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Melanoma neuronal learning

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https://www.readbyqxmd.com/read/24700102/maged1-co-interacting-with-creb-through-a-hexapeptide-repeat-domain-regulates-learning-and-memory-in-mice
#1
JianJun Yang, BeiBei Lai, AiLi Xu, Yu Liu, XiaoMin Li, YongNa Zhao, WeiFeng Li, MuHuo Ji, Gang Hu, Xiang Gao, Jun Gao
Maged1 is a member of the type II melanoma antigen (MAGE) family of proteins, which is highly conserved in the brain between mouse and human. Recently, Maged1 has been reported to be involved in depression and impaired sexual behavior. However, the role of Maged1 in learning and memory remains unknown. The aim of the present study was therefore to investigate whether Maged1 deficiency can impair learning and memory formation. By behavioral tests and electrophysiological recording, we observed that 5-6-month-old Maged1 knockout mice displayed the reduced basal synaptic transmission, pronounced hippocampal dysfunction, impaired spatial learning, and a deficit in long-term potentiation induction...
February 2015: Molecular Neurobiology
https://www.readbyqxmd.com/read/23622385/disorders-of-nucleotide-excision-repair
#2
REVIEW
Isabelle Rapin
Deficient repair of ubiquitous errors in the genome risks faulty transcription or replication. Its direct and indirect phenotypic consequences are rare, complex, dementing, lethal disorders of children with inadequately understood overlapping genotypes and variable severity. Mutations of CSA or CSB responsible for impaired transcription-coupled repair cause Cockayne syndrome (CS). Its characteristics are (1) profound growth deficiency affecting all tissues, including the brain, (2) premature aging marked by cachexia, vascular disease, exocrine deficiency, and osteopenia, but not cancer, and (3) a selective degenerative disorder of central and peripheral myelin and by neuronal loss in the retina and inner ear, and in the cerebellum and basal ganglia where it is associated with calcification...
2013: Handbook of Clinical Neurology
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