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Colorectal under 40

Yang-Ping Ding, Zi-Li Gao, Bing-Can Chen, Kanyasiri Rakariyatham, Hua-Yi Suo, Hua-Rong Tong, Hang Xiao
Backgroud: (-)-Epigallocatechin-3-gallate (EGCG), the major component of green tea, is well documented to induce apoptosis and cell cycle arrest in cancer by targeting multiple signal transduction pathways. However, EGCG is extremely unstable in general culture conditions and rapidly degraded. So, to what extent EGCG or which degradation products of EGCG play a role in anti-tumor is still unknown. In this study, we evaluated the effect of different treatments of EGCG on HCT116 cells. DESIGN: MTT assay was applied to evaluated the inhibitory effect of different treatments of EGCG on HCT116 cells...
December 4, 2018: Nutrition and Cancer
Jeroen R Huyghe, Stephanie A Bien, Tabitha A Harrison, Hyun Min Kang, Sai Chen, Stephanie L Schmit, David V Conti, Conghui Qu, Jihyoun Jeon, Christopher K Edlund, Peyton Greenside, Michael Wainberg, Fredrick R Schumacher, Joshua D Smith, David M Levine, Sarah C Nelson, Nasa A Sinnott-Armstrong, Demetrius Albanes, M Henar Alonso, Kristin Anderson, Coral Arnau-Collell, Volker Arndt, Christina Bamia, Barbara L Banbury, John A Baron, Sonja I Berndt, Stéphane Bézieau, D Timothy Bishop, Juergen Boehm, Heiner Boeing, Hermann Brenner, Stefanie Brezina, Stephan Buch, Daniel D Buchanan, Andrea Burnett-Hartman, Katja Butterbach, Bette J Caan, Peter T Campbell, Christopher S Carlson, Sergi Castellví-Bel, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Maria-Dolores Chirlaque, Sang Hee Cho, Charles M Connolly, Amanda J Cross, Katarina Cuk, Keith R Curtis, Albert de la Chapelle, Kimberly F Doheny, David Duggan, Douglas F Easton, Sjoerd G Elias, Faye Elliott, Dallas R English, Edith J M Feskens, Jane C Figueiredo, Rocky Fischer, Liesel M FitzGerald, David Forman, Manish Gala, Steven Gallinger, W James Gauderman, Graham G Giles, Elizabeth Gillanders, Jian Gong, Phyllis J Goodman, William M Grady, John S Grove, Andrea Gsur, Marc J Gunter, Robert W Haile, Jochen Hampe, Heather Hampel, Sophia Harlid, Richard B Hayes, Philipp Hofer, Michael Hoffmeister, John L Hopper, Wan-Ling Hsu, Wen-Yi Huang, Thomas J Hudson, David J Hunter, Gemma Ibañez-Sanz, Gregory E Idos, Roxann Ingersoll, Rebecca D Jackson, Eric J Jacobs, Mark A Jenkins, Amit D Joshi, Corinne E Joshu, Temitope O Keku, Timothy J Key, Hyeong Rok Kim, Emiko Kobayashi, Laurence N Kolonel, Charles Kooperberg, Tilman Kühn, Sébastien Küry, Sun-Seog Kweon, Susanna C Larsson, Cecelia A Laurie, Loic Le Marchand, Suzanne M Leal, Soo Chin Lee, Flavio Lejbkowicz, Mathieu Lemire, Christopher I Li, Li Li, Wolfgang Lieb, Yi Lin, Annika Lindblom, Noralane M Lindor, Hua Ling, Tin L Louie, Satu Männistö, Sanford D Markowitz, Vicente Martín, Giovanna Masala, Caroline E McNeil, Marilena Melas, Roger L Milne, Lorena Moreno, Neil Murphy, Robin Myte, Alessio Naccarati, Polly A Newcomb, Kenneth Offit, Shuji Ogino, N Charlotte Onland-Moret, Barbara Pardini, Patrick S Parfrey, Rachel Pearlman, Vittorio Perduca, Paul D P Pharoah, Mila Pinchev, Elizabeth A Platz, Ross L Prentice, Elizabeth Pugh, Leon Raskin, Gad Rennert, Hedy S Rennert, Elio Riboli, Miguel Rodríguez-Barranco, Jane Romm, Lori C Sakoda, Clemens Schafmayer, Robert E Schoen, Daniela Seminara, Mitul Shah, Tameka Shelford, Min-Ho Shin, Katerina Shulman, Sabina Sieri, Martha L Slattery, Melissa C Southey, Zsofia K Stadler, Christa Stegmaier, Yu-Ru Su, Catherine M Tangen, Stephen N Thibodeau, Duncan C Thomas, Sushma S Thomas, Amanda E Toland, Antonia Trichopoulou, Cornelia M Ulrich, David J Van Den Berg, Franzel J B van Duijnhoven, Bethany Van Guelpen, Henk van Kranen, Joseph Vijai, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Korbinian Weigl, Stephanie J Weinstein, Emily White, Aung Ko Win, C Roland Wolf, Alicja Wolk, Michael O Woods, Anna H Wu, Syed H Zaidi, Brent W Zanke, Qing Zhang, Wei Zheng, Peter C Scacheri, John D Potter, Michael C Bassik, Anshul Kundaje, Graham Casey, Victor Moreno, Goncalo R Abecasis, Deborah A Nickerson, Stephen B Gruber, Li Hsu, Ulrike Peters
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 × 10-8 , bringing the number of known independent signals for CRC to ~100...
