rodondi, Christa M Cobbaert, Jacobijn Gussekloo, Wendy P J den Elzen
Context: Anemia and thyroid dysfunction often co-occur and both increase with age. Human data on the relationship between thyroid disease and anemia are scarce. Objective: To investigate the cross-sectional and longitudinal associations between clinical thyroid status and anemia. Design: Individual participant data meta-analysis. Setting: Sixteen cohorts participating in the Thyroid Studies Collaboration (n=42 162). Main outcome measures: Primary outcome measure was anemia (hemoglobin <130 g/L in men and <120 g/L in women)...
August 2, 2018: Journal of Clinical Endocrinology and Metabolism
Rosa Silva, Sérgio Abrunheiro, Daniela Cardoso, Paulo Costa, Filipa Couto, Cátia Agrenha, João Apóstolo
OBJECTIVE: The objective of the review was to synthesize the effectiveness of multisensory stimulation in managing neuropsychiatric symptoms (NPS) in older adults with major neurocognitive disorder (NCD). INTRODUCTION: Major neurocognitive disorder is characterized by changes in specific cognitive domains with a progressive deterioration in cognitive ability and capacity for independent living. Most older adults with this condition have one or more concomitant symptoms known as NPS...
August 2018: JBI Database of Systematic Reviews and Implementation Reports
Devon J Boyne, Alexis T Mickle, Darren R Brenner, Christine M Friedenreich, Winson Y Cheung, Karen L Tang, Todd A Wilson, Diane L Lorenzetti, Matthew T James, Paul E Ronksley, Doreen M Rabi
Cardiovascular disease has been identified as one of the late complications of cancer therapy. The purpose of this study was to quantify the long-term risk of cardiovascular mortality among lymphoma survivors relative to that of the general population. A systematic review and meta-analysis were conducted. Articles were identified in November 2016 by searching EMBASE, MEDLINE, and CINAHL databases. Observational studies were included if they assessed cardiovascular mortality in patients with lymphoma who survived for at least 5 years from time of diagnosis or if they had a median follow-up of 10 years...
August 15, 2018: Cancer Medicine
Yan Wang, Zhiliang Guo, Dehong Fan, Haijiang Lu, Dong Xie, Dahai Zhang, Yongtian Jiang, Pei Li, Haijun Teng
Background: Traumatic cervical spinal cord injury (CSCI) is a common disease that has high complication, disability, and mortality rates and a poor prognosis. Tracheostomy is an important supportive therapy for patients with CSCI. However, a consensus on the predictive factors for tracheostomy after CSCI has not been reached. Objective: This meta-analysis study assessed the influencing factors for tracheostomy after CSCI. Methods: We searched for relevant studies on the influencing factors for tracheostomy after CSCI...
2018: BioMed Research International
Wondale Getinet, Tadele Amare, Berhanu Boru, Shegaye Shumet, Wubet Worku, Telake Azale
Introduction: Antenatal depression is a syndrome, in which women experience depressed mood, excessive anxiety, insomnia, and change in weight during the period of pregnancy. Maternal depression negatively influences child outcomes and maternal health. Antenatal depression was measured by different rating scales, namely, BDI, EPDS, and PHQ. The objective of this systematic review was to synthesize logical evidence about the prevalence and potential risk factors of antenatal depression in Ethiopia...
2018: Depression Research and Treatment
Sunil Badami, Sunil Upadhaya, Ravi Kanth Velagapudi, Pushyami Mikkilineni, Ranju Kunwor, Samer Al Hadidi, Ghassan Bachuwa
Background: We performed meta-analysis to gather more evidence regarding clinical-molecular subgroups associated with better overall survival (OS) in advanced melanoma treated with checkpoint inhibitors. Materials and Methods: We performed a systematic search of PubMed, Scopus, Cochrane Library, and clinical Randomized clinical trials that compared a checkpoint inhibitor (nivolumab or pembrolizumab) with investigator choice chemotherapy or ipilimumab were included in our study...
2018: Journal of Oncology
Duco Koenis, Lejla Medzikovic, Mariska Vos, Thijs J Beldman, Pieter B van Loenen, Claudia M van Tiel, Anouk Aj Hamers, Iker Otermin Rubio, Vivian de Waard, Carlie de Vries
Gene targeting via homologous recombination can occasionally result in incomplete disruption of the targeted gene. Here, we show that a widely-used Nur77-deficient transgenic mouse model expresses a truncated protein encoding for part of the amino-terminal domain of nuclear receptor Nur77. This truncated Nur77 protein is absent in a newly developed Nur77-deficient mouse strain generated using Cre-Lox recombination. Comparison of these two mouse strains using immunohistochemistry, flow cytometry and colony-forming assays shows that homologous recombination-derived Nur77-deficient mice - but not wild-type or Cre-Lox-derived Nur77-deficient mice - suffer from liver immune cell infiltrates, loss of splenic architecture, and increased numbers of bone marrow hematopoietic stem cells and splenic colony-forming cells with age...
August 15, 2018: Journal of Biological Chemistry
Mercè Pineda, Mark Walterfang, Marc C Patterson
OBJECTIVE: Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive, neurodegenerative disease associated with a wide variety of progressive neurological manifestations. Miglustat is indicated for the treatment of progressive neurological manifestations in both adults and children. Since approval in 2009 there has been a vast growth in clinical experience with miglustat. The effectiveness of miglustat has been assessed using a range of measures. METHODS: Comprehensive review of published data from studies of cellular neuropathological markers and structural neurological indices in the brain, clinical impairment/disability, specific clinical neurological manifestations, and patient survival...
August 15, 2018: Orphanet Journal of Rare Diseases
Getinet Ayano, Melat Solomon, Mebratu Abraha
BACKGROUND: Depression is the most prevalent psychiatric disorder among people living with HIV (PLWHIV) and is associated with poor quality of life, additional comorbidities, disability, unemployment, poorer therapeutic outcomes and risky behaviors. The present systematic review and meta-analysis aims to systematically summarize empirical evidence and to formulate recommendations for future research. METHODS: We searched PubMed, EMBASE, SCOPUS, and relevant literature for possible studies to include...
August 15, 2018: BMC Psychiatry
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