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https://www.readbyqxmd.com/read/30110565/epigenetic-modification-of-intestinal-smooth-muscle-cell-phenotype-during-proliferation
#1
Quinn A Bonafiglia, Sandra R Lourenssen, David J Hurlbut, Michael G Blennerhassett
Inflammation causes proliferation of intestinal smooth muscle cells (ISMC), which contributes to a thickened intestinal wall, and also to stricture formation in Crohn's disease. Proliferation of ISMC both in vitro and in vivo caused decreased expression of marker proteins, but the underlying cause is unclear. Since epigenetic change is important in other systems, we examined this in cell lines from rat colon at either low passage or after extended growth, using immunocytochemistry, immunoblotting and qPCR to evaluate phenotype...
August 15, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/30108662/jian-pi-yi-shen-formula-regulates-inflammatory-cytokines-production-in-5-6-nephrectomized-rats-via-suppression-of-nf-%C3%AE%C2%BAb-activation
#2
Jiandong Lu, Xinhui Liu, Yijiao Liao, Dongcai Wang, Jianping Chen, Shunmin Li
Jian-Pi-Yi-Shen formula (JPYSF) is a Chinese herbal decoction used for treating chronic kidney disease (CKD) for over 20 years with good efficiency. However, the mechanism lacks solid evidence. In the present study, we tested the hypothesis that JPYSF may retard CKD progression via inhibition of inflammation in 5/6 nephrectomy (5/6 Nx) rat model. The 5/6 Nx rats were randomly divided into 2 groups: 5/6 Nx group and JPYSF group. Sham-operated rats served as control. JPYSF (2.06 g/kg/d) were administrated by gavage to 5/6 Nx rats daily for 6 weeks...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30108638/cardiac-and-renal-fibrosis-and-oxidative-stress-balance-in-lipopolysaccharide-induced-inflammation-in-male-rats
#3
Fereshteh Asgharzadeh, Rahimeh Bargi, Mahmoud Hosseini, Mehdi Farzadnia, Majid Khazaei
BACKGROUND: Subclinical inflammation induced by persistent exposure to lipopolysaccharide (LPS) is found in some clinical conditions such as obesity or diabetes. This study aimed to investigate the effect of recurrent LPS exposure on inflammatory markers, oxidative stress balance and cardiac and renal fibrosis in male rats. METHODS: Male Wistar rats were divided into control and LPS-treated. LPS (10 mg/kg/week) was injected intraperitoneally. After 4 weeks, left ventricles and kidneys were homogenized and stained with hematoxylin and eosin (H&E) and Masson trichrome for histological examination...
March 2018: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/30108502/correction-of-anemia-in-chronic-kidney-disease-with-angelica-sinensis-polysaccharide-via-restoring-epo-production-and-improving-iron-availability
#4
Kaiping Wang, Jun Wu, Jingya Xu, Saisai Gu, Qiang Li, Peng Cao, Mingming Li, Yu Zhang, Fang Zeng
Given the limited efficacy and potential disadvantages of erythropoiesis-stimulating agents (ESAs) in treating anemia of chronic kidney disease (CKD), the development of better alternative therapies has become a priority. The primary purpose of this study is to investigate the effects of Angelica sinensis polysaccharide (ASP) and its underlying mechanism in the treatment of renal anemia. In the present study, we found that ASP could enhance hypoxic induction of EPO in Hep3B cells, with a mechanism that involved the stabilization of HIF-2α protein...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30107860/therapeutic-potential-of-stromal-cells-of-non-renal-or-renal-origin-in-experimental-chronic-kidney-disease
#5
Cinzia Rota, Marina Morigi, Domenico Cerullo, Martino Introna, Ornella Colpani, Daniela Corna, Chiara Capelli, Ton J Rabelink, Danielle G Leuning, Daniela Rottoli, Ariela Benigni, Carlamaria Zoja, Giuseppe Remuzzi
BACKGROUND: Mesenchymal stromal cell (MSC)-based therapy is a promising strategy for preventing the progression of chronic kidney disease (CKD), with the potential to induce tissue regeneration. In search of the best cellular source we compared, in the rat model of adriamycin (ADR) nephropathy, the regenerative potential of human stromal cells of non-renal origin, such as bone marrow (bm) MSCs and umbilical cord (uc) MSCs, with that of newly discovered stromal cells of renal origin, the kidney perivascular cells (kPSCs) known to exhibit tissue-specific properties...
