keyword
https://read.qxmd.com/read/38534000/microwave-coagulation-for-liver-metastases
#1
REVIEW
Dawid Storman, Mateusz J Swierz, Jerzy W Mitus, Michal Pedziwiatr, Ning Liang, Robert Wolff, Malgorzata M Bala
BACKGROUND: Liver metastases (i.e. secondary hepatic malignancies) are significantly more common than primary liver cancer. Long-term survival after radical surgical treatment is approximately 50%. For people in whom resection for cure is not feasible, other treatments must be considered. One treatment option is microwave coagulation utilising electromagnetic waves. It involves placing an electrode into a lesion under ultrasound or computed tomography guidance. OBJECTIVES: To evaluate the beneficial and harmful effects of microwave coagulation versus no intervention, other ablation methods, or systemic treatments in people with liver metastases regardless of the location of the primary tumour...
March 27, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38469604/the-prognostic-importance-of-cancer-stem-cells-in-colorectal-polyps
#2
JOURNAL ARTICLE
Aynur Safiyeva, Nuru Bayramov, Mustafa Cihat Avunduk
BACKGROUND: This purpose aims to investigate the usefulness of CD133, a stem cell marker, for the prognosis of colon polyps. This study aimed to assess the adenomatous polyps that have an essential role in the development of colorectal cancer. The risk of colorectal carcinogenesis can be reduced by polypectomy and close medical supervision of the patients with adenomatous polyps. The prominence of stem cells in carcinoma development is also a recognized verdict. It must be noted that stem cell evaluation in adenomatous polyps may provide information about carcinoma development...
2024: Annali Italiani di Chirurgia
https://read.qxmd.com/read/38464383/quantitative-peritumoral-magnetic-resonance-imaging-fingerprinting-improves-machine-learning-based-prediction-of-overall-survival-in-colorectal-cancer
#3
JOURNAL ARTICLE
Azadeh Tabari, Brian D'Amore, Janice Noh, Michael S Gee, Dania Daye
AIM: To investigate magnetic resonance imaging (MRI)-based peritumoral texture features as prognostic indicators of survival in patients with colorectal liver metastasis (CRLM). METHODS: From 2007-2015, forty-eight patients who underwent MRI within 3 months prior to initiating treatment for CRLM were identified. Clinicobiological prognostic variables were obtained from electronic medical records. Ninety-four metastatic hepatic lesions were identified on T1-weighted post-contrast images and volumetrically segmented...
2024: Exploration of targeted anti-tumor therapy
https://read.qxmd.com/read/38461798/uptake-and-detection-rate-of-colorectal-cancer-screening-with-colonoscopy-in-china-a-population-based-prospective-cohort-study
#4
JOURNAL ARTICLE
Zhikai Yu, Bibo Li, Shenglin Zhao, Jia Du, Yan Zhang, Xiu Liu, Qing Guo, Hong Zhou, Mei He
BACKGROUND: Colorectal cancer is the leading cause of cancer-related death worldwide. Colonoscopy is widely used as a screening test for detecting colorectal cancer in many countries. However, there is little evidence regarding the uptake and diagnostic yields of colonoscopy in population-based screening programs in countries with limited medical resources. OBJECTIVE: We reported the uptake of colonoscopy and the detection of colorectal lesions and explored related factors based on a colorectal cancer screening program in China...
February 20, 2024: International Journal of Nursing Studies
https://read.qxmd.com/read/38433226/plasma-metabolites-and-risk-of-seven-cancers-a-two-sample-mendelian-randomization-study-among-european-descendants
#5
JOURNAL ARTICLE
Yaxin Chen, Yufang Xie, Hang Ci, Zhengpei Cheng, Yongjie Kuang, Shuqing Li, Gang Wang, Yawen Qi, Jun Tang, Dan Liu, Weimin Li, Yaohua Yang
BACKGROUND: While circulating metabolites have been increasingly linked to cancer risk, the causality underlying these associations remains largely uninterrogated. METHODS: We conducted a comprehensive 2-sample Mendelian randomization (MR) study to evaluate the potential causal relationship between 913 plasma metabolites and the risk of seven cancers among European-ancestry individuals. Data on variant-metabolite associations were obtained from a genome-wide association study (GWAS) of plasma metabolites among 14,296 subjects...
