JianJun Yang, BeiBei Lai, AiLi Xu, Yu Liu, XiaoMin Li, YongNa Zhao, WeiFeng Li, MuHuo Ji, Gang Hu, Xiang Gao, Jun Gao
Maged1 is a member of the type II melanoma antigen (MAGE) family of proteins, which is highly conserved in the brain between mouse and human. Recently, Maged1 has been reported to be involved in depression and impaired sexual behavior. However, the role of Maged1 in learning and memory remains unknown. The aim of the present study was therefore to investigate whether Maged1 deficiency can impair learning and memory formation. By behavioral tests and electrophysiological recording, we observed that 5-6-month-old Maged1 knockout mice displayed the reduced basal synaptic transmission, pronounced hippocampal dysfunction, impaired spatial learning, and a deficit in long-term potentiation induction...
February 2015: Molecular Neurobiology