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Inflammation rats

Shanshan Liang, Sixiu Liu, Hua Liu, Xin He, Lingshuang Sun, Lei Chen, Meng Wei, Fanfan Gao, Hongli Jiang
BACKGROUND/AIMS: Previous studies have shown that homocysteine (Hcy) is an important intestinal-derived uremic toxin. However, whether Hcy is involved in the epithelial barrier dysfunction observed in uremia remains unclear. This study aimed to investigate the effect of Hcy on intestinal permeability and intestinal barrier structure and function in adenine-induced uremic rats. METHODS: Sprague-Dawley rats were divided into five groups: normal control (group NC), Hcy (group H), uremia (group U), uremia + Hcy (group UH), and uremia + Hcy + VSL#3 (group UHV)...
October 18, 2018: Kidney & Blood Pressure Research
Kavitha Yuvaraj, Arumugam Geetha
Background Chronic pancreatitis (CP) is a persistent inflammation of the pancreas clinically presented with severe abdominal pain, progressive fibrosis, and loss of exocrine and endocrine functions. Inflammasomes, cytosolic multiprotein complexes which regulate the formation of proinflammatory cytokines, are influenced by various factors including heat shock proteins (HSPs). Morus alba L., or white mulberry root bark is a valued traditional Asian medicine with a diverse array of phytochemicals. The aim of this investigation was to define the modulatory action of methanolic extract of Morus alba root bark (MEMARB) on NLRP3 inflammasome, and HSPs in pancreas subjected to inflammatory insult...
October 18, 2018: Journal of Complementary & Integrative Medicine
Zhijian Rao, Shiqiang Wang, Wyatt Paul Bunner, Yun Chang, Rengfei Shi
BACKGROUND AND OBJECTIVES: Intense exercise (IE) induced myocardial fibrosis (MF) showed contradictory findings in human studies, making the relationship between IE and the development of MF unclear. This study aims to demonstrate exercise induced MF is associated with cardiac damage, and inflammation is essential to the development of exercise induced MF. METHODS: Sprague-Dawley rats were submitted to daily 60-minutes treadmill exercise sessions at vigorous or moderate intensity, with 8-, 12-, and 16-week durations; time-matched sedentary rats served as controls...
November 2018: Korean Circulation Journal
Dandan Dou, Lixin Chen, Hong Di, Zhuoran Song, Shirui Li, Xinjie Bu, Qing Dai, Shuai Wang, Jing Xin Li, Xiaolong Zhu, Haiyan Jing
BACKGROUND: Inflammatory bowel disease (IBD) is a functional disorder with chronic and relapsing clinical features. Vasopressin (VP) is a hormone responsible for water and stress homeostasis and also regulates gastrointestinal inflammation and motility. We explored whether VP was related to IBD pathogenesis and its possible pathway. METHODS: Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) in mice. The disease activity and colonic damage were evaluated through a scoring system...
October 18, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Hassan Hassani-Bafrani, Hamed Najaran, Mazdak Razi, Hamid Rashtbari
The present study was performed to show the ameliorative effect of berberine (BBR), as an antioxidant and anti-inflammatory agent, against experimental varicocele (VCL)-induced molecular and histological damages. For this purpose, 50 mature Wistar rats were divided into control, control-sham, VCL-sole, 50 mg/kg and 100 mg/kg BBR-treated VCL-induced groups. The tissue levels of interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), nitric oxide (NO), total antioxidant capacity (TAC), malondialdehyde (MDA), superoxide dismutase (SOD) and gluthatione peroxidase (GSH-px) as well as the mRNA levels of testicular CuZn SOD, MnSOD, EC-SOD and GSH-px were evaluated...
October 17, 2018: Andrologia
Agnaldo Bruno Chies, Paula Carolina Grande Nakazato, Maria Angélica Spadella, Patrícia Zorzi, Maria Cecília Jordani Gomes, Luiz Augusto Carneiro D'Albuquerque, Orlando Castro-E-Silva
PURPOSE: To evaluate whether pre-treatment with rivastigmine is able to attenuate the I/R induced lesions in rat liver. METHODS: SHAM animals or those submitted to I/R, non-treated or pre-treated with rivastigminine (2mg/kg) either 50 or 15 minutes before ischemia, were used. After I/R protocol, these animals were killed and their livers were harvested to measurement of the mitochondrial swelling as well as the malondialdehyde (MDA), nitrite and nitrate tissue concentration...
September 2018: Acta Cirúrgica Brasileira
Huan Li, Sheng Song, Yuan Wang, Chun Huang, Feng Zhang, Jie Liu, Jau-Shyong Hong
A single injection of LPS produced low-grade neuroinflammation leading to Parkinson's disease (PD) in mice several months later. Whether such a phenomenon occurs in rats and whether such low-grade neuroinflammation would aggravate rotenone (ROT) neurotoxicity and disrupts circadian clock gene/protein expressions were examined in this study. Male rats were given two injections of LPS (2.5-7.5 mg/kg), and neuroinflammation and dopamine neuron loss were evident 3 months later. Seven months after a single LPS (5 mg/kg) injection, rats received low doses of ROT (0...
