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catalytic nanomedicine

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https://www.readbyqxmd.com/read/30063328/mercaptopyrimidine-conjugated-gold-nanoclusters-as-nanoantibiotics-for-combating-multidrug-resistant-superbugs
#1
Youkun Zheng, Weiwei Liu, Zhaojian Qin, Yun Chen, Hui Jiang, Xuemei Wang
Widespread bacterial resistance induced by the abuse of antibiotics eagerly needs the exploitation of novel antimicrobial agents and strategies. Gold nanoclusters (Au NCs) have recently emerged as an innovative nanomedicine, but study on their antibacterial properties especially towards multidrug resistant (MDR) bacteria is scarce. Herein, we demonstrate that a novel class of Au NCs, mercaptopyrimidine conjugated Au NCs, can act as potent nanoantibiotics targeting these intractable superbugs in vitro and in vivo, without induction of bacterial antibiotic resistance and noticeable cytotoxicity to mammalian cells...
July 31, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/30062803/functional-dna-driven-dynamic-nanoconstructs-for-biomolecule-capture-and-drug-delivery
#2
REVIEW
Jinhwan Kim, Donghyun Jang, Hyeongmok Park, Sungjin Jung, Dae Heon Kim, Won Jong Kim
The discovery of sequence-specific hybridization has allowed the development of DNA nanotechnology, which is divided into two categories: 1) structural DNA nanotechnology, which utilizes DNA as a biopolymer; and 2) dynamic DNA nanotechnology, which focuses on the catalytic reactions or displacement of DNA structures. Recently, numerous attempts have been made to combine DNA nanotechnologies with functional DNAs such as aptamers, DNAzymes, amplified DNA, polymer-conjugated DNA, and DNA loaded on functional nanoparticles for various applications; thus, the new interdisciplinary research field of "functional DNA nanotechnology" is initiated...
July 30, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29881657/recent-advances-and-future-prospects-of-iron-oxide-nanoparticles-in-biomedicine-and-diagnostics
#3
REVIEW
N V Srikanth Vallabani, Sanjay Singh
Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as chemically inert materials and, therefore, being extensively applied in the areas of imaging, targeting, drug delivery and biosensors. Their unique properties such as low toxicity, biocompatibility, potent magnetic and catalytic behavior and superior role in multifunctional modalities have epitomized them as an appropriate candidate for biomedical applications. Recent developments in the area of materials science have enabled the facile synthesis of Iron oxide nanoparticles (IONPs) offering easy tuning of surface properties and surface functionalization with desired biomolecules...
June 2018: 3 Biotech
https://www.readbyqxmd.com/read/29870667/dna-responsive-sio-2-nanoparticles-metal-organic-frameworks-and-microcapsules-for-controlled-drug-release
#4
Margarita Vázquez-González, Itamar Willner
Recent advances addressing the development of stimuli-responsive nucleic acid (DNA)-functionalized micro/nanocarriers for the controlled release of drugs are presented. The DNA associated with the drug-loaded carriers acts as capping units that lock the drugs in the carriers. In the presence of appropriate triggers, the capping units are unlocked, resulting in the release of the drugs. Three types of DNA-modified carriers are discussed, including mesoporous SiO2 nanoparticles (MP SiO2 NPs), metal-organic framework nanoparticles (NMOFs) and micro/nanocapsules...
June 25, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29613770/nanoenzyme-augmented-cancer-sonodynamic-therapy-by-catalytic-tumor-oxygenation
#5
Piao Zhu, Yu Chen, Jianlin Shi
Ultrasound (US)-triggered sonodynamic therapy (SDT) can solve the critical issue of low tissue-penetrating depth of traditional phototriggered therapies, but the SDT efficacy is still not satisfactorily high in combating cancer at the current stage. Here we report on augmenting the SDT efficacy based on catalytic nanomedicine, which takes the efficient catalytic features of nanoenzymes to modulate the tumor microenvironment (TME). The multifunctional nanosonosensitizers have been successfully constructed by the integration of a MnO x component with biocompatible/biodegradable hollow mesoporous organosilica nanoparticles, followed by conjugation with protoporphyrin (as the sonosensitizer) and cyclic arginine-glycine-aspartic pentapeptide (as the targeting peptide)...
