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https://www.readbyqxmd.com/read/30107089/ubxn2a-enhances-chip-mediated-proteasomal-degradation-of-oncoprotein-mortalin-2-in-cancer-cells
#1
Sanam Sane, Andre Hafner, Rekha Srinivasan, Daniall Masood, John L Slunecka, Collin J Noldner, Alex D Hanson, Taylor Kruisselbrink, Xuejun Wang, Yiyang Wang, Jun Yin, Khosrow Rezvani
Overexpression of oncoproteins is a major cause of treatment failure using current chemotherapeutic drugs. Drug-induced degradation of oncoproteins is feasible and can improve clinical outcomes in diverse types of cancers. Mortalin-2 (mot-2) is a dominant oncoprotein in several tumors, including colorectal cancer (CRC). In addition to inactivating the p53 tumor suppressor protein, mot-2 enhances tumor cell invasion and migration. Thus, mot-2 is considered a potential therapeutic target in several cancer types...
August 14, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/30106434/staurosporine-alleviates-cisplatin-chemoresistance-in-human-cancer-cell-models-by-suppressing-the-induction-of-sqstm1-p62
#2
Khaldoon Alsamman, Omar S El-Masry
Cancer is one of the leading causes of mortality worldwide. Platinum‑based chemotherapeutic agents such as cisplatin are the first line of treatment for many types of cancers. However, the development of cisplatin resistance after prolonged treatment is a common cause of cancer recurrence. In the present study, we investigated an approach designed to overcome resistance to cisplatin involving co‑treatment with a second chemotherapeutic agent, staurosporine, and examined the role of sequestosome 1 (SQSTM1/p62) in enhancing cellular sensitivity to cisplatin...
August 1, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30106414/impact-of-cyclooxygenase-2-over-expression-on-the-prognosis-of-colorectal-cancer-patients-an-experience-from-western-saudi-arabia
#3
Abdulkader M Albasri, Mohammed A Elkablawy, Akbar S Hussainy, Hala M Yousif, Ahmed S Alhujaily
OBJECTIVES: To evaluate cyclooxygenase-2 (COX-2) over-expression in colorectal cancer (CRC) and its role in carcinogenesis and prognosis. METHODS: It was a retrospective study. Archival samples were obtained from Pathology Department at King Fahad Hospital, Madinah, Saudi Arabia, over 11 years' period (January 2006 to December 2017). Samples were analyzed using immunohistochemistry for COX-2 and Ki67 over-expression in 324 CRC patients, 40 cases of colorectal adenomas and 20 cases of normal colonic mucosa...
August 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/30106318/prediction-of-microbe-disease-associations-by-graph-regularized-non-negative-matrix-factorization
#4
Yue Liu, Shu-Lin Wang, Jun-Feng Zhang
More and more evidence shows that microbes play crucial roles in human health and disease. The exploration of the relationship between microbes and diseases will help people to better understand the underlying pathogenesis and have important implications for disease diagnosis and prevention. However, the known associations between microbes and diseases are very less. We proposed a new method called non-negative matrix factorization microbe-disease associations (NMFMDA), which used Gaussian interaction profile kernel similarity measure, to calculate microbial similarity and disease similarity, and applied a logistic function to regulate disease similarity...
August 14, 2018: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/30106289/antitumor-activity-of-diterpenoids-from-jatropha-gossypiifolia-cell-cycle-arrest-and-apoptosis-inducing-activity-in-rko-colon-cancer-cells
#5
Chun-Yan Zhang, Li-Jun Zhang, Zhi-Cheng Lu, Chen-Yun Ma, Ying Ye, Khalid Rahman, Hong Zhang, Jian-Yong Zhu
Nine new minor diterpenoids, jatrogossones A-I (1-9), and six known analogues (10-15) were separated from an extract of the branches and leaves of Jatropha gosspiifolia. Compounds 4-6 and 10, possessing a 5/11 fused-ring skeleton, and 8, 9, and 13, with a 5/9/5 fused-ring skeleton, represent rare diterpenoid skeletons that have been found only in compounds isolated from plants of the Jatropha genus. The absolute configurations of 1-10 were defined by using a combination of electronic circular dichroism data analysis and single-crystal X-ray diffraction data...
