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https://www.readbyqxmd.com/read/28447717/knockdown-of-zfpl1-results-in-increased-autophagy-and-autophagy%C3%A2-related-cell-death-in-nci%C3%A2-n87-and-bgc%C3%A2-823-human-gastric-carcinoma-cell-lines
#1
Yong-Zheng Xie, Wan-Li Ma, Ji-Ming Meng, Xue-Qun Ren
Macroautophagy, which will hereafter be referred to as autophagy, is an evolutionarily conserved process, during which cells recycle and remove damaged organelles and proteins in response to cellular stress. However, the mechanisms underlying the regulation of autophagy remain to be fully elucidated. The present study demonstrated that knockdown of zinc finger protein like 1 (ZFPL1) induces autophagy and increases autophagic cell death in NCI‑N87 and BGC‑823 human gastric carcinoma cell lines. To examine the role of ZFPL1 in gastric carcinoma cells, ZFPL1 expression was downregulated by lentiviral infection...
March 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28427727/implementation-of-human-trafficking-education-and-treatment-algorithm-in-the-emergency-department
#2
Amber Egyud, Kimberly Stephens, Brenda Swanson-Bierman, Marge DiCuccio, Kimberly Whiteman
PROBLEM: Health care professionals have not been successful in recognizing or rescuing victims of human trafficking. The purpose of this project was to implement a screening system and treatment algorithm in the emergency department to improve the identification and rescue of victims of human trafficking. The lack of recognition by health care professionals is related to inadequate education and training tools and confusion with other forms of violence such as trauma and sexual assault...
April 17, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/28414397/childhood-headache-a-brief-review
#3
Heidi K Blume
Headaches are common in childhood and adolescence and can cause significant distress and disability for a child and their family. Providers need to be able to identify "red flags" for worrisome causes of secondary headaches and recognize typical primary headache characteristics to provide each patient with the best possible care to improve their quality of life and minimize disability. This article reviews the epidemiology of headaches in children, signs and symptoms of secondary headaches, definitions of some primary childhood headaches, and options for management of both acute and chronic pediatric migraine...
April 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28413225/pathological-burst-fracture-in-the-cervical-spine-with-negative-red-flags-a-12-year-follow-up
#4
Jocelyn Cox, Chris DeGrauuw, Erik Klein
In 2004, a 61-year-old male presented to a chiropractic clinic complaining of neck pain after hearing a 'crunch' when getting out of bed that morning. The initial history intake and physical examination identified no red flags or indications for the patient's pain, with the exception of traction being pain-provoking. Conventional radiographs were ordered, which identified a pathological burst fracture of the fourth cervical vertebra. This Imaging Case Review (ICR) is to provide clinicians with a follow-up to the patient's care and current state...
March 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28399548/adherence-to-back-pain-clinical-practice-guidelines-by-brazilian-physical-therapists-a-cross-sectional-study
#5
Fabrício Soares de Souza, Carlos Emílio Ladeira, Leonardo Oliveira Pena Costa
STUDY DESIGN: This was a cross-sectional observational study. OBJECTIVES: 1) To investigate whether Brazilian physical therapists make clinical decisions for patients with low back pain based upon clinical practice guidelines. 2) To determine whether the physical therapists are able to recognize differential diagnoses of low back pain associated with red or yellow flags. SUMMARY OF BACKGROUND DATA: Early adherence to clinical practice guidelines may accelerate recovery and reduce the costs associated with low back pain...
April 10, 2017: Spine
https://www.readbyqxmd.com/read/28388854/auditory-adaptation-testing-as-a-tool-for-investigating-tinnitus-origin-two-patients-with-vestibular-schwannoma
#6
Carol A Silverman, Shlomo Silman, Michele B Emmer
OBJECTIVE: To enhance the understanding of tinnitus origin by disseminating two case studies of vestibular schwannoma (VS) involving behavioural auditory adaptation testing (AAT). DESIGN: Retrospective case study. STUDY SAMPLE: Two adults who presented with unilateral, non-pulsatile subjective tinnitus and bilateral normal-hearing sensitivity. At the initial evaluation, the otolaryngologic and audiologic findings were unremarkable, bilaterally...
