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Bone scan osteoporosis

Michael R Goldberg, Liat Nachshon, Tali Sinai, Naama Epstein-Rigbi, Yael Oren, Eli Eisenberg, Yitzhak Katz, Arnon Elizur
BACKGROUND: Earlier studies noted that young adults with IgE-mediated cow's milk allergy (IgE-CMA) have significantly lower bone mineral density (BMD) than age- and gender-matched controls. We sought to identify additional risk factors contributing to the low BMD in IgE-CMA patients. METHODS: Post-pubertal (defined by Tanner stage V) IgE-CMA patients (n=78, 16-30-years-old females; 17.5-30-years-old males) were evaluated prospectively for BMD using a DXA scan, serum values of bone turnover factor, and dietary and lifestyle questionnaires...
August 11, 2018: Pediatric Allergy and Immunology
Muhammad Haroon, Kamil Khan, Lorraine Thong, Kabir Ali, Fayyaz Janjua
AIMS: (1) To calculate the absolute fracture risk by using the fracture risk assessment (FRAX) model among elderly medical inpatients; (2) to assess the risk of falls, especially among patients with increased risk of fractures; and (3) to design and implement a bone health protocol to improve the assessment of fracture risk. METHODS: The study participants were all inpatients admitted to the medical wards at University Hospital Kerry, Ireland. All consecutive eligible patients aged ≥ 65 years were prospectively evaluated to populate clinical risk factor variables used in the FRAX model and the fall assessment was made by using Fracture Risk Questionnaire...
August 11, 2018: Irish Journal of Medical Science
Dhurva Nandan Singh, Sriram Krishnamurthy, Sadish Kumar Kamalanathan, K T Harichandrakumar, Palanisamy Sivamurukan
BACKGROUND: Nephrotic syndrome (NS) in children is one of the most common chronic diseases with a remitting and relapsing course. Glucocorticoids (prednisolone) are considered to be the treatment of choice but are associated with osteoporosis. There are no uniform consensus guidelines regarding the optimum dose of calcium and vitamin D for osteoprotection. Some authorities suggest a daily dose of 1000 IU vitamin D for children for osteoprotection, while others suggest a daily dose of 400 IU...
August 9, 2018: Paediatrics and International Child Health
Cristiana Cipriani, Jessica Pepe, Barbara C Silva, Mishaela R Rubin, Natalie E Cusano, Donald J McMahon, Luciano Nieddu, Maurizio Angelozzi, Federica Biamonte, Daniele Diacinti, Didier Hans, Salvatore Minisola, John P Bilezikian
Parathyroid hormone (PTH) (1-84) improves lumbar spine (LS) areal bone mineral density (aBMD) and trabecular bone score (TBS) in hypoparathyroidism over a 2-year treatment period. Studies in osteoporosis have shown that with PTH(1-34) there is a significant increase in LS aBMD and TBS. In this article, we provide new data comparing the effects of the same form of PTH, namely recombinant human PTH, rhPTH(1-84), on aBMD and TBS in hypoparathyroid and osteoporotic patients over an 18-month treatment period. We studied 19 premenopausal (mean age 45...
July 24, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Stuart L Silverman, E Siris, D Belazi, C Recknor, A Papaioannou, J P Brown, D T Gold, E M Lewiecki, G Quinn, A Balasubramanian, S Yue, B Stolshek, D L Kendler
Persistence with prescribed medications for chronic diseases is important; however, persistence with osteoporosis treatments is historically poor. In this prospective cohort study of postmenopausal women treated for osteoporosis in real-world clinical practice settings in the USA and Canada, 24-month persistence with denosumab was 58%. PURPOSE: Patients who persist with their prescribed osteoporosis treatment have increased bone mineral density (BMD) and reduced risk of fracture. Twelve-month persistence with denosumab in routine clinical practice is as high as 95%, but there are limited data on longer-term persistence with denosumab in this setting...
August 7, 2018: Archives of Osteoporosis
Qasim Zaidi, Olumide Danisa, Wayne Cheng
STUDY DESIGN: Systematic Review OBJECTIVE.: To evaluate the clinical utility of assessing bone quality using computed tomography (CT) attenuation in Hounsfield units (HU). SUMMARY OF BACKGROUND DATA: Assessing bone quality prior to spine instrumentation is an essential step of preoperative planning. Dual energy x-ray absorptiometry (DEXA) has been the gold standard for assessing bone mineral density (BMD), however DEXA can result in spuriously elevated BMD measurements in patients with degenerative disease, compression fractures and/or vascular calcifications...
