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https://www.readbyqxmd.com/read/28817330/readiness-to-vaccinate-critical-personnel-during-an-influenza-pandemic-united-states-2015
#1
Danielle L Moulia, Stephanie A Dopson, Sara J Vagi, Thomas J Fitzgerald, Amy Parker Fiebelkorn, Samuel B Graitcer
OBJECTIVES: To assess the readiness to vaccinate critical infrastructure personnel (CIP) involved in managing public works, emergency services, transportation, or any other system or asset that would have an immediate debilitating impact on the community if not maintained. METHODS: We analyzed self-reported planning to vaccinate CIP during an influenza pandemic with data from 2 surveys: (1) the Program Annual Progress Assessment of immunization programs and (2) the Pandemic Influenza Readiness Assessment of public health emergency preparedness programs...
August 17, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28812808/history-structure-and-agency-in-global-health-governance-comment-on-global-health-governance-challenges-2016-are-we-ready
#2
Stephen Gill, Solomon R Benatar
Ilona Kickbusch's thought provoking editorial is criticized in this commentary, partly because she fails to refer to previous critical work on the global conditions and policies that sustain inequality, poverty, poor health and damage to the biosphere and, as a result, she misreads global power and elides consideration of the fundamental historical structures of political and material power that shape agency in global health governance. We also doubt that global health can be improved through structures and processes of multilateralism that are premised on the continued reproduction of the ecologically myopic and socially unsustainable market civilization model of capitalist development that currently prevails in the world economy...
August 29, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28810960/talk-to-the-hand-u-s-army-biophysical-testing
#3
William R Santee, Adam W Potter, Karl E Friedl
BACKGROUND: Many people are unaware of the science underlying the biophysical properties of Soldier clothing and personal protective equipment, yet there is a well-refined biomedical methodology initiated by Army physiologists in World War II. This involves a methodical progression of systematic material testing technologies, computer modeling, and human testing that enables more efficient development and rapid evaluation of new concepts for Soldier health and performance. Sophisticated manikins that sweat and move are a central part of this testing continuum...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28801256/new-innovative-ecosystems-in-france-to-develop-the-bioeconomy
#4
REVIEW
Thierry Stadler, Jean-Marie Chauvet
The cluster's policy initiated in France in 2005 was a formidable opportunity to boost innovation in the bioeconomy and to develop innovation platforms allowing industrial demonstration and feasibility at technology readiness level (TRL) from 5 to 9. The IAR Cluster (Industries and Agro-Resources), based in the Hauts-de-France and Grand Est regions is completely dedicated to the bioeconomy. IAR's work has contributed to build a complete innovation ecosystem on bioeconomy by opening up relationships between actors along the full value chain...
August 8, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28798225/ethical-issues-in-alzheimer-s-disease-research-involving-human-subjects
#5
Dena S Davis
As we aggressively pursue research to cure and prevent Alzheimer's disease, we encounter important ethical challenges. None of these challenges, if handled thoughtfully, would pose insurmountable barriers to research. But if they are ignored, they could slow the research process, alienate potential study subjects and do damage to research recruits and others. These challenges are (1) the necessity of very large cohorts of research subjects, recruited for lengthy studies, probably ending only in the subjects' death; (2) the creation of cohorts of 'study ready' volunteers, many of whom will be competent to consent at the beginning of the process, but move into cognitive impairment later; (3) reliance on adaptive trial design, creating challenges for informed consent, equipoise and justice; (4) the use of biomarkers and predictive tests that describe risk rather than certainty, and that can threaten participants' welfare if the information is obtained by insurance companies or long-term care providers; (5) the use of study partners that creates unique risks of harm to the relationship of subject and study partner...
August 10, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28796840/yes-research-matters
#6
Mari L Shinohara
My father was diagnosed with stomach cancer recently. Luckily, it was still at an early stage, and endoscopic surgery successfully took care of it. My father was fortunate; since people with stomach cancer do not show clear symptoms in the early stages, the disease is often not diagnosed until it becomes advanced. In his case, the diagnosis started from a suggestion by his doctor to check whether he had a gastric infection with Helicobacter pylori, a bacterial species found in the digestive tract. In Japan, where he lives, a majority of gastric cancer patients (more than 99%) have been infected with H...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28790149/evaluation-of-endotracheal-tube-scraping-on-airway-resistance
#7
J Brady Scott, Meagan N Dubosky, David L Vines, Adewunmi S Sulaiman, Kyle R Jendral, Gagan Singh, Ankeet Patel, Carl A Kaplan, David P Gurka, Robert A Balk
BACKGROUND: Spontaneous breathing trials (SBTs) are used to assess the readiness for discontinuation of mechanical ventilation. When airway resistance (Raw) is elevated, the imposed work of breathing can lead to prolongation of mechanical ventilation. Biofilm and mucus build-up within the endotracheal tube (ETT) can increase Raw. Scraping the ETT can remove the biofilm build-up and decrease mechanical Raw. The primary aim of this study was to evaluate the impact of ETT scraping on Raw...
