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https://www.readbyqxmd.com/read/29034719/the-tailored-activity-program-tap-to-address-behavioral-disturbances-in-frontotemporal-dementia-a-feasibility-and-pilot-study
#1
Claire M O'Connor, Lindy Clemson, Henry Brodaty, Lee-Fay Low, Yun-Hee Jeon, Laura N Gitlin, Olivier Piguet, Eneida Mioshi
PURPOSE: To explore the feasibility of implementing the Tailored Activity Program with a cohort of people with frontotemporal dementia and their carers (dyads). METHODS: The Tailored Activity Program is an occupational therapy based intervention that involves working collaboratively with family carers and prescribes personalized activities for behavioral management in people with dementia. Twenty dyads randomized into the study (Tailored Activity Program: n = 9; Control: n = 11) were assessed at baseline and 4-months...
October 15, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29030301/biodegradable-zwitterionic-sulfobetaine-polymer-and-its-conjugate-with-paclitaxel-for-sustained-drug-delivery
#2
Haotian Sun, Michael Yu Zarng Chang, Wei-I Cheng, Qing Wang, Alex Commisso, Meghan Capeling, Yun Wu, Chong Cheng
A fully biodegradable zwitterionic polymer and the corresponding conjugate with paclitaxel (PTX) were synthesized as promising biomaterials. Allyl-functionalized polylactide (PLA) was employed as the precursor of polymer backbones. UV-induced thiol-ene reaction was conducted to conjugate thiol-functionalized sulfobetaine (SB) with the PLA-based backbone. The resulting zwitterionic polymer did not exhibit considerable cytotoxicity. A polymer-drug conjugate was also obtained by thiol-ene reaction of both thiol-functionalized SB and PTX with allyl-functionalized PLA...
October 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29028444/development-and-in-house-validation-of-a-real-time-polymerase-chain-reaction-for-the-detection-of-listeria-monocytogenes-in-meat
#3
Camilo Reyes, Luciano H Linares, Fabiana Moredo, Juan P Lirón, Victoria Brusa, Alejandra Londero, Lucía Galli, Juan M Oteiza, Magdalena Costa, Gerardo A Leotta
Listeriosis is a foodborne disease caused by Listeria monocytogenes. The aims of this work were to develop and validate an in-house real-time polymerase chain reaction (RT-PCR) for the detection of L. monocytogenes, and to determine its prevalence in raw ground beef samples from 53 butcheries that also sell ready-to-eat foods. One set of primers and one hydrolysis probe were designed for hly gene detection and then challenged with pure strains. The detection was successful for all L. monocytogenes strains analyzed and negative for all non-L...
October 13, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29024363/prevalence-predictors-and-correlates-of-insomnia-in-us-army-soldiers
#4
Elizabeth A Klingaman, Janeese A Brownlow, Elaine M Boland, Caterina Mosti, Philip R Gehrman
The objective of this study was to investigate the rates, predictors and correlates of insomnia in a national sample of US Army soldiers. Data were gathered from the cross-sectional survey responses of the All-Army Study, of the Army Study to Assess Risk and Resilience in Service members. Participants were a representative sample of 21 499 US Army soldiers who responded to the All-Army Study self-administered questionnaire between 2011 and 2013. Insomnia was defined by selected DSM-5 criteria using the Brief Insomnia Questionnaire...
October 11, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/29020853/blood-based-protein-biomarkers-for-the-management-of-traumatic-brain-injuries-in-adults-presenting-with-mild-head-injury-to-emergency-departments-a-living-systematic-review-and-meta-analysis
#5
Stefania Mondello, Abayomi Sorinola, Endre Czeiter, Zoltán Vámos, Krisztina Amrein, Anneliese Synnot, Emma L Donoghue, János Sándor, Kevin K W Wang, Ramon Diaz-Arrastia, Ewout W Steyerberg, David Menon, Andrew Maas, Andras Buki
Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and intervention, but can be challenging in patients with mild TBI. A substantial number of studies have reported the use of circulating biomarkers as signatures for TBI, capable of improving diagnostic accuracy and clinical decision-making beyond current practice standards. We performed a systematic review and meta-analysis to comprehensively and critically evaluate the existing body of evidence for the use of blood protein biomarkers (S100B, GFAP, NSE, UCH-L1, Tau and Neurofilament proteins) for diagnosis of intracranial lesions on CT following mild TBI...