August 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30107848/neuroprotection-and-immunomodulation-following-intraspinal-axotomy-of-motoneurons-by-treatment-with-adult-mesenchymal-stem-cells
#6
A B Spejo, G B Chiarotto, A D F Ferreira, D A Gomes, R S Ferreira, B Barraviera, A L R Oliveira
BACKGROUND: Treatment of spinal cord injury is dependent on neuronal survival, appropriate synaptic circuit preservation, and inflammatory environment management. In this sense, mesenchymal stem cell (MSC) therapy is a promising tool that can reduce glial reaction and provide trophic factors to lesioned neurons. METHODS: Lewis adult female rats were submitted to a unilateral ventral funiculus cut at the spinal levels L4, L5, and L6. The animals were divided into the following groups: IA (intramedullary axotomy), IA + DMEM (Dulbecco's modified Eagle's medium), IA + FS (fibrin sealant), IA + MSC (106 cells), and IA + FS + MSC (106 cells)...
August 14, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/30107561/delayed-spironolactone-administration-prevents-the-transition-from-acute-kidney-injury-to-chronic-kidney-disease-through-improving-renal-inflammation
#7
Jonatan Barrera-Chimal, Leslie Rocha, Isabel Amador-Martínez, Rosalba Pérez-Villalva, Rafael González, Cesar Cortés-González, Norma Uribe, Victoria Ramírez, Nathan Berman, Gerardo Gamba, Norma A Bobadilla
Background: Acute kidney injury (AKI) is not as harmless as previously thought since it may lead to chronic kidney disease (CKD). Because most of the time ischemic AKI occurs unexpectedly, it is difficult to prevent its occurrence and there are no specific therapeutic approaches to prevent the AKI to CKD transition. We aimed to determine whether mineralocorticoid receptor blockade (MRB) in the first days after ischemia/reperfusion (IR) can prevent progression to CKD. Methods: Four groups of male Wistar rats were included: sham and three groups of bilateral renal ischemia for 45 min, one without treatment and the other two receiving spironolactone for 5 or 10 days, starting 24 h after IR...
August 9, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30107367/protective-effect-of-ginsenoside-metabolite-compound-k-against-diabetic-nephropathy-by-inhibiting-nlrp3-inflammasome-activation-and-nf-%C3%AE%C2%BAb-p38-signaling-pathway-in-high-fat-diet-streptozotocin-induced-diabetic-mice
#8
Wu Song, Lin Wei, Yanwei Du, Yimei Wang, Shuang Jiang
Though the antidiabetic effect of ginsenoside compound K (CK) has been well studied, the effect of CK on diabetic nephropathy (DN) is not clear. Whether CK would have a protective effect against DN and it could exert the protective effect by inhibiting the oxidative stress, NLRP3 inflammasome and NF-κB/p38 signaling pathway were investigated in this study. Here, the HFD (high fat diet)/STZ (streptozotocin)-induced DN mice model was established to assess the CK effect in vivo. Parallel experiments uncovering the molecular mechanism by which CK prevents from DN was performed in rat glomerular mesangial cell line HBZY-1 exposed to high glucose...
August 11, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30107348/curcumin-affects-tracheal-responsiveness-and-lung-pathology-in-asthmatic-rats
#9
Farzaneh Shakeri, Nama Mohamadian Roshan, Mahsa Kaveh, Naeima Eftekhar, Mohammad Hossein Boskabady
BACKGROUND: Curcumin has shown various pharmacological effects such as anti-inflammatory activities. In this study, the effects of curcumin on tracheal responsiveness and lung pathological features were evaluated in a rat model of asthma. METHODS: Tracheal responsiveness and lung pathological features were evaluated in control rats (C), ovalbumin (OVA)-sensitized rats (as an animal model of asthma; A), A rats treated with curcumin (Cu, 0.15, 0.30, and 0.60 mg/ml) and dexamethasone (D, 1...
April 22, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/30107253/evaluation-of-anti-arthritic-potential-of-trigonella-foenum-graecum-l-fenugreek-mucilage-against-rheumatoid-arthritis
#10
Sindhu G, Shyni G L, Chithra K Pushpan, Bala Nambisan, Helen A
Rheumatoid arthritis is a chronic inflammatory joint disease characterized by synovial proliferation and tissue destruction. Pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) play a key role in the disease process and elevate energy expenditure, which further increases the joint pain and stiffness. The present study was undertaken to explore the anti-arthritic potential of fenugreek mucilage in adjuvant induced arthritic rats. In the present study, paw volume was measured on the 7th , 14th and 21st day...
