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Susan L Stevens, Tao Liu, Frances Rena Bahjat, Vladislav A Petyuk, Athena A Schepmoes, Ryan L Sontag, Marina A Gritsenko, Chaochao Wu, Sheng Wang, Anil K Shukla, Jon M Jacobs, Richard D Smith, Karin D Rodland, G Alexander West, Steven G Kohama, Christine Glynn, Mary P Stenzel-Poore
Each year, thousands of patients are at risk of cerebral ischemic injury, due to iatrogenic responses to surgical procedures. Prophylactic treatment of these patients as standard care could minimize potential neurological complications. We have shown that protection of brain tissue, in a non-human primate model of cerebral ischemic injury, is possible through pharmacological preconditioning using the immune activator D192935. We postulate that preconditioning with D192935 results in neuroprotective reprogramming that is evident in the brain following experimentally induced cerebral ischemia...
October 19, 2018: Translational Stroke Research
Núbia de Cassia Almeida Queiroz, Michelle Pedroza Jorge, Ilza Maria de Oliveira Sousa, Carmen Silvia Passos Lima, Maria Christina de Miranda Matias, Ana Cristina Dal Rio, Eduardo Baldon Pereira, Victória Hahn Kakas Galassi, João Ernesto de Carvalho, Tais Freire Galvao, Mary Ann Foglio
INTRODUCTION: Oral mucositis is an iatrogenic condition of erythematous inflammatory changes which tends to occur on buccal and labial surfaces, the ventral surface of the tongue, the floor of the mouth and the soft palate of patients receiving chemotherapy. This protocol of ongoing randomised parallel group clinical trial aims to access the therapeutic effect of an herbal gel containing 2.5% Arrabidaea chica Verlot standardised extract on oral mucositis in patients with head and neck cancer compared with low-level laser therapy...
October 18, 2018: BMJ Open
Sara Abu-Ghanem, Shannon Rudy, Sandra Deane, Shu Wei Tsai, Liang-Chun Shih, Edward J Damrose, Chih-Kwang Sung
Vocal fold movement impairment may significantly compromise postoperative recovery and quality of life of patients following thoracic or cardiothoracic surgery or prolonged intubation. The literature is limited and there is no standard screening protocol for the optimal postoperative swallowing and aspiration evaluations. We performed retrospective review of adult patients undergoing early vocal fold (VF) injection laryngoplasty for acute postoperative Vocal fold movement impairment (<30 days) that had both pre- and postinjection speech language pathologist (SLP) performed swallowing/aspiration evaluations...
October 16, 2018: Journal of Voice: Official Journal of the Voice Foundation
Ivanka Temelkova, Michael Tronnier, Ivan Terziev, Uwe Wollina, Ilia Lozev, Mohamad Goldust, Georgi Tchernev
BACKGROUND: Kaposi's sarcoma was first described in 1872 by Moritz Kaposi. To date, it is considered a malignant disease is originating from the endothelial cells of the lymphatic vessels believed to be infected with HHV-8. The current classification defines four major epidemiological forms of Kaposi's sarcoma: classical, endemic, AIDS-associated, and iatrogenic. CASE REPORT: A 90-year-old male is presented with multiple plaques- and tumour-shaped brown-violet formations located on an erythematous-livid base in the area of both feet and both shanks...
September 25, 2018: Open Access Macedonian Journal of Medical Sciences
Reza Akhavan-Sigari, Dorothee Mielke, Afshin Farhadi, Veit Rohde
BACKGROUND: Gunshot wounds and blast injuries to the upper limbs produce complex wounds requiring management by multiple surgical specialities. AIM: We sought to determine the pattern of peripheral nerve injuries among Iraqi soldiers in the war. METHODS: We performed a 3 year retrospective cohort analysis based on medical records of patients with sustaining gunshot wounds and blast injuries to the upper limbs. Ethical approval was obtained from the institutional review board...
September 25, 2018: Open Access Macedonian Journal of Medical Sciences
Kathrin Neuhaus, Clemens Schiestl, Rosmarie Adelsberger, Lisa Weibel, Martin Meuli, Sophie Böttcher-Haberzeth
BACKGROUND: The scalp is the only hidden donor site for split thickness skin grafts. Nevertheless, it is underappreciated due to fear of iatrogenic scarring alopecia. Long-term data showing whether androgenetic hair loss can reveal previously hidden scarring alopecia is unavailable. We aimed to evaluate results and patient satisfaction up to 30years after skin harvest from the scalp. METHODS: Burn patients, hospitalized between 1977 and 1987 at the University Children's Hospital Zurich with scalp skin harvest and currently over 30years old, were studied...