August 8, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28789528/carbene-mediated-quaternarization-of-the-anomeric-position-of-carbohydrates-synthesis-of-allylic-ketopyranosides-access-to-the-missing-%C3%AE-gluco-and-%C3%AE-manno-stereoisomers-and-preparation-of-quaternary-2-deoxy-2-acetamido-sugars
#8
Kévin Mébarki, Marine Gavel, Floriane Heis, Antoine Yvan Philippe Joosten, Thomas Lecourt
Following our work on the C-H functionalization of carbohydrates by 1,5 insertion of metal-carbenes, we report herein the robust and scalable conversion of sugar γ-lactones into highly valuable glycosides having a quaternary anomeric position substituted by an allyl chain ready for further functionalization. A divergent synthetic approach furthermore provided a straightforward access to ketopyranosides with a large chemo- and stereodiversity at position 2.
August 9, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28783434/highly-stereoselective-heterogeneous-diene-polymerization-by-co-mfu-4l-a-single-site-catalyst-prepared-by-cation-exchange
#9
Romain Dubey, Robert J Comito, Zhenwei Wu, Guanghui Zhang, Adam J Rieth, Christopher H Hendon, Jeffrey T Miller, Mircea Dinca
Molecular catalysts offer tremendous advantages for stereoselective polymerization because their activity and selectivity can be optimized and understood mechanistically using the familiar tools of organometallic chemistry. Yet, this exquisite control over selectivity comes at an operational price that is generally not justifiable for the large-scale manufacture of polyfolefins. In this report we identify Co-MFU-4l, prepared by cation exchange in a metal-organic framework, as a solid catalyst for the polymerization of 1,3-butadiene with high stereoselectivity (>99 % 1,4-cis)...
August 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28782331/acceptability-of-a-microfinance-based-empowerment-intervention-for-transgender-and-cisgender-women-sex-workers-in-greater-kuala-lumpur-malaysia
#10
Priya Lall, Stacey A Shaw, Rumana Saifi, Susan Sherman, Nuruljannah Nor Azmi, Veena Pillai, Nabila El-Bassel, Adeeba Kamarulzaman, Jeffrey A Wickersham
INTRODUCTION: Cisgender and transgender woman sex workers (CWSWs and TWSWs, respectively) are key populations in Malaysia with higher HIV-prevalence than that of the general population. Given the impact economic instability can have on HIV transmission in these populations, novel HIV prevention interventions that reduce poverty may reduce HIV incidence and improve linkage and retention to care for those already living with HIV. We examine the feasibility of a microfinance-based HIV prevention intervention among CWSW and TWSWs in Greater Kuala Lumpur, Malaysia...
August 2, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28776349/lack-of-retirement-preparation-is-associated-with-increased-depressive-symptoms-in-the-elderly-findings-from-the-korean-retirement-and-income-panel-study
#11
Yeong Jun Ju, Woorim Kim, Sang Ah Lee, Joo Eun Lee, Hyojung Yoon, Eun Cheol Park
The aim of this study was to investigate the relationship between retirement preparation and depressive symptoms among Koreans 50 years of age or older. We used data from the 2009 to 2013 Korean Retirement and Income Panel Study (KReIS), which included data from the 365 baseline participants of 50 years of age or older. Our sample included only newly retired participants who worked in 2009, but had retired in the 2011 and 2013. To monitor the change in depressive symptoms according to retirement preparation, we used repeated measurement data...
September 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28774835/current-and-emerging-biomarkers-in-tumors-of-the-central-nervous-system-possible-diagnostic-prognostic-and-therapeutic-applications
#12
REVIEW
Ishaq N Khan, Najeeb Ullah, Deema Hussein, Kulvinder S Saini
Recent investments in research associated with the discovery of specific tumor biomarkers important for efficient diagnosis and prognosis are beginning to bear fruit. Key biomarkers could potentially outweigh traditional radiological or pathological methods by enabling specificity of early detection, when coupled with tumor molecular profiling and clinical associations. Only few biomarkers are approved by regulatory authorities for Central Nervous System Tumors (CNSTs), despite the evaluation of a large number of CNST related markers during clinical trials...
July 31, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28773183/study-of-the-technical-feasibility-of-increasing-the-amount-of-recycled-concrete-waste-used-in-ready-mix-concrete-production
#13
Esteban Fraile-Garcia, Javier Ferreiro-Cabello, Luis M López-Ochoa, Luis M López-González
The construction industry generates a considerable amount of waste. Faced with this undesirable situation, the ready-mix concrete sector, in particular, has invested energy and resources into reusing its own waste in its production process as it works towards the goal of more sustainable construction. This study examines the feasibility of incorporating two types of concrete waste, which currently end up in landfill, into the production process of ready-mix concrete: the waste generated during the initial production stage (ready-mix concrete waste), and waste created when demolition waste is treated to obtain artificial aggregate...