October 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28991845/a-purpose-driven-fourth-year-of-medical-school
#6
Mantosh Dewan, John Norcini
The fourth year of medical school has been repeatedly found to be ineffective, and concerns exist about its purpose and academic quality, as well as grade inflation. Since Flexner, the purpose of undergraduate medical training has moved from readiness for independent practice to readiness for postgraduate training. However, training directors report that medical graduates are inadequately prepared to enter residency. The authors propose a fourth year with two components: first, a yearlong, longitudinal ambulatory experience of at least three days each week on an interprofessional team with consistent faculty supervision and mentoring, increasing independence, and a focus on education; and second, rigorous clinical-scales-based assessment of meaningful outcomes...
October 3, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28991149/decisional-informatics-for-psychosocial-rehabilitation-a-feasibility-pilot-on-tailored-and-fluid-treatment-algorithms-for-serious-mental-illness
#7
Jimmy Choi, Paul H Lysaker, Morris D Bell, Lisa Dixon, Paul Margolies, Matthew Gold, Elizabeth Golden-Roose, Warren Thime, Lawrence C Haber, Michael J Dewberry, Michael Stevens, Godfrey D Pearlson, Joanna M Fiszdon
This study introduces a computerized clinical decision-support tool, the Fluid Outpatient Rehabilitation Treatment (FORT), that incorporates individual and ever-evolving patient needs to guide clinicians in developing and updating treatment decisions in real-time. In this proof-of-concept feasibility pilot, FORT was compared against traditional treatment planning using similar behavioral therapies in 52 adults with severe mental illness attending community-based day treatment. At posttreatment and follow-up, group differences and moderate-to-large effect sizes favoring FORT were detected in social function, work readiness, self-esteem, working memory, processing speed, and mental flexibility...
October 4, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28988138/mousetox-an-online-toxicity-assessment-tool-for-small-molecules-through-enalos-cloud-platform
#8
Dimitra-Danai Varsou, Georgia Melagraki, Haralambos Sarimveis, Antreas Afantitis
Advances in the drug discovery research substantially depend on in silico methods and techniques that capitalize on experimental data to enable the accurate property/activity assessment by employing a variety of computational techniques. These in silico tools can significantly reduce expensive and time consuming experimental procedures required and are strongly recommended to avoid animal testing, especially as far as toxicity evaluation and risk assessment is concerned. In this context, in the present work we aim to develop a predictive model for the cytotoxic effects of a wide range of compounds based solely on calculated molecular descriptors that account for their topological, geometric and structural characteristics...
October 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28983942/dentists-opinions-on-using-digital-technologies-in-dental-practice
#9
Marieke M van der Zande, Ronald C Gorter, Josef J M Bruers, Irene H A Aartman, Daniel Wismeijer
OBJECTIVES: To investigate which opinions among dentists are associated with level of technology use, when characteristics of the dentist and dental practice, as well as motivating work aspects are taken into account. METHODS: A total of 1000 general dental practitioners in the Netherlands received a questionnaire on digital technologies they use, opinions on using technologies and related motivating work aspects. Questions were derived from expert interviews, the Dentists' Experienced Job Resources Scale and literature on technology implementation...
October 6, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28980114/cancer-survivors-social-context-in-the-return-to-work-process-narrative-accounts-of-social-support-and-social-comparison-information
#10
M Armaou, L Schumacher, E A Grunfeld
Purpose Returning to work is a process that is intertwined with the social aspects of one's life, which can influence the way in which that person manages their return to work and also determines the support available to them. This study aimed to explore cancer patients' perceptions of the role of their social context in relation to returning to work following treatment. Methods Twenty-three patients who had received a diagnosis of either urological, breast, gynaecological, or bowel cancer participated in semi-structured interviews examining general perceptions of cancer, work values and perceptions of the potential impact of their cancer diagnosis and treatment on work...
