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REVIEW
Seunga Lee, Young Seo Park, Ji Hoon Rhee, Hyojeong Chu, Jennifer M Frost, Yeonhee Choi
Plants, known for their immobility, employ various mechanisms against stress and damage. A prominent feature is the formation of callus tissue-a cellular growth phenomenon that remains insufficiently explored, despite its distinctive cellular plasticity compared to vertebrates. Callus formation involves dedifferentiated cells, with a subset attaining pluripotency. Calluses exhibit an extraordinary capacity to reinitiate cellular division and undergo structural transformations, generating de novo shoots and roots, thereby developing into regenerated plants-a testament to the heightened developmental plasticity inherent in plants...
April 18, 2024: Plant Cell Reports
#2
JOURNAL ARTICLE
Yoo Min Han, Jeong Hee Yoon, Seokha Yoo, Su Jin Chung, Jeong Min Lee, Ji Min Choi, Eun Hyo Jin, Ji Yeon Seo
BACKGROUND AND AIMS: Visceral obesity is a risk factor for reflux esophagitis (RE). We investigated the risk of RE according to visceral adipose tissue (VAT) measured by deep neural network architecture using computed tomography and evaluated the longitudinal association between abdominal adipose tissue changes and the disease course of RE. METHODS: Individuals receiving health checkups who underwent esophagogastroduodenoscopy (EGD) and abdominal computed tomography (CT) at Seoul National University Healthcare System Gangnam Center between 2015 and 2016 were included...
April 18, 2024: American Journal of Gastroenterology
#3
JOURNAL ARTICLE
Time-traceable micro-taggants for anti-counterfeiting and secure distribution of food and medicines.
Cheolheon Park, Yunjin Jeong, Huiran Yeom, Seo Woo Song, Wook Park, Daewon Lee
This study presents an innovative solution for the enhanced tracking and security of pharmaceuticals through the development of microstructures incorporating environmentally responsive, coded microparticles. Utilizing maskless photolithography, we engineered these microparticles with a degradable masking layer with 30 μ m thickness that undergoes controlled dissolution. Quantitative analysis revealed that the protective layer's degradation, monitored by red fluorescence intensity, diminishes predictably over 144 h in phosphate-buffered saline under physiological conditions...
March 2024: Biomicrofluidics
#4
JOURNAL ARTICLE
Seung Yeob Yu, Byeong Seob Oh, Seoung Woo Ryu, Jeong Eun Bak, Eun Seo Heo, Jeong Chan Moon, Jae-Ho Jeong, Ju Huck Lee
A novel Gram-negative, obligate anaerobe, non-motile, flagella-lacking, catalase- and oxidase-negative, coccobacilli-shaped bacterial strain designated AGMB02718T was isolated from swine feces. The 16S rRNA gene analysis indicated that strain AGMB02718T belonged to the genus Mesosutterella with the highest similarity to M. multiformis 4NBBH2T (= DSM 106860T ) (sequence similarity of 96.2%), forming a distinct phylogenetic lineage. Its growth occurred at 25-45°C (optimal 37°C) and in 0.5-1% NaCl (optimal 0...
2024: Frontiers in Microbiology
#5
JOURNAL ARTICLE
Xuan Liu, Jay R Turner, Christopher R Oxford, Jacob McNeill, Brenna Walsh, Emmie Le Roy, Crystal L Weagle, Emily Stone, Haihui Zhu, Wenyu Liu, Zilin Wei, Nicole P Hyslop, Jason Giacomo, Ann M Dillner, Abdus Salam, Al-Amin Hossen, Zubayer Islam, Ihab Abboud, Clement Akoshile, Omar Amador-Muñoz, Nguyen Xuan Anh, Araya Asfaw, Rajasekhar Balasubramanian, Rachel Ying-Wen Chang, Craig Coburn, Sagnik Dey, David J Diner, Jinlu Dong, Tareq Farrah, Paterne Gahungu, Rebecca M Garland, Michel Grutter de la Mora, Sina Hasheminassab, Juanette John, Jhoon Kim, Jong Sung Kim, Kristy Langerman, Pei-Chen Lee, Puji Lestari, Yang Liu, Tesfaye Mamo, Mathieu Martins, Olga L Mayol-Bracero, Mogesh Naidoo, Sang Seo Park, Yoav Schechner, Robyn Schofield, Sachchida N Tripathi, Eli Windwer, Ming-Tsang Wu, Qiang Zhang, Michael Brauer, Yinon Rudich, Randall V Martin
Global ground-level measurements of elements in ambient particulate matter (PM) can provide valuable information to understand the distribution of dust and trace elements, assess health impacts, and investigate emission sources. We use X-ray fluorescence spectroscopy to characterize the elemental composition of PM samples collected from 27 globally distributed sites in the Surface PARTiculate mAtter Network (SPARTAN) over 2019-2023. Consistent protocols are applied to collect all samples and analyze them at one central laboratory, which facilitates comparison across different sites...
