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Chronic pulmonary obstructive disease

Y Tian, T Zeng, L Tan, Y Wu, J Yu, J Huang, Z Pei
No abstract text is available yet for this article.
August 14, 2018: British Journal of Biomedical Science
Henrik Svedsater, Helen A Doll, Jake Macey, Gail Miles, Lisa Bradshaw, Magdalena Vanya
INTRODUCTION: This study evaluated patients' experiences with fluticasone furoate/vilanterol (FF/VI) combination therapy in UK patients with asthma or chronic obstructive pulmonary disease (COPD). METHODS: Participants aged ≥ 18 years, with self-reported, physician-diagnosed asthma or COPD (≥ 1 year) who had been receiving FF/VI (≥ 3 months) were recruited from UK primary care. This two-phase, mixed-methods study consisted of a semi-structured, telephone-interview phase (qualitative) and a self-completed online/paper-survey phase (quantitative)...
August 13, 2018: Advances in Therapy
Mariela Razuc, Juliana Piña, María V Ramírez-Rigo
Ciprofloxacin is a broad-spectrum antibiotic for treatment of pulmonary diseases such as chronic obstructive pulmonary disease and cystic fibrosis. The purpose of this work was to rationally study the spray drying of ciprofloxacin in order to identify the formulation and operating conditions that lead to a product with aerodynamic properties appropriate for dry powder inhalation. A 24 - 1 fractional factorial design was applied to investigate the effect of selected variables (i.e., ciprofloxacin hydrochloride (CIP) concentration, drying air inlet temperature, feed flow rate, and atomization air flow rate) on several product and process parameters (i...
August 13, 2018: AAPS PharmSciTech
Xiaojiao Duan, Jiarui Wu, Xingyue Huang, Kaihuan Wang, Yi Zhao, Dan Zhang, Xinkui Liu, Xiaomeng Zhang
Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) imposes a huge economic burden on healthcare systems worldwide. Chinese herbal injections (CHIs) are widely used to treat AECOPD. In this study, we examined the efficacy of CHIs in the treatment of AECOPD using a network meta-analysis (NMA). Methods: Literature search was conducted from electronic databases of randomized controlled trials (RCTs) on CHIs plus Western medicine (WM) versus WM...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Gao Zhen, Wang Jing, Jing Jing, Dan Xu, Li Zheng, Fengsen Li
Objective. In China, the Chinese medicine formula modified zhisou powder (MZP) is commonly used to treat COPD with cold-dryness syndrome (CDSCOPD) to relieve cough and sputum. However, the underlying mechanisms of MZP on treating CDSCOPD remain to be elucidated. Methods . COPD and CDSCOPD rat models were established; MZP was given to CDSCOPD rats in the last 7 days of the 97-day model establishment. Then the rats were subjected to lung function measurement. Pathological changes in lungs were observed through paraffin section and H&E staining...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Adam J Białas, Paweł P Liberski, Anna Zielińska, Anna Kumor-Kisielewska, Karolina Szewczyk, Joanna Miłkowska-Dymanowska, Przemysław Sitarek, Wojciech J Piotrowski, Paweł Górski
Introduction: Exacerbations of chronic obstructive pulmonary disease (ECOPD) are important events in the course of the disease, negatively influencing health status and disease progression. Therefore, there is a strong need for deeper understanding of the pathology of ECOPD to elaborate new therapeutic approaches and ameliorate prognoses. Contributions of mitochondria to pathobiology of COPD are still under investigation, although growing evidence suggests their important role in this disease...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Wenqi Diao, Ning Shen, Yipeng Du, John R Erb-Downward, Xiaoyan Sun, Chenxia Guo, Qian Ke, Gary B Huffnagle, Margaret R Gyetko, Bei He
Background: The role of airway microbiota in COPD is highly debated. Symptomology assessment is vital for the management of clinically stable COPD patients; however, the link between symp toms and the airway microbiome is currently unknown. Purpose: The present study aimed to evaluate the relationship among stable COPD patients. Patients and methods: We conducted pyrosequencing of bacterial 16S rRNA using induced sputum samples in a Han Chinese cohort that included 40 clinically stable COPD patients and 19 healthy controls...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Jun-Ting Liou, Chen Wei Lin, Chen-Liang Tsai, Yun-Han Wang, Jyun-Heng Lai, Yu-Juei Hsu, Meng-Ting Wang
OBJECTIVE: To examine the risk of cardiovascular disease (CVD) from tiotropium added to inhaled long-acting β2 agonists (LABAs) and inhaled corticosteroids (ICSs) in a nationwide population with chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS: This nested case-control study included 65,966 patients with COPD treated with LABAs and ICSs identified from the Taiwan nationwide health care claims database from January 1, 2007, through June 30, 2011...
