Sant Kumar, Katherine M Conners, Joseph J Shearer, Jungnam Joo, Sarah Turecamo, Maureen Sampson, Anna Wolska, Alan T Remaley, Margery A Connelly, James D Otvos, Nicholas B Larson, Suzette J Bielinski, Véronique L Roger
BACKGROUND: Frailty is common in heart failure (HF) and is associated with death but not routinely captured clinically. Frailty is linked with inflammation and malnutrition, which can be assessed by a novel plasma multimarker score: the metabolic vulnerability index (MVX). We sought to evaluate the associations between frailty and MVX and their prognostic impact. METHODS AND RESULTS: In an HF community cohort (2003-2012), we measured frailty as a proportion of deficits present out of 32 physical limitations and comorbidities, MVX by nuclear magnetic resonance spectroscopy, and collected extensive longitudinal clinical data...
March 27, 2024: Journal of the American Heart Association