April 12, 2024: ACS EST Air
#6
JOURNAL ARTICLE
Sun Woo Kim, Juhyung Seo, Subin Lee, Daozhi Shen, Youngjin Kim, Hyun Ho Choi, Hocheon Yoo, Hyun Ho Kim
Due to the increasing complexity in miniaturization of electronic devices, reconfigurable field-effect transistors (RFETs) have emerged as a solution. Although the foundational concepts of RFETs have matured over two decades, ongoing breakthroughs are needed to address challenges such as improving the device performance as well as achieving balanced symmetry between n -type and p -type transport modes with long-term stability. Herein, we present a nonvolatile WSe2 -based RFET that utilizes photoassisted interfacial charge trapping at the h-BN and SiO2 interface...
April 17, 2024: ACS Applied Materials & Interfaces
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JOURNAL ARTICLE
Do Young Kim, Hyunmin Ahn, Sukyung Lee, Ikhyun Jun, Kyoung Yul Seo, Sang Yeop Kim, Tae-Im Kim
This prospective single-arm study aimed to evaluate the clinical efficacy and safety of a refractive multifocal contact lens for the correction of presbyopia in 22 patients. The participants underwent clinical examinations before and 1 week after wearing a refractive multifocal contact lens (OptaCon ZOOM). The primary endpoints were the corrected distance visual acuity (CDVA) and distance-corrected near visual acuity (DCNVA). Defocus curve, contrast sensitivity, and ocular surface disease index (OSDI) were analyzed...
April 17, 2024: Scientific Reports
#8
JOURNAL ARTICLE
Cheol-Jung Lee, Heejung Lee, Seo Ree Kim, Soo-Bin Nam, Ga-Eun Lee, Kyeong Eun Yang, Guk Jin Lee, Sang Hoon Chun, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Sung-Jun Cho, Yong-Yeon Cho
Accumulating evidence demonstrates that the activity regulation of ELK3, a member of the E26 transformation-specific oncogene family, is critical to regulating cell proliferation, migration, and survival in human cancers. However, the molecular mechanisms of how ELK3 induces chemoresistance in prostate cancer (PCa) have not been elucidated. In this study, we found that SPOP and ELK3 are an interacting partner. The interaction between SPOP and ELK3 resulted in increased ELK3 ubiquitination and destruction, assisted by checkpoint kinase-mediated ELK3 phosphorylation...
April 17, 2024: Cell Death & Disease
#9
JOURNAL ARTICLE
Caroline Vass, Marco Boeri, Gemma Shields, Jaein Seo
The interest in quantifying stated preferences for health and healthcare continues to grow, as does the technology available to support and improve health preference studies. Technological advancements in the last two decades have implications and opportunities for preference researchers designing, administering, analysing, interpreting and applying the results of stated preference surveys. In this paper, we summarise selected technologies and how these can benefit a preference study. We discuss empirical evaluations of the technology in preference research, with examples from health where possible...
April 17, 2024: Patient
#10
JOURNAL ARTICLE
Hyun Wook Yang, A Ra Kho, Song Hee Lee, Beom Seok Kang, Min Kyu Park, Chang Jun Lee, Se Wan Park, Seo Young Woo, Dong Yeon Kim, Hyun Ho Jung, Bo Young Choi, Won Il Yang, Hong Ki Song, Hui Chul Choi, Jin Kyu Park, Sang Won Suh
Epilepsy, a complex neurological disorder, is characterized by recurrent seizures caused by aberrant electrical activity in the brain. Central to this study is the role of lysosomal dysfunction in epilepsy, which can lead to the accumulation of toxic substrates and impaired autophagy in neurons. Our focus is on phosphodiesterase-4 (PDE4), an enzyme that plays a crucial role in regulating intracellular cyclic adenosine monophosphate (cAMP) levels by converting it into adenosine monophosphate (AMP). In pathological states, including epilepsy, increased PDE4 activity contributes to a decrease in cAMP levels, which may exacerbate neuroinflammatory responses...
