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https://www.readbyqxmd.com/read/30517925/upregulation-of-fibroblast-growth-factor-19-is-associated-with-the-initiation-of-colorectal-adenoma
#1
Dongyang Wang, Jianjun Zhang, Zengjun Li, Jianjun Han, Yongsheng Gao, Ming Chen, Yanqing Li
Fibroblast growth factor 19 (FGF19) promotes tumor growth in various types of cancer, but its function has not been investigated in the context of colorectal adenoma. Here, we report that FGF19 expression was greater in colorectal adenoma than in normal tissues, as measured by an enzyme-linked immunosorbent assay, quantitative reverse-transcription PCR and immunohistochemistry. FGF19 expression was also elevated in a subset of human colon cancer cell lines. Moreover, FGF receptor 4 (FGFR4), the cognate receptor for FGF19, was upregulated in colorectal adenoma tissues...
December 5, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/30516219/cytotoxic-homoleptic-ti-iv-compounds-of-ono-type-ligands-synthesis-structures-and-anti-cancer-activity
#2
Rajesh Manne, Maya Miller, Andrew Duthie, M Fátima C Guedes da Silva, Edit Y Tshuva, Tushar S Basu Baul
Eight Ti(iv) compounds 1-8, of the type [Ti(Ln)2] where Ln is a variously substituted dianionic tridentate acylhydrazone, were synthesized by reacting the appropriate hydrazide with 2-hydroxybenzaldehyde or 2'-hydroxyacetophenone and titanium(iv) tetra(isopropoxide) in a 2 : 2 : 1 molar ratio. The solid-state structures of 1-6 and 7·CH2Cl2 were deduced from the single crystal X-ray diffraction data, which indicated that each L2- ligand is fully deprotonated and coordinated to the Ti(iv) cation via the enolic oxygen, the imino nitrogen and the phenolic oxygen atoms (ONO donor set) in an enol tautomeric form, the metal assuming the distorted octahedral geometry...
December 5, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/30516087/divergent-impact-of-actin-isoforms-on-cell-cycle-regulation
#3
Vera Dugina, Galina Shagieva, Natalya Khromova, Pavel Kopnin
We have shown that cytoplasmic actin isoforms play different roles in neoplastic cell transformation. β-Cytoplasmic actin acts as a tumor suppressor, affecting epithelial differentiation, cell growth, cell invasion and tumor growth of colon and lung carcinoma cells. In contrast, γ-cytoplasmic actin enhances malignant features of tumor cells whose actin network regulation is carried out via the γ-actin isoform. The goal of this study was to describe the role of cytoplasmic actins in cell cycle regulation of breast cancer cell lines MCF-7 and MDA-MB-231...
December 5, 2018: Cell Cycle
https://www.readbyqxmd.com/read/30515835/pharmacological-explorations-of-eco-friendly-amide-substituted-z-%C3%AE-enaminones-as-anti-breast-cancer-drugs
#4
Palaniraja Subramamiam, Chandrasekaran Ramasubbu, Selvaraj Athiramu, Sivakumar Arumugam, Manikandan Alagumuthu
Amide substituted (Z)-β-enaminones were synthesized by green chemistry and stereo-specific synthetic pathway as novel phosphoinositide 3-kinase (PI3K) inhibitors and breast cancer drugs. PI3K inhibition was measured by competitive ELISA. A panel of cancer cell lines including MCF-7 (breast cancer), G-361 (skin cancer), and HCT 116 (colon cancer) were used to assess the anticancer potentials. In the PI3K assay, 2c and 2f were indolent for the proposed inhibitory action, which was recognized from the obtained IC50 (>1...
December 5, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/30515811/recent-advances-in-tmem16a-structure-function-and-disease
#5
REVIEW
Qiushuang Ji, Shuai Guo, Xuzhao Wang, Chunli Pang, Yong Zhan, Yafei Chen, Hailong An
TMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium-activated chloride channels, with ten transmembrane segments. Recently, atomic structures of the transmembrane domains of mouse TMEM16A (mTMEM16A) were determined by single-particle electron cryomicroscopy. This gives us a solid ground to discuss the electrophysiological properties and functions of TMEM16A. TMEM16A is reported to be dually regulated by Ca2+ and voltage. In addition, the dysfunction of TMEM16A has been found to be involved in many diseases including cystic fibrosis, various cancers, hypertension, and gastrointestinal motility disorders...