August 11, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/30107135/high-fat-diet-leads-to-adiposity-and-adipose-tissue-inflammation-the-effect-of-whey-protein-supplementation-and-aerobic-exercise-training
#11
Farhad Ahmadi-Kani Golzar, Rozita Fathi, Soleiman Mahjoub
There is little understanding about dietary proteins and their potential contribution to obesity-induced inflammation. This study investigates the effect of 10 weeks of aerobic training and whey protein (WP) supplementation on visceral adipose tissue inflammation in rats fed a high fat diet (HFD). In the first phase, 40 male Wistar rats were randomly divided into two groups: 1- normal diet (n=8), 2- high-fat diet (n=32). After this period-which lasted nine weeks-in the second phase, rats fed a HFD were randomly assigned into four groups: (n=8/group): 1- sedentary, 2- WP, 3- aerobic training, and 4- WP + aerobic training...
August 14, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/30106464/high-mobility-group-box-1-hmgb1-an-endogenous-ligand-of-toll-like-receptors-2-and-4-induces-astroglial-inflammation-via-nf-%C3%B2-%C3%AE-pathway
#12
Ebtisam A Al-Ofi, Badrah S Al-Ghamdi
Neuroinflammation has a definitive role in neurodegenerative diseases, such as Parkinson's and Alzheimer's disease. In addition to its pathogenic ligands, toll-like receptors (TLRs) can be activated by damaged endogenous molecules that induce inflammatory signalling pathways such as high-mobility group box 1 protein (HMGB1). Using an ex-vivo rat optic nerve (RON) model, we sought to determine the effects of lipopolysaccharides (LPS; TLR4 agonist), zymosan (TLR2 agonist) or HMGB1-with or without TLR2/4 antagonists, on the expression of glial fibrillary acidic protein (GFAP) and nuclear factor kappa B (NF-ҡβ) for signalling pathway and astrocyte reactivity, using double immunohistochemistry; as well as on the modulation of the neurotoxicity...
August 14, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/30106323/naringenin-palliates-cisplatin-and-doxorubicin-gonadal-toxicity-in-male-rats
#13
Amr A Fouad, Marwa M M Refaie, Manal I Abdelghany
Cisplatin (CP) and doxorubicin (DX) can cause testicular injury by inducing oxidative/nitrosative stress, inflammation, and apoptosis, Naringenin (NG) has antioxidant, antinitrative, anti-inflammatory, and anti-apoptotic effects. This study investigated the potential ability of NG to block gonadotoxicity induced CP and DX in male rats. The rats received one injection of either CP (10 mg/kg, i.p.) or DX (15 mg/kg, i,p.), and treated with NG (50 mg/kg/day, p.o.) for 10 days beginning 6 days prior to CP and DX administration...
August 14, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/30106319/a-comparative-study-of-intratracheal-and-aerosolization-instillations-of-bleomycin-inducing-experimental-lung-fibrosis-in-rat
#14
Anouar Abidi, Sana Bahri, Saloua Ben Khamsa, Alexandre Legrand
We aimed to investigate in the present work, using metabonomics approaches, the scalability of lung fibrosis-biomarkers, in bleomycin (BLM) model of pulmonary fibrosis in rats. Sixty male wistar rats, weighing 250±10 g, were randomly divided into three groups: a negative control group receiving normal saline treatment (G1 ), an intratracheal BLM instilled group (G2 ) and an aerosol BLM instilled group (G3 ). Rats were investigated at various times after BLM instillation. Metabolic changes observed in different biofluids have been integrated into the results of the histological examination (increase in inflammation, fibrosis score and TGF-β immunosatining) which provide a novel pathway of biomarkers in pulmonary fibrosis...
August 14, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/30106107/ghrelin-improves-pilocarpine%C3%A2-induced-cerebral-cortex-inflammation-in-epileptic-rats-by-inhibiting-nf%C3%A2-%C3%AE%C2%BAb-and-tnf%C3%A2-%C3%AE
#15
Kun Han, Qing-Yi Wang, Cai-Xia Wang, Shao-Yong Luan, Wen-Peng Tian, Yue Wang, Rui-Yun Zhang
Ghrelin has a protective function in the nervous system, including anti‑inflammatory and antiapoptotic. The objective of the present study was to examine the anti‑inflammatory effects of the ghrelin on nuclear factor‑κB (NF‑κB) and tumor necrosis factor‑α (TNF‑α) gene and protein expression in an epileptic seizure model. Epileptic seizures were induced in healthy male Wistar rats (~3 weeks old) with 300 mg/kg pilocarpine, and brains from rats with Racine stage IV or V seizures were investigated further in the present study...
