Read by QxMD icon Read

Mobile phase additive

Veronica Cimolin, Nicola Cau, Giovanna Malchiodi Albedi, Valentina Aspesi, Vanessa Merenda, Manuela Galli, Paolo Capodaglio
The purpose of this study was to validate Time Up and Go test (TUG) as measured by a single Inertial Measurement Unit (IMU) placed on the lower back to that measured by a stopwatch in obese and normal weight women; in addition, the comparison of the performance of TUG test between obese and healthy women using the instrumented TUG (iTUG). Forty-four severely obese women and 14 age-matched healthy women were assessed simultaneously by IMU and stopwatch. The comparison between manual and instrumented assessment of total time duration showed no significant differences both in the healthy (8...
December 5, 2018: Journal of Electromyography and Kinesiology
Jutti Levita, Dina Mulyana Syafitri, Rini Daud Supu, Mutakin Mutakin, Sandra Megantara, Maya Febrianti, Ajeng Diantini
Red ginger ( Zingiber officinale var. Rubrum) is among the most widely consumed medicinal herbs in Indonesia. Ginger rhizome contains phenol compounds including gingerol and shogaol. 10-gingerol has been reported to exhibit the greatest anti-inflammatory and anti-oxidant activities compared with those of other gingerols. Pharmacokinetic studies on ginger have been reported, but there is a lack of such study on red ginger. The present work studied the pharmacokinetics of 10-gingerol and 6-shogaol in the plasma of healthy subjects treated with a single dose of red ginger suspension...
December 2018: Biomedical Reports
Wojciech Kazimierz Marek, Wojciech Piątkowski, Dorota Antos
The retention behavior of polyethylene glycol (PEG) on different types of hydrophobic interaction chromatography (HIC) resins containing butyl, octyl, and phenyl ligands was analyzed. An incomplete elution or splitting of the polymer peak into two parts was observed, where the first one was eluted at the dead time of the column, whereas the second one was strongly retained. The phenomenon was attributed to conformation changes of the polymer upon its adsorption on hydrophobic surface. The effect enhanced with increasing molecular weight of the polymer and hydrophobicity of the HIC media...
2018: Chromatographia
Andrés Sotelo, Miguel A Torres, María A Madre, Juan C Diez
In this study, Ca0.9 Yb0.1 MnO₃ + x wt.% Ag (with x = 0, 1, 3, 5, and 10) thermoelectric materials were prepared via the classical ceramic method. In spite of the very high sintering temperature (1300 °C), no significant Ag losses were observed following this process. Moreover, Ag addition enhanced cation mobility during sintering due to the formation of a liquid phase. Microstructurally, it was found that Ag decreases porosity; this was confirmed by density measurements. Ag was also found to promote the formation of a Ca₂Mn₂O₅ secondary phase...
December 9, 2018: Materials
Qi Lin, Tom de Waal, Ann Van Schepdael, Erwin Adams
In this study, an improved liquid chromatographic (LC) method for the analysis of tylosin and its impurities has been developed. A Kinetex EVO C18 column (150 × 4.6 mm, 2.6 μm) packed with superficially porous particles was used as stationary phase. Gradient elution was applied with two mobile phases (A and B) containing acetonitrile, water and 0.2 M ammonium acetate at different ratios (20:10:70 (v/v/v) for A and 60:10:30 (v/v/v) for B). This volatile mobile phase enables the method to be coupled with mass spectrometry (MS) for additional detection and characterization of tylosin impurities...
December 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
Giuseppina Nocca, Cinzia Callà, Stefano Angelo Santini, Adriana Amalfitano, Luca Marigo, Diana Valeria Rossetti, Gianrico Spagnuolo, Massimo Cordaro
A reverse phase high performance liquid chromatographic (RP-HPLC) method was developed for identification and estimation of 18- β -glycyrrhetinic acid (GA) in HepG2 cell line. The analysis was carried out using a JASCO HPLC system with a C-18 (3  μ m) Supelco reversed phase column (150 x 4.7 mm) using a mobile phase of 80% CH3 OH and 20% of CH3 CN: tetrahydrofuran: water (10:80:10, v/v/v). The method was linear in the concentration range of 1.5-120  μ g /mL (n = 5). The LOD and LOQ were determined based on standard deviation of the y-intercept and the slope of the calibration curve...
2018: International Journal of Analytical Chemistry
Kevin Jooß, Sven W Meckelmann, Julia Klein, Oliver J Schmitz, Christian Neusüß
Capillary zone electrophoresis (CZE) based on electrophoretic mobility in the liquid phase and ion mobility spectrometry (IMS) based on mobilities in the gas phase are both powerful techniques for the separation of complex samples. Protein glycosylation is one of the most common post-translational modifications associated with a wide range of biological functions and human diseases. Due to their high structural variability, the analysis of glycans still represents a challenging task. In this work, the first on-line coupling of CZE with drift tube ion mobility-mass spectrometry (DTIM-MS) has been perfomed to further improve separation capabilities for the analysis of native and 8-aminopyrene-1,3,6-trisulfonic acid (APTS)-labeled N-glycans...
