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https://www.readbyqxmd.com/read/30116326/influence-of-vitamin-d-deficiency-on-t-cell-subsets-and-related-indices-during-spinal-tuberculosis
#1
Shao-Huai Zhou, Xin Wang, Ming-Yu Fan, Hong-Liang Li, Feng Bian, Tao Huang, Hong-Yu Fang
The present study investigated the effects of vitamin D deficiency on T cell subsets in patients with spinal tuberculosis. In addition, the influence of vitamin D deficiency was investigated on the expression of cytokines IL-1β, IL-6 and TNF-α in intervertebral disc lesions of patients. One hundred and seventeen patients with spinal tuberculosis who received operative treatment in the Department of Orthopedics in Wuhan City Third Hospital from March 2012 to March 2015 were collected. The patients were divided depending upon vitamin D content into the control group (64 cases, vitamin D content <25 nmol/l) and experimental group (53 cases, vitamin D content >50 nmol/l)...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30111320/surgical-treatment-of-children-with-total-colonic-aganglionosis-functional-and-metabolic-long-term-outcome
#2
Cristian Urla, Justus Lieber, Florian Obermayr, Andreas Busch, Roland Schweizer, Steven W Warmann, Hans-Joachim Kirschner, Jörg Fuchs
BACKGROUND: Total colonic aganglionosis (TCA) is a rare variant of Hirschsprung's disease occurring in 3-10% of the cases. Only few studies reported the long-term clinical and metabolic outcomes of patients with TCA. The aim of this study was to evaluate the functional and metabolic long-term outcomes of children undergoing surgical treatment for TCA. METHODS: A 15-year retrospective study was performed. Blood chemistry tests and stool analysis performed at the last follow-up visit were recorded...
August 15, 2018: BMC Surgery
https://www.readbyqxmd.com/read/30110122/pleiotropic-effect-of-vitamin-d-in-cystic-fibrosis
#3
Teresa Grzelak, Klaudia Mikołajczyk
Cystic fibrosis - CF - is the most common recessively autosomally and inherited disorder in the Caucasian population. It is incurable, multi-systemic disease with progressive course. CF is caused by CFTR gene mutation, the product of which is Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). CF patients are exposed to fat-soluble vitamins deficiency, including vitamin D. It is due to the fat malabsorption (caused by exacerbation exocrine pancreatic insufficiency), decreased sun exposure (caused by receiving antibiotics photophobia), reduction of adipose tissue and insufficient supply with food...
August 15, 2018: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/30104880/management-and-outcomes-of-hyperparathyroidism-a-case-series-from-a-single-institution-over-two-decades
#4
Hassan Al-Thani, Moamena El-Matbouly, Maryam Al-Sulaiti, Mohammad Asim, Ahmad Majzoub, Abdelhakem Tabeb, Ayman El-Menyar
Background: Hyperparathyroidism is a frequent endocrine disorder with variable clinical manifestations and outcomes. We aimed to evaluate clinical presentations, management and outcomes of hyperparathyroidism. Methods: A retrospective study was conducted to include all patients presented with hyperparathyroidism between 1995 and 2014 at a single tertiary hospital with an average follow-up period of 46 months. Data were reviewed for clinical presentations, diagnostic work-up, intraoperative findings, management, and outcomes...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/30100750/the-impact-of-abcb1-rs1045642-and-rs4148738-and-ces1-rs2244613-gene-polymorphisms-on-dabigatran-equilibrium-peak-concentration-in-patients-after-total-knee-arthroplasty
#5
Dmitriy Alekseevich Sychev, Alexander Nikolaevich Levanov, Tatiana Vladimirovna Shelekhova, Pavel Olegovich Bochkov, Natalia Pavlovna Denisenko, Kristina Anatolyevna Ryzhikova, Karin Badavievich Mirzaev, Elena Anatolyevna Grishina, Mikhail Alekseevich Gavrilov, Galina Vladislavovna Ramenskaya, Aleksei Vladimirovich Kozlov, Tanya Bogoslovsky
Background: Non-vitamin K oral anticoagulants (NOACs) are commonly used for prophylaxis of venous thromboembolism (VTE) in orthopedic patients. Despite known safety and high potency of NOACs, potential interactions of NOACs with genetic polymorphisms are poorly understood. Dabigatran etexilate is one of the most commonly prescribed direct thrombin inhibitors for the prevention of VTE. The objectives of this study were to assess the effect of ABCB1 (rs1045642 and rs4148738) and CES1 (rs2244613) polymorphisms on dabigatran pharmacokinetics in patients after total knee arthroplasty...
