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Ebv Vaccine

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https://www.readbyqxmd.com/read/30323928/contemporary-analysis-of-functional-immune-recovery-to-opportunistic-and-vaccine-preventable-infections-after-allogeneic-haemopoietic-stem-cell-transplantation
#1
Harini D de Silva, Rosemary A Ffrench, Maya Korem, Eva Orlowski, David J Curtis, Andrew Spencer, Sharon Avery, Sushrut Patil, Catherine Orla Morrissey
Objectives: Infections are a major cause of mortality after allogeneic haemopoietic stem cell transplantation (alloHSCT), and immune recovery is necessary for prevention. Novel transplant procedures have changed the epidemiology of infections but contemporary data on functional immune recovery are limited. In this pilot study, we aimed to measure immune recovery in the current era of alloHSCT. Methods: Twenty, 13, 11, 9 and 9 alloHSCT recipients had blood collected at baseline (time of conditioning) and 3-, 6-, 9-, and 12-months post-alloHSCT, respectively...
2018: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/30312417/differences-in-the-epstein-barr-virus-gp350-iga-antibody-response-are-associated-with-increased-risk-for-co-infection-with-a-second-strain-of-ebv
#2
Nicholas A Smith, Paul C Baresel, Conner L Jackson, Sidney Ogolla, Eunice N Toko, Sara Heit, Erwan Piriou, Odada P Sumba, Jaap M Middeldorp, Kathryn L Colborn, Rosemary Rochford
Background: The EBV viral glycoprotein gp350 has been proposed as a candidate antigen for an EBV vaccine. However, the proposed formulations of these vaccines have not taken into account the presence of two unique EBV strains (EBV-1 and EBV-2) present in areas of high incidence of the EBV associated cancer, Burkitt's lymphoma. Methods: In this study, we analyze the kinetics of EBV-1 and EBV-2 infection in an asymptomatic infant cohort from Kisumu, Kenya. We also analyzed the kinetics of the antibody response against five EBV antigens, gp350 (IgG and IgA), VCA (IgG), EBNA-1 (IgG), EAd (IgG), and Zta (IgG)...
October 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/30311576/immunotherapy-for-ebv-associated-nasopharyngeal-carcinoma
#3
Mengying Hong, Kejun Tang, Jing Qian, Hongyu Deng, Musheng Zeng, Shu Zheng, Kefeng Ding, Yushen Du, Ren Sun
Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is one of the most common head and neck malignancies in southern China and Southeast Asia. Unfortunately, 70% of NPC patients have locally advanced disease at the first diagnosis. Radiotherapy alone and concurrent chemoradiotherapy are important treatment approaches for NPC, but they have a limited effect on patients with locally advanced or distantly metastatic disease. 1-5 Nevertheless, the unique immune environment of the EBV-associated NPC provides rational targets for immunotherapy...
2018: Critical Reviews in Oncogenesis
https://www.readbyqxmd.com/read/30294429/a-single-epitope-of-epstein-barr-virus-stimulate-igg-production-in-mice
#4
Widodo, Bambang Pristiwanto, Muhaimin Rifa'i, Irfan Mustafa, Fahrul Zaman Huyop
Background: Epstein-Barr virus (EBV) is closely associated with the high incidence of nasopharyngeal carcinoma in worldwide. Vaccination is one strategy with the potential to prevent the occurrence of EBV-associated cancers, but a suitable vaccine is yet to be licensed. Much vaccine development research focuses on the GP350/220 protein of EBV as it contains an immunogenic epitope at residues 147-165, which efficiently stimulates IgG production in vitro . We examined the ability of this epitope (EBVepitope) to induce IgG production in mice...