October 17, 2018: Neurotoxicity Research
Yuqin Zhang, Guohong Yan, Chengtao Sun, Lihong Nan, Xiaoying Wang, Wei Xu, Kedan Chu
Compound 3R-(4'-hydroxyl-3'-O-β-D-glucopyranosyl phenyl)-dihydro isocoumarin (GDC) is a natural isocoumarin, recently isolated from the stems of H. paniculiflorum. However, we know little about the effects of GDC on rheumatoid arthritis (RA). This study aims to investigate the protective effects and potential mechanisms of GDC against LPS-induced inflammation in vitro. Fibroblast-like synoviocytes (FLSs) obtained from synovial tissue of rats were induced by lipopolysaccharide (LPS) and treated with GDC. Cell viability was determined by mitochondrial-respiration-dependent3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay...
October 17, 2018: Inflammation
Alan B Vasconcelos, Fernando K Nampo, Júlio C Molina, Miriam B Silva, Alan S Oliveira, Tarlyson R de Angelis, Amanda L Hasuda, Enilton A Camargo, Solange P Ramos
We compared the acute effects of different doses of 630 nm light-emitting diode therapy (LEDT) on skeletal muscle inflammation and hyperalgesia in rats submitted to exercise-induced muscle damage (EIMD). Wistar rats were divided into five experimental groups (n = 5-8/group): sedentary control (CON); exercise + passive recovery (PR); and exercise + LEDT (1.2 J/cm2 , 1.8 J; 4.2 J/cm2 , 6.3 J; 10.0 J/cm2 , 15 J). After 100 min of swimming, the rats in the LEDT groups were exposed to phototherapy on the triceps surae muscle...
October 17, 2018: Lasers in Medical Science
Yan-hui Bai, Yong Lv, Wei-qun Wang, Guang-li Sun, Hao-hao Zhang
Human corneal fibroblasts (HCFs) are implicated in corneal neovascularization (CRNV). The mechanisms underlying the inflammatory response in HCFs and the development of CRNV were explored in this study. Alkali burns were applied to the corneas of rats to establish a CRNV model. The expression of long noncoding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) and mRNA and protein levels of nuclear factor kappa B (NF-κB)- activating protein (NKAP) were examined by quantitative real-time (qRT-PCR) and Western blot methods, respectively...
October 15, 2018: Journal of Molecular Endocrinology
Haiyan Zhao, Yaping Zhao, Xin Li, Leiqian Xu, Fangxin Jiang, Wanju Hou, Lixia Dong, Jie Cao
PURPOSE: Obstructive sleep apnea and chronic obstructive pulmonary disease are independent risk factors of cardiovascular disease (CVD), and their coexistence is known as overlap syndrome (OS). Endothelial dysfunction is the initial stage of CVD; however, underlying mechanisms linking OS and CVD are not well understood. The aim of this study was to explore whether OS can lead to more severe inflammation and endothelial apoptosis by promoting endothelial dysfunction, and to assess the intervention effects of antioxidant tempol...
November 2018: Yonsei Medical Journal
Huiyi Liang, Bo Peng, Cong Dong, Lixin Liu, Jiaji Mao, Song Wei, Xinlu Wang, Hanshi Xu, Jun Shen, Hai-Quan Mao, Xiaohu Gao, Kam W Leong, Yongming Chen
Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here we show that ~40 nm cationic nanoparticles (cNP) can scavenge cfDNA derived from RA patients and inhibit the activation of primary synovial fluid monocytes and fibroblast-like synoviocytes. Using clinical scoring, micro-CT images, MRI, and histology, we show that intravenous injection of cNP into a CpG-induced mouse model or collagen-induced arthritis rat model can relieve RA symptoms including ankle and tissue swelling, and bone and cartilage damage...
October 16, 2018: Nature Communications
Shengchao Du, Yuan Sun, Bizeng Zhao
BACKGROUND Few studies have investigated systemic inflammation levels in degenerative cervical myelopathy (DCM). This study evaluated the concentration of inflammatory cytokines in DCM patients and assessed whether they can predict symptom severity. MATERIAL AND METHODS A total of 40 consecutive DCM patients and 10 healthy volunteers were included in this study. Concentrations of interleukin (IL)-1β, IL-6, interferon-γ, and tumor necrosis factor-α were compared between DCM patients and normal controls. Spearman's correlation coefficient was used to examine relationships of cytokines with age, body mass index (BMI), symptom duration, and symptom severity...
