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Abnormal invasion of the placenta

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https://www.readbyqxmd.com/read/30303745/bisphenol-a-exposure-alters-placentation-and-causes-preeclampsia-like-features-in-pregnant-mice-involved-in-reprogramming-of-dna-methylation-of-wnt2
#1
Yunzhen Ye, Yao Tang, Yu Xiong, Liping Feng, Xiaotian Li
Preeclampsia leads to adverse outcomes for pregnant women. Bisphenol A (BPA) is an environmental endocrine disruptor and has been shown to be positively associated with increased risk of preeclampsia in human studies. We investigated whether BPA exposure causes preeclampsia-like features in pregnant mice and the associated underlying mechanisms. Experiments were performed in animal models and cell cultures. In pregnant mice, BPA-exposed mice exhibited preeclampsia-like features including hypertension, disruption of the circulation, and the placental angiogenesis biomarkers fms-related tyrosine kinase 1 and placenta growth factor, and glomerular atrophy; urinary protein was not affected...
October 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30299280/pathophysiology-of-placenta-accreta-spectrum-disorders-a-review-of-current-findings
#2
Eric Jauniaux, Graham J Burton
Current findings continue to support the concept of a biologically defective decidua rather than a primarily abnormally invasive trophoblast. Prior cesarean sections increase the risk of placenta previa and both adherent and invasive placenta accreta, suggesting that the endometrial/decidual defect following the iatrogenic creation of a uterine myometrium scar has an adverse effect on early implantation. Preferential attachment of the blastocyst to scar tissue facilitates abnormally deep invasion of trophoblastic cells and interactions with the radial and arcuate arteries...
October 5, 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30288733/interpregnancy-interval-and-abnormally-invasive-placentation
#3
Kristina Martimucci, Robyn Bilinski, Anisha M Perez, Theresa Kuhn, Abdulla Al-Khan, Jesus R Alvarez-Perez
INTRODUCTION: The presence of a previous uterine scar is a strong risk factor for developing abnormally invasive placentation (AIP). We sought to determine if a short interpregnancy interval predisposes to AIP. We hypothesized that short interpregnancy interval after a previous cesarean delivery increase the risk of AIP in comparison to a longer interpregnancy interval. MATERIAL AND METHODS: We performed a retrospective cohort study of women with a histological diagnosis of AIP and a history of a previous cesarean section...
October 4, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/30278798/glycogen-synthase-kinase-gsk-3-in-pregnancy-and-parturition-a-systematic-review-of-literature
#4
Narmada Lavu, Lauren Richardson, Elizabeth Bonney, Ramkumar Menon
INTRODUCTION: Human reproduction is a multifaceted process reliant on proper blastocyst implantation, placental and fetal membrane development, and delivery of a healthy baby. Multiple factors and pathways have been reported as critical machineries for cell differentiation and survival during pregnancy, and most of them involve glycogen synthase kinase (GSK) 3α/β for cell differentiation and survival and for maintaining cellular homeostasis. Several reports on GSK3's functional role exist; however, the specific role of GSK3 in reproductive tissues and its contribution to normal or abnormal parturition are still unclear...
October 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30253427/follow-up-studies-of-cf-dna-testing-from-101-consecutive-fetuses-and-related-ultrasound-findings
#5
Seher Basaran, Recep Has, Ibrahim Halil Kalelioglu, Birsen Karaman, Melike Kirgiz, Tahir Dehgan, Bilge Nihan Satkin, Tugba Sarac Sivrikoz, Atil Yuksel
PURPOSE:  To determine the true- and false-positive rates of cf-DNA testing in a cohort of patients from tertiary care centers and assess the impact of ultrasound examinations in pregnancy management. MATERIALS AND METHODS:  Clinical, cytogenetic and ultrasound data of 101 consecutive fetuses were collected retrospectively. Cases were classified into five groups according to the ultrasound findings. Karyotyping, interphase FISH and microarray techniques were used for follow-up studies...