December 3, 2018: Nature Genetics
Clasine M de Klerk, Els Wieten, Iris Lansdorp-Vogelaar, Patrick M Bossuyt, Manon Cw Spaander, Evelien Dekker
BACKGROUND: Faecal immunochemical tests (FITs) are recommended for colorectal cancer screening. Two frequently used FIT methods (FOB-Gold, Sentinel Diagnostics, Milan, Italy and OC-Sensor, Eiken Chemical, Tokyo, Japan) perform similarly in detecting advanced neoplasia (ie, colorectal cancer and advanced adenoma) at a fixed positivity cutoff for faecal haemoglobin concentration. It is unclear whether the performance of the two methods is also comparable at other thresholds. We compared the accuracy of the two assays in detecting advanced neoplasia across various thresholds...
November 26, 2018: Lancet. Gastroenterology & Hepatology
Yvette Hm Claassen, Maxime Jm van der Valk, Anne J Breugom, Martine A Frouws, Esther Bastiaannet, Gerrit-Jan Liefers, Cornelis Jh van de Velde, Ellen Kapiteijn
BACKGROUND: For patients with asymptomatic, incurable, metastatic colorectal cancer, palliative, systemic treatment can be started immediately, or can be delayed until disease-related symptoms occur. How the potential survival benefit of starting palliative, systemic treatment immediately after diagnosis weighs up against the potential side effects is currently under debate, and was investigated in this review. OBJECTIVES: To assess the effects of immediate versus delayed chemotherapy, with or without targeted therapy, on overall survival, toxicity, quality of life, progression-free survival, and compliance with chemotherapy for individuals with asymptomatic, metastatic, incurable colorectal cancer...
November 21, 2018: Cochrane Database of Systematic Reviews
Lara F Nhola, Sahar S Abdelmoneim, Hector R Villarraga, Manish Kohli, Axel Grothey, Kimberly-Ann Bordun, Matthew Cheung, Ryan Best, David Cheung, Runqing Huang, Sergio Barros-Gomes, Marshall Pitz, Pawan K Singal, Davinder S Jassal, Sharon L Mulvagh
BACKGROUND: Cardio-oncology is a recently established discipline that focuses on the management of patients with cancer who are at risk for developing cardiovascular complications as a result of their underlying oncologic treatment. In metastatic colorectal cancer (mCRC) and metastatic renal cell carcinoma (mRCC), vascular endothelial growth factor inhibitor (VEGF-i) therapy is commonly used to improve overall survival. Although these novel anticancer drugs may lead to the development of cardiotoxicity, whether early detection of cardiac dysfunction using serial echocardiography could potentially prevent the development of heart failure in this patient population requires further study...
November 17, 2018: Journal of the American Society of Echocardiography
K Evert, C Stiegler, C Schäfer, K Palme, E Horndasch, S Reitinger, B M Rau, W Dietmaier, M Evert
Adenosquamous carcinoma (ASqC) is an exceedingly rare subtype of colorectal cancer without any known special guidelines for treatment. The biological behaviour and molecular background are widely unknown, although a few case studies report a worse prognosis compared to ordinary colorectal adenocarcinoma. We herein report for the first time the successful immune checkpoint inhibitor therapy in a 40-year-old patient suffering from metastasized right-sided colonic ASqC with unique molecular features, after having previously progressed under standard chemotherapy...
October 22, 2018: Der Pathologe
Po-Hong Liu, Kana Wu, Kimmie Ng, Ann G Zauber, Long H Nguyen, Mingyang Song, Xiaosheng He, Charles S Fuchs, Shuji Ogino, Walter C Willett, Andrew T Chan, Edward L Giovannucci, Yin Cao
Importance: Colorectal cancer (CRC) incidence and mortality among individuals younger than 50 years (early-onset CRC) are increasing. The reasons for such increases are largely unknown, although the increasing prevalence of obesity may be partially responsible. Objective: To investigate prospectively the association between obesity and weight gain since early adulthood with the risk of early-onset CRC. Design, Setting, and Participants: The Nurses' Health Study II is a prospective, ongoing cohort study of US female nurses aged 25 to 42 years at study enrollment (1989)...
