Juliana Guimarães Laguna, Andria Dos Santos Freitas, Fernanda Alvarenga Lima Barroso, Luís Cláudio Lima De Jesus, Octávio Augusto Greco Gomes De Vasconcelos, Ludmila Silva Quaresma, Monique Ferrary Américo, Gabriela Munis Campos, Rafael de Assis Glória, Joyce da Cruz Ferraz Dutra, Tales Fernando Da Silva, Kátia Duarte Vital, Simone O Fernandes, Ramon O Souza, Flaviano Dos Santos Martins, Enio Ferreira, Túlio Marcos Santos, Alexander Birbrair, Marcos Felipe Andrade De Oliveira, Ana Maria Caetano Faria, Rodrigo Dias de Oliveira Carvalho, Franco Maria Venanzi, Yves Le Loir, Gwénaël Jan, Éric Guédon, Vasco Ariston de Carvalho Azevedo
INTRODUCTION AND OBJECTIVE: p62 is a human multifunctional adaptor protein involved in key cellular processes such as tissue homeostasis, inflammation, and cancer. It acts as a negative regulator of inflammasome complexes. It may thus be considered a good candidate for therapeutic use in inflammatory bowel diseases (IBD), such as colitis. Probiotics, including recombinant probiotic strains producing or delivering therapeutic biomolecules to the host mucosal surfaces, could help prevent and mitigate chronic intestinal inflammation...
2024: Frontiers in Microbiology