October 4, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28977717/a-collaborative-in-situ-simulation-based-pediatric-readiness-improvement-program-for-community-emergency-departments
#11
Kamal Abulebda, Riad Lutfi, Travis Whitfill, Samer Abu-Sultaneh, Kellie J Leeper, Elizabeth Weinstein, Marc A Auerbach
BACKGROUND: More than 30 million children are cared for across 5,000 US emergency departments each year (ED). Most of these EDs are not facilities designed and operated solely for children. A web-based survey provided a national and state-by-state assessment of pediatric readiness and noted a national average score was 69 on a 100-point scale. This survey noted wide variations in ED readiness with scores ranging from 61 in low-pediatric-volume EDs to 90 in the high-pediatric-volume EDs...
October 4, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28970040/-the-private-pediatrician-in-the-clinical-care-pathway-for-children-affected-by-specific-learning-disorders-in-france
#12
T-N Willig, J P Blanc, R Assathiany
The clinical care pathway for children presenting specific learning disorders, including language, motor coordination, and attention disorders is based on different levels of assessment by the professionals involved. In France, a first step of organization was established in 2002 by founding of a network of structures devoted to clinical assessment of complex cases, research, and teaching for the professionals involved. Although this organization proved to contribute an essential service, the demand largely exceeded the availability of access...
September 29, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28969346/priorities-for-implementing-nutritional-science-into-practice-to-optimize-military-performance
#13
Pamela Elfenbaum, Cindy Crawford, Viviane Enslein, Kevin Berry
The Metabolically Optimized Brain study explores nutritional science believed to be ready to place into practice to help improve US service member mission-readiness and performance. To this end, an implementation expert panel considered how the US Department of Defense Subsistence Food Service Program, which is operated by each branch of the military in dining facilities within the continental United States, could apply the best nutritional science in a cost-effective manner. The work of this panel was facilitated through a series of thematic conversations guided by evidence generated through systematic reviews, which were performed to identify systems and process gaps and propose possible solutions...
June 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28968064/fully-stretchable-textile-triboelectric-nanogenerator-with-knitted-fabric-structures
#14
Sung Soo Kwak, Han Kim, Wanchul Seung, Jihye Kim, Ronan Hinchet, Sang-Woo Kim
Harvesting human-motion energy for power-integrated wearable electronics could be a promising way to extend the battery-operation time of small low-power-consumption electronics such as various sensors. For this purpose, a fully stretchable triboelectric nanogenerator (S-TENG) that has been fabricated with knitted fabrics and has been integrated with the directly available materials and techniques of the textile industry is introduced. This device has been adapted to cloth movement and can generate electricity under compression and stretching...
October 2, 2017: ACS Nano
https://www.readbyqxmd.com/read/28958192/the-effects-of-leadership-competencies-and-quality-of-work-on-the-perceived-readiness-for-organizational-change-among-nurse-managers
#15
Mahmoud Al-Hussami, Sawsan Hamad, Muhammad Darawad, Mahmoud Maharmeh
Purpose This paper aims to set a leadership guidance program that can promote nurses' knowledge of leadership and, at the same time, to enhance their leadership competencies and quality of work to promote their readiness for change in healthcare organizations. Design/methodology/approach A pre-experimental, one-group pretest-posttest design was utilized. Out of 90 invited to participate in this study, 61 nurses were accepted to participate. Findings The statistical analyses suggested several significant differences between pre- and in-service nurse managers about leadership competencies, quality of work and readiness for change...
