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Bone scan osteoporosis

Betül Ersoy, Deniz Özalp Kizilay, Seniha Kiremitci Yilmaz, Fatma Taneli, Gül Gümüşer
Peak bone mass is reached in late adolescence. Low peak bone mass is a well recognized risk factor for osteoporosis later in life. Our data do not support a link between vitamin D status, bone mineral density (BMD), and socioeconomic status (SES). However, there was a marked inadequacy of daily calcium intake and a high presence of osteopenia in females with low SES. PURPOSE: Our aims were to (1) examine the effects of different SES on BMD, vitamin D status, and daily calcium intake and (2) investigate any association between vitamin D status and BMD in female university students...
December 4, 2018: Archives of Osteoporosis
Hana Ben Hassine, Ramzi Zemni, Imen Ben Nacef, Asma Boumiza, Foued Slama, Khadija Baccouche, Najla Amri, Sarra Melayah, Zahid Shakoor, Adel Almogren, Elyes Bouajina, Rim Sghiri
OBJECTIVES: This study was aimed to investigate the association of the single nucleotide polymorphism of tumor necrosis factor receptor associated factor 6 (TRAF6), rs540386, with low bone mineral density (BMD) among patients with rheumatoid arthritis (RA). METHODS: TRAF6 rs540386 genotyping was performed by mutagenically separated PCR in a cohort of 188 (23 men, 165 women, median age, 56.2 years) adult RA patients and 224 age and gender-matched controls. BMD was measured using dual-energy X-ray absorptiometry (DXA) (Lunar Prodigy advance scans, GE Healthcare, USA)...
December 1, 2018: Clinical Rheumatology
Takashi Nakamoto, Akira Taguchi, Rinus Gerardus Verdonschot, Naoya Kakimoto
OBJECTIVES: Patients undergoing osteoporosis treatment benefit greatly from early detection. We previously developed a computer-aided diagnosis (CAD) system to identify osteoporosis using panoramic radiographs. However, the region of interest (ROI) was relatively small, and the method to select suitable ROIs was labor-intensive. This study aimed to expand the ROI and perform semi-automatized extraction of ROIs. The diagnostic performance and operating time were also assessed. METHODS: We used panoramic radiographs and skeletal bone mineral density data of 200 postmenopausal women...
April 25, 2018: Oral Radiology
Pedro Hoffiz Ricart, Sapan D Gandhi, Jonathon Geisinger, Kevin Baker, Daniel K Park
Background: Bone graft substitutes have been developed to circumvent donor site morbidity associated with iliac crest bone graft, but sparse literature compares the efficacy of various substitutes. Two commonly used bone graft substitutes used in lumbar fusion are β-tricalcium phosphate (BTP) and demineralized bone matrix (DBM). Methods: A retrospective review of patients who underwent instrumented posterolateral lumbar fusion was conducted by a single surgeon from January 2013 to December 2016...
September 2018: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
Aditya John Binu, Kripa Elizabeth Cherian, Nitin Kapoor, Nihal Thomas, Thomas V Paul
Referral patterns for bone mineral density testing by dual energy X-ray absorptiometry (DXA) scanning are seldom studied. In our study, the overall proportion of referrals from specialties remained low. This highlights the need for adequate utilisation of DXA by specialties treating subjects at risk for osteoporosis. PURPOSE/OBJECTIVES: The knowledge of referral patterns for DXA scanning (dual energy X-ray absorptiometry) for bone mineral density (BMD) measurement is relevant in a developing country like India...
November 20, 2018: Archives of Osteoporosis
Kara B Anderson, Kara L Holloway-Kew, Mohammadreza Mohebbi, Mark A Kotowicz, Didier Hans, Julie A Pasco
It has been established that degenerative-changes at the spine elevate bone mineral density at the lumbar spine. This study in men reports that trabecular bone score may be less affected by spinal degenerative-changes. PURPOSE: A recent tool for assessing trabecular microarchitecture at the lumbar spine, trabecular bone score (TBS), provides information about bone health complementary to lumbar spine areal BMD (here referred to as BMD). In men, mean BMD increases with increasing age due to degenerative-changes at the spine including osteophytes and aortic calcification...
November 16, 2018: Archives of Osteoporosis
P R Gabbai-Armelin, H W Kido, M A Cruz, J P S Prado, I R Avanzi, M R Custódio, A C M Renno, R N Granito
Bone fractures characterize an important event in the medical healthcare, being related to traumas, aging, and diseases. In critical conditions, such as extensive bone loss and osteoporosis, the tissue restoration may be compromised and culminate in a non-union consolidation. In this context, the osteogenic properties of biomaterials with a natural origin have gained prominence. Particularly, marine sponges are promising organisms that can be exploited as biomaterials for bone grafts. Thus, the objectives of this study were to study the physicochemical and morphological properties of biosilica (BS) from sponges by using scanning electron microscopy, Fourier-transform infrared, X-ray diffraction (SEM, FTIR and XRD respectively), mineralization, and pH...