August 14, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/30106268/the-diagnostic-potential-of-glutathione-s-transferase-gst-polymorphisms-in-patients-with-colorectal-cancer
#6
Joanna Waś, Monika Karasiewicz, Anna Bogacz, Karolina Dziekan, Małgorzata Górska-Paukszta, Marek Kamiński, Grzegorz Stańko, Adam Kamiński, Marcin Ożarowski, Bogusław Czerny
BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers in the world. Despite improvements in screening for early diagnosis, CRC is one of the leading causes of cancer deaths. OBJECTIVES: The aim of the study was to determine a potential association between the frequency of GSTM1 and GSTT1 null genotypes and the risk of CRC in the Polish population. Moreover, we analyzed the clinical parameters with the glutathione S-transferase (GST) gene polymorphisms in patients with CRC...
August 14, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30105529/benefits-of-using-a-self-expandable-metallic-stent-as-a-bridge-to-surgery-for-right-and-left-sided-obstructive-colorectal-cancers
#7
Shunji Morita, Kansuke Yamamoto, Atsuhiro Ogawa, Atsushi Naito, Hitoshi Mizuno, Shinichi Yoshioka, Tae Matsumura, Katsuya Ohta, Rei Suzuki, Chu Matsuda, Taishi Hata, Junichi Nishimura, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori
PURPOSE: To assess the benefit of placing a self-expandable metallic stent (SEMS) as a bridge to surgery for obstructive colorectal cancer (OCRC) according to the tumor site. METHODS: The subjects of this retrospective multicenter cohort study were 201 patients with OCRC, but without initial bowel perforation, who were treated either with a self-expandable metallic stent (SEMS) as a bridge to surgery (n = 109) or with primary surgery (PS; n = 92) between 2014 and 2016...
August 13, 2018: Surgery Today
https://www.readbyqxmd.com/read/30105080/ethanol-extract-of-lycopus-lucidus-turcz-ex-benth-inhibits-metastasis-by-downregulation-of-runx-2-in-mouse-colon-cancer-cells
#8
Kwang-Youn Kim, Tae Woo Oh, Jin-Yeul Ma, Kwang-Il Park
Lycopus lucidus Turcz. ex Benth (LT) has been broadly used as a traditional medicinal herb in Asia including Korea, China, and Japan due to its noted ability to promote blood circulation and remove blood stasis. However, its anticancer mechanism is not understood. This study aims to elucidate the effects of ethanol extracts of LT (ELT) relative to the role of Runt-related transcription factor- (Runx-) 2 in the invasive and metastatic potentials of mouse colon cancer to determine the underlying mechanisms involved...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30104899/p-tnm-staging-system-for-colon-cancer-combination-of-p-stage-and-ajcc-tnm-staging-system-for-improving-prognostic-prediction-and-clinical-management
#9
Qi Liu, Dakui Luo, Sanjun Cai, Qingguo Li, Xinxiang Li
Aim: This study focused on improving the American Joint Committee on Cancer TNM staging system and demonstrated an improvement in prognostic accuracy and clinical management of colon cancer using the P-TNM staging system. Patients and methods: Eligible patients (N=56,800) were identified from the Surveillance, Epidemiology, and End Results database between January 1, 2010, and December 31, 2014. The P-stage (P0 or P1) was assigned to each patient based on age at diagnosis, tumor grade, and tumor size...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30104549/synthesis-characterization-and-in-vitro-cancer-cell-growth-inhibition-evaluation-of-novel-phosphatidylcholines-with-anisic-and-veratric-acids
#10
Marta Czarnecka, Marta Świtalska, Joanna Wietrzyk, Gabriela Maciejewska, Anna Gliszczyńska
Phenolic acids and its methoxy derivatives are known to induce caspase-mediated apoptosis activity and exhibit cytotoxic effect towards various cancer cell lines. However, their low stability and poor bioavailability in the human organism extensively restrict the utility of this group of compounds as anticancer and health-promoting agents. In this report, a series of eight novel phosphatidylcholines ( 3a-b , 5a-b , 7a-b , 8a-b ) containing anisic or veratric acids ( 1a-b ) at sn -1 and/or sn -2 positions were synthesized...
