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Bone scan osteoporosis

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https://www.readbyqxmd.com/read/30342226/qct-of-the-femur-comparison-between-qctpro-ctxa-and-miaf-femur
#1
Ling Wang, Oleg Museyko, Yongbin Su, Keenan Brown, Ruopei Yang, Yong Zhang, Yangyang Duanmu, Zhe Guo, Wei Zhang, Dong Yan, Xiaoguang Cheng, Klaus Engelke
QCT is commonly employed in research studies and clinical trials to measure BMD at the proximal femur. In this study we compared two analysis software options, QCTPro CTXA and MIAF-Femur, using CT scans of the semi-anthropometric European Proximal Femur Phantom (EPFP) and in vivo data from 130 Chinese elderly men and women aged 60-80 years. Integral (Int), cortical (Cort) and trabecular (Trab) vBMD, volume, and BMC of the femur neck (FN), trochanter (TR), inter-trochanter (IT), and total hip (TH) VOIs were compared...
October 17, 2018: Bone
https://www.readbyqxmd.com/read/30327243/dxa-errors-are-common-and-reduced-by-use-of-a-reporting-template
#2
D Krueger, E Shives, E Siglinsky, J Libber, B Buehring, K E Hansen, N Binkley
OBJECTIVE: High quality dual energy X-ray absorptiometry (DXA) acquisition, analysis, and reporting demands technical and interpretive excellence. We hypothesized that DXA errors are common and of such magnitude that incorrect clinical decisions might result. In this 2-phase study, we evaluated DXA technical and interpretation error rates in a clinical population and subsequently assessed if implementing an interpretation template reduced errors. METHODS: In phase 1, DXA scans of 345 osteoporosis clinic referrals were reviewed by International Society for Clinical Densitometry-certified technologists (n = 3) and physicians (n = 3)...
September 13, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/30320955/identification-of-novel-loci-associated-with-hip-shape-a-meta-analysis-of-genome-wide-association-studies
#3
Denis A Baird, Daniel S Evans, Frederick K Kamanu, Jennifer S Gregory, Fiona R Saunders, Claudiu V Giuraniuc, Rebecca J Barr, Richard M Aspden, Deborah Jenkins, Douglas P Kiel, Eric S Orwoll, Steven R Cummings, Nancy E Lane, Benjamin H Mullin, Frances Mk Williams, J Brent Richards, Scott G Wilson, Tim D Spector, Benjamin G Faber, Deborah A Lawlor, Elin Grundberg, Claes Ohlsson, Ulrika Pettersson-Kymmer, Terence D Capellini, Daniel Richard, Thomas J Beck, David M Evans, Lavinia Paternoster, David Karasik, Jonathan H Tobias
We aimed to report the first genome-wide association study (GWAS) meta-analysis of dual-energy X-ray absorptiometry (DXA)-derived hip shape, which is thought to be related to the risk of both hip osteoarthritis and hip fracture. Ten hip shape modes (HSMs) were derived by statistical shape modelling using SHAPE software, from hip DXA scans in the Avon Longitudinal Study of Parents and Children (ALSPAC; adult females), TwinsUK (mixed-sex), Framingham Osteoporosis Study (FOS; mixed), Osteoporotic Fractures in Men study (MrOS) and Study of Osteoporotic Fractures (SOF; females) (total n = 15,934)...
October 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30309646/combined-treatment-with-cinnamaldehyde-and-pth-enhances-the-therapeutic-effect-on-glucocorticoid-induced-osteoporosis-through-inhibiting-osteoclastogenesis-and-promoting-osteoblastogenesis
#4
Zongyi Wu, Deyi Yan, Zhongjie Xie, Sheji Weng, Qiang Zhou, Hang Li, Bingli Bai, Viraj Boodhun, Zijian Shen, Jiahao Tang, Lei Yang
The study was to investigate the effect of combining treatment with cinnamaldehyde and parathyroid hormone (1-34) (PTH) on glucocorticoid-induced osteoporosis (GIO) and compare with monotherapy. Forty Sprague-Dawley male rats with GIO were divided into four groups randomly: control group (CON group, N = 10); group that intragastric administration with cinnamaldehyde (CIN group, N = 10); group that subcutaneous injection with PTH, three times per week(PTH group, N = 10); both administration with cinnamaldehyde and PTH (CIN + PTH group, N = 10)...