2018: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/30099843/hit-associated-thrombosis-from-arterial-to-venous-to-venous-limb-gangrene
#6
T E Warkentin
Heparin-induced thrombocytopenia (HIT) is an acquired immune-mediated hypercoagulability state strongly associated with thrombosis. During the 1970s and 1980s, the prevailing concept was that HIT was associated only with arterial thrombosis, through its unique pathogenesis via heparin-dependent, platelet-activating IgG antibodies. Yet, in 1990, when I began to encounter HIT in my clinical practice, I found that most such patients developed symptomatic venous thrombosis. This historical sketch summarizes some of the research that challenged the dogma of HIT as a mainly arterial prothrombotic disorder...
August 12, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/30094942/-i-think-we-ve-had-a-health-screen-new-offshore-screening-new-refugee-health-guidelines-new-syrian-and-iraqi-cohorts-recommendations-reality-results-and-review
#7
Rachel C Heenan, Thomas Volkman, Simon Stokes, Shidan Tosif, Hamish Graham, Andrea Smith, David Tran, Georgia Paxton
AIM: To examine refugee health assessments in Syrian and Iraqi children in the context of changes to offshore immigration screening, updated Australian refugee health guidelines and the primary care refugee health model in Victoria. METHODS: This is a retrospective audit of Syrian and Iraqi children aged 0-17 years attending a specialist immigrant health service from January 2015 to September 2017. RESULTS: We saw 128 children (7 months-16 years, 64...
August 9, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/30088350/bridging-anticoagulation-in-patients-treated-with-vitamin-k-antagonists-prior-to-trochanteric-and-hip-fracture-surgeries-the-current-practice
#8
Krzysztof Szklanny, Michał Jakubek, Katarzyna Zbierska-Rubinkiewicz, Anetta Undas
BACKGROUND: The strategies of perioperative bridging anticoagulation in orthopedic surgical patients during oral anticoagulation (OAC) therapy with vitamin K antagonists (VKA) vary from center to center. OBJECTIVES: The aim of this single-center study was to assess the risk of bleeding and thromboembolic events (TEs) in bridged patients on VKA who underwent orthopedic surgery due to trochanteric or hip fracture. MATERIAL AND METHODS: The retrospective study included 64 patients (mean age: 80 years) who received VKA for at least 3 months prior to orthopedic procedure...
August 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30076561/prevalence-and-factors-associated-with-helicobacter-pylori-in-patients-undergoing-bariatric-surgery-the-soon-cohort
#9
Sandrine Coumes, Bruno Froissart, Nelly Wion, Fabian Reche, Catherine Arvieux, Anne-Laure Borel
PURPOSE: Helicobacter Pylori (HP) infection is systematically screened for before carrying out bariatric surgery. Criteria to determine "at risk" patients and avoid systematic screening are lacking. We evaluated the prevalence of HP infection and associated predictive factors in a population of patients with class II and III obesity volunteering for bariatric surgery. MATERIALS AND METHODS: Observational, cross-sectional study of patients included in the severe obesity outcome network (SOON) cohort...
August 3, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/30076444/differences-in-total-blood-loss-and-transfusion-rate-between-different-indications-for-shoulder-arthroplasty
#10
Dominik Malcherczyk, Juliane Hack, Antonio Klasan, Asma Abdelmoula, Thomas J Heyse, Brandon Greene, Bilal F El-Zayat
PURPOSE: In this study, the total blood loss, transfusion rate and number of transfused blood units in patients with different indications for shoulder arthroplasty: primary, fracture and secondary were compared. Risk factors for bleeding and transfusion were analysed. METHODS: Medical records and the database of the institution's blood bank from 527 patients that received shoulder arthroplasty were analysed retrospectively. This study included 419 patients that were divided in three different groups: primary (n = 278), fracture (n = 110) and secondary (following prior osteosynthesis; n = 31) shoulder arthroplasty...