September 25, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/30246313/new-three-dimensional-four-dimensional-volume-rendering-imaging-software-for-detecting-the-abnormally-invasive-placenta
#6
Rozi Aditya Aryananda, Aldika Akbar, Manggala Pasca Wardhana, Khanisyah Erza Gumilar, Budi Wicaksono, Ernawati Ernawati, Agus Sulistyono, Aditiawarman Aditiawarman, Hermanto Tri Joewono, Erry Gumilar Dachlan, Anupam Parange, Gustaaf Albert Dekker
OBJECTIVE: This study aimed to determine the role of three-dimensional (3D)/four-dimensional (4D) volume rendering ultrasound (VRU) in the diagnosis of abnormally invasive placenta (AIP). MATERIALS AND METHODS: Twelve consecutive patients strongly suspected of having AIP on the basis of conventional ultrasound (US) and clinical history performed between September 2016 and December 2016 in the main tertiary referral hospital in Surabaya, East Java were included in this prospective observational study...
September 23, 2018: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/30239726/impact-of-assisted-reproduction-infertility-sex-and-paternal-factors-on-the-placental-dna-methylome
#7
Sanaa Choufani, Andrei L Turinsky, Nir Melamed, Ellen Greenblatt, Michael Brudno, Anick Bérard, William D Fraser, Rosanna Weksberg, Jacquetta Trasler, Patricia Monnier, For The D Cohort Study Group
Children conceived using Assisted Reproductive Technologies (ART) have a higher incidence of growth and birth defects, attributable in part to epigenetic perturbations. Both ART and germline defects associated with parental infertility could interfere with epigenetic reprogramming events in germ cells or early embryos. Mouse models indicate that the placenta is more susceptible to the induction of epigenetic abnormalities than the embryo, and thus the placental methylome may provide a sensitive indicator of 'at risk' conceptuses...
September 19, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/30218616/placental-thickness-in-the-lower-uterine-segment-and-invasive-placentation-will-the-promise-live-up
#8
LETTER
Arianna Laoreti, Basky Thilaganathan, Andrea Kaelin Agten, Aris Papageorghiou, Asma Khalil, James Uprichard, Edwin Chandraharan, Amarnath Bhide
No abstract text is available yet for this article.
September 15, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/30217189/potential-role-for-nectin-4-in-the-pathogenesis-of-pre-eclampsia-a-molecular-genetic-study
#9
Mayuko Ito, Haruki Nishizawa, Makiko Tsutsumi, Asuka Kato, Yoshiko Sakabe, Yoshiteru Noda, Akiko Ohwaki, Jun Miyazaki, Takema Kato, Kazuya Shiogama, Takao Sekiya, Hiroki Kurahashi, Takuma Fujii
BACKGROUND: Nectins are cell adhesion molecules that play a pivotal role in adherens junctions and tight junctions. Our previous study using whole-genome oligonucleotide microarrays revealed that nectin-4 was upregulated in pre-eclamptic placentas. We investigated the role of nectin-4 in the etiology of pre-eclampsia. METHODS: We investigated the expression of nectin-4 using real-time RT-PCR, western blot and immunostaining. Additionally, we performed matrigel invasion assay and cytotoxicity assay using cells overexpressing the nectin-4...
September 14, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/30210239/placenta-percreta-complicated-by-uterine-rupture-and-thrombotic-microangiopathy
#10
Dalia Laužikienė, Saulius Vosylius, Ieva Šiaudinytė, Emilis Laužikas, Diana Ramašauskaitė, Daiva Bartkevičienė
Background: Uterine rupture at the site of a previous caesarean scar with abnormal placental penetration through the uterus wall with bladder invasion is a rare and serious pregnancy complication. Our aim was to report a case of uterine rupture with placenta percreta complicated by thrombotic microangiopathy. Materials and methods: We did a literature review and analysed medical documentation retrospectively. Results: A patient was admitted with complaints of lower abdominal pain at 21 weeks of gestation...