October 15, 2018: Burns: Journal of the International Society for Burn Injuries
Brian Fiani, Syed A Quadri, Mudassir Farooqui, Massimo D'Apuzzo, Robert J Rosser, Blake W Berman, Jerry Noel, Xin S Xin, Behnam Badie, Anirudh Ramachandran, Javed Siddiqi
Brainstem tumors are rare, even rarer is a brainstem tumor containing tissues of an embryologic gynecologic origin. We report a very rare case of presence of a calcified heterogeneously contrast enhancing brainstem mass of Müllerian origin in a patient in a 38 year old female with no female genital tract cancer and past surgical history of ventriculoperitoneal (VP) shunt placement for congenital hydrocephalus. To our knowledge this is the very first and unusual case of a mass of gynecologic origin in the brainstem region especially in the setting of no history of gynecological tumor...
October 15, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Ewa Kuklik, Krzysztof Pyra, Łukasz Światłowski, Maryla Kuczyńska, Jan Sobstyl, Anna Drelich-Zbroja, Tomasz Jargiełło, Maria Tsitskari, Małgorzata Szczerbo-Trojanowska
Renal artery pseudoaneurysms and arteriovenous fistulae most often occur as an iatrogenic complication. The article discusses a case of a patient diagnosed with an arteriovenous fistula and a pseudoaneurysm. A 64-year-old woman was admitted to the hospital due to nonspecific pain in the lumbar region. Imaging showed a typical picture of clear cell renal carcinoma. The patient was qualified for surgical treatment. After tumor resection, the patient developed microhematuria. Arteriovenous fistula and renal pseudoaneurysm were diagnosed using Doppler and computed tomography scans...
2018: Journal of Ultrasonography
Tomasz Jargiełło, Jan Sobstyl, Łukasz Światłowski, Maryla Kuczyńska, Ewa Kuklik, Michał Sojka, Anna Drelich-Zbroja, Maciej Pech, Maciej Powerski
AIM: The purpose of this paper was to evaluate the efficacy of ultrasound-guided percutaneous thrombin injection as a treatment method for arterial access site pseudoaneurysm. MATERIALS AND METHODS: A total of 148 patients with iatrogenic arterial access site pseudoaneurysms were treated in the Department of Interventional Radiology and Neuroradiology, Medical University of Lublin. Of those, 142 pseudoaneurysms were located in the common femoral artery, 3 in the brachial artery and the remaining 3 in the radial artery...
2018: Journal of Ultrasonography
Siyuan Li, Ying Jie
PURPOSE OF REVIEW: This review aims to introduce recent updates in cataract surgery and lens implantation. RECENT FINDINGS: Compared to phacoemulsification, femtosecond laser-assisted cataract surgery (FLACS) may offer benefit for cataract patients with other complicated ocular diseases, such as corneal disease and vitreous abnormalities. Meanwhile, several types of novel intraocular lenses (IOLs) have been introduced to the market, and each of them has particular features in improving patients' visual acuity...
October 17, 2018: Current Opinion in Ophthalmology
Joe Iwanaga, Emily Simonds, Marc Vetter, Mayank Patel, Rod J Oskouian, R Shane Tubbs
The inferior gluteal nerve has been traditionally described as a solely motor branch innervating the gluteus maximus. However, during routine dissection of the gluteal region, a cutaneous branch of the inferior gluteal nerve was identified. As the gluteal region is vulnerable to the development of pressure ulcers and iatrogenic injury with for example, surgical approaches and injection therapies, a comprehensive understanding of its cutaneous innervation is important. Therefore, the aim of this study was to elucidate the anatomy of this cutaneous branch of the inferior gluteal nerve in a series of cadavers...
October 18, 2018: Clinical Anatomy
Zhiqing Cao, Jiangyi Chen, Zhixiong Li, Guoxin Li
BACKGROUND: Pediatric inguinal hernia is one of the most common diseases in children, and laparoscopy is the main surgical method. This study aims to evaluate the efficacy of a new modified 2-port laparoscopic herniorrhaphy with Kirschner wire (TLHK) for inguinal hernia in children. METHODS: A total of 5304 children with inguinal hernia hospitalized at the Jiangmen Center Hospital from June 2003 to May 2016 were enrolled in this retrospective study. Four thousand one hundred thirty-five children underwent TLHK that comprised the observation group, while 1169 received single incision laparoscopy (SIL) as the control group (CG)...
October 2018: Medicine (Baltimore)
Léa Hoisnard, Brigitte Santos-Eggimann, Pauline Chauvin, Anne Hiance-Delahaye, Marie Herr
PURPOSE: This study assessed the level of knowledge among community-dwelling older individuals about the purpose of medications and the characteristics that influenced that knowledge. We focused on drugs frequently used and/or often involved in iatrogenic events. METHODS: This cross-sectional survey included 2690 community-dwelling older adults, aged 68 years and above, who reported using at least one drug of interest, in the canton of Vaud, Switzerland. Participants reported drugs that they currently used and described their purpose...
