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https://www.readbyqxmd.com/read/30321666/discovery-of-new-non-steroidal-selective-glucocorticoid-receptor-agonists
#1
Constantinos Potamitis, Dimitra Siakouli, Konstantinos D Papavasileiou, Athina Boulaka, Vassiliki Ganou, Marina Roussaki, Theodora Calogeropoulou, Panagiotis Zoumpoulakis, Michael N Alexis, Maria Zervou, Dimitra J Mitsiou
Glucocorticoids (GCs) are widely used as potent anti-inflammatory drugs; however, GC therapy is often accompanied by adverse side effects. The anti-inflammatory action of GCs is exerted through the glucocorticoid receptor (GR) in part by antagonizing the pro-inflammatory nuclear factor k B (NF-kB) whereas the majority of side effects are assumed to be mediated by transactivation of GR target genes. We set out to identify novel non-steroidal selective GR agonists (SEGRA) favoring transrepression of NF-kB target genes over transactivation of genes associated with undesirable effects...
October 12, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/30319623/inflammation-a-double-edge-sword-for-cancer-and-other-age-related-diseases
#2
REVIEW
Subash Chandra Gupta, Ajaikumar B Kunnumakkara, Sadhna Aggarwal, Bharat B Aggarwal
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediates several chronic diseases including cancer, arthritis, obesity, diabetes, cardiovascular diseases, and neurological diseases. The inflammatory molecules and transcription factors, adhesion molecules, AP-1, chemokines, C-reactive protein (CRP), cyclooxygenase (COX)-2, interleukins (ILs), 5-lipooxygenase (5-LOX), matrix metalloproteinases (MMPs), nuclear factor (NF)-kB, signal transducer and activator of transcription 3 (STAT3), tumor necrosis factor (TNF), and vascular endothelial growth factor (VEGF) are molecular links between inflammation and chronic diseases...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30319196/increased-nuclear-factor-%C3%AE%C2%BAb-rela-expression-levels-in-human-colorectal-carcinoma-in-north-indian-patients
#3
Ram Rattan Negi, Satya Vati Rana, Rajesh Gupta, Vikas Gupta, Vijayta D Chadha, Devinder K Dhawan
Colorectal cancer is a major cause of cancer-related death in many countries. Inflammatory pathway is considered to play a major role in colorectal carcinogenesis. Nuclear factor kappa B (NF-κB) pathway is a link between inflammation and cancer. NF-κB is a transcription factor which belongs to the Rel family. Activation of NF-κB has been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis. The aim of the present study was to evaluate the expression levels of NF-κB/RelA in colorectal carcinoma using Real-time PCR...
October 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/30319075/p53-nf-%C3%AE%C2%BAb-crosstalk-in-febrile-temperature-treated-human-umbilical-cord-derived-mesenchymal-stem-cells
#4
Umesh Goyal, Malancha Ta
Mesenchymal Stem Cells (MSCs) are successful for their therapeutic application in immune and inflammatory contexts due to their anti-inflammatory, trophic and immunomodulatory roles. However, though MSCs have the potential to provide regenerative treatment towards a wide range of devastating diseases, massive cell death of transplanted MSCs remains an obstacle to overcome. The relation between MSCs and inflammation is multifactorial and challenging to comprehend. Fever is a critical component of the inflamed microenvironment...
October 15, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/30308218/impact-of-alterations-in-x-linked-irak1gene-and-mir-146a-on-susceptibility-and-clinical-manifestations-in-patients-with-systemic-sclerosis
#5
Misa Vreca, Marina Andjelkovic, Natasa Tosic, Ana Zekovic, Nemanja Damjanov, Sonja Pavlovic, Vesna Spasovski
Systemic sclerosis (SSc) is a heterogeneous multisystem autoimmune disease with unknown etiology. Numerous studies have indicated that the disease heterogeneity implies various genetic abnormalities. Considering that SSc is characterized by a strong sex bias and that the position of IRAK1 gene is on the X chromosome, we assume that variations in IRAK1 gene could explain female predominance of SSc. It was previously described that miR-146a has a role in 'fine-tuning' regulation of the TLR/NF-kB signaling pathway through down-regulation of IRAK1 gene...