October 11, 2018: JAMA Oncology
Leila Family, Yanli Li, Lie Hong Chen, John H Page, Zandra K Klippel, Chun Chao
Background: Previously identified patient-level risk factors for chemotherapy-induced febrile neutropenia (FN) indicate several potential underlying pathogenic mechanisms, including bone marrow suppression, impaired neutrophil function, or disturbances of barrier function. This study evaluated whether additional clinical characteristics related to these pathogenic mechanisms were risk factors for FN. Patients and Methods: The study population included patients diagnosed with non-Hodgkin's lymphoma or breast, lung, colorectal, ovarian, or gastric cancer between 2000 and 2009 at Kaiser Permanente Southern California and treated with myelosuppressive chemotherapy...
October 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Muriel Larauche, Nabila Moussaoui, Mandy Biraud, Won Ki Bae, Henri Duboc, Mulugeta Million, Yvette Taché
BACKGROUND: Water avoidance stress (WAS) induces a naloxone-independent visceral analgesia in male rats under non-invasive conditions of monitoring. The objective of the study was to examine the role of brain CRF signaling in acute stress-induced visceral analgesia (SIVA). METHODS: Adult male Sprague-Dawley rats were chronically implanted with an intracerebroventricular (ICV) cannula. The visceromotor response (VMR) to graded phasic colorectal distension (CRD: 10, 20, 40, 60 mm Hg, 20 seconds, 4 minutes intervals) was monitored using manometry...
October 9, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Hideyuki Chiba, Ken Ohata, Jun Tachikawa, Jun Arimoto, Keiichi Ashikari, Hiroki Kuwabara, Michiko Nakaoka, Toru Goto, Atsushi Nakajima
BACKGROUND: Endoscopic submucosal dissection (ESD) is an effective treatment for early-colorectal cancer. Although delayed bleeding is a serious potential complication, there is no consensus on the optimal protocol to determine which cases require emergency colonoscopy. AIMS: This study aimed to assess the risk factors for delayed bleeding after ESD and evaluate the "watch and wait" strategy for delayed bleeding. The "watch and wait" strategy was used for delayed bleeding, unless the shock index was ≥ 1 and/or a moderate amount of hematochezia occurred more than five occurrences...
October 3, 2018: Digestive Diseases and Sciences
Alvaro Romera, Sergiy Peredpaya, Yaroslav Shparyk, Igor Bondarenko, Giovanni Mendonça Bariani, Kathia Cristina Abdalla, Enrique Roca, Fábio Franke, Felipe Melo Cruz, Anita Ramesh, Vikas Ostwal, Pradeep Shah, Sajeed Abdul Rahuman, Alexandra Paravisini, Camino Huerga, Ana Del Campo García, Susana Millán
BACKGROUND: BEVZ92 is a proposed biosimilar to bevacizumab. The two molecules have similar physicochemical and functional properties in in-vitro and preclinical studies. In this clinical study, we compared the pharmacokinetic profile, efficacy, safety, and immunogenicity of BEVZ92 with reference bevacizumab as a first-line treatment in patients with metastatic colorectal cancer. METHODS: We did a randomised, open-label trial at 15 centres in Argentina, Brazil, India, Spain, and Ukraine...
September 24, 2018: Lancet. Gastroenterology & Hepatology
Kaja Tikk, David Czock, Walter E Haefeli, Annette Kopp-Schneider, Hermann Brenner
ᅟ: Immunochemical fecal occult blood tests (iFOBTs) are increasingly used for colorectal cancer (CRC) screening. In our preceding observational study, sensitivity for detecting advanced colorectal neoplasms by iFOBT was 70.8% among users of low-dose acetylsalicylic acid compared with 35.9% among non-users (p = 0.001), whereas there were only very small differences in specificity. In receiver operating characteristics (ROC) analyses, the area under the curve (AUC) was much higher for acetylsalicylic acid users than for non-users, with particularly strong differences in men (0...
September 24, 2018: BMC Cancer
Michael Hendryx, Juhua Luo
BACKGROUND: We tested whether Medicaid expansion under the Affordable care Act was associated with increased screening for cervical, breast, and colorectal cancer among low-income adults. METHODS: We analyzed Behavioral Risk Factor Surveillance System data, identifying 2012 as preexpansion and 2016 as postexpansion (2014 was treated as a wash-out, and 2013 and 2015 had missing screening data from most states). States (including District of Columbia) either expanded Medicaid in 2014 (n=28) or not (n=18); five states that expanded after 2014 were excluded...