October 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30306225/prediction-of-incident-vertebral-fracture-using-ct-based-finite-element-analysis
#5
B T Allaire, D Lu, F Johannesdottir, D Kopperdahl, T M Keaveny, M Jarraya, A Guermazi, M A Bredella, E J Samelson, D P Kiel, D E Anderson, S Demissie, M L Bouxsein
Prior studies show vertebral strength from computed tomography-based finite element analysis may be associated with vertebral fracture risk. We found vertebral strength had a strong association with new vertebral fractures, suggesting that vertebral strength measures identify those at risk for vertebral fracture and may be a useful clinical tool. INTRODUCTION: We aimed to determine the association between vertebral strength by quantitative computed tomography (CT)-based finite element analysis (FEA) and incident vertebral fracture (VF)...
October 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/30303279/osteoporosis-and-low-bone-mineral-density-osteopenia-in-rural-and-remote-queensland
#6
Campbell Bruce Macgregor, Jarrod D Meerkin, Stephanie Jade Alley, Corneel Vandelanotte, Peter John Reaburn
OBJECTIVE: To report that prevalence rates of osteoporosis and osteopenia differ according to different levels of remoteness in Queensland, Australia. DESIGN: Retrospective analysis of bone mineral density scans undertaken between April 2015 and April 2016. SETTING: Mobile laboratory housing a dual energy X-ray absorptiometry in rural and remote Queensland. PARTICIPANTS: Four-thousand-four-hundred-and-twenty-seven referred individuals 70 years of age or older...
October 2018: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/30295592/balloon-guided-cement-augmentation-of-iliosacral-screws-in-the-treatment-of-insufficiency-fractures-of-the-sacrum-description-of-a-new-method-and-preliminary-results
#7
G H Sandmann, U Stöckle, T Freude, F M Stuby
PURPOSE OF THE STUDY Fragility fractures of the pelvic ring in the elderly population are a serious problem in orthopaedics. The treatment options range from conservative treatment to diverse operative options. We present a balloon guided new technique of implanting cement augmented screws aiming at improved implant anchorage and reduced cement leakage. MATERIAL AND METHODS We describe a new technique of balloon- guided cement augmented iliosacral screws. After the balloon has been insufflated and contrast medium has been instillated for leakage detection, iliosacral screws can safely be placed with a relevant cement depot...
2018: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/30294189/patterns-of-age-and-sex-related-variations-in-bone-mineral-density-of-lumbar-spine-and-total-femur-a-retrospective-diagnostic-laboratory-based-study
#8
Manmohan Singh, Sanjay Arora, Amanpreet Kaur, Sukanya Ghildiyal, Rohit Kumar
Background: Osteoporosis is a major public health problem and should be a priority for healthcare providers and policymakers as it is an important reason of morbidity, mortality, and high-cost incurred in the management of its complications such as hip fractures. This study is designed to assess the bone mineral density (BMD) variation with age, site, and sex. Study is based on diagnostic laboratory data of BMD. Methods: A retrospective analysis was conducted on a sample population of 935 persons (73...
July 2018: Journal of Mid-life Health
https://www.readbyqxmd.com/read/30293198/bone-microstructure-in-response-to-vitamin-d3-supplementation-a-randomized-placebo-controlled-trial
#9
Lise Sofie Bislev, Lene Langagergaard Rødbro, Lars Rolighed, Tanja Sikjaer, Lars Rejnmark
Vitamin D supplementation is often used in the prevention and treatment of osteoporosis, but the role of vitamin D has lately been questioned. We aimed to investigate the effect of 3 months of daily vitamin D3 supplementation (70 µg [2800 IU] vs. placebo) initiated in winter months on bone health. This study is a double-blinded placebo-controlled randomized trial. Bone health was assessed by bone turnover markers, DXA, HRpQCT, and QCT scans. The participants were 81 healthy postmenopausal women with low 25(OH)D (< 50 nmol/l) and high PTH levels (> 6...
October 6, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/30288278/risk-factors-associated-with-osteoporosis-in-a-cohort-of-prospectively-diagnosed-adult-coeliac-patients
#10
Gloria Galli, Edith Lahner, Laura Conti, Gianluca Esposito, Maria Carlotta Sacchi, Bruno Annibale
Background: Up to 75% of patients with untreated coeliac disease (CD) present with osteopenia or osteoporosis. Guidelines do not express with certainty whether each patient with newly diagnosed CD should undergo a dual-energy x-ray absorptiometry (DEXA) scan. Aim: The aim of this article is to evaluate the prevalence of bone mineral density (BMD) alterations at diagnosis and risk factors associated with osteoporosis. Methods: A total of 214 adult patients (median age 38 years; female = 71...