August 10, 2018: Mayo Clinic Proceedings
Alireza Karimi, Reza Razaghi
The mechanical functions of the lungs are concerned with ventilating the alveoli and aiding venous return to the heart. The mechanical properties of the lung allow this to be fulfilled with a very small expenditure of energy. Smoking via chronic obstructive pulmonary disease (COPD) can affect this mechanical function through the alteration of the mechanical properties of the lung tissue. So far, no study has been conducted to experimentally compare the in vitro mechanical properties of the human lung tissue among the healthy nonsmokers and unhealthy smokers...
July 29, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Yuan Cao, Xiaoyan Zhou, Zixiao Yin, Xinbo Yu, Qing Yang, Qikun Guo, Duxue Tian, Xiaoliang Xiong, Guogang Xu, Xiaodong Kuang
The aim of this study is to investigate whether the lipoxin receptor agonist BML-111 exerts a protective effect against inflammation in a mouse model of chronic obstructive pulmonary disease (COPD) by regulating NLRP3 inflammasome activation and reactive oxygen species (ROS) production. In this study, mice were randomly divided into the following five groups: control group (Control), COPD model group (Model), BML-111 low-dose group (Low-BML), BML-111 high-dose group (High-BML) and Dexamethasone group (Dex)...
August 10, 2018: Prostaglandins & Other Lipid Mediators
M Baré, L Mora, N Torà, M J Gil, I Barrio, P Collera, D Suárez, M Redondo, A Escobar, N Fernández de Larrea, J M Quintana
BACKGROUND: The aim of this study was to assess factors associated with outcomes after surgery for colorectal cancer and to design and internally validate a simple score for predicting perioperative mortality. METHODS: Patients undergoing surgery for primary invasive colorectal cancer in 22 centres in Spain between June 2010 and December 2012 were included. Clinical variables up to 30 days were collected prospectively. Multiple logistic regression techniques were applied and a risk score was developed...
August 13, 2018: British Journal of Surgery
Shohei Kawachi, Keisaku Fujimoto
Objective This study was performed to determine the usefulness of a newly developed spirometer for the quantitative assessment of dynamic lung hyperinflation (DLH) following incremental hyperventilation in chronic obstructive pulmonary disease (COPD). Methods The subjects were 54 patients with COPD and 25 healthy volunteers. Each subject was asked to hyperventilate for 30 s with stepwise increments starting at the resting respiration rate and increasing to respiratory rates of 20, 30, and finally 40 breaths/min while using a newly developed spirometer...
August 10, 2018: Internal Medicine
James Brian Byrd, David E Newby, Julie A Anderson, Peter M A Calverley, Bartolome R Celli, Nicholas J Cowans, Courtney Crim, Fernando J Martinez, Jørgen Vestbo, Julie Yates, Robert D Brook
Aims: To characterize the relationship between blood pressure (BP) or heart rate and mortality and morbidity in chronic obstructive pulmonary disease (COPD). Methods and results: We performed post hoc analysis of baseline BP or heart rate and all-cause mortality and cardiovascular events in the SUMMIT trial. SUMMIT was a randomized double-blind outcome trial of 16 485 participants (65 ± 8 years, 75% male, and 47% active smokers) enrolled at 1368 sites in 43 countries...
August 7, 2018: European Heart Journal
Puneet Khanna, Ravinder Kumar Pandey, Chandralekha Chandralekha, Ankur Sharma, Neha Pangasa
Background and Objectives: Pain assessment of nonverbal, critically ill patients continues to present a challenge in Intensive Care Unit (ICU). The Critical-Care Pain Observation Tool (CPOT) rates critically ill patients' pain based on clinical observation. In the present study, the accuracy of CPOT was compared with physiological indicators of pain in mechanically ventilated, critically ill patients. Methods: This quantitative prospective observational study was conducted to assess pain in the critically ill, mechanically ventilated patients in comparison to physiologic indicators such as blood pressure and heart rate...
