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Colitis rats

Marisol I Gonzalez, Fernando Lopes, Derek M McKay, Jose L Reyes
Infection with helminth parasites evokes a complex cellular response in the host, where granulocytes (i.e. eosinophils, basophils and mast cells (MCs)) feature prominently.  In addition to being used as markers of helminthic infections, MCs have been implicated in worm expulsion since animals defective in c-kit signalling, which results in diminished MC numbers, can have delayed worm expulsion. The role of MCs in the rejection of the rat tapeworm, Hymenolepsis diminuta , from the non-permissive mosue host is not known...
October 19, 2018: Bioscience Reports
Dandan Dou, Lixin Chen, Hong Di, Zhuoran Song, Shirui Li, Xinjie Bu, Qing Dai, Shuai Wang, Jing Xin Li, Xiaolong Zhu, Haiyan Jing
BACKGROUND: Inflammatory bowel disease (IBD) is a functional disorder with chronic and relapsing clinical features. Vasopressin (VP) is a hormone responsible for water and stress homeostasis and also regulates gastrointestinal inflammation and motility. We explored whether VP was related to IBD pathogenesis and its possible pathway. METHODS: Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) in mice. The disease activity and colonic damage were evaluated through a scoring system...
October 18, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Yao-Xing Dou, Jiang-Tao Zhou, Tong-Tong Wang, Yan-Feng Huang, Vicky Ping Chen, You-Liang Xie, Zhi-Xiu Lin, Jian-Sheng Gao, Zi-Ren Su, Hui-Fang Zeng
Background: Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant Brucea javanica which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]). Methods: To improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) and BD. The physicochemical properties and pharmacokinetics of BD-SNEDDS were characterized, and its anti-UC activity and potential mechanism were evaluated in TNBS-induced UC rat model...
2018: International Journal of Nanomedicine
Nahid Fakhraei, Nina Javadian, Reza Rahimian, Fatemeh Nili, Nastaran Rahimi, Shiva Hashemizadeh, Ahmad Reza Dehpour
PURPOSE: There are several lines of evidence on the protective roles of opioids in gastrointestinal inflammatory conditions. This study aims to distinguish the central and peripheral roles of methadone, a non-selective opioid receptor agonist, in an acute model of ulcerative colitis in male rats. METHODS: Ulcerative colitis was induced by intrarectal administration of acetic acid 4%. Methadone was injected subcutaneously (s.c.), 5 and 10 mg/kg, and intracerebroventricular (i...
October 15, 2018: Inflammopharmacology
Wei He, Yongmin Li, Mengyang Liu, Haiyang Yu, Qian Chen, Yue Chen, Jingya Ruan, Zhijuan Ding, Yi Zhang, Tao Wang
Inflammatory bowel disease (IBD) is a serious digestive system disease, for which the clinical therapeutic choices remain limited. Dried fruits of Citrus aurantium L. (CAL) are a traditional medicine used for regulation of the digestive system. The aim of this study was to identify the regulatory effects of CAL on IBD and to clarify the mechanism of the active compounds. In trinitrobenzene sulfonic acid-induced IBD rats, 125 to 500 mg/kg of oral CAL significantly alleviated weight loss and diarrhea, decreased colitis inflammatory cell infiltration, and inhibited pro-inflammatory cytokine production...
October 7, 2018: International Journal of Molecular Sciences
Katia Fettucciari, Lara Macchioni, Magdalena Davidescu, Paolo Scarpelli, Camilla Palumbo, Lanfranco Corazzi, Andrea Marchegiani, Matteo Cerquetella, Andrea Spaterna, Pierfrancesco Marconi, Gabrio Bassotti
Clostridium difficile infection (CDI) causes nosocomial/antibiotic-associated diarrhea and pseudomembranous colitis, with dramatic incidence/mortality worldwide. C. difficile virulence factors are toxin A and toxin B (TcdB) which cause cytopathic/cytotoxic effects and inflammation. Until now studies were focused on molecular effects of C. difficile toxins (Tcds) on different cells while unexplored aspect is the status/fate of cells that survived their cytotoxicity. Recently we demonstrated that enteric glial cells (EGCs) are susceptible to TcdB cytotoxicity, but several EGCs survived and were irreversibly cell-cycle arrested and metabolically active, suggesting that EGCs could became senescent...
October 6, 2018: Biochimica et biophysica acta. Molecular cell research
Takamichi Sato, Junpei Konno, Akihiro Sekiguchi, Nao Yoneki, Kana Kawano, Tomohiro Hayashi, Yukina Ogawa, Aya Kikitsu, Takashi Aijima, Kazuhisa Hara, Shintaro Hara, Hitomi Hayashi, Kimiko Fuchigami, Naoko Igo, Yuki Takashima, Yuki Kobayashi, Masayuki Mori, Keiichiro Yamamoto, Makoto Niwa, Kan Saiga, Eiji Ichimura
AIM: Tacrolimus (TAC) is an important drug for inflammatory diseases. However, TAC has several limitations, such as variable trough concentrations among individuals and a high medication frequency. In this study, we created NK61060, a novel micellar TAC formulation, to circumvent these disadvantages. MATERIALS & METHODS: Immunosuppressive activity of NK61060 was determined in the collagen-induced arthritis rat model, mannan-induced arthritis mouse model and dextran sodium sulfate-induced colitis mouse model...
