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Xin Zhang, Seo Rin Kim, Christopher M Ferguson, Behzad Ebrahimi, Ahmad F Hedayat, Amir Lerman, Lilach O Lerman
Background: The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity-metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We hypothesized that MetS increased collateral circulation around the renal artery. Methods: Twenty-one domestic pigs were randomly divided into unilateral RAS fed an atherogenic (high-fat/high-fructose, MetS-RAS) or standard diet, or controls (n=7 each)...
August 9, 2018: American Journal of Hypertension
Shin Jung Park, Prakash Thapa, Hye-Jin Seo, Eun Seok Park, Seong Hoon Jeong
CKD-519, a potent cholestryl ester transfer protein (CETP) inhibitor, is a clinical candidate being developed for the treatment of dyslipidemia. It is considered a Biopharmaceutical Classification System II compound with low solubility and high permeability. The objective of this study was to develop early formulations focusing on the dissolution rate of the compound to achieve dose-dependent exposure. High performance formulation strategies including solid dispersion (SD) and a self-microemulsifying drug delivery system (SMEDDS) were investigated and their in vivo and in vitro correlations were also evaluated in monkeys along with dose optimization in human volunteers...
August 11, 2018: International Journal of Pharmaceutics
Yongbeom Seo, Jiayu Leong, Jun Dong Park, Yu-Tong Hong, Sang-Hyon Chu, Cheol Park, Dong Hyun Kim, Yu-Heng Deng, Vitaliy Dushnov, Joonghui Soh, Simon Rogers, Yi Yan Yang, Hyunjoon Kong
Bacterial biofilms form on and within many living tissues, medical devices, and engineered materials, threatening human health and sustainability. Removing biofilm remains a grand challenge despite tremendous efforts made so far, particularly when they are formed in confined spaces. One primary cause is the limited transport of anti-bacterial agents into extracellular polymeric substances (EPS) of the biofilm. In this study, we hypothesized that a microparticle engineered to be self-motile with microbubbles would clean a structure fouled by biofilm by fracturing the EPS and subsequently improving transports of the antiseptic reagent...
August 14, 2018: ACS Applied Materials & Interfaces
Jaewon Yang, Jing Liu, Florian Wiesinger, Anne Menini, Xucheng Zhu, Thomas A Hope, Youngho Seo, Peder E Z Larson
Respiratory motion causes misalignments between positron emission tomography (PET) and magnetic resonance (MR)-derived attenuation maps (<i>μ</i>-maps) in addition to artifacts on both PET and MR images in simultaneous PET/MRI for organs such as liver that can experience motion of several centimeters. To address this problem, we developed an efficient MR-based attenuation correction (MRAC) method to generate phase-matched <i>μ</i>-maps for quiescent period PET (PET<sub>Q</sub>) in abdominal PET/MRI...
August 14, 2018: Physics in Medicine and Biology
Haeseung Lee, Seung-Hun Lee, Min-Goo Seo, Ha-Young Kim, Jong Wan Kim, Yu-Ran Lee, Jong Ho Kim, Oh-Deog Kwon, Dongmi Kwak
Blastocystis is one of the most commonly detected intestinal protozoan parasites worldwide and has been found in humans and other animals. Therefore, many countries have actively researched this parasite. However, to our knowledge, no study of Blastocystis has been conducted in Korea. Therefore, we conducted a study of the current status of Blastocystis infection in domestic cattle, the various genotypes involved, and its zoonotic potential through a phylogenetic comparison with subtypes found in other studies...
July 15, 2018: Veterinary Parasitology
Ju Hwan Yang, Su Yeon Seo, Jeong Hwan Oh, In Soo Ryu, Jieun Kim, Dong Kun Lee, Yeonhee Ryu, Eun Sang Choe
Phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the striatum plays a crucial role in regulating the receptor-coupled signaling cascades leading to behavioral changes associated with psychostimulant exposure. The present study determined if activation of protein kinase G (PKG) contributes to the phosphorylation of AMPA receptor GluA1 subunit at the position of serine 831 (GluA1-S831) in the rat nucleus accumbens (NAc) after repeated cocaine administration. The results demonstrated that repeated intraperitoneal (i...
2018: Frontiers in Molecular Neuroscience
Seungjoo Yi, Won Kyu Lee, Ji-Ho Park, Jae-Seung Lee, Ji-Hun Seo
The goal of this study is to develop a simple one-pot method for the synthesis of a zwitterionic small molecule bearing disulfide moiety, which can effectively inhibit nonspecific protein adsorption on macroscopic and nanoscopic gold surfaces. To this end, the optimal molecular structure of a pyridine disulfide derivative was explored and a zwitterionic small molecule was successfully synthesized from the tertiary amine residue on the pyridine ring through a one-pot method. The coating conditions of the synthesized zwitterionic molecules on the gold surface were optimized through contact angle measurements, and the strong interactions between the gold surface and the disulfide moiety of the zwitterion small molecule were confirmed by surface plasmon resonance (SPR) analysis and X-ray photoelectron spectroscopy...