October 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/30255256/comparison-of-the-diagnostic-performance-of-ct-hounsfield-unit-histogram-analysis-and-dual-energy-x-ray-absorptiometry-in-predicting-osteoporosis-of-the-femur
#11
Hyun Kyung Lim, Hong Il Ha, Sun-Young Park, Kwanseop Lee
PURPOSE: To evaluate the diagnostic performance of Hounsfield unit histogram analysis (HUHA) of precontrast abdominal-pelvic CT scans for predicting osteoporosis. MATERIALS AND METHODS: The study included 271 patients who had undergone dual X-ray absorptiometry (DXA) and abdominal-pelvic CT within 1 month. HUHA was measured using commercial 3D analysis software (Aquarius iNtuition v4.4.12Ⓡ , TeraRecon) and expressed as a percentage of seven HU range categories related to the ROI: A < 0, 0 ≤ B < 25, 25 ≤ C < 50, 50 ≤ D < 75, 75 ≤ E < 100, 100 ≤ F < 130, and 130 ≤ G...
September 25, 2018: European Radiology
https://www.readbyqxmd.com/read/30243677/determination-of-bone-density-in-patients-with-sacral-fractures-via-ct-scan
#12
Josephine Berger-Groch, Darius M Thiesen, Dimitris Ntalos, Lars G Grossterlinden, Eric Hesse, Florian Fensky, Maximilian J Hartel
BACKGROUND: Gold standard to diagnose osteoporosis is standard dual-energy X-ray absorptiometry (DXA). CT is a standard diagnostic tool to detect injuries to the pelvic ring. The aim of the study was to collect information on bone density without DXA by determination of Hounsfield units (HU) in CT scans of patients with sacral fractures, to draw conclusions on the prevalence of osteoporosis in patients admitted to the investigating institution. HYPOTHESIS: Is the determination of HU in CT scans a useful method to gain more information about bone density in patients with sacral fractures? PATIENTS AND METHODS: We performed a retrospective analysis of all patients treated from 2004-2014 with sacral fractures confirmed with a CT scan...
September 19, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/30240466/low-yield-for-routine-laboratory-checks-in-follow-up-of-coeliac-disease
#13
Jordy P W Burger, Jouke J H van der Laan, Tom A Jansen, Joost P H Drenth, Elisabeth A Roovers, Margreet M S Wessels, Peter J Wahab
AIM: To evaluate the yield of routine laboratory tests and Dual Energy X-ray Absorptiometry (DEXA) scans in coeliac disease. METHODS: A retrospective analysis of medical files of all followed-up patients with coeliac disease attending Rijnstate Hospital in 2016 was conducted with respect to blood tests of hemoglobin, vitamin B12, folate acid, iron status, calcium, vitamin D, glucose, thyroid function, DEXA-scans and related symptoms or signs of abnormalities. All patients had positive coeliac serology and/or biopsy-proven coeliac disease and attended regular visits after diagnosis...
September 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/30232564/an-epidemiological-analysis-of-osteoporotic-characteristics-in-patients-affected-with-rheumatoid-arthritis-in-kazakhstan
#14
Gulzhan Gabdulina, Melody Kasher, Aliya Beissebayeva, Dana Mussabaeva, Alexander Tokarev, Gulmira Mominova, Gulnar Essirkepova, Ainash Amanzholova, Korlan Zaurbekova, Maira Saparbaeva, Maira Bizhanova, Moldir Kulshymanova, Gregory Livshits
PURPOSE: We aimed to assess which of the major risk factors associated with rheumatoid arthritis (RA) severity are also associated with osteoporosis-related phenotypes (OP-RP) in the native population of Kazakhstan. METHODS: Four hundred six RA patients (90.6% females) with 397 controls-unaffected first-degree relatives were recruited. Biochemical factors were recorded, and OP-RP were assessed using QCT scans and ultrasound densitometry (US) of the forearm to estimate cortical indices (CI), spongial bone mineral density (BMDSPN ), and US_T-scores...
September 19, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/30224063/leonurine-hydrochloride-promotes-osteogenic-differentiation-and-increases-osteoblastic-bone-formation-in-ovariectomized-mice-by-wnt-%C3%AE-catenin-pathway
#15
Liyu Yang, Shengye Liu, Shuai Mu, Xiangji Man, Gen Ba, Ran Guo, Yan Li, Long Zhou, Liqing Yang, Qin Fu
Leonurine hydrochloride (LH) is a synthetic chemical compound derived from leonurine that can be extracted from Leonurus sibiricus and possesses antioxidant, anti-apoptosis, and neuroprotective activities. In previous studies, LH has been demonstrated to attenuate osteoclast activity and prevent bone loss. However, it is unknown whether LH accelerates bone formation and promotes osteogenic differentiation. We systematically examined the effects of LH on ovariectomized-induced osteoporotic mice and the MC3T3-E1 osteoblastic cell line...