October 2018: Therapeutic Delivery
I V Byelinska, H M Kuznietsova, N V Dziubenko, O V Lynchak, T V Rybalchenko, Yu I Prylutskyy, O A Kyzyma, O Ivankov, V K Rybalchenko, U Ritter
The application of pristine С60 fullerene aqueous colloid solution (C60 FAS; 0.5 mg/kg body weight) for rats experienced acute colitis, either intraperitoneally or intrarectally (1) restores the colonic mucosa healing and epithelial barrier integrity, evidenced by autopsies and histological findings and the normalization of phenolsufonphthalein dye daily excretion; (2) attenuates the consequences of hemorrhages, such as signs of anemia and increased platelet count; (3) improves the liver redox status suppressing the lipid peroxidation (malonic dialdehyde and protein carbonyl group levels tended down) and stimulating the antioxidant defense system (glutathione peroxidase activity grew up)...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Taejun Eom, Wonjae Yoo, Sehoon Kim, Anzar Khan
Molecular design concepts are described for the preparation of azobenzene polymers capable of showing a tunable response to the rat liver microsome-induced side-chain self-immolation process under hypoxic conditions. It is shown that azobenzene nuclei carrying a donor/acceptor substitution pattern are the most active system towards the enzymatically triggered azobenzene cleavage reaction (half-life = t1/2  = 6 min). Their activity is followed by azobenzene nuclei carrying donor/donor (t1/2  = 20 min), electronically non-substituted (t1/2  = 72 min), and acceptor (t1/2  = 78 min) systems...
December 2018: Biomaterials
Yujin Liu, Yalan Dong, Xiwen Zhu, Heng Fan, Meng Xu, Qianyun Chen, Zhen Nan, Hui Wu, Shuangjiao Deng, Xingxing Liu, Dongmei Zuo, Jia Yang
Th17 cells play an important role in the immune imbalance and inflammatory state in colonic mucosa of Inflammatory Bowel Disease (IBD) and to clarify the mechanism that affect the differentiation of Th17 cells will help us find a new target for the treatment of IBD. MiR-155 which is reported to have an important role in regulating immune system function is also detected to be significantly up-regulated in colonic tissues of IBD patients. However, whether and how miR-155 affects the differentiation of Th17 cells in the colon of IBD patients is still worth studying...
September 22, 2018: International Immunopharmacology
Fani Gavresea, Costas Vagianos, Maria Korontzi, Georgia Sotiropoulou, Petroula Dadioti, John K Triantafillidis, Apostolos E Papalois
BACKGROUND/AIMS: The aim of this study was to investigate the influence of a synbiotic preparation (a mixture of six probiotics and a prebiotic) on aberrant crypt foci (ACF) formation, dysplasia, inflammation, and colitis-like lesions in experimental colon cancer in rats. MATERIALS AND METHODS: Sixty male rats were categorized into three groups of 20 animals each. Group A was administered 1,2-dimethylydrazine, 15 mg/kg body weight (BW), once a week for 2 weeks. Group B was administered 1,2-dimethylydrazine at the same dose plus synbiotic, started after the second dose of carcinogen and lasted for 5 weeks...
July 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Qin Xiang Ng, Alex Yu Sen Soh, Wayren Loke, Nandini Venkatanarayanan, Donovan Yutong Lim, Wee-Song Yeo
Irritable bowel syndrome (IBS) remains a prevalent and difficult-to-manage gastrointestinal condition. There is growing interest in the use of traditional medicine to manage IBS. In particular, curcumin, a biologically active phytochemical, has demonstrated anti-inflammatory and anti-oxidant properties and mucosal protective effects in rat models of colitis. This meta-analysis thus aimed to investigate the hypothesis that curcumin improves IBS symptoms. Using the keywords (curcumin OR turmeric OR Indian saffron OR diferuloylmethane OR curcuminoid) AND (irritable bowel syndrome OR IBS), a preliminary search on the PubMed, Medline, Embase, PsychINFO, Web of Science, and Google Scholar databases yielded 1080 papers published in English between 1 January 1988 and 1 May 2018...
September 22, 2018: Journal of Clinical Medicine
Jiangtao Zhou, Tongtong Wang, Yaoxing Dou, Yanfeng Huang, Chang Qu, Jiansheng Gao, Zijian Huang, Youliang Xie, Ping Huang, Zhixiu Lin, Ziren Su
Brusatol is a main bioactive component derived from the Chinese medicinal plant Brucea javanica, which is traditionally used for the treatment of dysentery (also known as ulcerative colitis, UC). Previously, we have designed a novel brusatol self-microemulsifying drug delivery system (BR-SMEDDS) to increase its solubility and bioavailability, and enhance its bioactivities. In the present study, we established 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis rat model in vivo and lipopolysaccharide (LPS)-induced RAW 264...