August 13, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Ji Woong Lim, Seok Kyu Kim, Seo Yun Choi, Dong Hoi Kim, Changdev G Gadhe, Hae Nim Lee, Hyo-Ji Kim, Jina Kim, Sung Jin Cho, Hayoung Hwang, Jihye Seong, Kyu-Sung Jeong, Jae Yeol Lee, Sang Min Lim, Jae Wook Lee, Ae Nim Pae
SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) is a lipid phosphatase that produce phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2 ) from phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3 ), and is involved in many diseases such as neurodegenerative diseases. A recent report demonstrating that SHIP2 inhibition decreased tau hyperphosphorylation induced by amyloid β and rescued memory impairment in a transgenic Alzheimer's disease mouse model indicates SHIP2 can be a promising therapeutic target for Alzheimer's disease...
August 3, 2018: European Journal of Medicinal Chemistry
Eun-Ji Seo, Jeong-Ah Ahn, Laura L Hayman, Chun-Ja Kim
PURPOSE: This study examined whether depressive symptoms and health-promoting lifestyle behaviors mediate the association between perceived stress and quality of life (QoL) in university students. METHODS: Using a cross-sectional survey, Korean university students (N = 187, M age = 23.97 years; 54.0% female) completed structured questionnaires with psychometric adequacy. A parallel multiple mediation model was used to test the mediating effect of depressive symptoms and health-promoting lifestyle behaviors on the relationship between perceived stress and QoL...
August 10, 2018: Asian Nursing Research
Moon Jong Chang, Jin Hwa Jeong, Chong Bum Chang, Young Jun Kim, Bo-Kyung Seo, Min Kyu Song, Taehoon Kang, Seung-Baik Kang
BACKGROUND: Some patients with recurrent symptomatic instability after primary anterior cruciate ligament (ACL) reconstruction have an extension deficiency (ED). This study 1) compared preoperative clinical conditions between the ED and non-ED groups undergoing revision ACL reconstruction, 2) documented clinical and arthroscopic findings in ACL-reconstructed patients with re-instability and ED, and 3) determined whether the ED could be resolved and whether the clinical results of revision surgery differed between the ED and non-ED groups METHODS: This study included 58 patients who underwent revision ACL reconstruction...
August 13, 2018: Scandinavian Journal of Medicine & Science in Sports
Jaedeok Kim, Hae-Ryun Kwak, Mikyeong Kim, Jang-Kyun Seo, Jung Wook Yang, Mi-Nam Chung, Eui-Joon Kil, Hong-Soo Choi, Sukchan Lee
Sweet potato is a vegetatively propagated crop that is produced for both growth in Korean fields and for export out of the country. The viruses that are present in introduced sweet potatoes can spread both domestically and to foreign countries. Determining the time and path of virus movement could help curtail its spread and prevent future dispersal of related viruses. Determining the consequences of past virus and sweet potato dispersal could provide insight into the ecological and economic risks associated with other sweet potato-infecting viral invasions...
2018: PloS One
Hee-Jeong Choi, Seo-Yun Lee
This paper outlines the development of a novel, low-cost, hybrid material from chitosan-methyl esterified sericite-tannin. The adsorbent material is then successfully utilized for the efficient removal of lake nutrients and harmful algae. In a FT-IR analysis, peaks related to -OH stretching, carbonyl and carboxylic groups, and CH stretching were newly created or expanded, and microcapsules were found to facilitate the removal of harmful algae and nutrients. The hybrid microcapsules obtained high removal efficiencies of 98% TN, 98% TP, and 99% Chl-a from the lake water by a quantity of hybrid microcapsules of 1 g/L, pH (7-8), and 30 min contact time at (25-30)°C...
August 13, 2018: Environmental Technology
Minkyo Lee, Min-Goo Seo, Seung-Hun Lee, In-Ohk Ouh, Young-Hoan Kim, Joong-Kew Kim, Youn-Kyoung Goo, Man-Hee Rhee, Tae-Hwan Kim, Oh-Deog Kwon, Dongmi Kwak
The purpose of this study was to assess tick-borne pathogenic infections in 42 wild Korean water deer (KWD) and 26 farmed elk in the Gyeongbuk and Gangwon Provinces of Korea. Among the 42 wild KWD tested, the eighteen (42.9%) and five (11.9%) samples tested positive for Anaplasma phagocytophilum and A. bovis, respectively, by PCR and DNA sequencing. All positive samples were only from wild KWD. All samples were negative for other tick-borne pathogens tested. Detected 16S rRNA sequences of A. phagocytophilum and A...