April 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29570975/in-situ-observation-of-chymotrypsin-catalytic-activity-change-actuated-by-nonheating-low-frequency-magnetic-field
#6
Maria V Efremova, Maxim M Veselov, Alexander V Barulin, Sergey L Gribanovsky, Irina M Le-Deygen, Igor V Uporov, Elena V Kudryashova, Marina Sokolsky-Papkov, Alexander G Majouga, Yuri I Golovin, Alexander V Kabanov, Natalia L Klyachko
Magnetomechanical modulation of biochemical processes is a promising instrument for bioengineering and nanomedicine. This work demonstrates two approaches to control activity of an enzyme, α-chymotrypsin immobilized on the surface of gold-coated magnetite magnetic nanoparticles (GM-MNPs) using a nonheating low-frequency magnetic field (LF MF). The measurement of the enzyme reaction rate was carried out in situ during exposure to the magnetic field. The first approach involves α-chymotrypsin-GM-MNPs conjugates, in which the enzyme undergoes mechanical deformations with the reorientation of the MNPs under LF MF (16-410 Hz frequency, 88 mT flux density)...
April 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29368503/water-on-graphene-coated-tio-2-role-of-atomic-vacancies
#7
Martina Datteo, Hongsheng Liu, Cristiana Di Valentin
Beyond two-dimensional (2D) materials, interfaces between 2D materials and underlying supports or 2D-coated metal or metal oxide nanoparticles exhibit excellent properties and promising applications. The hybrid interface between graphene and anatase TiO2 shows great importance in photocatalytic, catalytic, and nanomedical applications due to the excellent and complementary properties of the two materials. Water, as a ubiquitous and essential element in practical conditions and in the human body, plays a significant role in the applications of graphene/TiO2 composites for both electronic devices and nanomedicine...
February 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29226025/permeable-protein-loaded-polymersome-cascade-nanoreactors-by-polymerization-induced-self-assembly
#8
Lewis D Blackman, Spyridon Varlas, Maria C Arno, Alice Fayter, Matthew I Gibson, Rachel K O'Reilly
Enzyme loading of polymersomes requires permeability to enable them to interact with the external environment, typically requiring addition of complex functionality to enable porosity. Herein, we describe a synthetic route towards intrinsically permeable polymersomes loaded with functional proteins using initiator-free visible light-mediated polymerization-induced self-assembly (photo-PISA) under mild, aqueous conditions using a commercial monomer. Compartmentalization and retention of protein functionality was demonstrated using green fluorescent protein as a macro-molecular chromophore...
October 31, 2017: ACS Macro Letters
https://www.readbyqxmd.com/read/29168377/universal-porphyrinic-metal-organic-framework-coating-to-various-nanostructures-for-functional-integration
#9
Jin-Yue Zeng, Xiao-Shuang Wang, Ming-Kang Zhang, Zi-Hao Li, Dan Gong, Pei Pan, Lin Huang, Si-Xue Cheng, Han Cheng, Xian-Zheng Zhang
A universal strategy was reported that enables functional group-capped nanostructures with various morphologies and compositions to be coated by porphyrin metal-organic framework (MOF). Based on the nanostructure-induced heterogeneous nucleation, the controlled growth of MOF shell on the surface of nanostructures can be realized. It was demonstrated that this modification strategy can realize controlled growth of porphyrin MOF on a series of organic and inorganic nanostructures, such as polydopamine (PDA) nanoparticles, PDA@Pt nanoparticles, graphene oxide sheets, and Au nanorods...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29105872/dendritic-and-core-shell-corona-mesoporous-sister-nanospheres-from-polymer-surfactant-silica-self-entanglement
#10
Kun Zhang, Tai-Qun Yang, Bing-Qian Shan, Peng-Cheng Liu, Bo Peng, Qing-Song Xue, En-Hui Yuan, Peng Wu, Belén Albela, Laurent Bonneviot
Mesoporous nanospheres are highly regarded for their applications in nanomedicine, optical devices, batteries, nanofiltration, and heterogeneous catalysis. In the last field, the dendritic morphology, which favors molecular diffusion, is a very important morphology known for silica, but not yet for carbon. A one-pot, easy, and scalable co-sol-gel route by using the triphasic resol-surfactant-silica system is shown to yield the topologies of dendritic and core-shell-corona mesoporous sister nanospheres by inner radial phase speciation control on a mass-transfer-limited process, depending on the relative polycondensation rates of the resol polymer and silica phases...