October 8, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30308181/intracellular-calcium-and-nf-k-b-regulate-hypoxia-induced-leptin-vegf-il-6-and-adiponectin-secretion-in-human-adipocytes
#6
Azizah Al-Anazi, Ranjit Parhar, Soad Saleh, Reem Al-Hijailan, Angela Inglis, Mansour Al-Jufan, Mohammed Bazzi, Sarwar Hashmi, Walter Conca, Kate Collison, Futwan Al-Mohanna
AIMS: Hypoxia-induced adipokine release has been attributed mainly to HIF-1α. Here we investigate the role of intracellular calcium and NF-kB in the hypoxia-dependent release of leptin, VEGF, IL-6 and the hypoxia-induced inhibition of adiponectin release in human adipocytes. MAIN METHODS: We used intracellular calcium imaging to compare calcium status in preadipocytes and in adipocytes. We subjected both cell types to hypoxic conditions and measured the release of adipokines induced by hypoxia in the presence and absence of HIF-1α inhibitor YC-1, NF-κ B inhibitor SN50 and intracellular calcium chelator BAPTA-AM...
October 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/30304545/dysregulation-of-ftx-mir-545-signaling-pathway-downregulates-tim-3-and-is-responsible-for-the-abnormal-activation-of-macrophage-in-cirrhosis
#7
Xia Liu, Cong Li, Jie Zhu, Wenshuai Li, Qiang Zhu
BACKGROUND: Accumulating evidence has suggested the involvement of miR-545 and long noncoding RNA (lncRNA) FTX in a wide range of diseases. Therefore, this study aimed to investigate the molecular mechanism underlying the function of miR-545 and lncRNA FTX in hepatitis B virus (HBV)-related cirrhosis. METHOD: The level of Tim-3, TLR-4, and endotoxin was detected in CD14+ , CD14 + CD16 + , and CD14 + CD16 - monocytes isolated from both patients with cirrhosis and healthy controls...
October 10, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30302732/dysregulation-of-sqstm1-mitophagy-and-apoptotic-genes-in-chronic-exposure-to-arsenic-and-high-fat-diet-hfd
#8
Marzieh Zeinvand-Lorestani, Heibatullah Kalantari, Mohammad Javad Khodayar, Ali Teimoori, Najmaldin Saki, Akram Ahangarpour, Fakher Rahim, Layasadat Khorsandi
Arsenic (As) is a toxic and hazardous metalloid. Unfortunately, its presence in drinking water together with wrong nutritional patterns is associated with an increase in the occurrence of metabolic disorders in young people. Degradation of mitochondria is presented by a specific form of autophagy called mitophagy which is an important landmark leading to apoptosis during lipotoxicity. Lipotoxicity and cellular toxicity due to arsenic intake can lead to changes in mitophagy and apoptosis. The protein derived from SQSTM1 gene, also called p62, plays an important role in energy homeostasis in the liver, and it can contribute to the regulation of autophagic responses given its effect on signaling of mTOR, MAPK, and NF-KB...
October 9, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30302119/biological-evaluation-of-different-extracts-of-aerial-parts-of-nepeta-deflersiana-and-standardization-of-active-extracts-using-8-epi-7-deoxyloganic-acid-and-ursolic-acid-by-validated-hptlc-method
#9
Raha Orfali, Nasir Ali Siddiqui, Perwez Alam, Tawfeq Abdullah Alhowiriny, Areej Mohammad Al-Taweel, Sami Al-Yahya, Najwa Mohammed Majrashi, Rashad Mehmood, Shabana Iqrar Khan, Shagufta Perveen
Nepeta deflersiana (Lamiaceae) is a well-known medicinal plant that grows in Saudi Arabia. This plant is used in Saudi and Yemeni folk medicine as an anti-inflammatory, carminative, and antirheumatic agent. In order to prove its use in folk medicine, four different extracts from the aerial parts of the plant: petroleum ether, chloroform, ethyl acetate, and n -butanol extracts were subjected to biological assays to screen PPAR α and PPAR ϒ agnostic, antioxidant, anti-inflammatory, and cytotoxic activities...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30294329/systemic-st6gal-1-is-a-pro-survival-factor-for-murine-transitional-b-cells
#10
Eric E Irons, Joseph T Y Lau
Humoral immunity depends on intrinsic B cell developmental programs guided by systemic signals that convey physiologic needs. Aberrant cues or their improper interpretation can lead to immune insufficiency or a failure of tolerance and autoimmunity. The means by which such systemic signals are conveyed remain poorly understood. Hence, further insight is essential to understanding and treating autoimmune diseases and to the development of improved vaccines. ST6Gal-1 is a sialyltransferase that constructs the α2,6-sialyl linkage on cell surface and extracellular glycans...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30288658/selenium-rich-yeast-protects-against-aluminum-induced-peroxidation-of-lipide-and-inflammation-in-mice-liver
#11
Junchong Luo, Xiaowen Li, Xinran Li, Yongming He, Mengdan Zhang, Changyu Cao, Kai Wang
To investigate the effect of Selenium Rich Yeast (SeY) on hepatotoxicity of Aluminium (Al), SeY (0.1 mg/kg) was orally administrated to aluminium-exposed mice (10 mg/kg) for 28 days. The risk of oxidative stress was assessed by detecting the total antioxidant capacity (T-AOC), catalase activity, H2 O2 content, and mRNA levels of the Keap1/Nrf-2/HO-1 pathway. Inflammatory reactions were assessed by detecting the mRNA levels of inflammatory biomarkers. Our results showed that SeY protected against the liver histological changes induce by Al...