April 7, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28381256/double-or-nothing-red-flag-symptoms-of-critical-carotid-stenosis-a-case-report
#7
José Carlos Morán-Sánchez, Irene Gómez-Estévez, Yasmina El Berdei, José C Gómez-Sánchez, María E Ramos-Araque
BACKGROUND: Detailed knowledge of every possible manifestation of Internal Carotid Artery (ICA) disease is important. For improving detection and a timely adoption of secondary prevention procedures or treatments. Transient oculomotor nerve palsies have been described associated with stenosis or occlusion of the ICA. CASE PRESENTATION: We described a patient that develop a sequential combination of transient monocular loss of vision followed by binocular diplopia secondary to an unstable atherosclerotic preocclusive stenosis of an internal carotid artery previously treated with radiotherapy...
April 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28375914/low-back-pain
#8
Jinny O Tavee, Kerry H Levin
PURPOSE OF REVIEW: This article provides an overview of evaluating and treating low back pain in the outpatient setting. RECENT FINDINGS: As most cases of acute low back pain have a favorable prognosis, current guidelines on imaging studies recommend conservative treatment for 6 weeks prior to obtaining an MRI if no red flags are present. Of these red flags, a prior history of cancer is the strongest risk factor for a malignant etiology and requires urgent evaluation with MRI...
April 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28375913/bell-s-palsy
#9
Stephen G Reich
PURPOSE OF REVIEW: Bell's palsy is a common outpatient problem, and while the diagnosis is usually straightforward, a number of diagnostic pitfalls can occur, and a lengthy differential diagnosis exists. Recognition and management of Bell's palsy relies on knowledge of the anatomy and function of the various motor and nonmotor components of the facial nerve. Avoiding diagnostic pitfalls relies on recognizing red flags or features atypical for Bell's palsy, suggesting an alternative cause of peripheral facial palsy...
April 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28374416/retinal-haemorrhage-a-red-flag-for-raised-intracranial-pressure
#10
Waney Squier
No abstract text is available yet for this article.
April 4, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28366427/errors-in-diagnosis-of-spinal-epidural-abscesses-in-the-era-of-electronic-health-records
#11
Viraj Bhise, Ashley N D Meyer, Hardeep Singh, Li Wei, Elise Russo, Aymer Al-Mutairi, Daniel R Murphy
PURPOSE: To identify missed opportunities in diagnosis of spinal epidural abscesses to outline areas for process improvement. METHODS: Using a large national clinical data repository, we identified all patients with a new diagnosis of spinal epidural abscess in the Department of Veterans Affairs (VA) during 2013. Two physicians independently conducted retrospective chart reviews on 250 randomly selected patients and evaluated their records for red flags (e.g., unexplained weight loss, neurological deficits, and fever) 90 days prior to diagnosis...
March 30, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28365652/interstage-home-monitoring-after-newborn-first-stage-palliation-for-hypoplastic-left-heart-syndrome-family-education-strategies
#12
Jo Ann Nieves, Karen Uzark, Nancy A Rudd, Jennifer Strawn, Anne Schmelzer, Nancy Dobrolet
Children born with hypoplastic left heart syndrome are at high risk for serious morbidity, growth failure, and mortality during the interstage period, which is the time from discharge home after first-stage hypoplastic left heart syndrome palliation until the second-stage surgical intervention. The single-ventricle circulatory physiology is complex, fragile, and potentially unstable. Multicenter initiatives have been successfully implemented to improve outcomes and optimize growth and survival during the interstage period...
April 2017: Critical Care Nurse
https://www.readbyqxmd.com/read/28362251/syncope-in-pediatric-patients-a-practical-approach-to-differential-diagnosis-and-management-in-the-emergency-department
#13
Collen Fant, Arl Cohen
Syncope is a condition that is often seen in the emergency department. Most syncope is benign, but it can be a symptom of a life-threatening condition. While syncope often requires an extensive workup in adults, in the pediatric population, critical questioning and simple, noninvasive testing is usually sufficient to exclude significant or life-threatening causes. For low-risk patients, resource-intensive workups are rarely diagnostic, and add significant cost to medical care. This issue will highlight critical diseases that cause syncope, identify high-risk "red flags," and enable the emergency clinician to develop a cost-effective, minimally invasive algorithm for the diagnosis and treatment of pediatric syncope...
April 2017: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/28355977/three-patients-with-lower-extremity-tumors-referred-through-medical-channels-to-physical-therapists-a-description-of-clinical-reasoning-screening-and-collaborative-practice
#14
Seth Peterson, Thomas Denninger, Scott Porter
Study Design Resident's case problem. Background Although rare in the general population, bone and soft tissue tumors may be more frequently encountered in patients seeking physical therapy because of the propensity to mimic commonly treated musculoskeletal disorders. Screening for tumors requires the physical therapist be attentive to unexpected findings. The purpose of this paper was to describe the clinical reasoning and screening processes of physical therapists that facilitated the timely recognition of bone and soft tumors in 3 patients referred through medical channels...