January 9, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28842577/tumor-selective-catalytic-nanomedicine-by-nanocatalyst-delivery
#11
Minfeng Huo, Liying Wang, Yu Chen, Jianlin Shi
Tumor cells metabolize in distinct pathways compared with most normal tissue cells. The resulting tumor microenvironment would provide characteristic physiochemical conditions for selective tumor modalities. Here we introduce a concept of sequential catalytic nanomedicine for efficient tumor therapy by designing and delivering biocompatible nanocatalysts into tumor sites. Natural glucose oxidase (GOD, enzyme catalyst) and ultrasmall Fe3 O4 nanoparticles (inorganic nanozyme, Fenton reaction catalyst) have been integrated into the large pore-sized and biodegradable dendritic silica nanoparticles to fabricate the sequential nanocatalyst...
August 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28783260/plasma-proteome-association-and-catalytic-activity-of-stealth-polymer-grafted-iron-oxide-nanoparticles
#12
Miaoyi Wang, Ghizal Siddiqui, Ove J R Gustafsson, Aleksandr Käkinen, Ibrahim Javed, Nicolas H Voelcker, Darren J Creek, Pu Chun Ke, Thomas P Davis
Polyethylene glycol (PEG) is widely used as an antifouling and stealth polymer in surface engineering and nanomedicine. However, recent research has revealed adverse effects of bioaccumulation and immunogenicity following the administration of PEG, prompting this proteomic examination of the plasma protein coronae association with superparamagnetic iron oxide nanoparticles (IONPs) grafted with brushed PEG (bPEG) and an alternative, brushed phosphorylcholine (bPC). Using label-free quantitation by liquid chromatography tandem-mass spectrometry, this study determines protein abundances for the in vitro hard coronae of bare, bPC-, and bPEG-grafted IONPs in human plasma...
August 7, 2017: Small
https://www.readbyqxmd.com/read/28696452/platinum-nanoparticles-in-nanobiomedicine
#13
REVIEW
Deborah Pedone, Mauro Moglianetti, Elisa De Luca, Giuseppe Bardi, Pier Paolo Pompa
Oxidative stress-dependent inflammatory diseases represent a major concern for the population's health worldwide. Biocompatible nanomaterials with enzymatic properties could play a crucial role in the treatment of such pathologies. In this respect, platinum nanoparticles (PtNPs) are promising candidates, showing remarkable catalytic activity, able to reduce the intracellular reactive oxygen species (ROS) levels and impair the downstream pathways leading to inflammation. This review reports a critical overview of the growing evidence revealing the anti-inflammatory ability of PtNPs and their potential applications in nanomedicine...
August 14, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28382172/theranostic-dnazymes
#14
REVIEW
Wenhu Zhou, Jinsong Ding, Juewen Liu
DNAzymes are catalytically active DNA molecules that are obtained via in vitro selection. RNA-cleaving DNAzymes have attracted significant attention for both therapeutic and diagnostic applications due to their excellent programmability, stability, and activity. They can be designed to cleave a specific mRNA to down-regulate gene expression. At the same time, DNAzymes can sense a broad range of analytes. By combining these two functions, theranostic DNAzymes are obtained. This review summarizes the progress of DNAzyme for theranostic applications...
2017: Theranostics
https://www.readbyqxmd.com/read/27723942/covalent-and-non-covalent-dna-gold-nanoparticle-interactions-new-avenues-of-research
#15
REVIEW
Jose M Carnerero, Aila Jimenez-Ruiz, Paula M Castillo, Rafael Prado-Gotor
The interactions of DNA, whether long, hundred base pair chains or short-chained oligonucleotides, with ligands play a key role in the field of structural biology. Its biological activity not only depends on the thermodynamic properties of DNA-ligand complexes, but can and often is conditioned by the formation kinetics of those complexes. On the other hand, gold nanoparticles have long been known to present excellent biocompatibility with biomolecules and are themselves remarkable for their structural, electronic, magnetic, optical and catalytic properties, radically different from those of their counterpart bulk materials, and which make them an important asset in multiple applications...