March 4, 2024: BMC Medicine
https://read.qxmd.com/read/38425989/methylated-ctdna-predicts-early-recurrence-risk-in-patients-undergoing-resection-of-initially-unresectable-colorectal-cancer-liver-metastases
#6
JOURNAL ARTICLE
Zhi-Gang Chen, Xiao-Meng Ji, Yu-Xia Xu, William Pat Fong, Xiao-Yun Liu, Jie-Ying Liang, Qiong Tan, Lei Wen, Yan-Yu Cai, De-Shen Wang, Yu-Hong Li
BACKGROUND: Patients with initially unresectable colorectal cancer liver metastases (IU-CRLM) might benefit from using an effective systemic treatment followed by resection of liver metastases but the curative success rate is quite low. Indeed, nearly one-third of patients exhibit early recurrence within the first 6 months after surgery, and these individuals often have poor overall survival. OBJECTIVES: This study aims to clarify the application value of serial circulating tumor DNA (ctDNA) analysis in predicting the clinical outcome of IU-CRLM patients following liver metastasectomy...
2024: Therapeutic Advances in Medical Oncology
https://read.qxmd.com/read/38425009/performance-of-the-asia-pacific-colorectal-screening-score-in-stratifying-the-risk-of-advanced-colorectal-neoplasia-a-meta-analysis-and-systematic-review
#7
JOURNAL ARTICLE
Mai Ngoc Luu, Nhi Ai Trinh, Truc Le Thanh Tran, Thinh Phuong Dang, Toru Hiyama, Duc Trong Quach
BACKGROUND AND AIM: This study systematically reviewed and meta-analyzed the performance of the Asia-Pacific Colorectal Screening (APCS) score and its incorporation with the fecal immunochemical test (FIT) in stratifying the risk of advanced colorectal neoplasia (ACN). METHODS: We systematically searched for relevant articles in 12 electronic databases and registers on October 20, 2021, and updated the search to September 1, 2023. Random-effect models were used to obtain the pooled performance statistics of the APCS score for ACN risk...
February 29, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38381249/the-value-of-preoperative-diagnosis-of-colorectal-adenocarcinoma-pathological-t-staging-based-on-dual-layer-spectral-detector-computed-tomography-extracellular-volume-fraction-a-preliminary-study
#8
JOURNAL ARTICLE
Qi Sun, Xuelian Bian, Danqi Sun, Mi Wang, Hanyun Dong, Xiaoxiao Dai, Guohua Fan, Liyuan Zhang, Yonggang Li, Guangqiang Chen
PURPOSE: To investigate the value of preoperative diagnosis of colorectal adenocarcinoma (CRAC) pathological T staging based on dual-layer spectral-detector computed tomography (DLCT) extracellular volume fraction (ECV) of CRAC lesions. METHODS: We prospectively collected clinical and DLCT imaging data from 165 patients with CRAC who attended two hospitals from June 2022 to April 2023. The enrolled patients were divided into a training group (n = 110, from Hospital 1) and an external validation group (n = 55, from Hospital 2)...
February 21, 2024: Japanese Journal of Radiology
https://read.qxmd.com/read/38345316/dyadic-investigation-of-posttraumatic-stress-symptoms-and-daily-sleep-health-in-patients-with-cancer-and-their-caregivers
#9
JOURNAL ARTICLE
Thomas C Tsai, Hannah-Rose Mitchell, Jamie Zeitzer, Amanda Ting, Jean-Philippe Laurenceau, David Spiegel, Youngmee Kim
OBJECTIVE: Cancer can be a traumatic experience affecting multidimensional aspects of sleep among patients and caregivers. This study examined the differential associations of cancer-related post-traumatic stress symptoms (PTSS) with various sleep markers in this population. METHODS: Patients newly diagnosed with colorectal cancer (n = 138, mean age = 56.93 years, 31.88% female, 60.14% Hispanic, 6.53 months post-diagnosis) and their sleep-partner caregivers (n = 138, mean age = 55...
January 11, 2024: Psychosomatic Medicine
https://read.qxmd.com/read/38297397/a-randomized-trial-evaluating-the-utility-of-non-targeted-biopsies-for-colorectal-neoplasia-detection-in-adults-with-inflammatory-bowel-disease-a-pilot-study-protocol
#10
JOURNAL ARTICLE
Sanjay K Murthy, Luba Marderfeld, Dean Fergusson, Tim Ramsay, Charles N Bernstein, Geoffrey C Nguyen, Vipul Jairath, Robert Riddell
BACKGROUND: Persons with inflammatory bowel diseases are at increased risk of developing colorectal cancer and require frequent colonoscopy surveillance. Guidelines recommend taking 30 to 40 non-targeted biopsies throughout the colorectum to detect "invisible" neoplasia in this setting, despite a lack of evidence supporting this practice. We sought to assess the utility of this practice through a randomized controlled trial. We first propose an internal pilot study to assess recruitment potential, protocol adherence and data capture to guide the full trial...