July 2018: Saudi Journal of Anaesthesia
David Morley, Sarah Dummett, Laura Kelly, Crispin Jenkinson
Background: The recently validated Oxford Participation and Activities Questionnaire (Ox-PAQ) is a 23-item patient-reported outcome measure, theoretically grounded in the World Health Organization International Classification of Functioning, Disability and Health. The measure is specifically designed to assess participation and activity in people experiencing a range of health conditions. Initial validation of the Ox-PAQ identified three domains: Routine Activities (14 items), Emotional Well-Being (5 items), and Social Engagement (4 items)...
2018: Patient related Outcome Measures
Yong Suk Jo, Yee Hyung Kim, Jung Yeon Lee, Kyungjoo Kim, Ki-Suck Jung, Kwang Ha Yoo, Chin Kook Rhee
Background and objective: The rate of obesity is increasing in Asia, but the clinical impact of body mass index (BMI) on the outcome of chronic obstructive pulmonary disease (COPD) remains unknown. We aimed to assess this impact while focusing on the risk of exacerbation, health-care utilization, and medical costs. Methods: We examined 43,864 subjects registered in the Korean National Health and Nutrition Examination Survey (KNHANES) database from 2007 to 2012, and linked the data of COPD patients who had mild to moderate airflow obstruction (n = 1,320) to National Health Insurance (NHI) data...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Lena Heinbockel, Sebastian Marwitz, Andra B Schromm, Henrik Watz, Christian Kugler, Ole Ammerpohl, Karoline Schnepf, Klaus F Rabe, Daniel Droemann, Torsten Goldmann
Introduction: As part of a study aimed at illuminating at least some of the complex molecular events taking place in COPD, we screened tissues by means of transcriptome analyses. Materials and methods: Tissues were subjected to transcriptome analysis. Candidate genes were identified and validated by immunohistochemistry. Primary human lung cells were subjected to stimulation with cigarette smoke extract for further validation by real time PCR. Results: Six candidate genes were selected for further investigations: Aquaporin 3 ( AQP3 ), extracellular matrix protein 1 ( ECM1 ), four and a half LIM domain 1 ( FHL1 ), milk fat globule epidermal growth factor 8 ( MFGE8 , lactadherin), phosphodiesterase 4D-interacting protein ( PDE4DIP ), and creatine transporter SLC6A8 ...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Aurélien Belot, Helen Fowler, Edmund Njeru Njagi, Miguel-Angel Luque-Fernandez, Camille Maringe, Winnie Magadi, Aimilia Exarchakou, Manuela Quaresma, Adrian Turculet, Michael D Peake, Neal Navani, Bernard Rachet
INTRODUCTION: We investigated socioeconomic disparities and the role of the main prognostic factors in receiving major surgical treatment in patients with lung cancer in England. METHODS: Our study comprised 31 351 patients diagnosed with non-small cell lung cancer in England in 2012. Data from the national population-based cancer registry were linked to Hospital Episode Statistics and National Lung Cancer Audit data to obtain information on stage, performance status and comorbidities, and to identify patients receiving major surgical treatment...
August 12, 2018: Thorax
Carmen M Lara-Rojas, Luis M Pérez-Belmonte, María D López-Carmona, Ricardo Guijarro-Merino, María R Bernal-López, Ricardo Gómez-Huelgas
AIMS: To analyze national trends in the rates of hospitalizations (all-cause and by principal discharge diagnosis) in total diabetic population of Spain. METHODS: We carried out a nation-wide population-based study of all diabetic patients hospitalized between 1997 and 2010. All-cause hospitalizations, hospitalizations by principal discharge diagnosis, mean age, Charlson Comorbidity Index, readmission rates and length of hospital stay were examined. Annual rates adjusted for age and sex were analyzed and trends were calculated...
August 9, 2018: European Journal of Internal Medicine
Renate Jonker, Nicolaas E P Deutz, Gerdien C Ligthart-Melis, Anthony J Zachria, Eugene A Veley, Rajesh Harrykissoon, Mariëlle P K J Engelen
BACKGROUND & AIMS: Assessing the ability to respond anabolic to dietary protein intake during illness provides important insight in the capacity of lean body mass maintenance. We applied a newly developed stable tracer approach to assess in one session in patients with chronic obstructive pulmonary disease (COPD) and healthy older adults both the minimal amount of protein intake to obtain protein anabolism (anabolic threshold) and the efficiency of dietary protein to promote protein anabolism (anabolic capacity)...
July 31, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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