July 30, 2018: Spine
Raul Roncero-Martín, Ignacio Aliaga Vera, Luis J Moreno-Corral, Jose M Moran, Jesus M Lavado-Garcia, Juan D Pedrera-Zamorano, Maria Pedrera-Canal
Olive oil has been demonstrated to enhance various cardiometabolic risk factors. However, to our knowledge, the association between olive oil intake and cortical and trabecular bone microarchitecture has never been evaluated in Spanish women. We aimed to examine the association between olive oil intake and cortical and trabecular bone microarchitecture. We analyzed 523 women aged 50 (9) year, range (23⁻81) year. Participants underwent dual-energy X-ray absorptiometry and peripheral quantitative computed tomography scans...
July 26, 2018: Nutrients
Lydia P Bakalova, Christina M Andreasen, Jesper Skovhus Thomsen, Annemarie Brüel, Ellen-Margrethe Hauge, Birgitte Jul Kiil, Jean-Marie Delaisse, Thomas Levin Andersen, Mariana E Kersh PhD
During aging and in osteoporosis, cortical bone becomes more porous, making it more fragile and susceptible to fractures. The aim of this study was to investigate the intracortical compression- induced strain energy distribution, and determine whether intracortical pores associated with high strain energy density (SED) in the surrounding bone matrix have a different morphology, distribution and remodeling characteristics than matrix with normal SED. Fibular diaphyseal specimens from 20 patients undergoing a jaw reconstruction (age range 41-75 years, 14 men and 6 women) were studied...
July 26, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
May-Britt Skoradal, Eva Wulff Helge, Niklas R Jørgensen, Jann Mortensen, Pál Weihe, Peter Krustrup, Magni Mohr
The effects of football training on bone health were examined in 55- to 70-year-old sedentary women and men with prediabetes. Patients (n = 50) with prediabetes (age; 61 ± 9 years, BMI 29.7 ± 0.6 kg/m2 , body fat content; 37 ± 1%, VO2max ; 22.7 ± 0.8 mL/min/kg and mean arterial pressure; 104 ± 3 mm Hg) were randomized into a football training group (FTG; n = 27, 14 women) and a control group (CON; n = 23, 11 women). At baseline, 73% and 24% were diagnosed with femur osteopenia and osteoporosis, respectively...
July 26, 2018: Scandinavian Journal of Medicine & Science in Sports
Huey-En Tzeng, Po-Hao Huang, Chun-Hao Tsai, Gregory J Tsay, Yi-Ju Lee, Tsurng-Juhn Huang, Tzu-Hung Lin, Ying-Ming Chiu, Yi-Ying Wu
NC-8 (ent-16-oxobeyeran-19-N-methylureido) is an isosteviol-derived analogue with multiple biological effects, including anti-inflammation and anti-bacterial activities and inhibition of HBV viral surface antigen gene expression. In this study, we explored the effects of NC-8 on the formation of osteoclasts from RAW 264.7 cells. We found that NC-8 exerts the novel effect of inhibiting osteoclast-like cell formation. Our experiments showed that RANKL-induced ERK, p38, and JNK phosphorylation were inhibited by NC-8...
July 25, 2018: Scientific Reports
Nam Hoon Moon, Won Chul Shin, Min Uk Do, Seung Hun Woo, Seung Min Son, Kuen Tak Suh
BACKGROUND: Isolated greater trochanter (GT) fractures are relatively rare and few studies have assessed the appropriate diagnostic and therapeutic strategies for these fractures. When initial plain radiographs show an isolated GT fracture, underestimation of occult intertrochanteric extension may result in displacement of a previously non-displaced fracture. This study examined the clinical results and value of different diagnostic strategies in elderly patients with isolated GT fractures on plain radiographs...
July 25, 2018: BMC Musculoskeletal Disorders
David Donohue, Summer Decker, Jonathan Ford, Robert Foley, Kirstin Dunbar, Todd Kumm, Kyle Achors, Hassan Mir
OBJECTIVES: To present a technique for the use of computed tomography (CT) scans in opportunistic screening for osteoporosis in patients with pelvic and acetabular fractures and to quantify the potential clinical impact in a geriatric trauma population. DESIGN: Retrospective cohort study. SETTING: Level 1 trauma center. PATIENTS: A total of 335 patients older than 60 years of age who presented to a Level 1 trauma center with a diagnosis of pelvic or acetabular fracture and were evaluated with a CT scan between the years 2010 and 2016...
August 2018: Journal of Orthopaedic Trauma
A Villepelet, O Casiraghi, S Temam, A Moya-Plana
INTRODUCTION: Oncogenic osteomalacia is a very rare disease usually caused by a phosphaturic mesenchymal tumor, particularly the "mixed connective tissue type", secreting FGF-23 hormone. OBJECTIVE: The authors report a case of ethmoid tumor associated with oncogenic osteomalacia and discuss management based on a review of the literature. CASE SUMMARY: A 41-year-old woman with multiple fractures causing major disability was diagnosed with early-onset osteoporosis...