October 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30212736/a-wavelet-gradient-sparsity-based-algorithm-for-reconstruction-of-reduced-view-tomography-datasets-obtained-with-a-monochromatic-synchrotron-based-x-ray-source
#16
S Ali Melli, Khan A Wahid, Paul Babyn, David M L Cooper, Ahmed M Hasan
High-resolution synchrotron computed tomography (CT) is very helpful in the diagnosis and monitor of chronic diseases including osteoporosis. Osteoporosis is characterized by low bone mass and cortical bone porosity best imaged with CT. Synchrotron CT requires a large number of angular projections to reconstruct images with high resolution for detailed and accurate diagnosis. However, this poses great risks and challenges for serial in-vivo human and animal imaging due to a large amount of X-ray radiation dose required that can damage living specimens...
November 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/30211034/the-protocol-for-the-prospective-urban-rural-epidemiology-china-action-on-spine-and-hip-status-study
#17
Kai Li, Yong Zhang, Ling Wang, Yang-Yang Duanmu, Wei Tian, Hui Chen, Lu Yin, Jian Bo, Yang Wang, Wei Li, Li He, Wen-Hua Zhao, Shao-Qi Xu, Lin-Fen Zhao, Jun Zhou, Feng-Zhe Wang, Yu Liu, Lei Zhu, Yi-Zhong Chen, Xiao-Lin Zhang, Xiao-Guang Hao, Zhi-Wei Shi, Jun-Ying Wang, Ji-Man Shao, Zhi-Jian Chen, Ren-Sheng Lei, Gang Ning, Qian Zhao, Yong-Hong Jiang, Ya-Hong Zhi, Bao-Qing Li, Xiao Chen, Quan-Yong Xiang, Liang Wang, Yuan-Zheng Ma, Shi-Wei Liu, Xiao-Guang Cheng
The Prospective Urban Rural Epidemiology (PURE) China Action on Spine and Hip status (CASH) study focused on the prevalence of osteoporosis and spinal fracture in China. The aim of the PURE CASH study is to determine the prevalence of osteoporosis and spinal fracture, and explore the potential relationship between spinal fracture and bone mineral density (BMD). This study is a prospective large-scale population study with a community-based sampling and recruitment strategy. The aim is to determine the prevalence of osteoporosis and vertebral fracture in this population, to evaluate the association between vertebral fractures and BMD values, and to assess the prediction power of BMD for incident fractures...
August 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/30210963/spine-fractures-in-ankylosing-diseases-recommendations-of-the-spine-section-of-the-german-society-for-orthopaedics-and-trauma-dgou
#18
Maximilian Reinhold, Christian Knop, Christian Kneitz, Alexander Disch
Study Design: Review of literature and case series. Objectives: Update and review of current treatment concepts for spine fractures in patients with ankylosing spinal disorders. Methods: Case presentation and description of a diagnostic and therapeutic algorithm for unstable spinal injuries with an underlying ankylosing spinal disorder (ASD) of the cervical and thoracolumbar spine. Results: Nondisplaced fractures can be missed easily using conventional X-rays...
September 2018: Global Spine Journal
https://www.readbyqxmd.com/read/30199837/design-of-a-surrogate-for-evaluation-of-methods-to-predict-bone-bending-stiffness
#19
Caitlyn J Collins, Matthew Boyer, Thomas D Crenshaw, Heidi-Lynn Ploeg
The high incidence of osteoporosis and related fractures demands for the use and development of methods capable of detecting changes in bone mechanical properties. The most common clinical and laboratory methods used to detect changes in bone mechanical properties, such as stiffness, strength, or flexural rigidity, include: mechanical testing, medical imaging, medical image-based analytical calculations, and medical image-based finite element analysis. However, the innate complexity of bone makes validation of the results from each method difficult...
August 30, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/30178159/radiofrequency-echographic-multispectrometry-compared-with-dual-x-ray-absorptiometry-for-osteoporosis-diagnosis-on-lumbar-spine-and-femoral-neck
#20
M Di Paola, D Gatti, O Viapiana, L Cianferotti, L Cavalli, C Caffarelli, F Conversano, E Quarta, P Pisani, G Girasole, A Giusti, M Manfredini, G Arioli, M Matucci-Cerinic, G Bianchi, R Nuti, S Gonnelli, M L Brandi, M Muratore, M Rossini
An innovative, non-ionizing technique to diagnose osteoporosis on lumbar spine and femoral neck was evaluated through a multicenter study involving 1914 women. The proposed method showed significant agreement with reference gold standard method and, therefore, a potential for early osteoporosis diagnoses and possibly improved patient management. INTRODUCTION: To assess precision (i.e., short term intra-operator precision) and diagnostic accuracy of an innovative non-ionizing technique, REMS (Radiofrequency Echographic Multi Spectrometry), in comparison with the clinical gold standard reference DXA (dual X-ray absorptiometry), through an observational multicenter clinical study...
September 4, 2018: Osteoporosis International
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