November 2018: Medical Care
Yue Chen, Yuan Li, Xiao-Qian Wang, Yu Meng, Qi Zhang, Jian-Yun Zhu, Jia-Qi Chen, Wan-Shuang Cao, Xue-Qi Wang, Chun-Feng Xie, Xiao-Ting Li, Shan-Shan Geng, Jie-Shu Wu, Cai-Yun Zhong, Hong-Yu Han
Cancer stem cells (CSCs) are considered to play essential roles in the process of origination, proliferation, migration, and invasion of cancer, and their properties are regulated by Wnt/β-catenin pathway. Phenethyl isothiocyanate (PEITC) is a natural product obtained from cruciferous vegetables with anticancer activities. The present study aimed to investigate the inhibitory effect and the underlying mechanisms of PEITC on colorectal CSCs. In this study, we found that PEITC can significantly reduce the size and number of colorectal cancer cell spheroids in serum-free medium...
August 30, 2018: Phytotherapy Research: PTR
Enrique Pérez-Cuadrado-Robles, Lucille Quénéhervé, Walter Margos, Tom G Moreels, Ralph Yeung, Hubert Piessevaux, Emmanuel Coron, Anne Jouret-Mourin, Pierre H Deprez
Background and study aims:  Endoscopic submucosal dissection (ESD) has been developed as an option for treatment of esophageal, gastric and colorectal lesions. However, there is no consensus on the role of ESD in duodenal tumors. Methods:  This systematic review and meta-analysis compared ESD and endoscopic mucosal resection (EMR) in sporadic non-ampullary superficial duodenal tumors (NASDTs), including local experience. We conducted a search in PubMed, Scopus and the Cochrane library up to August 2017 to identify studies that compared both techniques reporting at least one main outcome (en-bloc/complete resection, local recurrence)...
August 2018: Endoscopy International Open
S Pamela K Shiao, James Grayson, Chong Ho Yu
For personalized healthcare, the purpose of this study was to examine the key genes and metabolites in the one-carbon metabolism (OCM) pathway and their interactions as predictors of colorectal cancer (CRC) in multi-ethnic families. In this proof-of-concept study, we included a total of 30 participants, 15 CRC cases and 15 matched family/friends representing major ethnic groups in southern California. Analytics based on supervised machine learning were applied, with the target variable being specified as cancer, including the ensemble method and generalized regression (GR) prediction...
August 6, 2018: Journal of Personalized Medicine
Haochang Hu, Cong Zhou, Bin Li, Yanfei Chen, Jie Dai, Yiyi Mao, Tianyi Huang, Hang Yu, Min Chen, Jun Zhao, Shiwei Duan
PURPOSE: Ras association domain family 1 isoform A (RASSF1A), a member of Ras association domain family, plays an important role in tumorigenesis. The goal of our meta-analysis was to assess the diagnostic value of RASSF1A hypermethylation in colorectal cancer (CRC). METHODS: PubMed, Embase, CNKI and Wanfang databases were used to conduct literature selection. The association between RASSF1A methylation and CRC risk was evaluated by odds ratios (ORs) and 95% confidence intervals (CIs)...
October 2018: Pathology, Research and Practice
Nam Hee Kim, Yoon Suk Jung, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND & AIMS: The incidence of colorectal cancer is increasing among persons 50 years old or younger. However, data on the epidemiology of young-onset colorectal neoplasia (CRN) are limited. Although some studies have investigated the epidemiology of CRN in persons younger than 50 years, most have focused on persons 40 years or older. We evaluated the prevalence of and risk factors for CRN in adults younger than 40 years. METHODS: We performed a cross-sectional analysis of 72,356 asymptomatic individuals, 20-39 years old, who underwent colonoscopies as participants in the Kangbuk Samsung Health Study in South Korea, from August 2004 through December 2015...
July 17, 2018: Clinical Gastroenterology and Hepatology
Qian Huang, Yonghai Peng, Fangwei Xie
OBJECTIVE: The purpose of this systematic review and meta-analysis was to evaluate the efficacy of fecal Fusobacterium nucleatum ( Fn) for detecting colorectal cancer. It is the first systematic review and meta-analysis to focus exclusively on fecal Fn for colorectal cancer. MATERIALS AND METHODS: Comprehensive searches of several databases before January 2018 were conducted. Fecal Fn for detecting colorectal cancer was evaluated via pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve...
July 1, 2018: International Journal of Biological Markers
Noémi Gede, Diána Reményi Kiss, István Kiss
BACKGROUND: This study aims to survey the level of awareness of colorectal cancer and screening and to identify sources of information among the population under investigation. METHODS: A cross-sectional study was conducted among 1150 adults between the ages of 40 and 70 using quota sampling. Data were collected through self-made questionnaires to be completed by respondents. RESULTS: 32.7% of the participants correctly identified the recommended beginning of colorectal cancer screening, these participants were more likely to see their physician more frequently in the past years than those answering to the qusetion incorrectly (p = 0...
June 30, 2018: BMC Family Practice
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