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https://www.readbyqxmd.com/read/30475108/results-from-flanders-2018-report-card-on-physical-activity-for-children-and-youth
#1
Jan Seghers, Stijn De Baere, Maïté Verloigne, Greet Cardon
No abstract text is available yet for this article.
November 1, 2018: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/30448437/characterization-of-stm3030-and-stm3031-genes-of-salmonella-enterica-serovar-typhimurium-in-relation-to-cephalosporin-resistance
#2
Ying-Hsiu Lin, Tsuey-Ching Yang, Wensi S Hu
BACKGROUND/PURPOSE: The outer membrane protein STM3031 had been shown to confer Salmonella enterica serovar Typhimurium resistance to ceftriaxone. In this study, the STM3030 was increased in strain R200 and decreased in strain R200(Δstm3031). How stm3030 and stm3031 contributing to antibiotic resistance was investigated. METHODS: The level of STM3030 protein in R200(Δstm3031) were compared between 01-4, R200, and R200(Δstm3031) by 2-DE analysis. The stm3030 gene deleted strain, R200(Δstm3030), was generated by the one-step inactivation chromosome gene method...
October 11, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/30447470/updated-use-of-tace-for-hepatocellular-carcinoma-treatment-how-and-when-to-use-it-based-on-clinical-evidence
#3
REVIEW
Jean-Luc Raoul, Alejandro Forner, Luigi Bolondi, Tan To Cheung, Roman Kloeckner, Thierry de Baere
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, representing the sixth leading cause of cancer and the third leading cause of cancer-related mortality. Patient stratification and treatment allocation are based on tumor stage, liver function, and performance status. According to the Barcelona Clinic Liver Cancer (BCLC) staging system, transarterial chemoembolization (TACE) is the first-line treatment for patients with intermediate stage HCC, including those with large or multinodular HCC, well-preserved liver function, and no cancer-related symptoms or evidence of vascular invasion or extrahepatic spread...
November 12, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/30429846/a-card9-founder-mutation-disrupts-nf-%C3%AE%C2%BAb-signaling-by-inhibiting-bcl10-and-malt1-recruitment-and-signalosome-formation
#4
Marieke De Bruyne, Levi Hoste, Delfien J Bogaert, Lien Van den Bossche, Simon J Tavernier, Eef Parthoens, Mélanie Migaud, Deborah Konopnicki, Jean Cyr Yombi, Bart N Lambrecht, Sabine van Daele, Ana Karina Alves de Medeiros, Lieve Brochez, Rudi Beyaert, Elfride De Baere, Anne Puel, Jean-Laurent Casanova, Jean-Christophe Goffard, Savvas N Savvides, Filomeen Haerynck, Jens Staal, Melissa Dullaers
Background: Inherited CARD9 deficiency constitutes a primary immunodeficiency predisposing uniquely to chronic and invasive fungal infections. Certain mutations are shown to negatively impact CARD9 protein expression and/or NF-κB activation, but the underlying biochemical mechanism remains to be fully understood. Objectives: To investigate a possible founder origin of a known CARD9 R70W mutation in five families of Turkish origin. To explore the biochemical mechanism of immunodeficiency by R70W CARD9. Methods: We performed haplotype analysis using microsatellite markers and SNPs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30402011/musculoskeletal-metastases-management-the-interventional-radiologist-s-toolbox
#5
REVIEW
Charles Mastier, Ana Gjorgjievska, Arnaud Thivolet, Amine Bouhamama, Marie Cuinet, Franck Pilleul, Lambros Tselikas, Thierry de Baère, Frederic Deschamps
The prevalence of patients with painful bone metastases is constantly increasing. This is related to the rising incidence of cancer and increasing life expectancy of patients with metastatic stage. Advances in imaging and development of percutaneous techniques have gradually allowed offering minimally invasive acts on these metastases: cementing, vertebral augmentation, osteosynthesis, percutaneous thermal ablation, neurolysis, embolization. The purpose of this article is to present the main tools available to date for the interventional radiologist so that each participant can understand their functioning, indications, and limits...
October 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/30402010/percutaneous-cement-injection-for-the-palliative-treatment-of-osseous-metastases-a-technical-review
#6
REVIEW
Steven Yevich, Lambros Tselikas, Guillaume Gravel, Thierry de Baère, Frederic Deschamps
The technical art to percutaneous injection of polymethyl methacrylate (PMMA) cement for the palliative treatment of osseous metastases is not without pitfalls. Pathologic fracture, cortical bone erosion, large lytic tumor, aggressive tumor biology, and tumor vascularity may increase the risk of cement leakage or limit complete consolidation. A calculated and determined approach is often necessary to achieve satisfactory patient-tailored results. This article reviews the challenges and potential complications during the consolidation of osseous metastases...