November 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/30258468/immunosenescence-and-lymphomagenesis
#5
REVIEW
Salvatrice Mancuso, Melania Carlisi, Marco Santoro, Mariasanta Napolitano, Simona Raso, Sergio Siragusa
One of the most important determinants of aging-related changes is a complex biological process emerged recently and called "immunosenescence". Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysregulation may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. At present, the relationship between immunosenescence and lymphoma in elderly patients is not defined in a satisfactory way...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30185062/malignancy-trends-in-hiv-infected-patients-over-the-past-10-years-in-a-single-center-retrospective-observational-study-in-the-united-states
#6
Nancy Rihana, Sowmya Nanjappa, Cara Sullivan, Ana Paula Velez, Narach Tienchai, John N Greene
The introduction of antiretroviral therapy (ART) in 1995 had a dramatic impact on the morbidity and mortality of the HIV population, and subsequently, the natural history of cancer has changed. The purpose of our study was to review the prevalence of AIDS-defining malignancies and non-AIDS defining cancers (NADC), taking into consideration racial and gender variations. After the institutional review board approval, the study was conducted as a retrospective chart review of 279 HIV-infected patients who were treated at the Moffitt Cancer Center between January 1, 2000 and December 31, 2010...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/30135622/cd40l-adjuvanted-dna-vaccine-carrying-ebv-lmp2-antigen-enhances-anti-tumor-effect-in-npc-transplantation-tumor-animal
#7
Lei Lei, Jianhui Li, Meiqing Liu, Xiaoming Hu, Ya Zhou, Shiming Yang
CD40L, a costimulatory molecule for dendritic cells (DCs) and B cells, can serve as an adjuvant for enhancing the specific immune response induced by DNA vaccine carrying tumor-associated antigens. In this study, we investigated the potential of CD40L as an adjuvant to enhance the anti-tumor effect mediated by a DNA vaccine based on the Epstein-Barr virus-latent membrane protein 2 (EBV-LMP2) antigen. The plasmids capable of expressing the fusion protein EBV-LMP2-CD40L were constructed. Expression vector pVAX1 and plasmid expressing the individual antigen EBV-LMP2 were used as control groups...
2018: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/30111570/sequence-variation-of-epstein-barr-virus-viral-types-geography-codon-usage-and-diseases
#8
Samantha Correia, Ray Bridges, Fanny Wegner, Cristina Venturini, Anne Palser, Jaap M Middeldorp, Jeffrey I Cohen, Mario A Lorenzetti, Irene Bassano, Robert E White, Paul Kellam, Judith Breuer, Paul J Farrell
138 new Epstein-Barr virus (EBV) genome sequences have been determined. 125 of these and 116 from previous reports were combined to produce a multiple sequence alignment of 241 EBV genomes, which we have used to analyze variation within the viral genome. The type 1/type2 classification of EBV remains the major form of variation and is defined mostly by EBNA2 and EBNA3, but the type 2 SNPs at the EBNA3 locus extend into the adjacent gp350 and gp42 genes, whose products mediate infection of B cells by EBV. A small insertion within the BART miRNA region of the genome was present in 21 EBV strains...
August 15, 2018: Journal of Virology
https://www.readbyqxmd.com/read/30053915/human-genetic-variants-and-age-are-the-strongest-predictors-of-humoral-immune-responses-to-common-pathogens-and-vaccines
#9
Petar Scepanovic, Cécile Alanio, Christian Hammer, Flavia Hodel, Jacob Bergstedt, Etienne Patin, Christian W Thorball, Nimisha Chaturvedi, Bruno Charbit, Laurent Abel, Lluis Quintana-Murci, Darragh Duffy, Matthew L Albert, Jacques Fellay
BACKGROUND: Humoral immune responses to infectious agents or vaccination vary substantially among individuals, and many of the factors responsible for this variability remain to be defined. Current evidence suggests that human genetic variation influences (i) serum immunoglobulin levels, (ii) seroconversion rates, and (iii) intensity of antigen-specific immune responses. Here, we evaluated the impact of intrinsic (age and sex), environmental, and genetic factors on the variability of humoral response to common pathogens and vaccines...