February 1, 2024: Pilot and Feasibility Studies
https://read.qxmd.com/read/38252282/the-protective-effect-of-teprenone-in-tnbs-induced-ulcerative-colitis-rats-by-modulating-the-gut-microbiota-and-reducing-inflammatory-response
#11
JOURNAL ARTICLE
Jianfeng Yao, Tao Sun, Songbai Zheng, Jianxia Ma, Qinglian Zeng, Kangwei Liu, Wei Zhang, Yang Yu
OBJECTIVE: Ulcerative colitis (UC), a chronic and refractory non-specific inflammatory bowel disease, affects millions of patients worldwide and increases the risk of colorectal cancer. Teprenone is an acylic polyisoprenoid that exerts anti-inflammatory properties in rat models of peptic ulcer disease. This in vitro and in vivo study was designed to investigate the effects of teprenone on UC and to explore the underlying mechanisms. METHODS: Human intestinal epithelial cells (Caco-2 cells) serve as the in vitro experimental model...
January 22, 2024: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/38223090/quantitative-parameters-of-dual-layer-spectral-detector-computed-tomography-for-evaluating-ki-67-and-human-epidermal-growth-factor-receptor-2-expression-in-colorectal-adenocarcinoma
#12
JOURNAL ARTICLE
Jinghua Chen, Liang Tang, Ping Xie, Tingting Qian, Jian Huang, Kefu Liu
BACKGROUND: Ki-67 and human epidermal growth factor receptor 2 (HER2) are key biomarkers in evaluating the prognosis of colorectal adenocarcinoma (CRAC). The purpose of this study was to investigate the value of quantitative parameters in dual-layer spectral detector computed tomography (SDCT) for evaluating the expression of Ki-67 and HER2 in CRAC. METHODS: In this retrospective, cross-sectional study, 88 eligible patients with pathologically confirmed CRAC were selected from Taicang Hospital of Traditional Chinese Medicine between May 2021 and April 2023...
January 3, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38223051/mono-algorithm-assessment-of-the-diagnostic-value-of-dual-energy-ct-for-high-risk-factors-for-colorectal-cancer-a-preliminary-study
#13
JOURNAL ARTICLE
Jun-Fan Chen, Jing Yang, Wei-Juan Chen, Xin Wei, Xiang-Ling Yu, Dou-Dou Huang, Hao Deng, Yin-Deng Luo, Xin-Jie Liu
BACKGROUND: Risk factors for colorectal cancer (CRC) affect the way patients are subsequently treated and their prognosis. Dual-energy computerized tomography (DECT) is an advanced imaging technique that enables the quantitative evaluation of lesions. This study aimed to evaluate the quality of DECT images based on the Mono+ algorithm in CRC, and based on this, to assess the value of DECT in the diagnosis of CRC risk factors. METHODS: This prospective study was performed from 2021 to 2023...
January 3, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38200678/prevalence-and-risk-factors-of-colorectal-neoplasia-in-individuals-aged-40-49%C3%A2-years-findings-from-screening-program-in-china
#14
JOURNAL ARTICLE
Mingqing Zhang, Yongdan Zhang, Wen Zhang, Yong Zhang, Lizhong Zhao, Haoren Jing, Xinyu Gao, Zhenguo Nie, Siwei Zhu, Shiwu Zhang, Xipeng Zhang
BACKGROUND AND AIM: The incidence of colorectal cancer (CRC) in individuals under 50 is increasing worldwide. We conducted an analysis of colonoscopy findings in high-risk individuals under 50 in the CRC screening program in Tianjin, China, to determine the detection rate and risk factors of advanced adenomas (AA), advanced colorectal neoplasia (ACN), colorectal neoplasia (CN). METHODS: Our study investigated individuals aged 40-49 who underwent CRC screening and completed colonoscopy, 2012-2020, while the 50-54 age group served as a control...
January 10, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38192593/combined-population-genomic-screening-for-three-high-risk-conditions-in-australia-a-modelling-study
#15
JOURNAL ARTICLE
Paul Lacaze, Clara Marquina, Jane Tiller, Adam Brotchie, Yoon-Jung Kang, Melissa A Merritt, Robert C Green, Gerald F Watts, Kristen J Nowak, Ranjit Manchanda, Karen Canfell, Paul James, Ingrid Winship, John J McNeil, Zanfina Ademi
BACKGROUND: No previous health-economic evaluation has assessed the impact and cost-effectiveness of offering combined adult population genomic screening for mutliple high-risk conditions in a national public healthcare system. METHODS: This modeling study assessed the impact of offering combined genomic screening for hereditary breast and ovarian cancer, Lynch syndrome and familial hypercholesterolaemia to all young adults in Australia, compared with the current practice of clinical criteria-based testing for each condition separately...