April 16, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
#11
JOURNAL ARTICLE
Minju Park, Seo-Yeong Mun, Wenwen Zhuang, Junsu Jeong, Hye Ryung Kim, Hongzoo Park, Eun-Taek Han, Jin-Hee Han, Wanjoo Chun, Hongliang Li, Won Sun Park
We explored the vasorelaxant effects of ipragliflozin, a sodium-glucose cotransporter-2 inhibitor, on rabbit femoral arterial rings. Ipragliflozin relaxed phenylephrine-induced pre-contracted rings in a dose-dependent manner. Pre-treatment with the ATP-sensitive K+ channel inhibitor glibenclamide (10 μM), the inwardly rectifying K+ channel inhibitor Ba2+ (50 μM), or the Ca2+ -sensitive K+ channel inhibitor paxilline (10 μM) did not influence the vasorelaxant effect. However, the voltage-dependent K+ (Kv) channel inhibitor 4-aminopyridine (3 mM) reduced the vasorelaxant effect...
April 15, 2024: European Journal of Pharmacology
#12
JOURNAL ARTICLE
Xiaona Chen, Jing Sun, Tian Wang, Qingyuan Tang, Lu Su, Yimin Sun, Liang Chen, Hyemyung Seo, Tianlin Cheng, Jian Wang, Bin Song
Mutations in CHCHD2 have been reported to be associated with familial Parkinson's disease (PD). We generated a human induced pluripotent stem cell (hiPSC) line by reprogramming dermal fibroblasts from a PD patient harboring a novel CHCHD2 mutation (c.434G > A, p.R145Q). This line exhibited human embryonic stem cell (hESC)-like clonal morphology, expression of undifferentiated stem cell markers, a normal karyotype and trilineage differentiation capacity and thus the potential to serve as a model for further investigating the underlying molecular mechanisms of CHCHD2 function in PD...
April 9, 2024: Stem Cell Research
#13
JOURNAL ARTICLE
Bogyeom Park, Yuwon Kim, Jinseok Park, Hojin Choi, Seong-Eun Kim, Hokyoung Ryu, Kyoungwon Seo
BACKGROUND: Early detection of mild cognitive impairment (MCI), a transitional stage between normal aging and Alzheimer disease, is crucial for preventing the progression of dementia. Virtual reality (VR) biomarkers have proven to be effective in capturing behaviors associated with subtle deficits in instrumental activities of daily living, such as challenges in using a food-ordering kiosk, for early detection of MCI. On the other hand, magnetic resonance imaging (MRI) biomarkers have demonstrated their efficacy in quantifying observable structural brain changes that can aid in early MCI detection...
April 17, 2024: Journal of Medical Internet Research
#14
JOURNAL ARTICLE
Dong Yeol Oh, Suk Bae Seo, Ye Ji Jang, Eun Joo Park, Kwang Ho Kim
BACKGROUND: A laser-induced needle-free microjet injector was developed for rapid, high-speed drug delivery of microliters into the skin. OBJECTIVE: This study evaluated the clinical rejuvenation effect of repeated dermal injections of the collagen simulator poly-dl-lactic acid (PDLA) using a laser-induced needle-free microjet injector. METHODS: Five PDLA injection sessions using a laser-induced needle-free microjet injector were conducted in patients concerned about aging skin...
