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https://www.readbyqxmd.com/read/30334198/different-pain-states-of-trigeminal-neuralgia-make-significant-changes-in-the-plasma-proteome-and-some-biochemical-parameters-a-preliminary-cohort-study
#1
Asghar Farajzadeh, S Zahra Bathaie, Jalil Arabkheradmand, Seyed Mohammad Ghodsi, Soghrat Faghihzadeh
Trigeminal neuralgia (TN) with chronic and severe neuropathic pain leads to remarkable interference in daily living activities of patients. Unknown molecular mechanisms involved in TN pathophysiology are a challenge for complete treatment of the disease. The present study was conducted to investigate changes in the plasma proteome beside biochemical parameters, including calcitonin gene-related peptide (CGRP), nitric oxide (NO), amino acids, and vitamin D (Vit D) in different pain states in TN patients. Plasma samples were obtained from the control group (#13) and patients with purely paroxysmal type of classical TN (#13) before and after microvascular decompression (MVD)...
October 17, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/30333517/impact-of-total-parenteral-nutrition-standardization-led-by-pharmacist-on-quality-in-postoperative-patients-with-colorectal-cancer
#2
Zeng Wang, Yunsong Peng, Xinjun Cai, Yingying Cao, Guonong Yang, Ping Huang
BACKGROUND/OBJECTIVES: Abdominal surgery significantly affects the structure and function of the gastrointestinal system of patients, total parenteral nutrition (TPN) is an important nutrition support method for postoperative patients. However, in the process of TPN practice, the excessive fat emulsion and compound amino-acid prescriptions ratio are often prescribed by doctors. To address the problem, we developed the computerized TPN prescription management system to promote the personalized provision of TPN...
October 17, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30333420/a-case-of-hypophosphatemic-osteomalacia-associated-with-adefovir-induced-fanconi-syndrome-initially-diagnosed-as-diabetic-kidney-disease-and-vitamin-d-deficiency
#3
Ryo Koda, Masafumi Tsuchida, Noriaki Iino, Ichiei Narita
A 68-year-old man with type 2 diabetes mellitus and chronic hepatitis B infection was referred to the nephrology department before planned surgery for hepatocellular carcinoma. He had been receiving low-dose adefovir dipivoxil (ADV) for 11 years. Laboratory findings revealed impaired re-absorption in the proximal renal tubules. He had been diagnosed with diabetic kidney disease and osteomalacia due to vitamin D deficiency; thus, ADV was not discontinued until he was referred to us. In this case, concomitant diabetes mellitus and vitamin D deficiency might have prevented the early diagnosis of ADV-induced Fanconi syndrome...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30327208/-evaluation-of-the-risk-of-postoperative-bleeding-complications-in-hand-surgery-without-interruption-of-anticoagulant-vitamin-k-antagonist-vka-a-retrospective-study
#4
B Gerenton, V Moris, H Shipkov, P J Regnard, D Guillier
OBJECTIVE: The management of patients on Vitamine K Antagonist (VKA) anticoagulation is a public health issue with surgery being the primary cause of VKA interruption. The aim of this study was to evaluate the bleeding risk in patients operated on hand surgery without interruption of VKA treatment. PATIENTS AND METHODS: This retrospective, monocentric study was conducted between 2013 and 2015. The inclusion criteria were, as follows: patients on VKA over 18 years of age who had emergency or scheduled surgery without interruption of VKA treatment; INR inferior to 3 analyzed less than 24h before surgery...
October 13, 2018: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/30322743/vitamin-d-deficiency-are-associated-with-subjective-disease-severity-in-chinese-patients-with-chronic-rhinosinusitis-with-nasal-polyps
#5
Feng Wang, Yang Yang, Haihong Chen
OBJECTIVE: To evaluate the serum vitamin D level in patients with chronic rhinosinusitis with nasal polyps and its correlation with the disease severity. SETTING: Hospital of Zhejiang University. STUDY DESIGN: Retrospective analysis of collected data. SUBJECTS AND METHODS: Patients with chronic rhinosinusitis with or without nasal polyps who underwent endoscopic sinus surgery were recruited. Demographic information including age, gender, body mass index, smoke history, atopic status and asthma was collected...