July 18, 2017: Materials
https://www.readbyqxmd.com/read/28771648/survey-of-hospital-employees-personal-preparedness-and-willingness-to-work-following-a-disaster
#14
Jane H Brice, David Gregg, Dalton Sawyer, Julianne M Cyr
OBJECTIVES: Little is known about the personal readiness of hospital staff for disasters. As many as 30% of hospital staff say that they plan not to report for work during a large-scale disaster. We sought to understand the personal disaster preparedness for hospital staff. METHODS: Surveys were distributed to the staff of a large academic tertiary-care hospital by either a paper-based version distributed through the departmental safety coordinators or a Web-based version distributed through employee e-mail services, depending on employee familiarity with and access to computer services...
August 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28770387/data-to-decisions-creating-a-culture-of-model-driven-drug-discovery
#15
Frank K Brown, Farida Kopti, Charlie Zhenyu Chang, Scott A Johnson, Meir Glick, Chris L Waller
Merck & Co., Inc., Kenilworth, NJ, USA, is undergoing a transformation in the way that it prosecutes R&D programs. Through the adoption of a "model-driven" culture, enhanced R&D productivity is anticipated, both in the form of decreased attrition at each stage of the process and by providing a rational framework for understanding and learning from the data generated along the way. This new approach focuses on the concept of a "Design Cycle" that makes use of all the data possible, internally and externally, to drive decision-making...
August 2, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28766707/taking-root-a-grounded-theory-on-evidence-based-nursing-implementation-in-china
#16
L Cheng, M E Broome, S Feng, Y Hu
BACKGROUND: Evidence-based nursing is widely recognized as the critical foundation for quality care. AIM: To develop a middle-range theory on the process of evidence-based nursing implementation in Chinese context. METHODS: A grounded theory study using unstructured in-depth individual interviews was conducted with 56 participants who were involved in 24 evidence-based nursing implementation projects in Mainland China from September 2015 to September 2016...
August 2, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28766091/maximizing-opportunities-family-planning-and-maternal-infant-and-young-child-nutrition-integration-in-bondo-sub-county-kenya
#17
Chelsea M Cooper, Angella Ogutu, Everlyn Matiri, Hannah Tappis, Devon Mackenzie, Anne Pfitzer, Rae Galloway
Purpose This article shares learning from an innovative demonstration program integrating maternal, infant, and young child nutrition (MIYCN) and family planning (FP) services in western Kenya, providing recommendations for future work to expand MIYCN and FP integration. Description Six health facilities reorganized to integrate MIYCN and FP services and community health volunteers (CHVs) promoted MIYCN and FP in adjacent communities in Bondo Sub-County over a 1-year period. At the facility level, each provider was directed to provide both sets of services in a single room during FP, antenatal care, postnatal care, or child consultation visits (a "one stop shop" approach)...
August 1, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28761571/extending-inferential-group-analysis-in-type-2-diabetic-patients-with-multivariate-glm-implemented-in-spm8
#18
Fábio S Ferreira, João M S Pereira, João V Duarte, Miguel Castelo-Branco
BACKGROUND: Although voxel based morphometry studies are still the standard for analyzing brain structure, their dependence on massive univariate inferential methods is a limiting factor. A better understanding of brain pathologies can be achieved by applying inferential multivariate methods, which allow the study of multiple dependent variables, e.g. different imaging modalities of the same subject. OBJECTIVE: Given the widespread use of SPM software in the brain imaging community, the main aim of this work is the implementation of massive multivariate inferential analysis as a toolbox in this software package...
2017: Open Neuroimaging Journal
https://www.readbyqxmd.com/read/28760848/comprehensive-arrayed-transposon-mutant-library-of-klebsiella-pneumoniae-outbreak-strain-kpnih1
#19
Beth Ramage, Roxanne Erolin, Kiara Held, Joe Gasper, Eli Weiss, Mitch Brittnacher, Larry Gallagher, Colin Manoil
Klebsiella pneumoniae and other carbapenem-resistant Enterobacteriaceae are a major cause of hospital-acquired infections, yet the basis of their success as nosocomial pathogens is poorly understood. To help provide a foundation for genetic analysis of K. pneumoniae, we created an arrayed, sequence-defined transposon mutant library of an isolate from the 2011 outbreak of infections at the U.S. National Institutes of Health Clinical Center. The library is made up of 12,000 individually arrayed mutants of a carbapenemase deletion parent strain and provides coverage of 85% of predicted genes...
July 31, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28759782/intergenerational-associations-in-executive-function-between-mothers-and-children-in-the-context-of-risk
#20
Matthew H Kim, Lisa Shimomaeda, Ryan J Giuliano, Elizabeth A Skowron
Executive functioning (EF) is critical for school readiness and other important life skills. Previous investigations have often neglected the important influence of parental EF skills in shaping their own children's EF. This study attempted to replicate recent empirical work that has shown that maternal EF is positively related to child EF. An ecological theoretical framework was used to examine the maternal EF-child EF link in family environments characterized by significant risk and socioeconomic adversity...
July 28, 2017: Journal of Experimental Child Psychology
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