August 3, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/30074500/nonalcoholic-steatohepatitis-obesity-and-cardiac-dysfunction
#11
Sherin E Mathews, Rekha B Kumar, Alpana P Shukla
PURPOSE OF REVIEW: Obesity and nonalcoholic steatohepatitis (NASH) are epidemiologically and pathophysiologically linked disorders. Here, we summarize the effect of obesity on NASH and how it has a cascading effect on cardiovascular dysfunction. We also review the current and emerging treatment options for NASH. RECENT FINDINGS: The link between NASH and cardiac dysfunction has been further delineated in recent studies demonstrating endothelial dysfunction, diastolic dysfunction, and increased coronary artery calcification in patients with known NASH...
August 1, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/30071650/prognostic-relevance-of-circulating-25ohd-fractions-for-early-recovery-and-survival-in-patients-with-hip-fracture-%C3%A2
#12
Erzsébet Toldy, Antal Salamon, Bernadette Kálmán, Katalin Ágota, Dániel Horváth, Zoltán Lőcsei
The relation between vitamin-D (VD) status and healing after hip fracture had not been sufficiently addressed. Currently serum total 25-hydroxy-VD (t-25OHD) is the most widely used indicator of VD status. It is unclear whether free or bioavailable VD are better markers of 25OHD availability for tissues. Validity of overall cut-off values of t-25OHD is limited. OBJECTIVES: (1) Assess serum levels of circulating forms of 25OHD in patients with hip fracture (PwHF: N = 199) compared to active controls without history of fracture ( N = 102); (2) determine relationship between 25OHD fractions and functional performance after surgery (FPAS) and survival...
August 1, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30066245/failed-sleeve-gastrectomy-single-anastomosis-duodenoileal-bypass-or-roux-en-y-gastric-bypass-a-multicenter-cohort-study
#13
Phillip J Dijkhorst, Abel B Boerboom, Ignace M C Janssen, Dingeman J Swank, René M J Wiezer, Eric J Hazebroek, Frits J Berends, Edo O Aarts
BACKGROUND: Sleeve gastrectomy (SG) has become the most performed bariatric procedure to induce weight loss worldwide. Unfortunately, a significant portion of patients show insufficient weight loss or weight regain after a few years. OBJECTIVE: To investigate the effectiveness of the single anastomosis duodenoileal (SADI) bypass versus the Roux-en-Y gastric bypass (RYGB) on health outcomes in morbid obese patients who had undergone SG previously, with up to 2 years of follow-up...
July 31, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/30064623/-treatment-of-non-alcoholic-fatty-liver-disease
#14
Sara Heebøll, Henrik Vilstrup, Henning Grønbæk
Non-alcoholic fatty liver disease and especially non-alcoholic steatohepatitis (NASH) and fibrosis are associated with severe liver disease and increased cardiovascular risk. It is therefore important to identify patients with NASH fibrosis. Therapeutical options include life style intervention and pharmacological treatment with vitamin E and pioglitazone; however, evidence of effect is scarce for all options. New treatments are under investigation and include glucagon-like peptide-1, farnesoid receptor as well as peroxisome proliferator-activated receptor-α/δ agonists...
July 30, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/30063291/variable-management-of-postoperative-hypoparathyroidism-at-nine-nhs-trusts-in-north-west-england-the-need-for-a-universal-protocol
#15
H M Htun, R Edmiston, K Kaimal, B N Kumar
Management of hypoparathyroidism following thyroid surgery should be reviewed and validated at a regional/national level A 'single' calcium measurement alone should not be used to diagnose or rule out postoperative hypoparathyroidism following thyroid surgery Combination of calcium and early postoperative PTH measurement is recommended to predict postoperative hypoparathyroidism 'Selective instead of routine' vitamin D supplementation is recommended based on calcium and PTH levels Optimisation of patient safety and cost savings may be achieved by adopting a 'user friendly easy to follow' algorithm This article is protected by copyright...