October 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Hua-Li Huang, Guo-du Tang, Zhi-Hai Liang, Meng-Bin Qin, Xian-Mo Wang, Ren-Jie Chang, He-Ping Qin
OBJECTIVE: To clarify the protective role of Wnt/β-Catenin pathway agonist SKL2001 in Caerulein-induced acute pancreatitis (AP). METHODS: AR42J cells and rats were divided into Control, Caerulein, SKL2001 + Caerulein and SKL2001 + Control groups respectively. Cell apoptosis was examined by flow cytometry. Hematoxylin-eosin (HE) staining was performed to observe pathological changes of pancreas and small intestinal tissues. Inflammatory cytokines were detected by enzyme linked immunosorbent assay (ELISA) while Wnt/β-Catenin pathway-related genes by quantitative real-time PCR (qRT-PCR)...
October 16, 2018: Canadian Journal of Physiology and Pharmacology
Maryam Ranjpour, Saima Wajid, Swatantra Kumar Jain
Identification of events leading to HCC progression is essential for understanding its pathophysiology. Present study was designed to identify differentially expressed proteins in serum of HCC-bearing rats vis-a-vis controls during cancer initiation, progression and tumorigenesis. HCC was chemically induced by administering N-Nitrosodiethylamine and 2-aminoacetylfluorine to male Wistar rats. Carcinogen administration caused inflammation leading to liver injury and HCC development. Liver inflammation was confirmed by increase in levels of IL-6 and TNF-α in carcinogen treated rats...
October 15, 2018: Anti-cancer Agents in Medicinal Chemistry
Yang Liu, Yuanhang Liu, Xuecheng Huang, Jingchang Zhang, Lihui Yang
OBJECTIVE: Coronary microembolization (CME) is a common complication during the percutaneous coronary intervention (PCI). CME-induced local myocardial inflammation and myocardial apoptosis are the primary causes of progressive cardiac dysfunction. Curcumin exerts a protective role in various cardiovascular diseases; however, its effects in CME are yet to be clarified. Therefore, the current study investigated the effects of curcumin on myocardial inflammatory responses, myocardial apoptosis, and cardiac dysfunctions induced by CME in rats...
October 15, 2018: Journal of Cellular Biochemistry
Suchada Saovieng, Jinfu Wu, Chih-Yang Huang, Chung-Lan Kao, Matthew F Higgins, Rungchai Chuanchaiyakul, Chia-Hua Kuo
Background: We have previously shown an accelerated recovery from muscle fatigue in men challenged by prolonged exercise after oral deep ocean minerals (DOM) supplementation. Here, we hypothesized a decrease in eccentric exercise-induced muscle inflammation in rats regularly consuming DOM-containing drinks (hardness 600 mg/L and fructose 11%). Methods: Forty-seven male Sprague Dawley rats were randomized into 4 groups: Control (C, N = 12), Fructose (F, N = 12), Fructose+Exercise (FE, N = 12), and Fructose+Exercise+DOM (FED, N = 11)...
2018: Frontiers in Physiology
Yasemin Sezgin, Mehtap Bilgin Çetin, Şule Bulut, Nilgün Özlem Alptekin, Pelin Börçek
BACKGROUND: Although postoperative complications occurs after periodontal plastic surgeries, an ideal treatment has not been found to overcome. AIMS: The aim of this study was evaluated the effects of topically applied Oral-norm gel on the healing of excisional wounds. STUDY DESIGN: Animal experimentation. METHODS: Excisional wounds with a 3 mm diameter were made in the center of the palatal mucosa in 63 Sprague Dawley rats...
October 16, 2018: Balkan Medical Journal
Daniela Caetano Gonçalves, Fábio Santos Lira, Alex Shimura Yamashita, Luiz Carlos Carnevali Junior, Robson Eder, Alessandro Laviano, Marília Cerqueira Leite Seelaender
BACKGROUND & AIMS: The liver is the main organ regulating metabolism. In spite of that, few studies examine liver metabolism in cachexia, a wasting syndrome associated with increased morbidity and mortality in cancer. Cachexia induces major metabolic disruption, inflammation and fat and lean mass loss. We have previously shown impairment of hepatic lipid metabolism in cancer cachexia that contributes to the aggravation of the symptoms. The present study addresses the effects of Conjugated Linoleic Acid supplementation upon liver lipid metabolism in cachectic rats...
September 25, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Jian-Zhong Zhang, Dan Chen, Li-Quan Lv, Zheng Xu, Yi-Ming Li, Jun-Yu Wang, Kai-Wei Han, Ming-Kun Yu, Cheng-Guang Huang, Li-Jun Hou
microRNAs (miRNAs) control several processes known to be involved in progression of aneurysm. Here, intracranial aneurysms (IAs) were surgically induced in Sprague-Dawley rats, and we found that miR-448-3p was downregulated and KLF5 was upregulated in IA rats. We identified Klf5 as a direct target of miR-448-3p in smooth muscle cells (SMCs). In addition, aneurysms size and the lumen area of the aneurysms were smaller 4 weeks after IA induction in the miR-448-3p-treated group. miR-448-3p treatment protected the wall thickness ratio and suppressed macrophage infiltration after IA induction...
October 12, 2018: Biochemical and Biophysical Research Communications
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