August 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30104445/evaluation-of-potential-anti-cancer-activity-of-cationic-liposomal-nanoformulated-lycopodium-clavatum-in-colon-cancer-cells
#11
Pragyan Paramita, Vimala Devi Subramaniam, Ramachandran Murugesan, Madhumala Gopinath, Ilangovan Ramachandran, Satish Ramalingam, Xiao Feng Sun, Antara Banerjee, Francesco Marotta, Surajit Pathak
Research dealing with early diagnosis and efficient treatment in colon cancer to improve patient's survival is still under investigation. Chemotherapeutic agent result in high systemic toxicity due to their non-specific actions on DNA repair and/or cell replication. Traditional medicine such as Lycopodium clavatum (LC) has been claimed to have therapeutic potentials against cancer. The present study focuses on targeted drug delivery of cationic liposomal nanoformulated LC (CL-LC) in colon cancer cells (HCT15) and comparing the efficacy with an anti-colon cancer drug, 7-ethyl-10-hydroxy-camptothecin (SN38) along with its nanoformulated form (CL-SN38)...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104241/paclitaxel-reduces-tumor-growth-by-reprogramming-tumor-associated-macrophages-to-an-m1-profile-in-a-tlr4-dependent-manner
#12
Carlos W Wanderley, David F Colon, Joao Paulo Mesquita Luiz, Francisco F Oliveira, Paula R Viacava, Caio A Leite, Janaina A Pereira, Camila M Silva, Cassia R Silva, Rangel L Silva, Cesar A Speck-Hernandez, Jose M Mota, Jose C Alves-Filho, Roberto C Lima-Júnior, Thiago M Cunha, Fernando Q Cunha
Paclitaxel (PCX) is an antineoplastic agent widely used to treat several solid tumor types. The primary mechanism of action of PCX is based on microtubule stabilization inducing cell cycle arrest. Here, we use several tumor models to show that PCX not only induces tumor cell cycle arrest, but also promotes antitumor immunity. In vitro, PCX reprogrammed M2-polarized macrophages to the M1-like phenotype in a TLR4-dependent manner, similarly to LPS. PCX also modulated the tumor-associated macrophages (TAMs) profile in mouse models of breast and melanoma tumors; gene expression analysis showed that PCX altered the M2-like signature of TAMs toward an M1-like profile...
August 13, 2018: Cancer Research
https://www.readbyqxmd.com/read/30104206/characterizing-the-interaction-between-insulin-like-growth-factor-2-mrna-binding-protein-1-imp1-and-kras-expression
#13
Sebastian Mackedenski, Chuyi Wang, Wai-Ming Li, Chow H Lee
Insulin-like growth factor 2 mRNA-binding protein-1 (IMP1) has high affinity for KRAS mRNA, and it can regulate KRAS expression in cells. We first characterized the molecular interaction between IMP1 and KRAS mRNA. Using IMP1 variants with a point mutation in the GXXG motif at each KH domain, we showed that all KH domains play a critical role for the binding of KRAS RNA. We mapped the IMP1-binding sites on KRAS mRNA and show that IMP1 has the highest affinity for nts 1-185. Although with lower affinity, IMP1 does bind to other coding regions and the 3'UTR of KRAS mRNA...
August 13, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/30104156/the-use-of-chemotherapy-in-older-patients-with-stage-ii-and-iii-colon-cancer-variation-by-age-and-era-of-diagnosis
#14
Susan L Green, David E Dawe, Zoann Nugent, Winson Y Cheung, Piotr M Czaykowski
OBJECTIVE: We aim to examine the use and outcomes of adjuvant chemotherapy in older patients with stage II and III colon cancer. MATERIAL AND METHODS: Using data from the SEER-Medicare database, we analyzed patients aged 66 or greater, diagnosed with stage II or III colon cancer between 1991 and 2007 who received surgery. Using Medicare claims, receipt of adjuvant chemotherapy was identified, and compared between age bands. Logistic regression modeling was performed to assess predictors of receipt of adjuvant chemotherapy, and Cox proportional hazards modeling was performed to assess predictors of mortality...
August 10, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/30104051/adrenocortical-carcinoma-acc-when-and-why-should-we-consider-germline-testing
#15
Elisabeth Joye Petr, Tobias Else
Adrenocortical carcinoma (ACC), particularly when occurring during childhood, has been a traditional component of the tumor spectrum of Li-Fraumeni syndrome. Recent research has defined a significant risk increase of ACC with other familial cancer syndromes, such as Lynch syndrome and multiple endocrine neoplasia. ACC patients can serve as index patients for a new family diagnosis of a hereditary syndrome, allowing for further family cascade genetic testing, impacting the care and surveillance for patients and at risk family members...