December 4, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30515752/colitis-induced-colorectal-cancer-and-intestinal-epithelial-estrogen-receptor-beta-impact-gut-microbiota-diversity
#6
Ahmed Ibrahim, Luisa Hugerth, Linnea Hases, Ashish Saxena, Maike Seifert, Quentin Thomas, Jan-Åke Gustafsson, Lars Engstrand, Cecilia Williams
Chronic inflammation of the colon (colitis) is a risk factor for colorectal cancer (CRC). Hormone-replacement therapy reduces CRC incidences, and the estrogen receptor beta (ERβ/ESR2) has been implicated in this protection. Gut microbiota is altered in both colitis and CRC and may influence the severity of both. Here we test the hypothesis that intestinal ERβ impacts the gut microbiota. Mice with and without intestine-specific deletion of ERβ (ERβKOVil ) were generated using the Cre-LoxP system. Colitis and CRC were induced with a single intraperitoneal injection of azoxymethane (AOM) followed by administration of three cycles of dextran sulfate sodium (DSS) in drinking water...
December 4, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30515556/normocytic-anaemia-is-associated-with-systemic-inflammation-and-poorer-survival-in-patients-with-colorectal-cancer-treated-with-curative-intent
#7
Stephen T McSorley, Mark Johnstone, Colin W Steele, Campbell S D Roxburgh, Paul G Horgan, Donald C McMillan, David Mansouri
BACKGROUND: The present study aimed to characterise the prevalence and prognostic impact of normocytic anaemia in patients undergoing curative treatment for colorectal cancer. METHODS: All individuals invited to the first round of bowel cancer screening, diagnosed with colorectal cancer and treated with curative intent from April 2009 to March 2011 in a single health board were included. The modified Glasgow prognostic score (mGPS) was used to quantify preoperative systemic inflammation...
December 4, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/30515418/prognostic-characteristics-of-macc1-expression-in-epithelial-ovarian-cancer
#8
Hoiseon Jeong, Jiyoon Jung, Hwa Eun Oh, Jung-Woo Choi, Eung Seok Lee, Young-Sik Kim, Ju-Han Lee
Recent studies have shown that overexpression of metastasis-associated in colon cancer 1 (MACC1) is significantly associated with adverse prognoses of patients with different kinds of cancer. However, the exact survival effect of MACC1 on epithelial ovarian cancer (EOC) patients has not yet been established. Thus, the objective of this study was to explore the prognostic role of MACC1 mRNA in EOC by using Kaplan-Meier (KM) plotter and ONCOMINE database. Our results indicated that MACC1 mRNA high expression was significantly associated with unfavorable overall survival (hazard ratio (HR) = 1...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30515005/the-level-short-chain-fatty-acids-and-hsp-70-in-colorectal-cancer-and-non-colorectal-cancer
#9
Fauzi Yusuf, Siti Adewiah, Fatchiyah Fatchiyah
Introduction: Microbial involvement in colorectal cancer (CRC) is now well established. Short Chain Fatty Acids (SCFA) is the main products of anaerobic microbial fermentation in the large intestine and affects colonic health. SCFA mainly produced as microbial metabolites, acetate, propionate, and butyrate acids. Several in vitro studies showed that butyrate induce expression of heat shock protein (HSP) 70 that has function in the beginning of apoptosis. Aim: The aim of this study was investigating the differences level SCFA and HSP 70 expression in CRC compared with non-CRC patients...
October 2018: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/30514852/bst-2-promotes-survival-in-circulation-and-pulmonary-metastatic-seeding-of-breast-cancer-cells
#10
Wadie D Mahauad-Fernandez, Wasifa Naushad, Tyler D Panzner, Amani Bashir, Geeta Lal, Chioma M Okeoma
Bone marrow stromal antigen 2 (BST-2) mediates various facets of cancer progression and metastasis. Here, we show that BST-2 is linked to poor survival in invasive breast cancer patients as its expression positively correlates with disease severity. However, the mechanisms that drive the pro-metastatic functions of BST-2 are not fully understood. Correlation of BST-2 expression and tumor aggressiveness was analyzed in human tissue samples. Migration, invasion, and competitive experimental metastasis assays were used to measure the cellular responses after silencing BST-2 expression...