December 10, 2018: Analytical and Bioanalytical Chemistry
Jong Gyun Ahn, Yoonsun Bae, Dongjik Shin, Jiho Nam, Kyu Yeun Kim, Dong Soo Kim
Objectives: Kawasaki disease (KD) is an acute systemic vasculitis of unknown aetiology that affects infants and young children. Recent reports of elevated serum high mobility group box 1 (HMGB1) level during the acute phase of KD and its relationship to poor response to IVIG treatment suggest a possible association of HMGB1 polymorphisms with KD. We investigated the association between the polymorphisms of the HMGB1 gene, KD susceptibility, coronary artery lesions, and KD response to IVIG treatment...
December 7, 2018: Rheumatology
Jing Li, Li Xu, Zhi-Guo Shi
In this study, the ethyl-bridged hybrid silica microsphere with hierarchically meso-macroporous structure was initially synthesized through a method combining dispersion polymerization with sol-gel transition and phase separation. The flow-through macropores rendered the microsphere a rough surface like a waxberry, and thus the material was named as waxberry-like ethyl-bridged hybrid silica sphere (WEHS). WEHS was characteristic of appropriate alkali-stability, which was highly difficult for the pure silica...
November 29, 2018: Journal of Chromatography. A
Andrew J Hobson, Douglas I Stewart, Robert J G Mortimer, William M Mayes, Mike Rogerson, Ian T Burke
Steelmaking wastes stored in landfill, such as slag and spent refractory liners, are often enriched in toxic trace metals (including V). These may become mobile in highly alkaline leachate generated during weathering. Fresh steelmaking waste was characterised using XRD, XRF, and SEM-EDX. Batch leaching tests were performed under aerated, air-excluded and acidified conditions to determine the impact of atmospheric CO2 and acid addition on leachate chemistry. Phases commonly associated with slag including dicalcium silicate, dicalcium aluminoferrite, a wüstite-like solid solution and free lime were identified, as well as a second group of phases including periclase, corundum and graphite which are representative of refractory liners...
November 2018: Waste Management
Dong Yan, Jingming Xin, Weiping Li, Sha Liu, Hongbin Wu, Wei Ma, Jiannian Yao, Chuanlang Zhan
In this article, we report 13%-efficiency quaternary polymer solar cell. By introducing bis-PC71BM:PC71BM into a known nonfullerene systemPBDB-T:IT-M, the quaternary solar cell significantly outperforms the nonfullerene binary and the ternary (PBDB-T:IT-M:fullerene) devices with the significant increase in short-circuit current-density (18.2 vs 16.5 and 16.8-17.5 mA/cm2) and fill-factor (0.73 vs. 0.67 and 0.707-0.726), and hence, large power conversion efficiency (13% for quaternary vs. 11% for the binary and 12% for the ternary)...
December 10, 2018: ACS Applied Materials & Interfaces
Yanhui Wang, Susan V Olesik
Recent advances in analysis of proteins have increased the demand for more efficient techniques to separate intact proteins. Enhanced-fluidity liquid chromatography (EFLC) involves the addition of liquefied CO2 to conventional liquid mobile phases. The addition of liquefied CO2 increases diffusivity and decreases viscosity, which inherently leads to a more efficient separation. Herein, EFLC is applied to hydrophobic interaction chromatography (HIC) stationary phases for the first time to study the impact of liquefied CO2 to the chromatographic behavior of proteins...
December 7, 2018: Analytical Chemistry
Luca Francaviglia, Gözde Tütüncüoglu, Federico Matteini, Anna Fontcuberta I Morral
Nanoscale variations in the composition of an Al x Ga1-x As shell around a GaAs nanowire affect the nanowire functionality and can lead to the formation of localized quantum emitters. These composition fluctuations can be the consequence of variations of crystal phase and/or nanoscale adatom mobility. By applying electron-microscopy-related techniques we correlate the optical, compositional and structural properties at the nanoscale on the same object. The results indicate a clear correlation between the twin density in the nanowire and the quantum-emitter density as well as a significant redshift in the emission...
February 1, 2019: Nanotechnology
Jin Zhang, Shuai Zhang, Xianqi Lin, Yong Fan, Gert Frølund Pedersen
This paper proposes a 3D radiation pattern reconfigurable antenna (RPRA) and a reconfigurable phased array (RPA) for 5G mobile communication. The antenna and array are working at 28 GHz, which is selected as a 5G communication band in many countries. The proposed phased array will be applied as sensors to find out the optimal transmitting⁻receiving angle in a randomly changed cellular wireless scenarios. The RPRA and RPA are fed by Substrate Integrated Waveguide (SIW) and have three switchable radiation modes: Broadside 1, Broadside 2 and Endfire...
