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Ki Eun Pyo, Chang Rok Kim, Minkyoung Lee, Jong-Seo Kim, Keun Il Kim, Sung Hee Baek
Unc-51-like-kinase 1 (ULK1) is a target of both the mechanistic target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK), whose role is to facilitate the initiation of autophagy in response to starvation. Upon glucose starvation, dissociation of mTOR from ULK1 and phosphorylation by AMPK leads to the activation of ULK1 activity. Here, we provide evidence that ULK1 is the attachment of O-linked N-acetylglucosamine (O-GlcNAcylated) on the threonine 754 site by O-linked N-acetylglucosamine transferase (OGT) upon glucose starvation...
December 4, 2018: Cell Reports
Jin-Wook Lee, Il Jeon, Haosheng Lin, Seungju Seo, Tae-Hee Han, Anton Anisimov, Esko I Kauppinen, Yutaka Matsuo, Shigeo Maruyama, Yang Yang
Single-walled carbon nanotubes (CNTs) has been considered as a promising material for a top electrode of perovskite solar cells owing to its hydrophobic nature, earth-abundance, and mechanical robustness. However, its poor conductivity, a shallow work function, and non-reflective nature have limited further enhancement in power conversion efficiency (PCE) of top CNT electrode-based perovskite solar cells. Here, we introduced a simple and scalable method to address these issues by utilizing an ex-situ vapor-assisted doping method...
December 5, 2018: Nano Letters
Su-Jeong Lee, Jun-Gi Ahn, Jihwan Seo, Heun-Jong Ha, Chang-Woo Cho
An efficient diarylprolinol triphenylsilyl ether-catalyzed enantioselective aza-Michael reaction of pyrimidines as N-centered nucleophiles to α,β-unsaturated aldehydes, followed by reduction, provided chiral acyclic pyrimidine nucleosides in good yields (51-78% yields for two steps) and excellent enantioselectivities (91-98% ee). In addition, the chiral acyclic pyrimidine nucleoside having the tert-butyldiphenylsilyl-protected hydroxyl substituent was successfully applied to the synthesis of the corresponding chiral cyclic pyrimidine nucleoside analogue bearing the tetrahydrofuranyl ring...
December 5, 2018: Organic & Biomolecular Chemistry
Minjung Seo, Nam Du Ha, Jae-Cheol Jo, Seol Hoon Park
We report two cases of supra-scrotal vasitis incidentally detected in patients who had undergone mesh herniorrhaphy. PET/CT in patients undergoing lymphoma work-up and health check-up revealed hypermetabolic dilatation of vas deferens in the external iliac area. There were no symptoms, and blood test results did not indicate acute inflammation. Interestingly, both had undergone herniorrhaphy for inguinal hernia. Herniorrhaphy is reported to cause vasal complications such as obstruction or inflammation, although most are asymptomatic and probably under-reported...
December 3, 2018: Clinical Nuclear Medicine
Eoi Jong Seo, Taewoong Um, Young Hee Yoon
IMPORTANCE: Analyzing choroidal flow in central serous chorioretinopathy (CSC) with novel device BACKGROUND: To examine the abnormal morphology of choriocapillary flow with optical coherence tomography angiography (OCTA) according to the presence of subretinal fluid (SRF) in CSC. DESIGN: A hospital-based retrospective study PARTICIPANTS: We analyzed OCTA results of 68 eyes (68 patients) diagnosed as CSC with or without SRF (active and resolved CSC, respectively) at the Asan Medical Center...
December 5, 2018: Clinical & Experimental Ophthalmology
Seung-Ho Seo, Eun-Ju Kim, Seong-Eun Park, Sung-Hoon Byun, Soon-Young Lee, So-Hyeon Bok, Dae-Hun Park, Hong-Seok Son
GC/MS coupled with multivariate statistical analysis was performed to identify marker metabolites in serum of mice after healing ovalbumin- (OVA-) induced asthma using Opuntia humifusa . Principal component analysis (PCA) score plot showed separation among groups, with metabolite profiles of serum showing differences according to various treatments for the asthma murine model. Levels of stearic acid and arachidic acid were significantly lower in the serum from OVA-induced group than those from the control group...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Jae-Hyun Seo, Yong-Hyuk Kim
The KDD CUP 1999 intrusion detection dataset was introduced at the third international knowledge discovery and data mining tools competition, and it has been widely used for many studies. The attack types of KDD CUP 1999 dataset are divided into four categories: user to root (U2R), remote to local (R2L), denial of service (DoS), and Probe. We use five classes by adding the normal class. We define the U2R, R2L, and Probe classes, which are each less than 1% of the total dataset, as rare classes. In this study, we attempt to mitigate the class imbalance of the dataset...