December 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30514676/-expression-of-secreted-frizzled-related-protein-4-in-dna-mismatch-repair-deficient-and-mismatch-repair-proficient-colorectal-cancers
#11
Kexu Chen, Hanlin Liang, Jiewen Peng, Yanfang Zheng
OBJECTIVE: To investigate the expressions of secreted frizzled-related protein 4 (SFRP4) in stage Ⅱ DNA mismatch repair-deficient (dMMR) and mismatch repair- proficient (pMMR) colorectal cancers and explore their clinical significance. METHODS: We collected fresh stage Ⅱ colon cancer tissues with different MMR status detected by immunohistochemistry (IHC). The differentially expressed mRNAs between dMMR and pMMR tumors were identified by Affymetrix Human oeLncRNA gene chip, and the expression of SFRP4 in these cancer tissues and in colorectal cancer cell lines were detected using Western blotting and real- time quantitative PCR...
November 30, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/30514325/cancer-survivors-needs-during-various-treatment-phases-after-multimodal-treatment-for-colon-cancer-is-there-a-role-for-ehealth
#12
C M den Bakker, F G Schaafsma, J A F Huirne, E C J Consten, H B A C Stockmann, C J Rodenburg, G J de Klerk, H J Bonjer, J R Anema
BACKGROUND: More colon cancer patients are expected to fully recover after treatment due to earlier detection of cancer and improvements in general health- and cancer care. The objective of this study was to gather participants' experiences with full recovery in the different treatment phases of multimodal treatment and to identify their needs during these phases. The second aim was to propose and evaluate possible solutions for unmet needs by the introduction of eHealth. METHODS: A qualitative study based on two focus group discussions with 22 participants was performed...
December 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30514318/prognostic-significance-of-sealed-off-perforation-in-colon-cancer-a-prospective-cohort-study
#13
Kil-Yong Lee, Ji Won Park, Inho Song, Ki-Young Lee, Sangsik Cho, Yoon-Hye Kwon, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
BACKGROUND: Perforated colon cancer is a rare complication, but has a high risk of recurrence. However, most studies have not distinguished sealed-off perforation from free perforation, and the prognosis is unclear. The aim of this study was to evaluate the oncologic outcome of colon cancer with sealed-off perforation. METHODS: Eighty-six consecutive patients who underwent resection for colon cancer with sealed-off or free perforation were included. We defined sealed-off perforation as a colon perforation with localized abscess identified on operative, computed tomography, or pathologic findings, with no evidence of free perforation, including fecal contamination and dirty fluid collection in the peritoneal cavity...
December 4, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30514263/physical-activity-patterns-and-the-risk-of-colorectal-cancer-in-the-norwegian-women-and-cancer-study-a-population-based-prospective-study
#14
Sunday Oluwafemi Oyeyemi, Tonje Braaten, Idlir Licaj, Eiliv Lund, Kristin Benjaminsen Borch
INTRODUCTION: Colorectal cancer (CRC) remains the second most common cancer in women worldwide. Physical activity (PA) has been associated with reduced risk of CRC; however, this has been demonstrated more consistently in men, while results of studies in women have been largely equivocal. We aimed to further examine the relationship between PA patterns and the risk of CRC in women, using repeated measurements. METHODS: We followed participants of the Norwegian Women and Cancer (NOWAC) Study - a nationally representative cohort...
December 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30514262/the-asamet-trial-a-randomized-phase-ii-double-blind-placebo-controlled-multicenter-2-%C3%A3-2-factorial-biomarker-study-of-tertiary-prevention-with-low-dose-aspirin-and-metformin-in-stage-i-iii-colorectal-cancer-patients
#15
Marilena Petrera, Laura Paleari, Matteo Clavarezza, Matteo Puntoni, Silvia Caviglia, Irene Maria Briata, Massimo Oppezzi, Eva Mihajlovic Mislej, Borut Stabuc, Michael Gnant, Thomas Bachleitner-Hofmann, Wilfried Roth, Dominique Scherer, Walter-E Haefeli, Cornelia M Ulrich, Andrea DeCensi
BACKGROUND: Epidemiological studies and cardiovascular prevention trials have shown that low-dose aspirin can reduce colorectal cancer (CRC) incidence and mortality, including inhibition of distant metastases. Metformin has also been associated with decreased colon adenoma recurrence in clinical trials and lower CRC incidence and mortality in epidemiological studies in diabetics. While both drugs have been tested as single agents, their combination has not been tested in cancer prevention trials...