April 17, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
#15
JOURNAL ARTICLE
Jae Wook Jung, Kwang Hyun Kim, Jaeseob Yun, Young Dae Kim, JoonNyung Heo, Hyungwoo Lee, Jin Kyo Choi, Il Hyung Lee, In Hwan Lim, Soon-Ho Hong, Byung Moon Kim, Dong Joon Kim, Na Young Shin, Bang-Hoon Cho, Seong Hwan Ahn, Hyungjong Park, Sung-Il Sohn, Jeong-Ho Hong, Tae-Jin Song, Yoonkyung Chang, Gyu Sik Kim, Kwon-Duk Seo, Kijeong Lee, Jun Young Chang, Jung Hwa Seo, Sukyoon Lee, Jang-Hyun Baek, Han-Jin Cho, Dong Hoon Shin, Jinkwon Kim, Joonsang Yoo, Minyoul Baik, Kyung-Yul Lee, Yo Han Jung, Yang-Ha Hwang, Chi Kyung Kim, Jae Guk Kim, Chan Joo Lee, Sungha Park, Soyoung Jeon, Hye Sun Lee, Sun U Kwon, Oh Young Bang, Ji Hoe Heo, Hyo Suk Nam
IMPORTANCE: The associations between blood pressure (BP) decreases induced by medication and functional outcomes in patients with successful endovascular thrombectomy remain uncertain. OBJECTIVE: To evaluate whether BP reductions induced by intravenous BP medications are associated with poor functional outcomes at 3 months. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was a post hoc analysis of the Outcome in Patients Treated With Intra-Arterial Thrombectomy-Optimal Blood Pressure Control trial, a comparison of intensive and conventional BP management during the 24 hours after successful recanalization from June 18, 2020, to November 28, 2022...
April 1, 2024: JAMA Network Open
#16
JOURNAL ARTICLE
Chewon Yim, Yeonji Chung, Sungjoon Son, Jeesoo Kim, Jong-Seo Kim, Hyun Kim
The signal peptidase complex (SPC) mediates processing of signal peptides of secretory precursors. But, recent studies show that the eukaryotic SPC also cleaves internal transmembrane segments of some membrane proteins, and its non-catalytic subunit, Spc1/SPCS1 plays a critical role in this process. To assess the impact of Spc1 on membrane proteostasis, we carried out quantitative proteomics of yeast cells with and without Spc1. Our data show that the abundance of the membrane proteome in yeast cells lacking Spc1 is in general reduced compared to that in wild-type cells, implicating its role in controlling the cellular levels of membrane proteins...
April 17, 2024: Journal of Membrane Biology
#17
JOURNAL ARTICLE
Young-Ji Seo, Nikhil Chervu, Peyman Benharash, James X Wu
BACKGROUND: Thyroid storm is a rare but potentially lethal manifestation of thyrotoxicosis. Guidelines recommend nonoperative management of thyroid storm, but thyroidectomy can be performed if patients fail medical therapy or need immediate resolution of the storm. Outcomes of thyroidectomy for management of thyroid storm remain ill-defined. METHODS: Using the National Inpatient Sample from 2016 to 2020, a retrospective analysis was conducted of patients admitted with thyroid storm...
April 17, 2024: American Surgeon
#18
JOURNAL ARTICLE
Kangmin Seo, Hyun-Woo Cho, Min Young Lee, Chan Ho Kim, Ki Hyun Kim, Ju Lan Chun
To predict the apparent total tract digestibility (ATTD) of crude protein (CP) in dogs we developed an in vitro system using an in vitro digestion method and a statistical analysis. The experimental diets used chicken meat powder as the protein source, with CP levels of 20% (22.01%, analyzed CP value as dry-based), 30% (31.35%, analyzed CP value as dry-based), and 40% (41.34%, analyzed CP value as dry-based). To simulate in vivo digestive processes a static in vitro digestion was performed in two steps; stomach and small intestine...
March 2024: Journal of Animal Science and Technology
#19
JOURNAL ARTICLE
Dalnim Lee, Eun Shil Cha, Soojin Park, Hyoju Sung, Eunbi Noh, Haesu Jeong, Won-Il Jang, Songwon Seo
No abstract text is available yet for this article.
April 11, 2024: International Journal of Epidemiology
#20
JOURNAL ARTICLE
Hanjin Seo, Hyomin Lee
The ability to precisely control in vitro enzymatic reactions in synthetic cells plays a crucial role in the bottom-up design of artificial cell models that can recapitulate the key cellular features and functions such as metabolism. However, integration of enzymatic reactions has been limited to bulk or microfluidic emulsions without a membrane, lacking the ability to design more sophisticated higher-order artificial cell communities for reconstituting spatiotemporal biological information at multiple length scales...
April 16, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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