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low cholesterol high cancer

Mohammad N Oskouie, Nazanin S Aghili Moghaddam, Alexandra E Butler, Parvin Zamani, Amirhossein Sahebkar
Curcumin, the bioactive pigment of turmeric which has polyphenolic-hydrophobic components, has been used for the treatment of a variety of diseases. However, due to its insignificant intestinal-liver metabolism, low stability, quick systemic elimination and its hydrophobic property with low solubility, curcumin has limited bioavailability. Exosomes are nanovesicles (30-100 nm) released from diverse cell types into extracellular and, ultimately, into bio-fluids in a tightly regulated manner. Exosomes are capable of transferring lipids, proteins, RNAs and DNAs, both with and without direct cell-to-cell contact...
October 14, 2018: Journal of Cellular Physiology
Vaidehi Ulaganathan, Mirnalini Kandiah, Zalilah Mohd Shariff
BACKGROUND: Obesity has frequently been associated with the dyslipidemic state and with the risk of various chronic diseases. OBJECTIVE: The objective of this study was to determine the relationship between obesity and blood lipids with a risk of colorectal cancer (CRC). METHODOLOGY: Histologically confirmed CRC patients from five local hospitals were matched with cancer-free controls for age, gender, and ethnicity ( n = 140: 280). The study participants underwent physical assessment for the presence of obesity and 10 mL of fasting blood was drawn for blood lipid analysis...
2018: Journal of Carcinogenesis
Mark F McCarty, James J DiNicolantonio
Many cancers and pre-cancerous lesions convert membrane-bound arachidonic acid (AA) to eicosanoids that promote the survival, growth, and spread of cancer. In contrast, the long-chain omega-3s eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can competitively inhibit AA's interaction with the enzymes that give rise to eicosanoids, while acting as precursors for alternative eicosanoids which oppose cancer development and growth. Hence, minimizing the AA content of cancer membranes, while boosting that of EPA and DHA, is a rational strategy for cancer prevention and control...
October 1, 2018: Nutrition and Cancer
Shahid Ahmed Junejo, Liang Zhang, Liping Yang, Naifu Wang, Yibin Zhou, Yuesheng Xia, Haisong Wang
BACKGROUND: Wheat bran has been shown to have health-promoting benefits in relation to diabetes, colorectal cancer, cardiovascular disease, constipation, irritable bowel syndrome, diverticulitis, and gastrointestinal disease. However, its effects on obesity, hyperglycaemia, hepatotoxicity, and hyperlipidaemia are not yet clear. The effects of wheat bran of different particle sizes (coarse, 427.55μm versus ultra-fine, 11.63μm) were investigated on body weight, serum glucose, liver, and blood lipid metabolism levels in high-fat-diet induced rats fed for 5 weeks...
October 1, 2018: Journal of the Science of Food and Agriculture
Keum Ji Jung, Hyein Koh, Yoonjeong Choi, Sun Ju Lee, Eunjung Ji, Sun Ha Jee
BACKGROUND AND AIMS: A few studies examined association between familial hypercholesterolemia (FH) and atherosclerotic cardiovascular disease (ASCVD) in Asians with low levels of serum cholesterol. The objectives of this study were to estimate the prevalence of familial hypercholesterolemia phenotype (FH-P) and examined their associations with cardiovascular mortality among Korean population. METHODS: The Korea National Health and Nutrition Examination Survey (KNHANES) data and data from a cohort study were used to obtain the prevalence estimate of FH-P and the association of FH-P with mortality, respectively...
September 14, 2018: Atherosclerosis
H M K Akalanka, S Ekanayake, K Samarasinghe
Objectives: To determine and compare the serum lipid profiles and anthropometric parameters of newly diagnosed BC patients and healthy women. Methods: Serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), triglyceride (TG) and TC: HDL-C were measured in consent obtained newly diagnosed BC patients (n=155) and age matched apparently healthy females (n=75). Weight (W), height (H), waist circumference (WC), hip circumference (HC) and mid upper arm circumference (MUC) of each women were recorded...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Julian C van Capelleveen, Sang-Rok Lee, Rutger Verbeek, John J P Kastelein, Nicholas J Wareham, Erik S G Stroes, G Kees Hovingh, Kay-Tee Khaw, S Matthijs Boekholdt, Joseph L Witztum, Sotirios Tsimikas
BACKGROUND: Plasma apolipoprotein C-III (apoC-III) levels are associated with coronary artery disease (CAD) risk. OBJECTIVE: To assess whether lipoprotein-associated apoC-III levels predict risk of CAD events. METHODS: apoC-III associated with apoB, apoAI, and Lp(a) (apoCIII-apoB, apoCIII-apoAI, and apoCIII-Lp(a), respectively) were measured using high-throughput chemiluminescent enzyme-linked immunoassays in 2711 subjects (1879 controls and 832 cases with CAD) in the European Prospective Investigation into Cancer and Nutrition-Norfolk prospective population study with 7...