August 10, 2018: Journal of Veterinary Medical Science
M K Seo, E J Park, S Y Ko, E W Choi, S Kim
Kefir is a fermented product from yeast and lactic acid bacteria, and has been associated with various health benefits including relieving inflammatory bowel disease. Recently, it has been shown that gram-positive bacteria produce extracellular vesicles (EV). The EV could be appearing as potentially important mediators of cell to cell interaction. In this study, we explored the role of kefir grain Lactobacillus-derived EV in modulating inflammation responses via alleviating the production of inflammatory cytokines in tumor necrosis factor-α (TNF-α)-induced inflammation in Caco-2 cells and the 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease mouse model...
August 9, 2018: Journal of Dairy Science
Jee Young Kim, Changsu Lee, Min Seo Jeon, Jaewon Park, Yoon-E Choi
In this study, we investigated the effects of electrical treatment on Haematococcus pluvialis growth. The slow growth of H. pluvialis is a major limitation for its mass production. We discovered that electrical treatment may promote the growth of H. pluvialis. To evaluate optimal growth-promoting conditions, the algal growth rate was investigated at various voltages. The optimum current was identified as 100 mA (voltage: 25 V). In comparison with the non-treated cells, those subjected to electrical treatment showed a 1...
August 4, 2018: Bioresource Technology
Hye Soo Chung, Hwan-Jin Hwang, Soon Young Hwang, Nam Hoon Kim, Ji-A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi, Hye Jin Yoo
AIMS: Previous in-vitro and in-vivo experimental studies have shown that Sestrin2 attenuates oxidative stress and the pro-inflammatory pathway, resulting in improving metabolic homeostasis. However, the relationship between circulating Sestrin2 concentration and cardiometabolic risks in humans has not been explored. METHODS: Sestrin2 concentration was measured in 240 subjects (46 without diabetes and 194 with diabetes), and the associations between Sestrin2 level and various cardiometabolic risk factors including body composition, insulin resistance, and atherosclerosis was assessed...
August 9, 2018: Diabetes Research and Clinical Practice
Yu-Seong Seo, Man Jin Eom, Jun Sung Kim, Chang-Jong Kang, Byung Il Min, Jungseek Hwang
An interesting van der Waals material, Ta2 NiSe5 has been known one of strong excitonic insulator candidates since it has very small or zero bandgap and can have a strong exciton binding energy because of its quasi-one-dimensional crystal structure. Here we investigate a single crystal Ta2 NiSe5 using optical spectroscopy. Ta2 NiSe5 has quasi-one-dimensional chains along the a-axis. We have obtained anisotropic optical properties of a single crystal Ta2 NiSe5 along the a- and c-axes. The measured a- and c-axis optical conductivities exhibit large anisotropic electronic and phononic properties...
August 10, 2018: Scientific Reports
Seo Young Choi, Ji-Yeong Jang, Eun Hye Oh, Jae-Hwan Choi, Ji Yun Park, Seong-Han Lee, Kwang-Dong Choi
OBJECTIVE: To determine the prevalence of central lesions in persistent geotropic positional nystagmus, and characteristics and anatomical substrates of the nystagmus in cerebellar lesions. METHODS: We prospectively recruited 58 patients with persistent geotropic positional nystagmus at the Dizziness Clinic of Pusan National University Hospital. Seven patients with unilateral cerebellar lesions were subjected to analysis of clinical characteristics, oculographic data, and MRI lesions...
August 10, 2018: Neurology
Jisun Lim, Moon-Won Yoo, Seo Young Kang, Hye Soon Park
BACKGROUND: With the increase in the prevalence of overweight, percentage of overweight patients with gastric cancer has also increased. This 5-year retrospective cohort study was performed to investigate long-term changes in the metabolic and nutritional parameters of early gastric cancer (EGC) patients with overweight after gastrectomy. METHODS: EGC patients who underwent gastrectomy were followed up over a 5-year period. We included 393 patients (261 men, 132 women) who had an initial body mass index (BMI) of ≥23 kg/m2 , and analyzed the longitudinal changes in the metabolic and nutritional parameters...
August 7, 2018: Asian Journal of Surgery
Hong-Man Cho, Jae-Woong Seo, Hyun-Ju Lee, Kyu-Bok Kang, Jung-Ryul Kim, Ho-Wook Wee
OBJECTIVE: There is limited literature concerning the outcomes and role of THA as a surgical option for amputee patients. The aim of this study is to determine the mid-to long-term survival and complication rates of cementless total hip arthroplasty (THA) in patients with contralateral below knee amputations. METHODS: A retrospective review of 54 patients with below knee amputation were perfomed who underwent THA for osteoarthritis of the contralateral hip over a 5-year period between 1999 and 2014...
August 7, 2018: Acta Orthopaedica et Traumatologica Turcica
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