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Colorectal under 40

Muriel Larauche, Nabila Moussaoui, Mandy Biraud, Won Ki Bae, Henri Duboc, Mulugeta Million, Yvette Taché
BACKGROUND: Water avoidance stress (WAS) induces a naloxone-independent visceral analgesia in male rats under non-invasive conditions of monitoring. The objective of the study was to examine the role of brain CRF signaling in acute stress-induced visceral analgesia (SIVA). METHODS: Adult male Sprague-Dawley rats were chronically implanted with an intracerebroventricular (ICV) cannula. The visceromotor response (VMR) to graded phasic colorectal distension (CRD: 10, 20, 40, 60 mm Hg, 20 seconds, 4 minutes intervals) was monitored using manometry...
October 9, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Hideyuki Chiba, Ken Ohata, Jun Tachikawa, Jun Arimoto, Keiichi Ashikari, Hiroki Kuwabara, Michiko Nakaoka, Toru Goto, Atsushi Nakajima
BACKGROUND: Endoscopic submucosal dissection (ESD) is an effective treatment for early-colorectal cancer. Although delayed bleeding is a serious potential complication, there is no consensus on the optimal protocol to determine which cases require emergency colonoscopy. AIMS: This study aimed to assess the risk factors for delayed bleeding after ESD and evaluate the "watch and wait" strategy for delayed bleeding. The "watch and wait" strategy was used for delayed bleeding, unless the shock index was ≥ 1 and/or a moderate amount of hematochezia occurred more than five occurrences...
October 3, 2018: Digestive Diseases and Sciences
Alvaro Romera, Sergiy Peredpaya, Yaroslav Shparyk, Igor Bondarenko, Giovanni Mendonça Bariani, Kathia Cristina Abdalla, Enrique Roca, Fábio Franke, Felipe Melo Cruz, Anita Ramesh, Vikas Ostwal, Pradeep Shah, Sajeed Abdul Rahuman, Alexandra Paravisini, Camino Huerga, Ana Del Campo García, Susana Millán
BACKGROUND: BEVZ92 is a proposed biosimilar to bevacizumab. The two molecules have similar physicochemical and functional properties in in-vitro and preclinical studies. In this clinical study, we compared the pharmacokinetic profile, efficacy, safety, and immunogenicity of BEVZ92 with reference bevacizumab as a first-line treatment in patients with metastatic colorectal cancer. METHODS: We did a randomised, open-label trial at 15 centres in Argentina, Brazil, India, Spain, and Ukraine...
September 24, 2018: Lancet. Gastroenterology & Hepatology
Kaja Tikk, David Czock, Walter E Haefeli, Annette Kopp-Schneider, Hermann Brenner
ᅟ: Immunochemical fecal occult blood tests (iFOBTs) are increasingly used for colorectal cancer (CRC) screening. In our preceding observational study, sensitivity for detecting advanced colorectal neoplasms by iFOBT was 70.8% among users of low-dose acetylsalicylic acid compared with 35.9% among non-users (p = 0.001), whereas there were only very small differences in specificity. In receiver operating characteristics (ROC) analyses, the area under the curve (AUC) was much higher for acetylsalicylic acid users than for non-users, with particularly strong differences in men (0...
September 24, 2018: BMC Cancer
Michael Hendryx, Juhua Luo
BACKGROUND: We tested whether Medicaid expansion under the Affordable care Act was associated with increased screening for cervical, breast, and colorectal cancer among low-income adults. METHODS: We analyzed Behavioral Risk Factor Surveillance System data, identifying 2012 as preexpansion and 2016 as postexpansion (2014 was treated as a wash-out, and 2013 and 2015 had missing screening data from most states). States (including District of Columbia) either expanded Medicaid in 2014 (n=28) or not (n=18); five states that expanded after 2014 were excluded...
November 2018: Medical Care
Yue Chen, Yuan Li, Xiao-Qian Wang, Yu Meng, Qi Zhang, Jian-Yun Zhu, Jia-Qi Chen, Wan-Shuang Cao, Xue-Qi Wang, Chun-Feng Xie, Xiao-Ting Li, Shan-Shan Geng, Jie-Shu Wu, Cai-Yun Zhong, Hong-Yu Han
Cancer stem cells (CSCs) are considered to play essential roles in the process of origination, proliferation, migration, and invasion of cancer, and their properties are regulated by Wnt/β-catenin pathway. Phenethyl isothiocyanate (PEITC) is a natural product obtained from cruciferous vegetables with anticancer activities. The present study aimed to investigate the inhibitory effect and the underlying mechanisms of PEITC on colorectal CSCs. In this study, we found that PEITC can significantly reduce the size and number of colorectal cancer cell spheroids in serum-free medium...