March 29, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28352279/development-of-a-double-nuclear-gene-targeting-method-by-two-step-transformation-based-on-a-newly-established-chloramphenicol-selection-system-in-the-red-alga-cyanidioschyzon-merolae
#15
Takayuki Fujiwara, Mio Ohnuma, Tsuneyoshi Kuroiwa, Ryudo Ohbayashi, Shunsuke Hirooka, Shin-Ya Miyagishima
The unicellular red alga Cyanidioschyzon merolae possesses a simple cellular architecture that consists of one mitochondrion, one chloroplast, one peroxisome, one Golgi apparatus, and several lysosomes. The nuclear genome content is also simple, with very little genetic redundancy (16.5 Mbp, 4,775 genes). In addition, molecular genetic tools such as gene targeting and inducible gene expression systems have been recently developed. These cytological features and genetic tractability have facilitated various omics analyses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28341902/red-flags-for-maltese-adults-with-congenital-heart-disease-poorer-dental-care-and-less-sports-participation-compared-to-other-european-patients-an-approach-is-substudy
#16
Maryanne Caruana, Silke Apers, Adrienne H Kovacs, Koen Luyckx, Corina Thomet, Werner Budts, Maayke Sluman, Katrine Eriksen, Mikael Dellborg, Malin Berghammer, Bengt Johansson, Alexandra Soufi, Edward Callus, Philip Moons, Victor Grech
Studies in recent years have explored lifestyle habits and health-risk behaviours in adult congenital heart disease (ACHD) patients when compared to controls. The aim of this study was to investigate differences in lifestyle habits between Maltese and other European ACHD patients. Data on alcohol consumption, cigarette smoking, substance misuse, dental care and physical activity collected in 2013-2015 during "Assessment of Patterns of Patient-Reported Outcomes in Adults with Congenital Heart disease-International Study" (APPROACH-IS) were analysed...
March 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28326433/application-of-electronic-algorithms-to-improve-diagnostic-evaluation-for-bladder-cancer
#17
Daniel R Murphy, Ashley N D Meyer, Viralkumar Vaghani, Elise Russo, Dean F Sittig, Kyle A Richards, Li Wei, Louis Wu, Hardeep Singh
BACKGROUND: Strategies to ensure timely diagnostic evaluation of hematuria are needed to reduce delays in bladder cancer diagnosis. OBJECTIVE: To evaluate the performance of electronic trigger algorithms to detect delays in hematuria follow-up. METHODS: We developed a computerized trigger to detect delayed follow-up action on a urinalysis result with high-grade hematuria (>50 red blood cells/high powered field). The trigger scanned clinical data within a Department of Veterans Affairs (VA) national data repository to identify all patient records with hematuria, then excluded those where follow-up was unnecessary (e...
March 22, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28325786/impact-on-hospital-resources-of-systematic-evaluation-and-management-of-suspected-nonaccidental-trauma-in-patients-less-than-4-years-of-age
#18
Bethann M Pflugeisen, Mauricio A Escobar, Dustin Haferbecker, Yolanda Duralde, Elizabeth Pohlson
OBJECTIVE: There has been an increasing movement worldwide to create systematic screening and management procedures for atypical injury patterns in children with the hope of better detecting and evaluating nonaccidental trauma (NAT). A legitimate concern for any hospital considering implementation of a systematic evaluation process is the impact on already burdened hospital resources. We hypothesized that implementation of a guideline that uses red flags related to history, physical, or radiologic findings to trigger a standardized NAT evaluation of patients <4 years would not negatively affect resource utilization at our level II pediatric trauma center...
March 21, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28325780/gps-are-warned-of-costs-of-missing-red-flags-for-spinal-condition
#19
Ingrid Torjesen
No abstract text is available yet for this article.
March 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28316289/post-stapedectomy-granuloma-a-devastating-complication
#20
E Watts, H R F Powell, S R Saeed, R M Irving
OBJECTIVES: This paper reports three cases of severe post-stapedectomy granuloma, emphasising the variable presentation of this devastating complication and the challenges of its management. METHODS: A retrospective review was conducted of three cases of post-stapedectomy granuloma requiring surgical debulking between 2010 and 2015. Clinical symptoms, serial imaging, histopathology and post-operative outcomes were considered. RESULTS: Intra-operatively, extensive granulation tissue with erosion of the otic capsule was found...
March 20, 2017: Journal of Laryngology and Otology
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