July 27, 2018: Genome Medicine
https://www.readbyqxmd.com/read/30035101/role-of-epstein-barr-virus-in-the-pathogenesis-of-head-and-neck-cancers-and-its-potential-as-an-immunotherapeutic-target
#10
REVIEW
Queenie Fernandes, Maysaloun Merhi, Afsheen Raza, Varghese Philipose Inchakalody, Nassima Abdelouahab, Abdul Rehman Zar Gul, Shahab Uddin, Said Dermime
The role of Epstein-Barr virus (EBV) infection in the development and progression of tumor cells has been described in various cancers. Etiologically, EBV is a causative agent in certain variants of head and neck cancers such as nasopharyngeal cancer. Proteins expressed by the EVB genome are involved in invoking and perpetuating the oncogenic properties of the virus. However, these protein products were also identified as important targets for therapeutic research in the past decades, particularly within the context of immunotherapy...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29995221/a-variety-of-alu-mediated-copy-number-variations-can-underlie-il-12r%C3%AE-1-deficiency
#11
Jérémie Rosain, Carmen Oleaga-Quintas, Caroline Deswarte, Hannah Verdin, Stéphane Marot, Garyfallia Syridou, Mahboubeh Mansouri, S Alireza Mahdaviani, Edna Venegas-Montoya, Maria Tsolia, Mehrnaz Mesdaghi, Liudmyla Chernyshova, Yuriy Stepanovskiy, Nima Parvaneh, Davood Mansouri, Sigifredo Pedraza-Sánchez, Anastasia Bondarenko, Sara E Espinosa-Padilla, Marco A Yamazaki-Nakashimada, Alejandro Nieto-Patlán, Gaspard Kerner, Nathalie Lambert, Corinne Jacques, Emilie Corvilain, Mélanie Migaud, Virginie Grandin, María T Herrera, Fabienne Jabot-Hanin, Stéphanie Boisson-Dupuis, Capucine Picard, Patrick Nitschke, Anne Puel, Frederic Tores, Laurent Abel, Lizbeth Blancas-Galicia, Elfride De Baere, Christine Bole-Feysot, Jean-Laurent Casanova, Jacinta Bustamante
PURPOSE: Inborn errors of IFN-γ immunity underlie Mendelian susceptibility to mycobacterial disease (MSMD). Autosomal recessive complete IL-12Rβ1 deficiency is the most frequent genetic etiology of MSMD. Only two of the 84 known mutations are copy number variations (CNVs), identified in two of the 213 IL-12Rβ1-deficient patients and two of the 164 kindreds reported. These two CNVs are large deletions found in the heterozygous or homozygous state. We searched for novel families with IL-12Rβ1 deficiency due to CNVs...
July 11, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29896681/vaccine-development-for-epstein-barr-virus
#12
Jeffrey I Cohen
Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and is associated with several malignancies, including nasopharyngeal carcinoma, gastric carcinoma, Hodgkin lymphoma, Burkitt lymphoma, and lymphomas in immunocompromised persons, as well as multiple sclerosis. A vaccine is currently unavailable. While monomeric EBV gp350 was shown in a phase 2 trial to reduce the incidence of infectious mononucleosis, but not the rate of EBV infection, newer formulations of gp350 including multimeric forms, viruslike particles, and nanoparticles may be more effective...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29875738/identification-of-two-lpp20-cd4-t-cell-epitopes-in-helicobacter-pylori-infected-subjects
#13
Yunshan Ning, Jianbin Ye, Junjie Wen, Danlin Wu, Zhongbiao Chen, Yanqing Lin, Bingxin Hu, Meiqun Luo, Jun Luo, Lijun Ning, Yan Li
Antigen-specific CD4+ T cells play an essential role in effective immunity against Helicobacter pylori ( H. pylori ) infection. Lpp20, a conserved lipoprotein of H. pylori , has been investigated as one of major protective antigens for vaccination strategies. Our previous study identified two H-2d -restricted CD4+ T cell epitopes within Lpp20 and an epitope vaccine based on these epitopes was constructed, which protected mice in prophylactic and therapeutic vaccination against H. pylori infection. Immunodominant CD4+ T cell response is an important feature of antiviral, antibacterial, and antitumor cellular immunity...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29765376/immunization-with-fc-based-recombinant-epstein-barr-virus-gp350-elicits-potent-neutralizing-humoral-immune-response-in-a-balb-c-mice-model
#14
Bingchun Zhao, Xiao Zhang, Claude Krummenacher, Shuo Song, Ling Gao, Haojiong Zhang, Miao Xu, Lin Feng, Qisheng Feng, Musheng Zeng, Yuting Xu, Yixin Zeng
Epstein-Barr virus (EBV) was the first human virus proved to be closely associated with tumor development, such as lymphoma, nasopharyngeal carcinoma, and EBV-associated gastric carcinoma. Despite many efforts to develop prophylactic vaccines against EBV infection and diseases, no candidates have succeeded in effectively blocking EBV infection in clinical trials. Previous investigations showed that EBV gp350 plays a pivotal role in the infection of B-lymphocytes. Nevertheless, using monomeric gp350 proteins as antigens has not been effective in preventing infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29728427/to-ebv-or-not-to-ebv-rational-vaccine-design-for-a-common-infection
#15
Sarah E Henrickson
A human antibody that prevents EBV infection is identified by studying memory B cells that recognize core EBV fusion proteins.