October 17, 2018: European Journal of Clinical Pharmacology
Yugeesh R Lankadeva, Roger G Evans, Junko Kosaka, Lindsea C Booth, Naoya Iguchi, Rinaldo Bellomo, Clive N May
Expansion of extracellular fluid volume with crystalloid solutions is a common medical intervention, but its effects on renal cortical and medullary oxygenation are poorly understood. Therefore, we instrumented sheep under general anesthesia to enable continuous measurement of systemic and renal hemodynamics, global renal oxygen delivery and consumption, and intra-renal tissue perfusion and oxygen tension (pO2 ) in conscious animals (n=7). The effects of three sequential intermittent infusions of 500 mL of compound sodium lactate solution, administered at hourly intervals, were determined...
October 17, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Philippe Musso, Sebastian Carballo
Sudden death of young athletes is often the first clinical manifestation of underlying cardiac pathology. It is defined as an unexpected natural, non traumatic and non iatrogenic event. International screening policies and recommendations to avoid sudden cardiac death vary considerably. Certain studies suggest a benefit from systematic screening of young adults (12‑35 years old) engaging in sports. We chose to evaluate the current approach to screening for lethal pathologies in athletes in Geneva, as well as the interest of introducing a standard screening procedure in the future...
October 17, 2018: Revue Médicale Suisse
José Marcus Raso Eulálio, Manoel Luiz Ferreira, Paulo César Silva, José Eduardo Ferreira Manso, Andrei Ferreira Costa Nicolau, Thales Penna de Carvalho, Julia Radicetti de Siqueira Paiva E Silva, Adrielle Rodas Fernandes, Alberto Schanaider
PURPOSE: To evaluate a novel and adapted low-cost set model for laparoscopic surgery in rats. METHODS: Nine Wistar rats underwent two different laparoscopic procedures, splenectomy (n=3) and distal pancreatectomy with splenectomy (n = 6), after assembling a low-cost set replacing the conventional one (monitor, micro camera, image processor, light source, laparoscope and insufflator). The new set included an Android Tablet 10.5 ", a 5mm USB Endoscope and semiautomatic sphygmomanometer monitor...
September 2018: Acta Cirúrgica Brasileira
Bahram Eshraghi, Hadi Ghadimi, Mojgan Nikdel, Fazl Hajizadeh
BACKGROUND: Synkinesis is a recognized complication following peripheral facial nerve paralysis. Different types of synkinesis have been described, with oral-ocular and ocular-oral synkinesis being the most common. Ocular-nasal synkinesis has been reported in two patients following cosmetic rhinoplasty. However, synkinesis between the orbicularis oculi and procerus muscles has not been reported by now. METHODS: This is an interventional case report. RESULTS: Two women, aged 42 and 37 years, presented with unilateral contraction of the medial eyebrow muscles (procerus) with spontaneous or voluntary blinking, 4 and 5 months after cosmetic rhinoplasty, respectively...
October 16, 2018: Aesthetic Plastic Surgery
James Kennedy, Andrew Berg, Luke Welsh, Jaysheel Mehta
The role of lateral release is widely accepted and regarded as a key step in the management of hallux valgus. There remains however debate in the literature in regards to which structures should be divided and the method of approach. As such, a technique of lateral release using a curved blade placed inferior to the metatarsal head to divide the lateral metatarsosesamoid suspensory ligament and incise the lateral joint capsule has been developed. This technique was performed on fourteen fresh frozen cadaveric specimens which were then dissected...
May 1, 2018: Foot
Solomon Husain, Babak Sadoughi, Niv Mor, Lucian Sulica
OBJECTIVE: To clarify the time course of recovery in patients with iatrogenic vocal fold paralysis. STUDY DESIGN: Retrospective chart review. METHODS: Medical records for all patients with iatrogenic vocal fold paralysis over a 10-year period were reviewed to obtain demographic and clinical information, including onset of disease and recovery of vocal function. Stroboscopic exams of patients who recovered voice were reviewed blindly to assess return of vocal fold motion...
October 16, 2018: Laryngoscope
Khadija Mzoughi, Ihsen Zairi, Fadoua BenGhorbel, Mouna Ben Kilani, Sofien Kamoun, Fethia Ben Moussa, Sana Fennira, Sondos Kraiem
INTRODUCTION: Vitamin K antagonists (VKA) are currently the most prescribed oral anticoagulant treatment in Tunisia. Despite the standardization of biological monitoring and the better definition of therapeutic objectives, their side effects are a frequent reason for hospitalization. AIM: To evaluate patients' knowledge about their VKA treatment. METHODS: We realized a cross-sectional descriptive study in the Cardiology Department of HabibThameur Hospital from September to October 2016...
March 2018: La Tunisie Médicale
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