August 10, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30106098/dexmedetomidine-pretreatment-inhibits-cerebral-ischemia-reperfusion%C3%A2-induced-neuroinflammation-via-activation-of-ampk
#16
Zhenhong Wang, Wei Zhou, Haiping Dong, Xiaoxiao Ma, Zhenzhou He
Focal ischemia/reperfusion (I/R) injury induced cerebral inflammation, aggravates brain damage. The aim of the present study was to investigate the protective mechanisms of dexmedetomidine (DEX) on I/R brain injury in rats. Sprague‑Dawley rats were divided to seven experimental groups (18 rats/group): Sham surgery; middle cerebral artery occlusion (MCAO) surgery (90 min); DEX10 [10 µg/kg intraperitoneal (i.p.) injection 30 min prior to MCAO]; DEX50 (50 µg/kg i.p. 30 min prior to MCAO); DEX100 (100 µg/kg i...
August 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30106086/microrna%C3%A2-214-suppresses-propofol%C3%A2-induced-neuroapoptosis-through-activation-of-phosphoinositide-3%C3%A2-kinase-protein-kinase-b-signaling-by-targeting-phosphatase-and-tensin-homolog-expression
#17
Xukeng Guo, Minghua Cheng, Weiqi Ke, Yuting Wang, Xuan Ji
The present study aimed to investigate the effects of microRNA (miR)‑214 on neuroapoptosis induced by propofol and the possible mechanism of its anti‑apoptotic effects. Initially, it was observed that miR‑214 expression was upregulated in propofol‑induced neuroapoptosis rats. Next, propofol‑treated nerve cells were transfected with miR‑214 mimics. The results revealed that miR‑214 overexpression induced apoptosis, inhibited cell proliferation, inhibited cyclin D1 protein expression, promoted caspase‑3 activity and B‑cell lymphoma 2‑associated X protein expression, and enhanced the levels of inflammation factors in nerve cells treated with propofol...
August 8, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30106084/hypoxic-preconditioned-bone-mesenchymal-stem-cells-ameliorate-spinal-cord-injury-in-rats-via-improved-survival-and-migration
#18
Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
The unique hypoxic inflammatory microenvironment observed in the spinal cord following spinal cord injury (SCI) limits the survival and efficacy of transplanted bone mesenchymal stem cells (BMSCs). The aim of the present study was to determine whether hypoxic preconditioning (HP) increased the therapeutic effects of BMSC on SCI. BMSCs were pretreated with cobalt chloride (CoCl2) in vitro, and the proliferative apoptotic and migratory abilities of these hypoxic BMSCs (H‑BMSCs) were assessed. BMSCs and H‑BMSCs derived from green fluorescent protein (GFP) rats were transplanted into SCI rats in vivo...
August 7, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30106055/acupuncture-through-baihui-du20-to-qubin-gb7-mitigates-neurological-impairment-after-intracerebral-hemorrhage
#19
Xiao-Ying Liu, Xiao-Hong Dai, Wei Zou, Xue-Ping Yu, Wei Teng, Ying Wang, Wei-Wei Yu, Hui-Hui Ma, Qiu-Xin Chen, Peng Liu, Rui-Qiao Guan, Shan-Shan Dong
Inflammation plays an important role in nerve defects caused by intracerebral hemorrhage. Repairing brain damage by inhibiting the macrophage-inducible C-type lectin/spleen tyrosine kinase (Mincle/Syk) signaling pathway is a potential new target for treating cerebral hemorrhage. In this study, we aimed to determine whether acupuncture through Baihui (DU20) to Qubin (GB7) is an effective treatment for intracerebral hemorrhage through the Mincle/Syk signaling pathway. An intracerebral hemorrhage rat model was established by autologous blood infusion into the caudate nucleus...
August 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30105078/chaihu-shugan-san-decoction-modulates-intestinal-microbe-dysbiosis-and-alleviates-chronic-metabolic-inflammation-in-nafld-rats-via-the-nlrp3-inflammasome-pathway
#20
Yinji Liang, Yupei Zhang, Yuanjun Deng, Shu Liang, Yifang He, Yanning Chen, Chan Liu, Chenli Lin, Li Han, Guifang Tu, Qinhe Yang
We evaluate the effects of the Chaihu-Shugan-San decoction on intestinal microbe dysbiosis and chronic metabolic inflammation via the NLRP3 pathway in NAFLD rats that were fed a high-fat diet. Twenty-four SD rats (male, six weeks old, 200 ± 20 g) were randomly divided into three groups: normal control group (NC group), high-fat diet-fed group (HFD group), and Chaihu-Shugan-San decoction intervention group (CH group). The NC group rats were given standard feed, the HFD group rats were all fed a high-fat diet (83% standard feed + 10% lard oil + 5% sucrose + 1...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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