August 29, 2018: Journal of Clinical Lipidology
Ya-Fei Tian, Cui-Fang Ning, Fang He, Bin-Cheng Yin, Bang-Ce Ye
Exosomes, as important signal transmitters, play a key role in intercellular communication, especially in cancer metastasis. There is considerable evidence that exosomes can be used as an indicator of cancer. However, convenient and sensitive methods for detecting exosomes are still technically challenging. Here, we present a convenient and highly sensitive surface-enhanced Raman scattering (SERS) based method by combining immunoaffinity, SERS nanoprobes, and portable Raman devices for specific isolation and accurate quantification of exosomes...
September 18, 2018: Analyst
Yeli Wang, Jingwen Zhu, Aase Handberg, Kim Overvad, Anne Tjønneland, Eric B Rimm, Majken K Jensen
BACKGROUND AND AIMS: CD36 is a cholesterol receptor involved in the uptake of oxidized low-density lipoprotein cholesterol and development of atherosclerotic plaques. Cross-sectional studies have shown correlations between plasma CD36 and atherosclerosis but no prospective study has examined the association yet. We prospectively examined the association between plasma CD36 levels and risk of incident coronary heart disease (CHD) in a Danish population. METHODS: Plasma CD36 levels were measured in a case-cohort study nested within the Danish population-based cohort, the Diet, Cancer and Health Study...
October 2018: Atherosclerosis
J K Yashveer, Devendra Pankaj
Oral sub mucous fibrosis is the most common precancerous lesion in India. Lipids are the major cell membrane components essential for various biological function including cell growth and division for the maintenance of cell integrity of normal and malignant tissue. Low levels of lipids serves as a marker and prognostic indicator in the early detection of oral precancerous and cancerous states. In spite of high prevalence and its potential to undergo malignant transformation, this condition has not widely been investigated with respect to serum lipid levels...
September 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
Yoon Jin Choi, Dong Ho Lee, Kyung-Do Han, Cheol Min Shin, Nayoung Kim
Metabolic syndrome (MetS) and its components has been thought to be involved in the development of colorectal cancer (CRC). However, the results is often inconsistent according to gender or anatomical location of tumor. This study aimed to investigate the association between MetS and its components and CRC development by gender and tumor location. We evaluated the data of 22,809,722 Korean individuals of the National semi-compulsive cohort who underwent regular health check-ups between 2009 and 2012. Compared to subjects without MetS components, the hazard ratio for CRC development in patients with MetS was 1...
September 8, 2018: European Journal of Epidemiology
Mai Stafford, Christian von Wagner, Sarah Perman, Jayne Taylor, Diana Kuh, Jessica Sheringham
BACKGROUND: Evidence of the possible health benefits of social connectedness is increasing. We aimed to examine poor social connectedness as a possible barrier to participation in preventive health services among older people (aged 53-69 years). METHODS: We analysed data from a prospective cohort study of 5362 socially stratified births from the Medical Research Council National Survey of Health and Development enrolled in England, Scotland, and Wales in March 1946...
September 2018: Lancet. Public Health
Shigekazu Ukawa, Akiko Tamakoshi, Yoshitaka Murakami, Yutaka Kiyohara, Michiko Yamada, Masato Nagai, Atsushi Satoh, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, EPOCH-JAPAN Research Group
Objective: We employed a large-scale pooled analysis to investigate the association of liver cancer-related mortality with being overweight/obese and total cholesterol (TC) levels, since limited and inconsistent data on these associations exist in Japan. Methods: A total of 59,332 participants (23,853 men and 35,479 women) from 12 cohorts without a history of cancer who were followed for a median of 14.3 years were analyzed. A sex-specific stratified Cox proportional hazards model adjusted for age and other potential confounders was used to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for liver cancer-related mortality...
August 24, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Guohui Fan, Dan Hu, Feng Peng, Guodong Xu, Xiandong Lin, Binying Liang, Hejun Zhang, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu
Objectives: We here attempted to evaluate the prediction of different "ABO" blood groups for postsurgical gastric cancer-specific mortality by using data from the ongoing Fujian prospective investigation of cancer (FIESTA) study. Methods: Initially, a total of 3413 patients with gastric cancer were consecutively enrolled between January 2000 and December 2010 to receive radical gastrectomy, and they were followed up until December 2015. Study patients were divided into the "O+" group and the blood type "O-" group...