July 31, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/30060468/vitamin-c-to-improve-organ-dysfunction-in-cardiac-surgery-patients-review-and-pragmatic-approach
#16
REVIEW
Aileen Hill, Sebastian Wendt, Carina Benstoem, Christina Neubauer, Patrick Meybohm, Pascal Langlois, Neill Kj Adhikari, Daren K Heyland, Christian Stoppe
The pleiotropic biochemical and antioxidant functions of vitamin C have sparked recent interest in its application in intensive care. Vitamin C protects important organ systems (cardiovascular, neurologic and renal systems) during inflammation and oxidative stress. It also influences coagulation and inflammation; its application might prevent organ damage. The current evidence of vitamin C's effect on pathophysiological reactions during various acute stress events (such as sepsis, shock, trauma, burn and ischemia-reperfusion injury) questions whether the application of vitamin C might be especially beneficial for cardiac surgery patients who are routinely exposed to ischemia/reperfusion and subsequent inflammation, systematically affecting different organ systems...
July 27, 2018: Nutrients
https://www.readbyqxmd.com/read/30060279/-update-esc-guideline-2017-dual-antiplatelet-therapy
#17
Steffen Massberg, Amin Polzin
DAPT DURATION DEPENDS ON THE INDIVIDUAL ISCHEMIC- VS. BLEEDING RISK: The updated ESC guidelines on dual antiplatelet therapy (DAPT) focus on individualization of therapy. It is recommended to plan DAPT duration depending on the individual ischemic- vs. bleeding risk of the patient. Evaluation of ischemic- and bleeding risk may be done using heart teams and risk scores respectively. It is underlined that the decision regarding DAPT duration is dynamic and should be re-assessed on a regular basis...
August 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/30060273/-anti-thrombotic-treatment-of-patients-with-peripheral-artery-disease-pad
#18
Christine Espinola-Klein
Patients with peripheral artery disease are at high-risk for cardiovascular events. Anti-thrombotic treatment is very important for secondary prevention. In symptomatic patients single antiplatelet therapy with clopidogrel or Aspirin is recommended. After peripheral revascularisation transient dual antiplatelet therapy is widely used although there is only little evidence. Following peripheral bypass surgery most patients are treated with single antiplatelet therapy, in some cases (prostetic bypass grafts) dual antiplated therapy can be useful and selected patients with complex venous grafts might profit from anticoagulation with vitamin K antagonists...
August 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/30060226/primary-hyperparathyroidism
#19
John P Bilezikian
Background: Primary hyperparathyroidism (PHPT), the most common cause of hypercalcemia, is most often identified in postmenopausal women. The clinical presentation of PHPT has evolved over the past 40 years to include 3 distinct clinical phenotypes each of which has been studied in detail and has led to evolving concepts about target organ involvement, natural history, and management. Methods: In this review, I provide an evidence-based summary of this disorder as it has been studied world-wide citing key concepts and data that have helped to shape our concepts about this disease...
July 27, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30050932/vitamin-k-and-bone-metabolism-a-review-of-the-latest-evidence-in-preclinical-studies
#20
REVIEW
Solmaz Akbari, Amir Alireza Rasouli-Ghahroudi
Bone is a metabolically active tissue that renews itself throughout one's life. Cytokines along with several hormonal, nutritional, and growth factors are involved in tightly regulated bone remodeling. Accordingly, vitamin K as a multifunctional vitamin has been recently deemed appreciable as a topic of research as it plays a pivotal role in maintenance of the bone strength, and it has been proved to have a positive impact on the bone metabolism. Vitamin K exerts its anabolic effect on the bone turnover in different ways such as promoting osteoblast differentiation, upregulating transcription of specific genes in osteoblasts, and activating the bone-associated vitamin k dependent proteins which play critical roles in extracellular bone matrix mineralization...
2018: BioMed Research International
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