December 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30514249/projected-lifetime-cancer-risks-from-occupational-radiation-exposure-among-diagnostic-medical-radiation-workers-in-south-korea
#16
Won Jin Lee, Yeongchull Choi, Seulki Ko, Eun Shil Cha, Jaeyoung Kim, Young Min Kim, Kyoung Ae Kong, Songwon Seo, Ye Jin Bang, Yae Won Ha
BACKGROUND: Timely assessment of cancer risk from current radiation exposure among medical radiation workers can contribute to the development of strategies to prevent excessive occupational radiation exposure. The purpose of the present study is to estimate the lifetime risk of cancers induced by occupational radiation exposure among medical radiation workers. METHODS: Using estimated organ doses and the RadRAT risk assessment tool, the lifetime cancer risk was estimated among medical radiation workers who were enrolled in the Korean National Dose Registry from 1996 to 2011...
December 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30514228/the-lymph-node-status-as-a-prognostic-factor-in-colon-cancer-comparative-population-study-of-classifications-using-the-logarithm-of-the-ratio-between-metastatic-and-nonmetastatic-nodes-lodds-versus-the-pn-tnm-classification-and-ganglion-ratio-systems
#17
Carlos Fortea-Sanchis, David Martínez-Ramos, Javier Escrig-Sos
BACKGROUND: pN stage in the TNM classification has been the "gold standard" for lymph node staging of colorectal carcinomas, but this system recommends collecting at least 12 lymph nodes for the staging to be reliable. However, new prognostic staging systems have been devised, such as the ganglion quotients or lymph node ratios and natural logarithms of the lymph node odds methods. The aim of this study was to establish and validate the predictive and prognostic ability of the lymph node ratios and natural logarithms of the lymph node odds staging systems and to compare them to the pN nodal classification of the TNM system in a population sample of patients with colon cancer...
December 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30514068/prognostic-implications-of-extranodal-extension-in-relation-to-colorectal-cancer-location
#18
Chan Wook Kim, Jihun Kim, Yangsoon Park, Dong-Hyung Cho, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Purpose: Extranodal extension (ENE) is closely associated with the aggressiveness of both colon and rectal cancer. This study evaluated the clinicopathologic significance and prognostic impact of ENE in separate populations of patients with colon and rectal cancers. Materials and Methods: The medical records of 2,346 patients with colorectal cancer (CRC) who underwent curative surgery at our institution between January 2003 and December 2011 were clinically and histologically reviewed...
November 29, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30513496/colonic-metastasis-from-infiltrating-ductal-breast-carcinoma-in-a-male-patient-a-case-report
#19
Ashley Jones, Madison R Kocher, Ashlee Justice, Fernando Navarro
INTRODUCTION: A colonic metastasis from infiltrating breast ductal carcinoma is a rare phenomenon in the literature, especially in a male. PRESENTATION OF CASE: We present a rare case of a 55-year-old male with a past medical history of breast cancer who presented with signs and symptoms of appendicitis. A computed tomography (CT) scan revealed acute appendicitis in addition to a 2.3 cm cecal mass that correlated with a hypermetabolic region on positron emission testing (PET) the previous year...
November 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30513126/establishment-of-inflammation-biomarkers-based-nomograms-to-predict-prognosis-of-advanced-colorectal-cancer-patients-based-on-real-world-data
#20
Guifang Guo, Xiuxing Chen, Wenzhuo He, Haohua Wang, Yixing Wang, Pili Hu, Yuming Rong, Lei Fan, Liangping Xia
PURPOSE: To establish three novel prognostic nomograms with inflammatory factors for advanced colorectal cancer (ACRC), right-sided colon cancer (RSCC) and left-sided colorectal cancer (LSCRC) according to real world data. MATERIALS AND METHODS: ACRC patients receiving medicine therapy from January 1st, 2005 to September 31th, 2015 in Sun Yat-sen University Cancer Center were enrolled. Inflammatory indicators such as the neutrophil-to-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), lactate dehydrogenase (LDH) and C-reactive protein (CRP) were analyzed for establishing nomograms predicting overall survival (OS)...
2018: PloS One
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