2018: Journal of Cancer
Abdulbari Bener, Yasar Ozdenkaya, Abdulla O A A Al-Hamaq, Cem Cahit Barisik, Mustafa Ozturk
Background: The aim of this study was to investigate the relationship between vitamin D deficiency and thyroid diseases among type 2 diabetes mellitus (T2DM) patients. Methods: This was a cohort case and control study, 546 T2DM patients and 546 control study participants were enrolled, aged between 25 and 65 years. The subjects were also investigated for fasting blood glucose levels (FBG), post prandial glucose (PPG,) glycosylated hemoglobin (HbA1c), thyroid stimulating hormone (TSH), T3, T4, and presence of other comorbid conditions...
September 2018: Journal of Clinical Medicine Research
Fangfang Zhu, Xinxin Xu, Beibei Shi, Linchai Zeng, Luhui Wang, Xueqing Wu, Haiyan Zhu
OBJECTIVE: To evaluate the prognostic impact of preoperative plasma lipid profile, glucose, and body mass index in patients with ovarian cancer. METHODS: A retrospective study was performed among women with ovarian cancer who underwent surgical resection between January 1, 2001, and December 1, 2015, at the First Affiliated Hospital of Wenzhou Medical University, China. Data were evaluated using Cox regression analyses, Kaplan-Meier survival analysis and landmark survival analysis...
November 2018: International Journal of Gynaecology and Obstetrics
Sidharth Totadri, Amita Trehan, Anish Bhattacharya, Deepak Bansal, Savita Verma Attri, Radhika Srinivasan
Chylothorax is an uncommon complication in children. Although surgery and trauma are the most common causes encountered, hematological as well as solid malignancies can present with chylothorax. This study aimed to describe the presentation and management of malignant chylothorax in children. This is a case series from a pediatric hematology-oncology unit. Chylothorax was diagnosed by demonstrating high triglyceride content in the pleural fluid and a low cholesterol concentration in relation to the serum cholesterol...
October 2017: Indian Journal of Cancer
Dan Hu, Feng Peng, Xiandong Lin, Gang Chen, Binying Liang, Ying Chen, Chao Li, Hejun Zhang, Guohui Fan, Guodong Xu, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu
BACKGROUND: As we previously reported, the presence of preoperative metabolic syndrome can predict the significant risk of gastric cancer mortality. As a further extension, we evaluated the prediction of three lipid derivatives generated from triglycerides (TG), total cholesterol (TC), high- and low-density lipoprotein cholesterol (HDLC and LDLC) at baseline for postoperative gastric cancer mortality by prospectively analysing 3012 patients. The three lipid derivatives included the ratio of TC minus HDLC to HDLC known as atherogenic index (AI), the ratio of TG to HDLC abbreviated as THR and the ratio of LDLC to HDLC abbreviated as LHR...
August 6, 2018: BMC Cancer
Kun Ling Ma, Tie Kai Gong, Ze Bo Hu, Yang Zhang, Gui Hua Wang, Liang Liu, Pei Pei Chen, Jian Lu, Chen Chen Lu, Bi Cheng Liu
BACKGROUND: Increased plasma level of lipoprotein(a) (Lpa) is a risk factor of cardiovascular diseases. This study aimed to explore the role of Lpa in the progression of atherosclerosis in patients with end-stage renal disease (ESRD) and to investigate whether its potential mechanism is mediated by CXC chemokine ligand 16 (CXCL16) and low-density lipoprotein receptor (LDLr). METHODS: This is a retrospective clinical study. From January 2015 to April 2016, forty-six ESRD patients from Danyang First People's Hospital were investigated...
August 2, 2018: BMC Nephrology
Nobuya Daitoku, Yuji Miyamoto, Ryuma Tokunaga, Yuki Sakamoto, Yukiharu Hiyoshi, Masaaki Iwatsuki, Yoshifumi Baba, Shiro Iwagami, Naoya Yoshida, Hideo Baba
BACKGROUND/AIM: The Controlling Nutritional Status (CONUT) score is a useful nutritional evaluation, that is calculated from serum albumin, total cholesterol concentrations, and total lymphocyte count. This study aimed to investigate the association between the CONUT score and prognosis in patients with metastatic colorectal cancer (mCRC). PATIENTS AND METHODS: The CONUT score was retrospectively calculated in 211 patients with mCRC receiving first-line chemotherapy...
August 2018: Anticancer Research
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