December 2023: EClinicalMedicine
https://read.qxmd.com/read/38172695/impact-of-prognostic-nutritional-index-change-on-prognosis-after-colorectal-cancer-surgery-under-propofol-or-sevoflurane-anesthesia
#16
JOURNAL ARTICLE
Longtang Zhang, Chong Liu, Qiang Yan, Xiaoli Cai
BACKGROUND: The alteration of the prognostic nutritional index (PNI) or the utilization of distinct anesthesia strategies has been linked to the prognosis of various cancer types, but the existing evidence is limited and inconclusive, particularly for colorectal cancer (CRC). Our objective was to evaluate the association between PNI change and progression free survival (PFS) and overall survival (OS) in patients treated with CRC surgery after propofol-based or sevoflurane-based anesthesia...
January 3, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38123998/protein-biomarkers-and-alternatively-methylated-cell-free-dna-detect-early-stage-pancreatic-cancer
#17
JOURNAL ARTICLE
Roni Ben-Ami, Qiao-Li Wang, Jinming Zhang, Julianna G Supplee, Johannes F Fahrmann, Roni Lehmann-Werman, Lauren K Brais, Jonathan Nowak, Chen Yuan, Maureen Loftus, Ana Babic, Ehsan Irajizad, Tal Davidi, Aviad Zick, Ayala Hubert, Daniel Neiman, Sheina Piyanzin, Ofer Gal-Rosenberg, Amit Horn, Ruth Shemer, Benjamin Glaser, Natalia Boos, Kunal Jajoo, Linda Lee, Thomas E Clancy, Douglas A Rubinson, Kimmie Ng, John A Chabot, Fay Kastrinos, Michael Kluger, Andrew J Aguirre, Pasi A Jänne, Nabeel Bardeesy, Ben Stanger, Mark H O'Hara, Jacob Till, Anirban Maitra, Erica L Carpenter, Andrea J Bullock, Jeanine Genkinger, Samir M Hanash, Cloud P Paweletz, Yuval Dor, Brian M Wolpin
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed at an advanced stage. Liquid biopsy approaches may facilitate detection of early stage PDAC when curative treatments can be employed. DESIGN: To assess circulating marker discrimination in training, testing and validation patient cohorts (total n=426 patients), plasma markers were measured among PDAC cases and patients with chronic pancreatitis, colorectal cancer (CRC), and healthy controls...
December 13, 2023: Gut
https://read.qxmd.com/read/38113199/diagnostic-accuracy-of-endocytoscopy-via-artificial-intelligence-in-colorectal-lesions-a-systematic-review-and-meta%C3%A2-analysis
#18
JOURNAL ARTICLE
Hangbin Zhang, Xinyu Yang, Ye Tao, Xinyi Zhang, Xuan Huang
BACKGROUND: Endocytoscopy (EC) is a nuclei and micro-vessels visualization in real-time and can facilitate "optical biopsy" and "virtual histology" of colorectal lesions. This study aimed to investigate the significance of employing artificial intelligence (AI) in the field of endoscopy, specifically in diagnosing colorectal lesions. The research was conducted under the supervision of experienced professionals and trainees. METHODS: EMBASE, PubMed, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI) database, and other potential databases were surveyed for articles related to the EC with AI published before September 2023...
2023: PloS One
https://read.qxmd.com/read/38084910/understanding-the-impact-of-enhanced-recovery-programs-on-social-vulnerability-race-and-colorectal-surgery-outcomes
#19
JOURNAL ARTICLE
Burkely P Smith, Meghna Katta, Robert H Hollis, Connie Shao, Bayley Jones, Marshall C McLeod, Tze-Woei Tan, Daniel I Chu
BACKGROUND: Increasing social vulnerability measured by the social vulnerability index has been associated with worse surgical outcomes. However, less is known about social vulnerability's impact on colorectal surgery patients under enhanced recovery programs. OBJECTIVE: We hypothesized that increasing social vulnerability is associated with worse outcomes prior to enhanced recovery implementation, but following implementation, disparities in outcomes would be reduced...
December 11, 2023: Diseases of the Colon and Rectum
https://read.qxmd.com/read/38050241/hsa_circ_0124554-may-serve-as-a-biomarker-for-the-diagnosis-of-colorectal-cancer-an-observational-study
#20
JOURNAL ARTICLE
Kexin Li, Tong Li, Zhuocheng Yu, Qingqing Yuan, Yanping Qing
Circular RNAs (circRNAs) play important roles in the occurrence and development of cancer, and have been shown with diagnostic values in various cancers. The latest research showed that hsa_circ_0124554 is closely related to liver metastasis and vascular invasion in colorectal cancer (CRC). This study aimed to investigate whether hsa_circ_0124554 can be used as a diagnostic marker for CRC. In this study, quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was used to detect hsa_circ_0124554 expression levels in 40 pairs of CRC tissues and adjacent non-tumor intestinal tissues derived from CRC patients and 32 paired plasma specimens...
December 1, 2023: Medicine (Baltimore)
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