July 16, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
Nima Montazeri-Najafabady, Younes Ghasemi, Mohammad Hossein Dabbaghmanesh, Pedram Talezadeh, Farhad Koohpeyma, Ahmad Gholami
Osteoporosis is a major health problem that occurs as a result of an imbalance between bone formation and bone resorption. Different approaches have been established for treating osteoporosis. Recently, because of their health benefits and also low adverse reaction, probiotics have been receiving considerable attention. In this study, we compared the effectiveness of five probiotic strains, Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus casei, Bifidobacterium longum, and Bacillus coagulans, in protecting rats from ovariectomized (OVX)-induced bone loss...
July 17, 2018: Probiotics and Antimicrobial Proteins
Massimo Varenna, Chiara Crotti
Complex Regional Pain Syndrome type 1 (CRPS-1) is a disabling painful disease whose hallmark is pain disproportionate to inciting event. CRPS is also characterized by symptoms and signs, such as vasomotor, sudomotor, trophic and motor changes. Therapeutic approach of CRPS-1 still remains a challenge for clinicians treating a disease with potential heavy consequences on patient prognosis. In the past years, the treatment with bisphosphonates (BPs) has gained some success as confirmed by the results of a number of meta-analyses...
July 14, 2018: Rheumatology International
Song Liu, Jian-Qun Wu, Ji-Jie Hu, Le Wang, Zhao Wang, Huan Meng, Ling-Jian Zhuo, Jian-Xiong Zheng
OBJECTIVE: To investigate the effects of neuropeptide Y (NPY) Y1 receptor antagonist PD160170 in promoting osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and accelerating healing of femoral defect in rats. METHODS: The third generation of rat BMSCs were treated with PBS (control) or 10-6 , 10-7 , or 10-8 mol/L NPY Y1 receptor antagonist PD160170. After 7 and 14 days of treatment, the cells were examined for osteogenic differentiation with alkaline phosphatase (ALP) and alizarin red staining...
June 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Mirella Lopez Picazo, Alba Magallon Baro, Luis M Del Rio Barquero, Silvana Di Gregorio, Yves Martelli, Jordi Romera, Martin Steghofer, Miguel A Gonzalez Ballester, Ludovic Humbert
Dual Energy X-ray Absorptiometry (DXA) is the standard exam for osteoporosis diagnosis and fracture risk evaluation at the spine. However, numerous patients with bone fragility are not diagnosed as such. In fact, standard analysis of DXA images does not differentiate between trabecular and cortical bone; neither specifically assess of the bone density in the vertebral body, which is where most of the osteoporotic fractures occur. Quantitative Computed Tomography (QCT) is an alternative technique that overcomes limitations of DXA-based diagnosis...
June 11, 2018: IEEE Transactions on Medical Imaging
Bo Liu, Wei Feng, Tomoka Hasegawa, Norio Amizuka, Minqi Li
To investigate type 1 diabetes mellitus (T1DM) affecting bone remodeling in the context of menopause in female rats. The animals were subjected to either ovariectomy (OVX) which was performed to mimic postmenopausal estrogen deficiency, and/or type 1 diabetes mellitus which was established by the intra-abdominal administration of 50 mg/kg streptozotocin (STZ). Single-loaded groups were the OVX group and the STZ group, while the combined group was the OVX+STZ group. Bone histomorphometry was performed on the tibial metaphysis by Micro-CT scanning...
July 11, 2018: Histology and Histopathology
Hussein A El Oraby, Mona M Abdelsalam, Yara M Eid, Rana El Hilaly, Heba A Marzouk
INTRODUCTION: Charcot arthropathy is one of the disabling diabetes complications. There are enigmatic areas concerning its underlying pathophysiology and risk predictors. Osteoporosis and local osteopenia has been postulated to have a role in Charcot arthropathy development, but it is still controversial AIM: To Compare bone mineral density among type 2 diabetics with and without Charcot arthropathy. METHODOLOGY: Two groups with type 2 diabetes participated in this study...
July 10, 2018: Current Diabetes Reviews
Mithila Boche, Varsha Pokharkar
Alendronate (ALD) is clinically indicated for the treatment of osteoporosis, but its therapeutic use has been marred by severe GIT adverse effects affecting quality of life in patients. In this study, we selected novel transdermal microemulsion (TDME) as a suitable carrier for ALD as the way of avoiding intestinal toxicity and highlighted its anti-osteoporotic efficacy with extensive pharmacokinetic and pharmacodynamic analysis. TDME achieved two fold increase in bioavailability as compared to oral administration in pharmacokinetic studies...
July 9, 2018: Drug Delivery and Translational Research
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