August 30, 2018: Phytotherapy Research: PTR
Enrique Pérez-Cuadrado-Robles, Lucille Quénéhervé, Walter Margos, Tom G Moreels, Ralph Yeung, Hubert Piessevaux, Emmanuel Coron, Anne Jouret-Mourin, Pierre H Deprez
Background and study aims:  Endoscopic submucosal dissection (ESD) has been developed as an option for treatment of esophageal, gastric and colorectal lesions. However, there is no consensus on the role of ESD in duodenal tumors. Methods:  This systematic review and meta-analysis compared ESD and endoscopic mucosal resection (EMR) in sporadic non-ampullary superficial duodenal tumors (NASDTs), including local experience. We conducted a search in PubMed, Scopus and the Cochrane library up to August 2017 to identify studies that compared both techniques reporting at least one main outcome (en-bloc/complete resection, local recurrence)...
August 2018: Endoscopy International Open
S Pamela K Shiao, James Grayson, Chong Ho Yu
For personalized healthcare, the purpose of this study was to examine the key genes and metabolites in the one-carbon metabolism (OCM) pathway and their interactions as predictors of colorectal cancer (CRC) in multi-ethnic families. In this proof-of-concept study, we included a total of 30 participants, 15 CRC cases and 15 matched family/friends representing major ethnic groups in southern California. Analytics based on supervised machine learning were applied, with the target variable being specified as cancer, including the ensemble method and generalized regression (GR) prediction...
August 6, 2018: Journal of Personalized Medicine
Haochang Hu, Cong Zhou, Bin Li, Yanfei Chen, Jie Dai, Yiyi Mao, Tianyi Huang, Hang Yu, Min Chen, Jun Zhao, Shiwei Duan
PURPOSE: Ras association domain family 1 isoform A (RASSF1A), a member of Ras association domain family, plays an important role in tumorigenesis. The goal of our meta-analysis was to assess the diagnostic value of RASSF1A hypermethylation in colorectal cancer (CRC). METHODS: PubMed, Embase, CNKI and Wanfang databases were used to conduct literature selection. The association between RASSF1A methylation and CRC risk was evaluated by odds ratios (ORs) and 95% confidence intervals (CIs)...
October 2018: Pathology, Research and Practice
Nam Hee Kim, Yoon Suk Jung, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND & AIMS: The incidence of colorectal cancer is increasing among persons 50 years old or younger. However, data on the epidemiology of young-onset colorectal neoplasia (CRN) are limited. Although some studies have investigated the epidemiology of CRN in persons younger than 50 years, most have focused on persons 40 years or older. We evaluated the prevalence of and risk factors for CRN in adults younger than 40 years. METHODS: We performed a cross-sectional analysis of 72,356 asymptomatic individuals, 20-39 years old, who underwent colonoscopies as participants in the Kangbuk Samsung Health Study in South Korea, from August 2004 through December 2015...
July 17, 2018: Clinical Gastroenterology and Hepatology
Qian Huang, Yonghai Peng, Fangwei Xie
OBJECTIVE: The purpose of this systematic review and meta-analysis was to evaluate the efficacy of fecal Fusobacterium nucleatum ( Fn) for detecting colorectal cancer. It is the first systematic review and meta-analysis to focus exclusively on fecal Fn for colorectal cancer. MATERIALS AND METHODS: Comprehensive searches of several databases before January 2018 were conducted. Fecal Fn for detecting colorectal cancer was evaluated via pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve...
July 1, 2018: International Journal of Biological Markers
Noémi Gede, Diána Reményi Kiss, István Kiss
BACKGROUND: This study aims to survey the level of awareness of colorectal cancer and screening and to identify sources of information among the population under investigation. METHODS: A cross-sectional study was conducted among 1150 adults between the ages of 40 and 70 using quota sampling. Data were collected through self-made questionnaires to be completed by respondents. RESULTS: 32.7% of the participants correctly identified the recommended beginning of colorectal cancer screening, these participants were more likely to see their physician more frequently in the past years than those answering to the qusetion incorrectly (p = 0...
June 30, 2018: BMC Family Practice
Zhuan-Peng Chen, Jian-Chang Wei, Qiang Wang, Ping Yang, Wang-Lin Li, Feng He, Hua-Cui Chen, He Hu, Jun-Bin Zhong, Jie Cao
Colorectal cancer (CRC) is the third most common type of cancer; however, the molecular mechanisms underlying colorectal tumor metastasis and growth remain elusive. Recently, accumulating evidence has indicated that long non‑coding RNAs (lncRNAs) play a critical role in CRC progression and metastasis; however, the biological role and clinical significance of lncRNA 00152 (lnc00152) in CRC remains largely unknown. Thus, in this study, lnc00152 expression was measured in 80 human CRC tissue samples, 40 non‑cancerous tissue samples, and 3 CRC cell lines (SW480, SW620 and LoVo) using RT‑qPCR...
September 2018: International Journal of Oncology
D Badrudin, L Sideris, F A Leblond, V Pichette, A S Cloutier, P Drolet, P Dubé
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) with oxaliplatin (OX) is the standard of care for selected patients with peritoneal carcinomatosis of colorectal origin. Because 5-FU is mandatory to improve efficacy of OX when used by systemic route, several teams now empirically combine intravenous (IV) 5-FU with HIPEC OX, but this practice has yet to be supported by preclinical data. Using a murine model, we studied the impact of IV 5-FU on peritoneal absorption of HIPEC OX...