September 13, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/30322254/a-comparative-analysis-of-the-metabolic-and-coagulative-profiles-in-patients-with-idiopathic-scoliosis-congenital-scoliosis-and-healthy-controls-a-case-control-study
#6
Kaustubh Ahuja, Bhavuk Garg, Buddhadev Chowdhuri, Raj Kumar Yadav, Pradeep Kumar Chaturvedi
Study Design: Single-center, observational, case-control study. Purpose: Comparison and analysis of the metabolic and coagulative profiles in patients with idiopathic scoliosis, patients with congenital scoliosis, and healthy controls. Overview of Literature: Serum melatonin deficiency has been a controversial topic in the etiopathogenesis of scoliosis. Low bone mineral density, low vitamin D3 levels, and high parathyroid hormone levels are common metabolic abnormalities associated with scoliosis that may be responsible for its pathogenesis...
October 16, 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/30321947/role-of-anti-oxidant-vitamin-c-in-post-operative-pain-relief-in-foot-and-ankle-trauma-surgery-a-prospective-randomized-trial
#7
Sumit Kumar Jain, Mohammad Yahya Dar, Sanjeev Kumar, Arun Yadav, Stephen R Kearns
BACKGROUND: Post-operative pain may adversely affect a patient's quality of life. Studies have shown that vitamin C, being an anti-oxidant and neuro-modulating agent, can help to reduce pain in a variety of clinical settings. The objective of this randomized controlled trial was to assess the effectiveness of vitamin C in reducing post-operative pain, analgesia requirements and improving functional outcome. METHODS: Patients with isolated foot and ankle trauma, who had undergone surgery, were randomly assigned to receive either vitamin C 500mg or a placebo tablet twice a day...
May 24, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/30317121/jaw-tumor-in-recurrent-primary-hyperparathyroidism-a-case-report
#8
Farzaneh Amini Nezhad, Moloud Payab, Sara Nayebandi, Shirin Hasani-Ranjbar
BACKGROUND: Brown tumor may present as uni/multilocular osteolytic lesions with bone expansion, bone pain or pathologic fracture in primary, secondary and tertiary hyperparathyroidism. However, recently, such presentation is rare due to early detection using blood screening techniques before symptomatic bone lesions appear. CASE REPORT: A 65-year-old woman was admitted to our hospital with generalized bone pain and a progressive painless mass in her jaw appeared since 6 months ago...
October 4, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30311896/preventive-use-of-ascorbic-acid-for-atrial-fibrillation-after-coronary-artery-bypass-graft-surgery
#9
Mohsen Mirmohammadsadeghi, Amir Mirmohammadsadeghi, Mahsa Mahmoudian
BACKGROUND: Atrial fibrillation is one of the most frequent complications and a major risk of morbidity and mortality after cardiac surgery. Antioxidants such as vitamin C are used for prevention of this arrhythmia. Different results of studies have been reported, but most of them have shown efficiency of vitamin C in prophylaxis of postoperative AF. We tried to examine this efficacy with larger sample size. METHODS: Three hundred and fourteen on pump coronary artery bypass graft surgery alone...
October 1, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/30309324/osteoporosis-development-and-vertebral-fractures-after-abdominal-irradiation-in-patients-with-gastric-cancer
#10
Gokhan Yaprak, Cengiz Gemici, Sule Temizkan, Sevim Ozdemir, Berfu Cinkit Dogan, Ozgur Ozan Seseogullari
BACKGROUND: Decrease in bone mineral density, osteoporosis development, bone toxicity and resulting insufficiency fractures as late effect of radiotherapy are not well known. Osteoporosis development related to radiotherapy has not been investigated properly and insufficiency fractures are rarely reported for vertebral bones. METHODS: Ninety-seven patients with gastric adenocarcinoma were evaluated for adjuvant treatment after surgery. While 73 out of 97 patients treated with adjuvant chemoradiotherapy comprised the study group, 24 out of 97 patients with early stage disease without need of adjuvant treatment comprised the control group...
