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https://www.readbyqxmd.com/read/19273704/efficacy-of-sequential-high-dose-doxorubicin-and-ifosfamide-compared-with-standard-dose-doxorubicin-in-patients-with-advanced-soft-tissue-sarcoma-an-open-label-randomized-phase-ii-study-of-the-spanish-group-for-research-on-sarcomas
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RANDOMIZED CONTROLLED TRIAL
Joan Maurel, Antonio López-Pousa, Ramón de Las Peñas, Joaquín Fra, Javier Martín, Josefina Cruz, Antonio Casado, Andrés Poveda, Javier Martínez-Trufero, Carmen Balañá, María Auxiliadora Gómez, Ricardo Cubedo, Oscar Gallego, Belen Rubio-Viqueira, Jordi Rubió, Raquel Andrés, Isabel Sevilla, Juan Jose de la Cruz, Xavier García Del Muro, Jose María Buesa
PURPOSE: To assess the progression-free survival (PFS) and antitumor response to standard-dose doxorubicin compared with sequential dose-dense doxorubicin and ifosfamide in first-line treatment of advanced soft tissue sarcoma. PATIENTS AND METHODS: Patients with measurable advanced soft tissue sarcoma, Eastern Cooperative Oncology Group (ECOG) performance status (PS) < 2, between the ages 18 and 65 years, and with adequate bone marrow, liver, and renal function were entered in the study...
April 10, 2009: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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