October 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/30402006/percutaneous-fixation-by-internal-cemented-screw-for-the-treatment-of-unstable-osseous-disease-in-cancer-patients
#7
REVIEW
Frederic Deschamps, Steven Yevich, Guillaume Gravel, Charles Roux, Antoine Hakime, Thierry de Baère, Lambros Tselikas
Interventional radiology expertise in image guidance has expanded the treatment options for cancer patients with unstable osseous disease. Percutaneous fixation by internal cemented screw (FICS) describes the technique by which the interventional radiologist stabilizes a fracture or impending fracture with the percutaneous placement of a cannulated screw that is locked in position by polymethyl methacrylate cement. The durable metallic screws provide added resistance to torque and tension stresses that complement the axial compression resistance of cement...
October 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/30402005/integrated-ct-fluoroscopy-equipment-improving-the-interventional-radiology-approach-and-patient-experience-for-treatment-of-musculoskeletal-malignancies
#8
REVIEW
Steven Yevich, Bruno C Odisio, Rahul Sheth, Lambros Tselikas, Thierry de Baère, Frederic Deschamps
Integrated CT-fluoroscopy equipment augments the comprehensive approach to the treatment of musculoskeletal (MSK) malignancy by interventional radiology techniques. As the role of minimally invasive treatment expands to meet the highly variable presentation of MSK malignancy, creative solutions to treatment challenges are required to improve locoregional tumor control and durability of pain palliation. Challenges to effective treatment can often be attributed to a combination of aggressive tumor biology, large size, forbidding location, and adverse vascularity...
October 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/30350173/reiterative-radiofrequency-ablation-in-the-management-of-pediatric-patients-with-hepatoblastoma-metastases-to-the-lung-liver-or-bone
#9
Steven Yevich, Marco Calandri, Guillaume Gravel, Brice Fresneau, Laurence Brugières, Dominique Valteau-Couanet, Sophie Branchereau, Christophe Chardot, Isabelle Aerts, Thierry de Baere, Lambros Tselikas, Frederic Deschamps
BACKGROUND AND PURPOSE: Conventional treatments of systemic chemotherapy and surgical resection for recurrent or metastatic hepatoblastoma (HB) may be inhibitive for the pediatric patient and family who have already been through extensive therapies. This single-institution case series evaluates the safety and efficacy of percutaneous radiofrequency ablation (RFA) in the management of metastatic HB. MATERIALS AND METHODS: Between March 2008 and February 2015, RFA was used as part of multidisciplinary management for HB recurrence or metastasis in 5 children (median 5...
January 2019: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/30346890/transcranial-photobiomodulation-for-the-treatment-of-major-depressive-disorder-the-elated-2-pilot-trial
#10
Paolo Cassano, Samuel R Petrie, David Mischoulon, Cristina Cusin, Husam Katnani, Albert Yeung, Luis De Taboada, Abigal Archibald, Eric Bui, Lee Baer, Trina Chang, Justin Chen, Paola Pedrelli, Lauren Fisher, Amy Farabaugh, Michael R Hamblin, Jonathan E Alpert, Maurizio Fava, Dan V Iosifescu
OBJECTIVE: Our objective was to test the antidepressant effect of transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light in subjects suffering from major depressive disorder (MDD). BACKGROUND: t-PBM with NIR light is a new treatment for MDD. NIR light is absorbed by mitochondria; it boosts cerebral metabolism, promotes neuroplasticity, and modulates endogenous opioids, while decreasing inflammation and oxidative stress. MATERIALS AND METHODS: We conducted a double-blind, sham-controlled study on the safety and efficacy (change in Hamilton Depression Rating Scale [HAM-D17 ] total score at end-point) of adjunct t-PBM NIR [823 nm; continuous wave (CW); 28...
October 20, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/30344184/paternal-exercise-improves-glucose-metabolism-in-adult-offspring
#11
Kristin I Stanford, Morten Rasmussen, Lisa A Baer, Adam C Lehnig, Leslie A Rowland, Joseph D White, Kawai So, Ana Luisa De Sousa-Coehlo, Michael F Hirshman, Mary-Elizabeth Patti, Oliver J Rando, Laurie J Goodyear
Poor paternal diet has emerged as a risk factor for metabolic disease in offspring, and alterations in sperm may be a major mechanism mediating these detrimental effects of diet. While exercise in the general population is known to improve health, the effects of paternal exercise on sperm and offspring metabolic health are largely unknown. Here, we studied seven wk-old C57BL/6 male mice fed a chow or high fat diet, and housed either in static cages (sedentary) or cages with attached running wheels (exercise-trained)...