October 11, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30307307/vitamin-a-nutritional-status-in-patients-with-coronary-artery-disease-and-its-correlation-with-the-severity-of-the-disease
#11
Andrea Matos, Vanessa Moreira da Silveira Gonçalves, Gisele Souza, Suelem Pereira da Cruz, Sabrina Cruz, Andréa Ramalho
INTRODUCTION: the purpose of this study was to assess the vitamin A (VA) nutritional status of patients with coronary artery disease (CAD) and its correlation with the severity of the disease, taking into consideration zinc concentration and oxidative stress. METHODS: the patients were preoperative inpatients awaiting myocardial revascularization surgery. The serum concentrations of retinol, β-carotene, zinc, malondialdehyde (MDA) and C-reactive protein (CRP) were quantified...
October 8, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/30300686/genetic-hypercalcemia
#12
Catherine Cormier
A genetic disorder should be suspected in patients with hypercalcemia, notably those who are young; have family members with hypercalcemia; or have had a tumor of the endocrine pancreas, thyroid, pituitary, adrenal gland, or jaw bone. All forms of hypercalcemia should be interpreted according to the serum level of parathyroid hormone (PTH). Genetic forms are thus classified as related or unrelated to a parathyroid gland disorder. When the PTH level is elevated or is not depressed despite the hypercalcemia, findings that suggest hyperparathyroidism due to a genetic cause include syndromic manifestations in the patient or family members, parathyroid cancer (either suspected before surgery or confirmed during parathyroidectomy), multiple or recurrent parathyroid tumors, a family history of primary hyperparathyroidism, and the onset of primary hyperthyroidism before 50 years of age...
October 6, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/30300532/the-effect-of-surgery-on-fat-mass-lipid-and-glucose-metabolism-in-mild-primary-hyperparathyroidism
#13
Kristin Godang, Karolina Lundstam, Charlotte Mollerup, Fougner Fougner, Ylva Pernow, Jörgen Nordenström, Thord Rosén, Svante Jansson, Mikael Hellström, Jens Bollerslev, Ansgar Heck
Context: Mild primary hyperparathyroidism has been associated with increased body fat mass and unfavorable cardiovascular risk factors. Objective: To assess the effect of parathyroidectomy on fat mass, glucose and lipid metabolism. Design, patients, interventions, main outcome measures: 119 patients previously randomized to observation (OBS; n = 58) or parathyroidectomy (PTX; n = 61) within the Scandinavian Investigation of Primary Hyperparathyroidism (SIPH) trial, an open randomized multicenter study, were included...
August 1, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/30297559/preoperative-vitamin-d-levels-and-respiratory-complications-of-general-anesthesia
#14
N Tas, T Noyan, O Yagan, V Hanci, E Canakci
Aims: This research aims to investigate whether there is a correlation between the respiratory complications occurring in patients under general anesthesia and preoperative Vitamin D levels. Settings and Design: The study was a prospective observational study. Materials and Methods: This study included 95 adult cases. The cases had total 25-hydroxyvitamin D (25OHD) levels identified in blood samples before the operation. Patients given routine general anesthesia and were assessed in terms of respiratory complications during anesthesia induction, extubation, anesthesia recovery, and the first 24-h postoperative...
October 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/30296870/andexanet-alfa-for-the-treatment-of-hemorrhage
#15
Andrea Cervi, Mark Crowther
While associated life-threatening and fatal bleeding events are less frequent with the direct factor Xa inhibitors compared to vitamin K antagonists, significant concern surrounding management of major bleeds and urgent periprocedural interruption of these agents exists among clinicians. Andexanet alfa is a recombinant human factor Xa decoy protein developed in response to this clinical gap in the care of patients receiving anticoagulation with factor Xa inhibitors. Areas covered: This paper reviews results from preclinical and healthy-volunteer studies demonstrating the ability of andexanet to rapidly and reliably normalize coagulation indices in patients treated with both direct and indirect factor Xa inhibitors...