May 4, 2018: Science Immunology
https://www.readbyqxmd.com/read/29723986/ebv-positive-diffuse-large-b-cell-lymphoma-and-chronic-lymphocytic-leukemia-patients-exhibit-increased-anti-dutpase-antibodies
#16
Marshall Williams, Maria Eugenia Ariza
The Epstein-Barr virus (EBV), which is a ubiquitous γ-herpesvirus, establishes a latent infection in more than 90% of the global adult population. EBV-associated malignancies have increased by 14.6% over the last 20 years, and account for approximately 1.5% of all cancers worldwide and 1.8% of all cancer deaths. However, the potential involvement/contribution of lytic proteins to the pathophysiology of EBV-associated cancers is not well understood. We have previously demonstrated that the EBV-deoxyuridine triphosphate nucleotidohydrolase (dUTPase) modulates innate and adaptive immune responses by engaging the Toll-Like Receptor 2 (TLR2), which leads to the modulation of downstream genes involved in oncogenesis, chronic inflammation, and in effector T-cell function...
May 1, 2018: Cancers
https://www.readbyqxmd.com/read/29718378/evaluation-of-total-and-iga-specific-antibody-targeting-epstein-barr-virus-glycoprotein-350-and-nasopharyngeal-carcinoma-risk
#17
Anna E Coghill, Wei Bu, Wan-Lun Hsu, Hanh Nguyen, Kelly J Yu, Yin-Chu Chien, Chien-Jen Chen, Jeffrey I Cohen, Allan Hildesheim
Background: We previously reported that higher levels of antibody targeting Epstein-Barr virus (EBV) glycoprotein350 (gp350), an EBV vaccine candidate, were protective against nasopharyngeal carcinoma (NPC) in genetically high-risk families from Taiwan. The current study attempted to extend this association to a general population cohort. Methods: We compared total and IgA-specific gp350 antibody levels in 35 incident NPC cases and 81 disease-free controls from the Cancer Screening Program in Taiwan (23943 individuals recruited 1991-1992)...
August 14, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29669253/an-antibody-targeting-the-fusion-machinery-neutralizes-dual-tropic-infection-and-defines-a-site-of-vulnerability-on-epstein-barr-virus
#18
Joost Snijder, Michael S Ortego, Connor Weidle, Andrew B Stuart, Matthew D Gray, M Juliana McElrath, Marie Pancera, David Veesler, Andrew T McGuire
Epstein-Barr virus (EBV) is a causative agent of infectious mononucleosis and is associated with 200,000 new cases of cancer and 140,000 deaths annually. Subunit vaccines against this pathogen have focused on the gp350 glycoprotein and remain unsuccessful. We isolated human antibodies recognizing the EBV fusion machinery (gH/gL and gB) from rare memory B cells. One anti-gH/gL antibody, AMMO1, potently neutralized infection of B cells and epithelial cells, the two major cell types targeted by EBV. We determined a cryo-electron microscopy reconstruction of the gH/gL-gp42-AMMO1 complex and demonstrated that AMMO1 bound to a discontinuous epitope formed by both gH and gL at the Domain-I/Domain-II interface...
April 17, 2018: Immunity
https://www.readbyqxmd.com/read/29669245/inhibiting-ebv-the-key-to-carefree-smooching
#19
Shee-Mei Lok
There are no vaccines or therapies to treat Epstein-Barr virus (EBV). Snijder et al. (2018) isolated a potent human antibody against EBV that blocks infection of both B cells and epithelial cells. Structural analysis of the antibody complexed with a viral surface protein complex identified a site that may be useful in vaccine development.
April 17, 2018: Immunity
https://www.readbyqxmd.com/read/29599765/herpesviruses-in-the-activated-phosphatidylinositol-3-kinase-%C3%AE-syndrome
#20
REVIEW
Jeffrey I Cohen
The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is important for multiple stages of herpesvirus replication including virus entry, replication, latency, and reactivation. Recently, patients with gain-of-function mutations in the p110δ-catalytic subunit of PI3K or in the p85-regulatory subunit of PI3K have been reported. These patients have constitutively active PI3K with hyperactivation of Akt. They present with lymphoproliferation and often have infections, particularly recurrent respiratory infections and/or severe virus infections...
2018: Frontiers in Immunology
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