June 2018: Surgical Oncology
Wanxia Gai, Lu Ji, W K Jacky Lam, Kun Sun, Peiyong Jiang, Anthony W H Chan, John Wong, Paul B S Lai, Simon S M Ng, Brigette B Y Ma, Grace L H Wong, Vincent W S Wong, Henry L Y Chan, Rossa W K Chiu, Y M Dennis Lo, K C Allen Chan
BACKGROUND: Measurement of DNA derived from different tissues in the circulating DNA pool can provide important information regarding the presence of many pathological conditions. However, existing methods involving genome-wide bisulfite sequencing are relatively expensive and may present challenges for large-scale analysis. METHODS: Through identifying differentially methylated regions in the liver and colon compared with other tissues, we identified 2 markers and developed corresponding droplet digital PCR assays...
August 2018: Clinical Chemistry
Reinier G S Meester, Elisabeth F P Peterse, Amy B Knudsen, Anne C de Weerdt, Jennifer C Chen, Anna P Lietz, Andrea Dwyer, Dennis J Ahnen, Rebecca L Siegel, Robert A Smith, Ann G Zauber, Iris Lansdorp-Vogelaar
BACKGROUND: Colorectal cancer (CRC) risk varies by race and sex. This study, 1 of 2 microsimulation analyses to inform the 2018 American Cancer Society CRC screening guideline, explored the influence of race and sex on optimal CRC screening strategies. METHODS: Two Cancer Intervention and Surveillance Modeling Network microsimulation models, informed by US incidence data, were used to evaluate a variety of screening methods, ages to start and stop, and intervals for 4 demographic subgroups (black and white males and females) under 2 scenarios for the projected lifetime CRC risk for 40-year-olds: 1) assuming that risk had remained stable since the early screening era and 2) assuming that risk had increased proportionally to observed incidence trends under the age of 40 years...
July 15, 2018: Cancer
Shaohua Guo, Jiajin Zhang, Baishi Wang, Bingdong Zhang, Xuning Wang, Liang Huang, Hongyi Liu, Baoqing Jia
Objective: The study aimed to screen microRNAs (miRNAs) that can be used for the early detection of colorectal cancer (CRC) based on differential expression of miRNA in serum. Materials and methods: A three-stage study was designed with a total of 217 CRCs, 168 colorectal adenomas (CRAs), and 190 healthy controls (HCs). A quantitative reverse transcription polymerase chain reaction was performed in three stages. We screened 528 miRNA expression profiles in the sera of 40 patients (CRC n=20, CRA n=10, and HC n=10) for candidate miRNAs, then 210 serum samples (CRC n=90, CRA n=60, and HC n=60) were used for screening of candidate miRNAs...
2018: OncoTargets and Therapy
Lior Segev, Matthew F Kalady, James M Church
BACKGROUND: National databases show a recent significant increase in the incidence of colorectal cancer in people younger than 50. With current recommendations to begin average-risk screening at age 50, these patients do not have the opportunity to be screened. We hypothesized that most of the cancers among the young would be left sided, which would create an opportunity for screening the young by flexible sigmoidoscopy. OBJECTIVE: This study aims to analyze the anatomic distribution of sporadic colorectal cancers in patients under the age of 50...
August 2018: Diseases of the Colon and Rectum
Huijuan Zhu, Meijuan Liu, Nianrong Zhang, Hui Pan, Guole Lin, Naishi Li, Linjie Wang, Hongbo Yang, Kemin Yan, Fengying Gong
Objectives: To explore zinc-α2-glycoprotein (ZAG), leptin, high-molecular-weight adiponectin (HMW-ADPN), and tumor necrosis factor-alpha (TNF-α) levels in serum and subcutaneous and visceral white adipose tissue (sWAT and vWAT) among normal weight (NW) and overweight/obese (OW/OB) patients with colorectal cancer (CRC). Methods: A total of 76 Chinese CRC patients (42 NW + CRC, 34 OW/OB + CRC) and 40 healthy controls were recruited. Serum levels of the adipokines of interest were measured by an enzyme-linked immunosorbent assay method, and their mRNA levels in sWAT and vWAT were determined by reverse transcription quantitative PCR methods...
2018: Frontiers in Endocrinology
Christine Le Bihan-Benjamin, Natalie Hoog-Labouret, Delphine Lefeuvre, Frédérique Carré-Pigeon, Philippe Jean Bousquet
OBJECTIVE: A significant proportion of cancer survivors experience chronic health sequelae, one of them being fertility impairment. However, even if many reports, guidelines and positions papers focus on fertility preservation and its needs, access to fertility preservation is not currently offered to all the patients concerned, and the targeted population is not well counted. STUDY DESIGN: A cross sectional study was conducted using the French cancer cohort, a cohort covering the whole French population and including around 7 million of cancer patients...
June 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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