September 28, 2017: Leadership in Health Services
https://www.readbyqxmd.com/read/28951467/a-low-pressure-oxygen-storage-system-for-oxygen-supply-in-low-resource-settings
#16
Roger P Rassool, Bryn A Sobott, David J Peake, Bagayana S Mutetire, Peter P Moschovis, Jim Fp Black
BACKGROUND: Widespread access to medical oxygen would reduce global pneumonia mortality. Oxygen concentrators are one proposed solution, but they have limitations, in particular vulnerability to electricity fluctuations and failure during blackouts. The low-pressure oxygen storage system addresses these limitations in low-resource settings. This study reports testing of the system in Melbourne, Australia, and nonclinical field testing in Mbarara, Uganda. METHODS: The system included a power-conditioning unit, a standard oxygen concentrator, and an oxygen store...
September 26, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28945633/a-theory-based-and-culturally-aligned-training-program-on-breast-and-cervical-cancer-prevention-for-south-asian-community-health-workers-a-feasibility-study
#17
Winnie K W So, Alice N L Kwong, Joanne M T Chen, Joanne C Y Chan, Bernard M H Law, Janet W H Sit, Carmen W H Chan
BACKGROUND: Cancer screening uptake among South Asian ethnic minorities is reported to be relatively low. An outreach program, led by community health workers (CHWs), may increase the minority group's awareness of the importance of cancer screening. OBJECTIVE: The aim of this study was to assess the feasibility and effectiveness of a theory-based, culturally sensitive program to train South Asian women in Hong Kong as CHWs. METHODS: A CHW training program, guided by the Empowerment Model and the Health Belief Model, was developed and implemented...
September 23, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28941691/dynamic-profiling-of-different-ready-to-drink-fermented-dairy-products-a-comparative-study-using-temporal-check-all-that-apply-tcata-temporal-dominance-of-sensations-tds-and-progressive-profile-pp
#18
Erick A Esmerino, John C Castura, Juliana P Ferraz, Elson R Tavares Filho, Ramon Silva, Adriano G Cruz, Mônica Q Freitas, Helena M A Bolini
Despite the several differences in ingredients, processes and nutritional values, dairy foods as yogurts, fermented milks and milk beverages are widely accepted worldwide, and although they have their sensory profiling normally covered by descriptive analyses, the temporal perception involved during the consumption are rarely considered. In this sense, the present work aimed to assess the dynamic sensory profile of three categories of fermented dairy products using different temporal methodologies: Temporal Dominance of Sensations (TDS), Progressive Profiling (PP), Temporal CATA (TCATA), and compare the results obtained...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28934063/openness-to-adopting-evidence-based-practice-in-public-substance-use-treatment-in-south-africa-using-task-shifting-caseload-size-matters
#19
Jessica F Magidson, Jasper S Lee, Kim Johnson, Warren Burnhams, J Randy Koch, Ron Manderscheid, Bronwyn Myers
BACKGROUND: In response to the lack of coverage for substance use treatment in the Western Cape province of South Africa, the local government expanded funding for evidence-based practices (EBPs) for treating substance use. Yet, little is known about provider and staff attitudes towards adopting EBPs in this setting, which is particularly relevant in this context where task shifting clinical care increases demands on paraprofessional providers. This study aimed to (1) assess attitudes towards adopting EBPs among a range of staff working in substance use treatment in Cape Town using a task shifting model; and (2) evaluate factors associated with openness towards adopting EBPs in this setting...
September 21, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28931479/are-new-nurses-work-ready-the-impact-of-preceptorship-an-integrative-systematic-review
#20
REVIEW
Karen-Leigh Edward, Karen Ousey, John Playle, Jo-Ann Giandinoto
The aim of this integrative systematic review was to systematically search, critically appraise, and summarise reported research related to readiness to practice and types of clinical support offered to newly registered nurses and preregistration nurses (such as, mentoring, preceptorship, or clinical facilitation). The review was undertaken in February 2017. The databases of Medline, CINAHL, Academic Search Complete, and Cochrane Library were searched. The search returned 137 articles. The final number of papers (after screening and exclusions) was 15 articles related to the topic...
September 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
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