November 30, 2018: Sensors
Mei-Li Liu, Meng Huang, Lian-Yu Tian, Li-Hong Zhao, Bin Ding, Debin Kong, Quan-Hong Yang, Jiao-Jing Shao
Two-dimensional (2D) nanochannel arrays are constructed by a bottom-up re-assembly montmorillonite monolayers that are obtained by liquid phase exfoliating its layered crystals, and the as-constructed interstitial space between these monolayers is uniform and provides ions with nanoscale transport channels. Surface charge-controlled ion transport behavior is observed through these nanochannels as the electrolyte concentration reduces to 10-4 M at room temperature. Furthermore, the nanochannel structure remains even after 400 ºC heat treatment, and nanofluidic devices based on the annealed nanochannel arrays still exhibit surface charge-governed ion transport at low electrolyte concentrations...
December 4, 2018: ACS Applied Materials & Interfaces
Emmanuelle Lipka, Anca-Elena Dascalu, Yasmine Messara, Eka Tsutsqiridze, Tivadar Farkas, Bezhan Chankvetadze
In this short communication preliminary results are reported on the separation of enantiomers of underivatized amino acids on polysaccharide-based chiral columns in sub/super-critical fluid chromatography (SFC). Racemic mixtures of 14 amino acids were used to evaluate the chiral recognition ability of 8 different polysaccharide-based chiral columns with coated or covalently immobilized chiral selectors. Among the studied columns, the one based on cellulose (3,5-dichlorophenylcarbamate) exhibited the most universal chiral recognition ability providing baseline resolution for the enantiomers of 10 studied amino acids...
November 22, 2018: Journal of Chromatography. A
Ran Li, Bingru Zhang, Ying Wang, Yankai Zhao, Fengting Li
The presence of toxic metals in municipal solid waste incineration fly ash is of great concern due to their leaching potential in landfills. To prevent groundwater or soil contamination caused by metal leaching from fly ash, recently the Chinese government began to require that the leachate concentrations of toxic metals not only satisfied the GB 16889-2008 criteria prior to landfilling but also introduced a series of measures to monitor the groundwater quality in the landfill site and its adjacent areas (GB/T 18772-2017)...
November 24, 2018: Journal of Environmental Management
Chungen Li, Caili Chen, Qi An, Tao Yang, Zitai Sang, Yang Yang, Yuan Ju, Aiping Tong, Youfu Luo
The transcription factor STAT3 is an attractive target for a variety of cancers therapy. Napabucasin, applied in phase III clinical trials for the treatment of a variety of cancers, was regarded as one of the most promising anticancer drug by targeting STAT3. Herein, a novel series of napabucasin derivatives were designed and synthesized, which presented a potent inhibitory activity on a variety of cancers cells. Among the derivatives compound 8q exhibited potent inhibitory activity on U251, HepG2, HT29 and CT26 cells with the IC50 values of 0...
November 1, 2018: European Journal of Medicinal Chemistry
Monika Jiru, Milena Stranska-Zachariasova, Zbynek Dzuman, Kamila Hurkova, Monika Tomaniova, Radim Stepan, Petr Cuhra, Jana Hajslova
Popularity of natural-based preparations supporting the sexual potency significantly increased in recent years, which also led to the increase of illegal use of phosphodiesterase type 5 inhibitor (PDE-5) in sexual performance enhancement products. In this study, a rapid U-HPLC‒HRMS/MS method has been developed to simultaneously determine 59 PDE-5 inhibitors and their analogues. Within the development of sensitive method for analysis of 59 PDE-5 inhibitors and their analogues, both sample preparation procedure, as well as separation / detection conditions have been optimized...
November 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
Eun-Jung Lee, Jin-Sun Park, Yu-Young Lee, Do-Yeon Kim, Jihee Lee Kang, Hee-Sun Kim
BACKGROUND: Recent evidence suggests that reactive astrocytes play an important role in neuroinflammation and neurodegenerative diseases. Thus, controlling astrocyte reactivity has been suggested as a promising strategy for treating neurodegenerative diseases. In the present study, we investigated whether a matrix metalloproteinase (MMP)-8 inhibitor, M8I, could control neuroinflammation in lipoteichoic acid (LTA)-stimulated rat primary astrocytes. METHODS: The effects of M8I on the expression of inducible nitric oxide synthase, cytokines, and MMPs were examined in LTA-stimulated rat primary astrocytes by ELISA, RT-PCR, and Western blot analysis...
November 23, 2018: Journal of Neuroinflammation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"