November 16, 2018: Marine Biotechnology
Perry J Pickhardt, Scott J Lee, Jiamin Liu, Jianhua Yao, Nathan Lay, Peter M Graffy, Ronald M Summers
METHODS: The automated BMD tool was retrospectively applied to non-contrast abdominal CT scans in 1603 consecutive asymptomatic adults (mean age, 55.9 years; 770 M/833 F) undergoing longitudinal screening (mean interval, 5.7 years; range, 1.0-12.3 years). The spinal column was automatically segmented, with standardized L1 and L2 anterior trabecular ROI placement. Automated and manual L1 HU values were compared, as were automated supine-prone measures. L1-L2 CT attenuation values were converted to BMD values through a linear regression model...
November 28, 2018: British Journal of Radiology
Simona Portaro, Elisabetta Morini, Maria Elena Santoro, Maria Accorinti, Pietro Marzullo, Antonino Naro, Rocco Salvatore Calabrò
RATIONALE: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative multisystem disorder, presenting with limb or bulbar onset. To date, there is no cure for ALS. At some stage of the disease, patients may complain of breathlessness due to respiratory failure, thus needing a noninvasive mechanical ventilation (NIMV) support. However, breathlessness is a symptom that may be induced by different causes that must be taken into consideration in ALS management. PATIENTS CONCERNS: We report the case of an 81-year-old man, with a spinal onset ALS, who was admitted to our clinic to start NIMV because of respiratory involvement...
November 2018: Medicine (Baltimore)
Marco Di Monaco, Carlotta Castiglioni, Edoardo Milano, Giuseppe Massazza
BACKGROUND AND AIMS: Subjects with osteosarcopenia, the concurrent presence of sarcopenia and osteoporosis, have prognostic disadvantages and can benefit from treatments targeted at both the conditions. Our aim was to elucidate whether the available definitions of low appendicular lean mass (aLM) capture or not the men with associated low bone mineral density (BMD) following a hip fracture. METHODS: 80 men admitted to our rehabilitation hospital underwent a dual-energy X-ray absorptiometry scan 19...
December 2018: Aging Clinical and Experimental Research
Pernille Ravn Jakobsen, Anne Pernille Hermann, Jens Søndergaard, Uffe Kock Wiil, Jane Clemensen
Objectives: This study aims to test a mobile health application (mHealth app) developed to meet the needs of women newly diagnosed with asymptomatic osteoporosis. We investigate how the women experience using an mHealth app upon diagnosis of osteoporosis and whether the app can help them to be prepared for treatment decision-making and support them in osteoporosis self-management. We also tested the usability of the app, to find out whether any adjustments were necessary prior to implementation...
2018: SAGE Open Medicine
J Štulík, P Nesnídal, K Kozelnická, M Barna
PURPOSE OF THE STUDY An optimal technique to surgically treat high-grade high-dysplastic (HG HD)spondylolistheses remains disputable. There are multiple surgical procedures described, ranging from a simple posterior fusion in situ without fixation through a standalone anterior lumbar interbody fusion with the oblique insertion of a structural bonegraft to instrumented full reduction and 360-degree fusion. At our department, preference is given to the instrumented monosegmental reduction and fixation by a fixator with Schanz screws...
2018: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
Bi-Hua Lv, Wei Tan, Chang-Cai Zhu, Xuejun Shang, Ling Zhang
BACKGROUND Parathyroid hormone (PTH) is required for the maintenance of normal bone physiology. This study describes the properties of a sustained-release formulation of recombinant human PTH (rhPTH) using chitosan and silk fibroin microparticles as carriers for drug delivery, developed using a spray-drying method. MATERIAL AND METHODS Chitosan, silk fibroin, and chitosan/silk fibroin microparticles loaded with rhPTH were studied with scanning electron microscopy (SEM) to estimate the particle size and surface morphology...
October 22, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Li-Juan Chai, Yue Zhang, Pan-Yang Zhang, Ya-Nan Bi, Xiao-Mei Yuan, Yu-Hong Li, Yan-Yan Wang, Lei Song, Li-Kang Sun, Kun Zhou
We investigated the beneficial effects and underlying mechanisms of Zhuanggu Guanjie (ZGGJ) pill in osteoporosis in vitro and in vivo . Bone marrow macrophages from 4-6-week-old mice were cultured in the presence of macrophage colony-stimulating factor (15 ng/mL) and receptor activator of nuclear factor- κ B ligand (30 ng/mL). Osteoclast differentiation was determined by quantification of tartrate-resistant acid phosphatase activity. Gelatin zymography was used to detect the activity of matrix metalloproteinases in osteoclasts...