2018: Computational Intelligence and Neuroscience
Shubhabrata Mukherjee, Jesse Mez, Emily H Trittschuh, Andrew J Saykin, Laura E Gibbons, David W Fardo, Madeline Wessels, Julianna Bauman, Mackenzie Moore, Seo-Eun Choi, Alden L Gross, Joanne Rich, Diana K N Louden, R Elizabeth Sanders, Thomas J Grabowski, Thomas D Bird, Susan M McCurry, Beth E Snitz, M Ilyas Kamboh, Oscar L Lopez, Philip L De Jager, David A Bennett, C Dirk Keene, Eric B Larson, Paul K Crane
Categorizing people with late-onset Alzheimer's disease into biologically coherent subgroups is important for personalized medicine. We evaluated data from five studies (total n = 4050, of whom 2431 had genome-wide single-nucleotide polymorphism (SNP) data). We assigned people to cognitively defined subgroups on the basis of relative performance in memory, executive functioning, visuospatial functioning, and language at the time of Alzheimer's disease diagnosis. We compared genotype frequencies for each subgroup to those from cognitively normal elderly controls...
December 4, 2018: Molecular Psychiatry
Natalia M Gonzales, Jungkyun Seo, Ana I Hernandez Cordero, Celine L St Pierre, Jennifer S Gregory, Margaret G Distler, Mark Abney, Stefan Canzar, Arimantas Lionikas, Abraham A Palmer
The LG/J x SM/J advanced intercross line of mice (LG x SM AIL) is a multigenerational outbred population. High minor allele frequencies, a simple genetic background, and the fully sequenced LG and SM genomes make it a powerful population for genome-wide association studies. Here we use 1,063 AIL mice to identify 126 significant associations for 50 traits relevant to human health and disease. We also identify thousands of cis- and trans-eQTLs in the hippocampus, striatum, and prefrontal cortex of ~200 mice. We replicate an association between locomotor activity and Csmd1, which we identified in an earlier generation of this AIL, and show that Csmd1 mutant mice recapitulate the locomotor phenotype...
December 4, 2018: Nature Communications
Mi-Jin An, Dae-Hyun Kim, Chul-Hong Kim, Mijin Kim, Sangmyung Rhee, Sang-Beom Seo, Jung-Woong Kim
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most lethal cancer worldwide. Although gene mutations associated with HCC development have been intensively studied, how epigenetic factors specifically modulate the functional properties of HCC by regulating target gene expression is unclear. Here we demonstrated the overexpression of KDM3B in liver tissue of HCC patients using public RNA-seq data. Ablation of KDM3B by CRISPR/Cas9 retarded the cell cycle and proliferation of hepatocarcinoma HepG2 cells...
December 1, 2018: Biochemical and Biophysical Research Communications
Won Jin Lee, Yeongchull Choi, Seulki Ko, Eun Shil Cha, Jaeyoung Kim, Young Min Kim, Kyoung Ae Kong, Songwon Seo, Ye Jin Bang, Yae Won Ha
BACKGROUND: Timely assessment of cancer risk from current radiation exposure among medical radiation workers can contribute to the development of strategies to prevent excessive occupational radiation exposure. The purpose of the present study is to estimate the lifetime risk of cancers induced by occupational radiation exposure among medical radiation workers. METHODS: Using estimated organ doses and the RadRAT risk assessment tool, the lifetime cancer risk was estimated among medical radiation workers who were enrolled in the Korean National Dose Registry from 1996 to 2011...
December 4, 2018: BMC Cancer
Sangjae Seo, Wataru Shinoda
Heterogeneity is essential for multicomponent lipid membranes. Especially, sterol-induced domain formation in membranes has recently attracted attention because of its biological importance. To investigate such membrane domains at molecular level, coarse-grained molecular dynamics (CG-MD) simulations are a promising approach since they allow to consider the temporal and spatial scales involved in domain formation. In this paper, we present a new CG force field, named SPICA, which can accurately predict domain formation within various lipids in membranes...
December 4, 2018: Journal of Chemical Theory and Computation
Youra Kang, Ji-Ha Lee, Young Ho Seo, Jung-Hee Jang, Chul-Ho Jeong, Sooyeun Lee, Gil-Saeng Jeong, Byoungduck Park
Methamphetamine (METH) acts strongly on the nervous system and damages neurons and is known to cause neurodegenerative diseases such as Alzheimer's and Parkinson's. Flavonoids, polyphenolic compounds present in green tea, red wine and several fruits exhibit antioxidant properties that protect neurons from oxidative damage and promote neuronal survival. Especially, epicatechin (EC) is a powerful flavonoid with antibacterial, antiviral, antitumor and antimutagenic effects as well as antioxidant effects. We therefore investigated whether EC could prevent METH-induced neurotoxicity using HT22 hippocampal neuronal cells...