2018: Acta Medica Lituanica
https://www.readbyqxmd.com/read/30198918/the-role-of-centers-of-excellence-with-multidisciplinary-teams-in-the-management-of-abnormal-invasive-placenta
#11
Alireza A Shamshirsaz, Karin A Fox, Hadi Erfani, Michael A Belfort
Abnormal invasive placenta (AIP) causes significant maternal and perinatal morbidity and mortality. With the increasing incidence of cesarean delivery, this condition is dramatically more common in the last 20 years. Advances in grayscale and Doppler ultrasound have facilitated prenatal diagnosis of abnormal placentation to allow the development of multidisciplinary management plans. Outcomes are improved when delivery is accomplished in centers with multidisciplinary expertise and experience in the care of AIP...
September 6, 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30193384/clinical-diagnosis-of-placenta-accreta-and-clinicopathological-outcomes
#12
Joshua I Rosenbloom, Jonathan S Hirshberg, Molly J Stout, Alison G Cahill, George A Macones, Methodius G Tuuli
OBJECTIVE:  To investigate the association between the intraoperative diagnosis of placenta accreta at the time of cesarean hysterectomy and pathological diagnosis. STUDY DESIGN:  This is a retrospective cohort study of all patients undergoing cesarean hysterectomy for suspected placenta accreta from 2000 to 2016 at Barnes-Jewish Hospital. The primary outcome was the presence of invasive placentation on the pathology report. We estimated predictive characteristics of clinical diagnosis of placenta accreta using pathological diagnosis as the correct diagnosis...
September 7, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/30187503/unexpected-finding-of-uniparental-disomy-mosaicism-in-term-placentas-is-it-a-common-feature-in-trisomic-placentas
#13
Diane Van Opstal, Karin E M Diderich, Marieke Joosten, Lutgarde C P Govaerts, Joke Polak, Marjan Boter, Jasper J Saris, Wai Yee Cheung, Stefanie van Veen, Robert van de Helm, Attie T J I Go, Maarten F C M Knapen, Dimitri N M Papatsonis, Anneke Dijkman, Femke de Vries, Robert-Jan H Galjaard, Lies H Hoefsloot, Malgorzata I Srebniak
OBJECTIVE: Non-invasive prenatal testing (NIPT) detects placental chromosome aberrations. When amniocentesis reveals a normal karyotype, confined placental mosaicism (CPM) may be assumed. In order to confirm this, placental cytogenetic studies were performed. METHOD: NIPT was conducted in the course of the Dutch TRIDENT study. Placentas of 10 cases with NIPT results indicating an autosomal trisomy and showing a normal (N = 9) or low mosaic karyotype (N = 1) in amniotic fluid (AF) were investigated...
September 6, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/30150055/diagnostic-accuracy-of-magnetic-resonance-imaging-in-assessing-placental-adhesion-disorder-in-patients-with-placenta-previa-correlation-with-histological-findings
#14
S Maurea, V Romeo, P P Mainenti, M I Ginocchio, G Frauenfelder, F Verde, R Liuzzi, M D'Armiento, L Sarno, M Morlando, M Petretta, P Martinelli, A Brunetti
OBJECTIVE: To evaluate MRI accuracy in assessing placental adhesion disorders (PAD) in patients with placenta previa correlating imaging results with histological findings. MATERIALS AND METHODS: Sixty-one patients who underwent abdomino-pelvic magnetic resonance imaging (MRI) for ultrasound suspicion of PAD were prospectively evaluated. T1- and T2-weighted images, with and without fat suppression, were obtained in the three conventional planes using a 1.5 T MRI scanner...
September 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/30126531/long-non-coding-rna-hox-transcript-antisense-rna-hotair-suppresses-the-angiogenesis-of-human-placentation-by-inhibiting-vascular-endothelial-growth-factor-a-expression
#15
Kejia Wu, Fulin Liu, Wanrong Wu, Yurou Chen, Hanshu Wu, Wei Zhang
HOX transcript antisense RNA (HOTAIR) is a long non-coding RNA located within the Homeobox C (HOXC) gene cluster on chromosome 12. Previous studies have revealed that HOTAIR is overexpressed in many types of cancers and is associated with metastasis and poor survival rates; however, few reports have mentioned the relationship between HOTAIR and angiogenesis of the human placenta. The aim of the present study was to investigate the correlation between HOTAIR and vascular endothelial growth factor (VEGF) A in the human placenta...