2018: BioMed Research International
Ling Wang, Oleg Museyko, Yongbin Su, Keenan Brown, Ruopei Yang, Yong Zhang, Yangyang Duanmu, Zhe Guo, Wei Zhang, Dong Yan, Xiaoguang Cheng, Klaus Engelke
QCT is commonly employed in research studies and clinical trials to measure BMD at the proximal femur. In this study we compared two analysis software options, QCTPro CTXA and MIAF-Femur, using CT scans of the semi-anthropometric European Proximal Femur Phantom (EPFP) and in vivo data from 130 Chinese elderly men and women aged 60-80 years. Integral (Int), cortical (Cort) and trabecular (Trab) vBMD, volume, and BMC of the neck (FN), trochanter (TR), inter-trochanter (IT), and total hip (TH) VOIs were compared...
October 17, 2018: Bone
D Krueger, E Shives, E Siglinsky, J Libber, B Buehring, K E Hansen, N Binkley
OBJECTIVE: High quality dual energy X-ray absorptiometry (DXA) acquisition, analysis, and reporting demands technical and interpretive excellence. We hypothesized that DXA errors are common and of such magnitude that incorrect clinical decisions might result. In this 2-phase study, we evaluated DXA technical and interpretation error rates in a clinical population and subsequently assessed if implementing an interpretation template reduced errors. METHODS: In phase 1, DXA scans of 345 osteoporosis clinic referrals were reviewed by International Society for Clinical Densitometry-certified technologists (n = 3) and physicians (n = 3)...
September 13, 2018: Journal of Clinical Densitometry
Denis A Baird, Daniel S Evans, Frederick K Kamanu, Jennifer S Gregory, Fiona R Saunders, Claudiu V Giuraniuc, Rebecca J Barr, Richard M Aspden, Deborah Jenkins, Douglas P Kiel, Eric S Orwoll, Steven R Cummings, Nancy E Lane, Benjamin H Mullin, Frances Mk Williams, J Brent Richards, Scott G Wilson, Tim D Spector, Benjamin G Faber, Deborah A Lawlor, Elin Grundberg, Claes Ohlsson, Ulrika Pettersson-Kymmer, Terence D Capellini, Daniel Richard, Thomas J Beck, David M Evans, Lavinia Paternoster, David Karasik, Jonathan H Tobias
We aimed to report the first genomewide association study (GWAS) meta-analysis of dual-energy X-ray absorptiometry (DXA)-derived hip shape, which is thought to be related to the risk of both hip osteoarthritis and hip fracture. Ten hip shape modes (HSMs) were derived by statistical shape modeling using SHAPE software, from hip DXA scans in the Avon Longitudinal Study of Parents and Children (ALSPAC; adult females), TwinsUK (mixed sex), Framingham Osteoporosis Study (FOS; mixed), Osteoporotic Fractures in Men study (MrOS), and Study of Osteoporotic Fractures (SOF; females) (total N = 15,934)...
October 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Zongyi Wu, Deyi Yan, Zhongjie Xie, Sheji Weng, Qiang Zhou, Hang Li, Bingli Bai, Viraj Boodhun, Zijian Shen, Jiahao Tang, Lei Yang
The study was to investigate the effect of combining treatment with cinnamaldehyde and parathyroid hormone (1-34) (PTH) on glucocorticoid-induced osteoporosis (GIO) and compare with monotherapy. Forty Sprague-Dawley male rats with GIO were divided into four groups randomly: control group (CON group, N = 10); group that intragastric administration with cinnamaldehyde (CIN group, N = 10); group that subcutaneous injection with PTH, three times per week(PTH group, N = 10); both administration with cinnamaldehyde and PTH (CIN + PTH group, N = 10)...
November 2, 2018: Biochemical and Biophysical Research Communications
B T Allaire, D Lu, F Johannesdottir, D Kopperdahl, T M Keaveny, M Jarraya, A Guermazi, M A Bredella, E J Samelson, D P Kiel, D E Anderson, S Demissie, M L Bouxsein
Prior studies show vertebral strength from computed tomography-based finite element analysis may be associated with vertebral fracture risk. We found vertebral strength had a strong association with new vertebral fractures, suggesting that vertebral strength measures identify those at risk for vertebral fracture and may be a useful clinical tool. INTRODUCTION: We aimed to determine the association between vertebral strength by quantitative computed tomography (CT)-based finite element analysis (FEA) and incident vertebral fracture (VF)...
October 10, 2018: Osteoporosis International
Campbell Bruce Macgregor, Jarrod D Meerkin, Stephanie Jade Alley, Corneel Vandelanotte, Peter John Reaburn
OBJECTIVE: To report that prevalence rates of osteoporosis and osteopenia differ according to different levels of remoteness in Queensland, Australia. DESIGN: Retrospective analysis of bone mineral density scans undertaken between April 2015 and April 2016. SETTING: Mobile laboratory housing a dual energy X-ray absorptiometry in rural and remote Queensland. PARTICIPANTS: Four-thousand-four-hundred-and-twenty-seven referred individuals 70 years of age or older...
October 2018: Australian Journal of Rural Health
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