October 21, 2018: Diabetes
https://www.readbyqxmd.com/read/30297699/correction-mapping-the-genomic-landscape-of-inherited-retinal-disease-genes-prioritizes-genes-prone-to-coding-and-noncoding-copy-number-variations
#12
Kristof Van Schil, Sarah Naessens, Stijn Van de Sompele, Marjolein Carron, Alexander Aslanidis, Caroline Van Cauwenbergh, Anja K Mayer, Mattias Van Heetvelde, Miriam Bauwens, Hannah Verdin, Frauke Coppieters, Michael E Greenberg, Marty G Yang, Marcus Karlstetter, Thomas Langmann, Katleen De Preter, Susanne Kohl, Timothy J Cherry, Bart P Leroy, Elfride De Baere
The original version of this Article contained an error in the spelling of the author Anja K. Mayer, which was incorrectly given as Anja Kathrin Mayer. This has now been corrected in both the PDF and HTML versions of the Article.
October 8, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/30295695/starting-the-fight-in-the-tumor-expert-recommendations-for-the-development-of-human-intratumoral-immunotherapy-hit-it
#13
A Marabelle, R Andtbacka, K Harrington, I Melero, R Leidner, T de Baere, C Robert, P A Ascierto, J-F Baurain, M Imperiale, S Rahimian, D Tersago, E Klumper, M Hendriks, R Kumar, M Stern, K Öhrling, C Massacesi, I Tchakov, A Tse, J-Y Douillard, J Tabernero, J Haanen, J Brody
A European Society for Medical Oncology (ESMO)-sponsored expert meeting was held in Paris on 08 March 2018 which comprised 11 experts from academia, 11 experts from the pharmaceutical industry and two clinicians who were representatives of ESMO. The focus of the meeting was exclusively on the intratumoral injection/delivery of immunostimulatory agents with the aim of harmonizing the standard terms and methodologies used in the reporting of human intratumoral immunotherapy (HIT-IT) clinical trials to ensure quality assurance and avoid a blurring of the data reported from different studies...
October 8, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/30223224/image-guided-tumour-biopsies-in-a-prospective-molecular-triage-study-moscato-01-what-are-the-real-risks
#14
Clara Prud'homme, Fréderic Deschamps, Adrien Allorant, Christophe Massard, Antoine Hollebecque, Steve Yevich, Maud Ngo-Camus, Guillaume Gravel, Claudio Nicotra, Stefan Michiels, Jean-Yves Scoazec, Ludovic Lacroix, Eric Solary, Jean-Charles Soria, Thierry De Baere, Lambros Tselikas
PURPOSE: To evaluate efficacy, complications and preprocedural risk factors for percutaneous image-guided core needle biopsy of malignant tumours for genomic tumour analysis. MATERIALS AND METHODS: Procedural data for core biopsies performed at a single centre for the MOSCATO-01 clinical trial were prospectively recorded between December 2011 and March 2016. Data assessed included patient demographics, tumour characteristics, procedural outcomes and complications...
September 14, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/30143031/radiofrequency-ablation-of-stage-ia-non-small-cell-lung-cancer-in-patients-ineligible-for-surgery-results-of-a-prospective-multicenter-phase-ii-trial
#15
MULTICENTER STUDY
J Palussière, F Chomy, M Savina, F Deschamps, J Y Gaubert, A Renault, O Bonnefoy, F Laurent, C Meunier, C Bellera, S Mathoulin-Pelissier, T de Baere
BACKGROUND: A prospective multicenter phase II trial to evaluate the survival outcomes of percutaneous radiofrequency ablation (RFA) for patients with stage IA non-small cell lung cancer (NSCLC), ineligible for surgery. METHODS: Patients with a biopsy-proven stage IA NSCLC, staging established by a positron emission tomography-computed tomography (PET-CT), were eligible. The primary objective was to evaluate the local control of RFA at 1-year. Secondary objectives were 1- and 3-year overall survival (OS), 3-year local control, lung function (prior to and 3 months after RFA) and quality of life (prior to and 1 month after RFA)...