October 4, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30288388/tlr4-myd88-mediated-ccl2-production-by-lipopolysaccharide-endotoxin-implications-for-metabolic-inflammation
#12
Nadeem Akhter, Amal Hasan, Steve Shenouda, Ajit Wilson, Shihab Kochumon, Shamsha Ali, Jaakko Tuomilehto, Sardar Sindhu, Rasheed Ahmad
Background: Obese human and mice were reported to have higher circularity endotoxin (LPS) levels as compared to their lean counter parts. The current study was aimed to reveal the molecular mechanisms underlying the LPS mediated induction of CCL2 in human monocytes/macrophages. Methods: Human monocytic cell line THP-1, THP-1 cells derived macrophages and primary macrophages were treated with LPS and TNF-α (positive control). CCL2 expression was determined with real-time RT-PCR and ELISA...
June 2018: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/30285722/inhibition-of-rankl-stimulated-osteoclast-differentiation-by-schisandra-chinensis-through-down-regulation-of-nfatc1-and-c-fos-expression
#13
Eun-Jung Kim, Haesu Lee, Mi Hye Kim, Woong Mo Yang
BACKGROUND: Schisandra chinenesis (SC) has been reported to have ameliorative effect on osteoporosis. However, the mechanisms underlying the anti-osteoporosis activity of SC have not been clearly elucidated. In the present study, we determined the effects of SC on The receptor activator of NF-kB ligand (RANKL)-induced osteoclastogenesis and its potential mechanism. METHODS: Raw 264.7 cells were treated with 0.6, 6 and 60 μg/mL SC in the presence of 100 ng/mL RANKL for 7 days...
October 1, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/30276150/astaxanthin-rich-haematococcus-pluvialis-algal-hepatic-modulation-in-d-galactose-induced-aging-in-rats-role-of-nrf2
#14
Farouk Kamel El-Baz, Rehab Ali Hussein, Gehad Abdel Raheem Abdel Jaleel, Dalia Osama Saleh
Purpose: Aging is associated with hepatic morphological and physiological deterioration due to the accumulation of endogenous and exogenous free radicals and the resultant oxidative stress. The present study aims to investigate the effect of Haematococcus pluvialis microalgae on hepatic changes associated with D-galactose (D-Gal)-induced aging in rats. Methods: Aging was induced in rats by daily intraperitoneal injection of D-Gal (200 mg/kg/day) for eight consecutive weeks. D-Gal-injected rats were treated by astaxanthin (ATX)-rich H...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30275391/aurantoside-c-targets-and-induces-apoptosis-in-triple-negative-breast-cancer-cells
#15
Sumi Shrestha, Anabel Sorolla, Jane Fromont, Pilar Blancafort, Gavin R Flematti
Triple negative breast cancer (TNBC) is a subtype of breast cancers that currently lacks effective targeted therapy. In this study, we found that aurantoside C (C828), isolated from the marine sponge Manihinea lynbeazleyae collected from Western Australia, exhibited higher cytotoxic activities in TNBC cells compared with non-TNBC (luminal and normal-like) cells. The cytotoxic effect of C828 was associated to the accumulation of cell at S-phase, resulting in the decline of cyclin D1, cyclin E1, CDK4, and CDK6, and an increase in p21...