January 4, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27341699/cell-membrane-penetration-and-mitochondrial-targeting-by-platinum-decorated-ceria-nanoparticles
#16
Adriano A Torrano, Rudolf Herrmann, Claudia Strobel, Markus Rennhak, Hanna Engelke, Armin Reller, Ingrid Hilger, Achim Wixforth, Christoph Bräuchle
In this work we investigate the interaction between endothelial cells and nanoparticles emitted by catalytic converters. Although catalyst-derived particles are recognized as growing burden added to environmental pollution, very little is known about their health impact. We use platinum-decorated ceria nanoparticles as model compounds for the actual emitted particles and focus on their fast uptake and association with mitochondria, the cell's powerhouse. Using live-cell imaging and electron microscopy we clearly show that 46 nm platinum-decorated ceria nanoparticles can rapidly penetrate cell membranes and reach the cytosol...
July 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27268019/alloyed-crystalline-au-ag-hollow-nanostructures-with-high-chemical-stability-and-catalytic-performance
#17
Renxiao Liu, Jianhua Guo, Gang Ma, Peng Jiang, Donghui Zhang, Dexing Li, Lan Chen, Yuting Guo, Guanglu Ge
For bimetallic nanoparticles (NPs), the degree of alloying is beginning to be recognized as a significant factor affecting the NP properties. Here, we report an alloyed crystalline Au-Ag hollow nanostructure that exhibits a high catalytic performance, as well as structural and chemical stability. The Au-Ag alloyed hollow and porous nanoshell structures (HPNSs) with different morphologies and subnanoscale crystalline structures were synthesized by adjusting the size of the sacrificial Ag NPs via a galvanic replacement reaction...
July 6, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26788907/wo3-pt-nanoparticles-promote-light-induced-lipid-peroxidation-and-lysosomal-instability-within-tumor-cells
#18
Andrea J Clark, Howard R Petty
Although metal-metal oxide nanoparticles have attracted considerable interest as catalysts, they have attracted little interest in nanomedicine. This is likely due to the fact that metal oxide semiconductors generally require biologically harmful ultraviolet excitation. In contrast, this study focuses upon WO3/Pt nanoparticles, which can be excited by visible light. To optimize the nanoparticles' catalytic performance, platinization was performed at alkaline pH. These nanoparticles destroyed organic dyes, consumed dissolved oxygen and produced hydroxyl radicals...
February 19, 2016: Nanotechnology
https://www.readbyqxmd.com/read/26344402/exploring-environment-dependent-effects-of-pd-nanostructures-on-reactive-oxygen-species-ros-using-electron-spin-resonance-esr-technique-implications-for-biomedical-applications
#19
Tao Wen, Weiwei He, Yu Chong, Yi Liu, Jun-Jie Yin, Xiaochun Wu
Recently, because of the great advances in tailoring their shape and structure, palladium nanoparticles (Pd NPs) have been receiving increasing attention in biomedical fields apart from their traditional application as industrial catalysts. When considering the potential uses of Pd NPs in biomedicine, their catalytic properties need to be evaluated under physiologically relevant conditions. In this article, we demonstrate that Pd nanostructures (NSs, both commercial Pd NPs and in-house-prepared Au@Pd nanorods) can induce O2 or ˙OH production depending on pH values in the presence of H2O2...
October 14, 2015: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/26104191/plasma-treatment-for-next-generation-nanobiointerfaces
#20
REVIEW
Igor Levchenko, Michael Keidar, Anne Mai-Prochnow, Martina Modic, Uros Cvelbar, Jinghua Fang, Kostya Ken Ostrikov
Energy deficiency, global poverty, chronic hunger, chronic diseases, and environment conservation are among the major problems threatening the whole mankind. Nanostructure-based technologies could be a possible solution. Such techniques are now used for the production of many vitally important products including cultured and fermented food, antibiotics, various medicines, and biofuels. On the other hand, the nanostructure-based technologies still demonstrate low efficiency and controllability, and thus still are not capable to decisively address the global problems...
2015: Biointerphases
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