August 21, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/30122078/ultrasound-predictors-of-candidates-for-segmental-resection-in-pregnants-with-placenta-accreta
#16
Evrim Bostancı, Cetin Kılıccı, Enis Özkaya, Cigdem Abide Yayla, Ezgi Darıcı, Gamze Berkel, Mustafa Eroglu, Canan Kabaca Kocakusak
OBJECTIVE: We aimed to assess the predictive values of individual sonographic findings of abnormal placentation to determine the candidates for segmental resection Study design: This was a retrospective review of 43 pregnancies with at least one prior cesarean delivery who received an ultrasound diagnosis of placenta previa or low-lying placenta with suspected abnormal placentation in the third trimester at our institution from 2015 through 2017. Sonographic images were reviewed by an investigator blinded to pregnancy outcome...
September 19, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30078346/regulatory-effect-of-mir-195-in-the-placental-dysfunction-of-preeclampsia
#17
Tuba Gunel, Nilufer Kamali, Mohammad K Hosseini, Ece Gumusoglu, Ali Benian, Kilic Aydinli
PURPOSE: Preeclampsia (PE) is a pregnancy specific disease soon after 20 weeks of gestation where major symptoms are hypertension and proteinuria. The underlying pathology is believed to be abnormal placentation. Epigenetic and genetic factors have significant roles in abnormal placental development. MicroRNA's (miRNAs), being one of the most important epigenetic regulators, take part in abnormal placentation. Hsa-miR-195 is a molecule associated with abnormal placental growth mechanisms such as impaired cellular proliferation, inadequate trophoblastic invasion causing defective spiral artery remodeling and apoptosis...
August 5, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30057649/placenta-accreta-spectrum-a-review-of-pathology-molecular-biology-and-biomarkers
#18
REVIEW
Helena C Bartels, James D Postle, Paul Downey, Donal J Brennan
Background . Placenta accreta spectrum (PAS) is a condition of abnormal placental invasion encompassing placenta accreta, increta, and percreta and is a major cause of severe maternal morbidity and mortality. The diagnosis of a PAS is made on the basis of histopathologic examination and characterised by an absence of decidua and chorionic villi are seen to directly adjacent to myometrial fibres. The underlying molecular biology of PAS is a complex process that requires further research; for ease, we have divided these processes into angiogenesis, proliferation, and inflammation/invasion...
2018: Disease Markers
https://www.readbyqxmd.com/read/30048504/increased-incidence-of-respiratory-distress-syndrome-in-neonates-of-mothers-with-abnormally-invasive-placentation
#19
Nicole T Spillane, Stacy Zamudio, Jesus Alvarez-Perez, Tracy Andrews, Themba Nyirenda, Manuel Alvarez, Abdulla Al-Khan
BACKGROUND: The incidence of abnormally invasive placentation (AIP) is increasing. Most of these pregnancies are delivered preterm. We sought to characterize neonatal outcomes in AIP pregnancies. METHODS: In this retrospective case-control study (2006-2015), AIP neonates (n = 108) were matched to two controls each for gestational age, antenatal glucocorticoid exposure, sex, plurity, and delivery mode. Medical records were reviewed for neonatal and maternal characteristics/outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/30031727/amyloid-precursor-protein-overexpression-in-down-syndrome-trophoblast-reduces-cell-invasiveness-and-interferes-with-syncytialization
#20
Oscar G W Wong, Claire L Y Cheung, Philip P C Ip, Hextan Y S Ngan, Annie N Y Cheung
The placentas of Down syndrome (DS) pregnancies exhibit morphologic and functional abnormalities. Although the increase in dosage of certain genes on chromosome 21 has been associated with the DS phenotype, the effects on placenta have seldom been studied. Herein, we examine the expression of four dosage-sensitive genes (APP, ETS2, SOD1, and HMGN1) in normal and DS placentas. We demonstrated significant overexpression of amyloid precursor protein (APP) in DS placentas at RNA and protein levels by real-time quantitative PCR, Western blot analysis, and immunohistochemistry...
October 2018: American Journal of Pathology
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