October 1, 2018: Marine Drugs
https://www.readbyqxmd.com/read/30273982/high-mobility-group-box-1-induces-pro-inflammatory-signaling-in-human-nucleus-pulposus-cells-via-toll-like-receptor-4-dependent-pathway
#16
Bhranti S Shah, Kevin G Burt, Timothy Jacobsen, Tiago D Fernandes, D Olivier Alipui, Kathryn T Weber, Mitchell Levine, Sangeeta S Chavan, Huan Yang, Kevin J Tracey, Nadeen O Chahine
Intervertebral disc (IVD) degeneration (DD) is associated with low back pain, the leading cause of disability worldwide. Damage-associated molecular patterns (DAMPs) that contribute to inflammation and trigger DD have not been well characterized. Extracellular high mobility group box-1 (HMGB1) protein has been implicated as a potent DAMP and pro-inflammatory stimulus in the immune system. In this study, we show that HMGB1 and IL-6 levels increase in patients with advanced DD in comparison to early DD. This study further tested the hypothesis that HMGB1 promotes inflammatory signaling driving DD in human nucleus pulposus (NP) cells and tissue...
October 1, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30271706/the-creative-psychosocial-genomic-healing-experience-cpghe-and-gene-expression-in-breast-cancer-patients-a-feasibility-study
#17
Francisco V Muñoz, Linda Larkey
Background: Biomarkers associated with inflammation and immune function are increasingly being used to examine mechanisms of the effects of mind-body therapies. Less researched are biomarkers associated with cognitive and executive functioning in the study of mind-body therapy mechanisms and effects. This study explored the feasibility of recruiting breast cancer patients (BCPs) and implementation fidelity of participation in a research project utilizing the 4-stage Creative Psychosocial Genomic Healing Experience (CPGHE), a mind-body protocol that is theorized to create epigenetic effects via targeted psychological change in emotional triggers in coping with cancer...
April 2018: Advances in Integrative Medicine
https://www.readbyqxmd.com/read/30271656/the-synergy-of-aging-and-lps-exposure-in-a-mouse-model-of-parkinson-s-disease
#18
Yong-Fei Zhao, Qiong-Zhang, Jian-Feng Zhang, Zhi-Yin Lou, Hen-Bing Zu, Zi-Gao Wang, Wei-Cheng Zeng, Kai-Yao, Bao-Guo Xiao
Aging is an inevitable physiological challenge occurring in organisms over time, and is also the most important risk factor of neurodegenerative diseases. In this study, we observed cellular and molecular changes of different age mice and LPS-induced Parkinson disease (PD) model. The results showed that behavioral performance and dopaminergic (DA) neurons were declined, accompanied by increased expression of pro-inflammatory factors (TLR2, p-NF-kB-p65, IL-1β and TNF-α), as well as pro-oxidative stress factor gp91phox in aged mice compared with young mice...
October 2018: Aging and Disease
https://www.readbyqxmd.com/read/30267989/sodium-selenite-inhibits-mitophagy-downregulation-and-mislocalization-of-blood-testis-barrier-proteins-of-bovine-sertoli-cell-exposed-to-microcystin-leucine-arginine-mc-lr-via-tlr4-nf-kb-and-mitochondrial-signaling-pathways-blockage
#19
E O Adegoke, Wang Xue, N S Machebe, S O Adeniran, Wang Hao, Wang Chen, Zhang Han, Zhang Guixue, Zheng Peng
This study was conducted to investigate the ameliorative effect of selenium on microcystin-LR induced toxicity in bovine Sertoli cells. Bovine Sertoli cells were pretreated with selenium (Na2 SeO3 ) for 24 h after which selenium pretreated and non-pretreated Sertoli cells were cultured in medium containing 10% heat activated fetal bovine serum FBS+ 80 µg/L MC-LR to assess its ameliorative effect on MC-LR toxicity. The results show that selenium pretreatment inhibited the MC-LR induced mitophagy, downregulation and mislocalization of blood-testis barrier constituent proteins in bovine Sertoli cells via NF-kB and cytochrome c release blockage...
December 30, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30267786/review-on-molecular-and-biochemical-insights-of-arsenic-mediated-male-reproductive-toxicity
#20
REVIEW
Kaviyarasi Renu, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, Vinayagam Sathishkumar, V G Abilash
Arsenic is a natural metalloid found in abundance, in the environment. Exposure to arsenic can cause health issues due to its carcinogenic nature. The primary source of arsenic contact is drinking water. Exposure to arsenic in drinking water can cause reproductive dysfunction in males through a reduction in testes weight, accessory sex organ weight, viability, and motility of sperm, epididymal sperm count, decreased gonadotrophins level, decreased testosterone, and steroidogenesis disruption. This review focuses on the mechanisms by which arsenic impairs the quality of semen, based on epidemiological observations in humans, and experimental studies in different biological research models...
September 26, 2018: Life Sciences
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