October 9, 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/30283909/compromised-activation-of-vitamin-d-after-elective-surgery-a-prospective-pilot-study
#16
Martin Blomberg Jensen, Henrik Husted, Poul Jannik Bjerrum, Anders Juul, Henrik Kehlet
Surgical stress reduces concentrations of most proteins in serum and necessitates a rapid adjustment of hormones dependent on protein binding. Activation of vitamin D by renal 1α-hydroxylation is dependent on protein binding because 1,25-dihydroxyvitamin D (1,25(OH)2 D3 ) is formed after megalin-mediated reabsorption of 25-hydroxyvitamin D (25OHD) bound to vitamin D binding protein (DBP). Postoperative alterations in serum concentrations of DBP and albumin may therefore impair 1,25(OH)2 D3 production. Our objective was to determine sex-specific changes in serum concentrations of vitamin D metabolites and sex steroids 2, 6, 24, and 48 hours and 3 weeks postoperatively...
September 2018: JBMR Plus
https://www.readbyqxmd.com/read/30276648/ascorbic-acid-induced-oxalate-nephropathy-a-case-report-and-discussion-of-pathologic-mechanisms
#17
Weijie Violet Lin, Christie Gloria Turin, David Walter McCormick, Christopher Haas, Gregory Constantine
Oxalate nephropathy is associated with hereditary hyperoxaluria, Crohn disease, and previous gastric or intestinal surgery, especially in the setting of increased oxalate intake or ethylene glycol ingestion. We present a patient whose intake of vitamin C supplements (2 g/day), exacerbated by predisposing factors of prior small bowel obstruction and resection, and benign prostate hyperplasia (BPH), resulted in acute kidney injury due to oxalate nephropathy. We review past reports of vitamin C-induced oxalate nephropathy and discuss the underlying precipitating factors...
October 1, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/30270775/bleeding-in-patients-receiving-non-vitamin-k-oral-anticoagulants-clinical-trial-evidence
#18
Arthur Bracey, Wassim Shatila, James Wilson
In optimizing anticoagulation therapy, it is essential to balance treatment efficacy with the major adverse effect of anticoagulant treatment, bleeding risk. This narrative review examines the efficacy and safety of the non-vitamin K antagonist oral anticoagulants (NOACs) dabigatran, rivaroxaban, apixaban, and edoxaban compared with standard anticoagulation or placebo. NOAC therapies provide equivalent to superior protection versus standard therapy, with similar or superior safety, and potential benefits in convenience...
September 30, 2018: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/30265643/results-of-octaplex-for-reversal-of-warfarin-anticoagulation-in-patients-with-hip-fracture
#19
Richard Ng, Meer-Taher Shabani-Rad
BACKGROUND: Patients with hip fracture who present anticoagulated with warfarin often require reversal of anticoagulation for safe hip fracture surgery. Vitamin K is typically administered for this, but requires 24-48 hours for maximal effect. These patients have an increased delay to surgery and increased mortality. Octaplex is a prothrombin complex concentrate (PCC) that reverses warfarin anticoagulation in less than an hour. This study assesses the effectiveness and safety of Octaplex for reversal of warfarin anticoagulation for hip fracture surgery...
October 1, 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/30264828/-non-alcoholic-fatty-liver-disease-in-patients-with-hiv-infection
#20
Marianthi Papagianni, Konstantinos Tziomalos
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in patients with HIV infection and appears to be more severe than in HIV-uninfected patients. Both metabolic (e.g., obesity and insulin resistance) and HIV-related factors (e.g., antiretroviral treatment and inflammation) play a role in the pathogenesis of NAFLD in this population. Accordingly, all patients with HIV infection should be evaluated for the presence of NAFLD. Ultrasound is the first-line diagnostic procedure, but non-alcoholic steatohepatitis has to be diagnosed with liver biopsy...
2018: AIDS Reviews
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