December 5, 2018: Biomolecules & Therapeutics
Seonghyun Park, Janghoo Seo
Improved quality of life has led to a growing demand for better indoor air quality (IAQ). Buildings are becoming more airtight and insulated in order to minimize energy consumption. The importance of both energy conservation and IAQ improvement has been recognized and addressed by many studies. Bake-out is the process of using indoor heating to remove volatile compounds present in building materials and furnishings so that they can be vented out into the atmosphere. Indiscriminate use of heating to increase the surface temperature of materials during this process can result in significant loss of energy...
December 3, 2018: International Journal of Environmental Research and Public Health
Zhimin Chai, Jungho Seo, Salman A Abbasi, Ahmed Busnaina
Carbon nanotubes (CNTs) are promising building blocks for emerging wearable electronics and sensors due to their outstanding electrical and mechanical properties. However, the practical applications of the CNTs face challenges of efficiently and precisely placing them at the desired location with controlled orientation and density. Here, we introduce an electro-fluidic assembly process to assemble highly aligned and densely packed CNTs selectively on a substrate with patterned wetted areas at a high rate. An electric field is applied during the electro-fluidic assembly process, which drives the CNTs close to the patterned regions and shortens the assembly time...
December 4, 2018: ACS Nano
Jiawei Yu, Do Bang, Rahul Mishra, Rajagopalan Ramaswamy, Jung Hyun Oh, Hyeon-Jong Park, Yunboo Jeong, Pham Van Thach, Dong-Kyu Lee, Gyungchoon Go, Seo-Won Lee, Yi Wang, Shuyuan Shi, Xuepeng Qiu, Hiroyuki Awano, Kyung-Jin Lee, Hyunsoo Yang
Spintronics relies on magnetization switching through current-induced spin torques. However, because spin transfer torque for ferromagnets is a surface torque, a large switching current is required for a thick, thermally stable ferromagnetic cell, and this remains a fundamental obstacle for high-density non-volatile applications with ferromagnets. Here, we report a long spin coherence length and associated bulk-like torque characteristics in an antiferromagnetically coupled ferrimagnetic multilayer. We find that a transverse spin current can pass through >10-nm-thick ferrimagnetic Co/Tb multilayers, whereas it is entirely absorbed by a 1-nm-thick ferromagnetic Co/Ni multilayer...
December 3, 2018: Nature Materials
Sung Hee Youn, Hyun Lim, Yeonmi Ju, Jae Seung Soh, Ji Won Park, Ho Suk Kang, Sung Eun Kim, Sung Hoon Moon, Jong Hyeok Kim, Choong Kee Park, Seung In Seo, Woon Geon Shin
OBJECTIVES: Direct oral anticoagulants (DOACs) are effective in the prevention and treatment of thromboembolism; however, they are associated with upper gastrointestinal bleeding (UGIB). In this study, we evaluated the efficacy of gastroprotective agents (GPAs) in reducing the risk of UGIB in patients receiving DOACs. METHODS: We retrospectively reviewed the medical records of 2076 patients who received DOACs for the prevention or treatment of thromboembolic events between January 2008 and July 2016...
December 3, 2018: Scandinavian Journal of Gastroenterology
Szu-Ying Chen, Kai Kristiansen, Dongjin Seo, Nicholas A Cadirov, Howard A Dobbs, Yair Kaufman, Alex M Schrader, Roberto Carlos Andresen Eguiluz, Mohammed B Alotaibi, Subhash C Ayirala, James R Boles, Ali A Yousef, Jacob N Israelachvili
Over the past few decades, field and laboratory scale studies have shown enhancements in oil recovery when reservoirs, which contain high-salinity formation water (FW), are waterflooded with modified-salinity salt water (widely referred to as the "low-salinity", "dilution", or "SmartWater" effect for improved oil recovery). In this study, we investigated the time-dependence of the physico-chemical processes that occur during diluted seawater ( i.e., SmartWater) waterflooding processes of specific relevance to carbonate oil reservoirs...
December 3, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Dong Gi Seo, Jeongwook Choi
No abstract text is available yet for this article.
2018: Journal of Educational Evaluation for Health Professions
Jin-Sun Park, Kyoung-Woo Seo, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Seung-Jea Tahk, Joon-Han Shin
The ratio between the absolute number of neutrophils and the number of lymphocytes (NLR) has recently emerged as a potential new biomarker predicting worse clinical conditions ranging from infectious disease to cardiovascular disease. Prognostic significance of NLR in patients with ST-elevation myocardial infarction (STEMI) is not established. This study aimed to investigate prognostic impact of NLR in patients with STEMI.We analyzed the data and clinical outcomes of 30-day survivors with STEMI who received successful coronary intervention from 2006 to 2010...
November 2018: Medicine (Baltimore)
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