September 12, 2018: International Immunopharmacology
Vazhaikkurichi M Rajendran, Geoffrey I Sandle
The colon has large capacities for K+ absorption and K+ secretion, but its role in maintaining K+ homeostasis is often overlooked. For many years, passive diffusion and/or solvent drag were thought to be the primary mechanisms for K+ absorption in human and animal colon. However, it is now clear that apical H+ ,K+ -ATPase, in coordination with basolateral K+ -Cl- cotransport and/or K+ and Cl- channels operating in parallel, mediate electroneutral K+ absorption in animal colon. We now know that K+ absorption in rat colon reflects ouabain-sensitive and ouabain-insensitive apical H+ ,K+ -ATPase activities...
September 14, 2018: Comprehensive Physiology
Margaret Delday, Imke Mulder, Elizabeth T Logan, George Grant
Background: Alterations in the gut microbiota are strongly associated with the development of inflammatory bowel disease (IBD), particularly with Crohn's disease, which is characterized by reduced abundance of commensal anaerobic bacteria including members of the Bacteroides genus. Our aim was to investigate the protective effects of Bacteroides thetaiotaomicron, an abundant member of this genus, in different rodent models of IBD. Methods: We assessed the effect of B...
September 12, 2018: Inflammatory Bowel Diseases
Fatin Rustu Polat, Ihsan Karaboga, Muhammed Semih Polat, Zeynep Erboga, Ahsen Yilmaz, Savas Güzel
In our study, the effect of hesperetin on inflammatory and oxidative status in trinitrobenzene sulfonic acid (TNBS)-induced experimental colitis model was investigated through different methods. Eighteen Wistar albino male rats were divided in to three groups: Group I (Control, n = 8; 1 ml physiological saline), Group II (Colitis, n = 8; 1 ml TNBS), Group III (Hesperetin, n = 8; 1 ml TNBS and 100 mg/kg hesperetin). Macroscopic and microscopic scores were calculated to determine the damage to the colon at the end of the experiment...
August 30, 2018: Cellular and Molecular Biology
Mariana F Fragoso, Guilherme R Romualdo, Lisa A Vanderveer, Janusz Franco-Barraza, Edna Cukierman, Margie L Clapper, Robson F Carvalho, Luis F Barbisan
This study evaluated the possible protective effects of lyophilized açaí pulp (AP) in a colitis-associated carcinogenesis (CAC) rat model and the modifying effect of cyanidin 3-rutinoside (C3R) on the motility of RKO colon adenocarcinoma cells, using the wound healing assay. Male Wistar rats were induced to develop CAC using 1,2-dimethylhydrazine (DMH) and 2,4,6-trinitrobenzene acid (TNBS). Animals were randomly assigned to different groups that received basal diet or basal diet supplemented with 5.0% or 7...
September 6, 2018: Food and Chemical Toxicology
Jozef Kováč, Monika Vítězová, Ivan Kushkevych
Sulfate-reducing bacteria (SRB) are anaerobic microorganisms, which use sulfate as an electron acceptor in the process of dissimilatory sulfate reduction. The final metabolic product of these anaerobic microorganisms is hydrogen sulfide, which is known as toxic and can lead to damage to epithelial cells of the large intestine at high concentrations. Different genera of SRB are detected in the large intestine of healthy human and animals, and with diseases like Crohn's disease and ulcerative colitis. SRB isolated from rodents with ulcerative colitis have produced 1...
2018: Open Medicine (Warsaw, Poland)
Xuewei Ma, Yichen Hu, Xin Li, Xiaoting Zheng, Yitao Wang, Jinming Zhang, Chaomei Fu, Funeng Geng
Periplaneta americana , a magic medicinal insect being present for over 300 million years, exhibits desirable therapeutic outcome for gastrointestinal ulcer treatment. Nowadays, P. americana ethanol extract (PAE) has been shown to ameliorate ulcerative colitis (UC) by either single-use or in combination with other therapeutic agents in clinics. However, its underlying mechanisms are still seldom known. Herein, we investigated the anti-UC activity of PAE by alleviating intestinal inflammation and regulating the disturbed gut microbiota structure in dextran sulfate sodium (DSS)-induced UC rats...
2018: Frontiers in Pharmacology
Xiong Chen, Rui Liu, Xiaoming Liu, Canxia Xu, Xiaoyan Wang
Aim: To investigate the role of Coxsackie-adenovirus receptor (CAR) in inflammatory bowel disease (IBD). Background: CAR, a type I transmembrane protein with functions in virus attachment, has been shown to be associated with epithelial tight junctions (TJs) and mediates cell adhesion, implying its potential roles in the pathogenesis of IBD. Methods and Materials: To determine the effect of CAR in IBD using QPCR and Western blotting to determine the expression of CAD in TNF- α induced NCM460 and SW480 cells and IBD tissues compared to control groups...
2018: BioMed Research International
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