August 24, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/30105367/the-spectrum-of-structural-and-functional-abnormalities-in-female-carriers-of-pathogenic-variants-in-the-rpgr-gene
#16
Mays Talib, Mary J van Schooneveld, Caroline Van Cauwenbergh, Jan Wijnholds, Jacoline B Ten Brink, Ralph J Florijn, Nicoline E Schalij-Delfos, Gislin Dagnelie, Maria M van Genderen, Elfride De Baere, Magda A Meester-Smoor, Julie De Zaeytijd, Frans P M Cremers, L Ingeborgh van den Born, Alberta A Thiadens, Carel B Hoyng, Caroline C Klaver, Bart P Leroy, Arthur A Bergen, Camiel J F Boon
Purpose: The purpose of this study was to investigate the phenotype and long-term clinical course of female carriers of RPGR mutations. Methods: This was a retrospective cohort study of 125 heterozygous RPGR mutation carriers from 49 families. Results: Eighty-three heterozygotes were from retinitis pigmentosa (RP) pedigrees, 37 were from cone-/cone-rod dystrophy (COD/CORD) pedigrees, and 5 heterozygotes were from pedigrees with mixed RP/CORD or unknown diagnosis...
August 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30081865/postoperative-hepatic-arterial-chemotherapy-in-high-risk-patients-as-adjuvant-treatment-after-resection-of-colorectal-liver-metastases-a-randomized-phase-ii-iii-trial-pacha-01-nct02494973
#17
Diane Goéré, Jean-Pierre Pignon, Maximiliano Gelli, Dominique Elias, Léonor Benhaim, Frédéric Deschamps, Caroline Caramella, Valérie Boige, Michel Ducreux, Thierry de Baere, David Malka
BACKGROUND: After curative-intent surgery for colorectal liver metastases (CRLM), liver recurrence occurs in more than 60% of patients, despite the administration of perioperative or adjuvant chemotherapy. This risk is even higher after resection of more than three CRLM. As CRLM are mostly supplied by arterial blood flow, hepatic arterial infusion (HAI) of chemotherapeutic agents after resection of CRLM is an attractive approach. Oxaliplatin-based HAI chemotherapy, in association with systemic fluoropyrimidines, has been shown to be safe and highly active in patients with CRLM...
August 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30080950/mutations-in-the-gene-pde6c-encoding-the-catalytic-subunit-of-the-cone-photoreceptor-phosphodiesterase-in-patients-with-achromatopsia
#18
Nicole Weisschuh, Katarina Stingl, Isabelle Audo, Saskia Biskup, Béatrice Bocquet, Kari Branham, Marie S Burstedt, Elfride De Baere, Meindert J De Vries, Irina Golovleva, Andrew Green, John Heckenlively, Bart P Leroy, Isabelle Meunier, Elias Traboulsi, Bernd Wissinger, Susanne Kohl
Biallelic PDE6C mutations are a known cause for rod monochromacy, better known as autosomal recessive achromatopsia (ACHM), and early-onset cone photoreceptor dysfunction. PDE6C encodes the catalytic α'-subunit of the cone photoreceptor phosphodiesterase, thereby constituting an essential part of the phototransduction cascade. Here, we present the results of a study comprising 176 genetically preselected patients who remained unsolved after Sanger sequencing of the most frequent genes accounting for ACHM, and were subsequently screened for exonic and splice site variants in PDE6C applying a targeted next generation sequencing approach...
October 2018: Human Mutation
https://www.readbyqxmd.com/read/30054018/serological-monitoring-on-milk-and-serum-samples-in-a-bvd-eradication-program-a-field-study-in-belgium-showing-antibody-elisa-performances-and-epidemiological-aspects
#19
Jean-Baptiste Hanon, Miet De Baere, Camille de la Ferté, Sophie Roelandt, Gilles Guillot, Yves Van der Stede, Brigitte Cay
In a cross-sectional field study involving 51 cattle herds in Belgium, 3159 serum samples and 557 individual milk samples were collected and tested by four different commercial antibody (Ab) ELISAs on serum and two Ab ELISAs on milk. A virus neutralization test (VNT) was performed on serum samples with discording ELISA results and on all samples from non-vaccinating herds. An epidemiological survey was carried out in the same herds to collect information about herd characteristics, management practices, BVD vaccination and BVD infection status...
November 15, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/30016205/in-vitro-model-to-assess-the-adsorption-of-oral-veterinary-drugs-to-mycotoxin-binders-in-a-feed-and-aflatoxin-b1-containing-buffered-matrix
#20
Siegrid De Baere, Thomas De Mil, Gunther Antonissen, Mathias Devreese, Siska Croubels
Mycotoxin binders are feed additives which are mixed in the feed to adsorb mycotoxins and thereby reducing their toxic effects on animals. Interactions with orally administered veterinary medicinal products, such as antimicrobials or coccidiostats, have been reported previously. This paper describes an in vitro model to screen the interaction between mycotoxin binders and veterinary drugs with respect to the non-specific binding of drugs. It is designed as a static setup using a single concentration of drug and binder in a feed-containing or a feed-plus-mycotoxin-containing matrix, buffered at different pH values...
September 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
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