August 10, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/30103733/early-increase-in-blood-supply-eibs-is-associated-with-tumor-risk-in-the-azoxymethane-model-of-colon-cancer
#16
Sarah Ruderman, Adam Eshein, Vesta Valuckaite, Urszula Dougherty, Anas Almoghrabi, Andrew Gomes, Ajaypal Singh, Baldeep Pabla, Hemant K Roy, John Hart, Marc Bissonnette, Vani Konda, Vadim Backman
BACKGROUND: The present study aimed to investigate the role of blood supply in early tumorigenesis in colorectal cancer. We leveraged the renin angiotensin system (RAS) to alter colonic blood supply and determine the effect on tumor initiation and progression. METHODS: To test the effect of blood supply on tumorigenesis, 53 male A/J mice were randomly assigned to one of three RAS modulation groups and one of two AOM treatments. The RAS modulation groups were I) water (RAS-unmodulated) as a control group, II) angiotensin-II and III) the angiotensin receptor blocker, Losartan...
August 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30103475/4-acetyl-antroquinonol-b-suppresses-sod2-enhanced-cancer-stem-cell-like-phenotypes-and-chemoresistance-of-colorectal-cancer-cells-by-inducing-hsa-mir-324-re-expression
#17
Oluwaseun Adebayo Bamodu, Ching-Kuo Yang, Wei-Hong Cheng, David T W Tzeng, Kuang-Tai Kuo, Chun-Chih Huang, Li Deng, Michael Hsiao, Wei-Hwa Lee, Chi-Tai Yeh
BACKGROUND: Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality in both sexes globally. This is not unconnected with the heterogeneity and plasticity of CRC stem cells (CRC-SCs) which stealthily exploit the niche-related and (epi)genetic factors to facilitate metastasis, chemoresistance, tumor recurrence, and disease progression. Despite the accumulating evidence of the role of dysregulated microRNAs in malignancies, the therapeutic efficacy of pharmacological-targeting of CRC-SC-associated microRNAs is relatively under-explored...
August 10, 2018: Cancers
https://www.readbyqxmd.com/read/30103472/magnolol-a-neolignan-from-the-magnolia-family-for-the-prevention-and-treatment-of-cancer
#18
REVIEW
Abhishek Manoj Ranaware, Kishore Banik, Vishwas Deshpande, Ganesan Padmavathi, Nand Kishor Roy, Gautam Sethi, Lu Fan, Alan Prem Kumar, Ajaikumar B Kunnumakkara
The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted...
August 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30103409/phenolic-compounds-and-bioactivity-of-cytisus-villosus-pourr
#19
Amel Bouziane, Boulanouar Bakchiche, Maria Inês Dias, Lillian Barros, Isabel C F R Ferreira, Husam A AlSalamat, Sanaa K Bardaweel
The present study focuses on the chemical composition, antioxidant, antimicrobial, and antiproliferative activities of the ethyl acetate and aqueous extracts obtained from the aerial parts of Cytisus villosus Pourr. HPLC-DAD-ESI/MSn was used to identify the phenolic compounds, being (epi)gallocatechin dimer the major compound (111 ± 5 µg/g·dw) in the aqueous extract, while myricetin- O -rhamnoside (226 ± 9 µg/g·dw) was the main molecule in the ethyl acetate extract. Both extracts exhibited good scavenging activities against DPPH radical (EC50 µg/mL of 59 ± 2 and 31 ± 2 for aqueous and ethyl acetate extracts, respectively)...
August 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30102336/semaphorin-3a-inhibits-multiple-myeloma-progression-in-a-mouse-model
#20
Noa Lavi, Ofra Kessler, Keren Ziv, Inbal Nir-Zvi, Yelena Mumblat, Nasrene Eiza, Yael Paran, Benjamin Brenner, Zahava Vadasz, Gera Neufeld
Previous studies revealed that progression of multiple myeloma (MM) is associated with down regulation of semaphorin-3A (sema3A) expression in bone marrow endothelial cells. We therefore determined if serum sema3A concentrations are correlated with MM progression and if sema3A can affect MM progression. We find that the concentration of sema3A in sera of MM patients is strongly reduced and that the decrease is correlated with disease progression. A similar depletion is found in AML and ALL leukemia patients but not in cancer forms that do not involve the bone marrow such as in colon cancer...
August 9, 2018: Carcinogenesis
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