Read by QxMD icon Read

Abnormal invasion of the placenta

Levin Gabriel, Rottenstreich Amihai, Benshushan Avi, Dior Uri, Shveiky David, Shushan Asher, Elchalal Uriel
OBJECTIVE: While surgical management is the treatment of choice for abnormally invasive placenta, the role of supracervical hysterectomy in this setting is not well established. We aimed to compare supracervical versus total cesarean hysterectomy as a surgical option for abnormally invasive placenta. METHODS: We carried out a 8-year retrospective case-control study. Six cases of patient treated by total hysterectomy were matched and compared to 30 controls treated by supracervical hysterectomy...
November 28, 2018: Journal of Maternal-fetal & Neonatal Medicine
Hüseyin Çağlayan Özcan, Mete Gurol Uğur, Seyhun Sucu, Özcan Balat
PURPOSE: This study described a new technique to minimize the bleeding resulted from aberrant engorged vessels and unintended bladder injury in cases with abnormally invaded placenta adjacent to posterior bladder wall at cesarean hysterectomy. METHODS: After filling the bladder with 300 ml saline aberrant engorged vessels were identified and skeletonized between lower uterine segment and bladder with blunt dissection by index finger down to the distal end point of cervix...
November 28, 2018: Journal of Maternal-fetal & Neonatal Medicine
Daniele Di Mascio, Giuseppe Calì, Francesco D'antonio
Placenta accreta spectrum (PAS) disorders is a multifactorial process that encompasses a heterogeneous group of conditions characterized by an abnormal invasion of trophoblastic tissue through the myometrium and uterine serosa. PAS is associated with a high burden of adverse maternal outcomes including severe life-threatening hemorrhage, need for blood transfusion, damage to adjacent organs, and death. Prenatal screening of PAS is mandatory so that women may be counselled about the severity of this condition to plan management with a multidisciplinary team and delivery in a specialized center...
November 27, 2018: Minerva Ginecologica
Kun-Long Huang, Ching-Chang Tsai, Hung-Chun Fu, Hsin-Hsin Cheng, Yun-Ju Lai, Hsuan-Ning Hung, Leo Leung-Chit Tsang, Te-Yao Hsu
OBJECTIVES: The purpose of this article is to investigate the estimated blood loss in pregnant women undergoing cesarean section and placental extirpation to treat abnormal placentation and compare the outcomes of those who underwent prophylactic transcatheter arterial embolization (TAE) with those who did not. METHODS: A retrospective study was conducted on 17 pregnant women diagnosed with abnormal placentation in 2001⁻2018 in a single tertiary center. The patients were diagnosed by surgical finding, ultrasound, or magnetic resonance imaging (MRI)...
November 21, 2018: Journal of Clinical Medicine
Sonia DaSilva-Arnold, Che-Ying Kuo, Viralkumar Davra, Yvonne Remache, Peter C W Kim, John P Fisher, Stacy Zamudio, Abdulla Al-Khan, Raymond B Birge, Nicholas P Illsley
STUDY QUESTION: Does the upregulation of the zinc finger E-box binding homeobox 2 (ZEB2) transcription factor in human trophoblast cells lead to alterations in gene expression consistent with an epithelial-mesenchymal transition (EMT) and a consequent increase in invasiveness? SUMMARY ANSWER: Overexpression of ZEB2 results in an epithelial-mesenchymal shift in gene expression accompanied by a substantial increase in invasive capacity of human trophoblast cells. WHAT IS KNOWN ALREADY: In-vivo results have shown that cytotrophoblast differentiation into extravillous trophoblast involves an epithelial-mesenchymal transition...
November 21, 2018: Molecular Human Reproduction
Shlomit Maymon, Ron Maymon, Jacob Bornstein, Josef Tovbin, Yaakov Melcer, Maya Frank Wolf
AIMS: To compare the maternal and newborn outcome between cases that underwent conservative surgery with uterine preservation (Group A) to cesarean hysterectomy (Group B). BACKGROUND: Placenta accreta defines abnormally adherent and invasive placentation into the myometrium and in some cases invades adjacent organs. In recent years the incidence of placenta accreta cases has risen due to the increasing prevalence of cesarean delivery. The clinical manifestation of placenta accreta might be life threatening maternal bleeding during the attempt to detach the placenta following delivery...
November 2018: Harefuah
Davide De Vita, Giampiero Capobianco, Giovanni Gerosolima, Carmen Sciorio, Ermenegilda Coppola, Fabio Parazzini, Maurizio Silvestri, Anna Paola Caruso, Maddalena Morlando, Raffaele Petta, Alessandro Pascarella, Salvatore Dessole, Elsa Viora
BACKGROUND/AIMS: Abnormally invasive placenta (AIP) includes placenta accreta, increta, and percreta and represents major complications of pregnancy. This study was designed to assess the role of ultrasonography in the identification of AIP among pregnant women with antepartum diagnosis of placenta previa. METHODS: A cross-sectional study was performed between May 2015 and April 2016 in 11 centers, including 242 women with antepartum diagnosis of placenta previa...
November 16, 2018: Gynecologic and Obstetric Investigation
Ahmed M Abbas
No abstract text is available yet for this article.
December 2018: Journal of Obstetrics and Gynaecology of India
A MacGibbon, Y M Ius
We present the case of a midtrimester intrauterine foetal demise (IUFD) in the context of abnormally invasive placentation. This was a grade 4 placenta previa with placenta increta in a patient requesting fertility conservation and was managed conservatively without immediate surgical intervention. The patient spontaneously delivered the fetus after 33 days, followed by a large obstetric haemorrhage requiring immediate laparotomy and hysterotomy. Her uterus was preserved and she went on to recover without further significant complication...
2018: Case Reports in Obstetrics and Gynecology
Bethany Hart, Elizabeth Morgan, Emilyn Alejandro
Fetal growth restriction is one of the most common obstetrical complications resulting in significant perinatal morbidity and mortality. The most frequent etiology of human singleton fetal growth restriction is placental insufficiency, which occurs secondary to reduced utero-placental perfusion, abnormal placentation, impaired trophoblast invasion and spiral artery remodeling, resulting in altered nutrient and oxygen transport. Two nutrient-sensing proteins involved in placental development and glucose and amino acid transport are mechanistic target of rapamycin (mTOR) and O-linked N-acetylglucosamine transferase (OGT), which are both regulated by availability of oxygen...
October 1, 2018: Journal of Molecular Endocrinology
Will Sargent, Sally L Collins
INTRODUCTION: The aim of this study was to investigate the planned place of delivery for women antenatally diagnosed with abnormally invasive placenta (AIP) in England and identify how many units regard themselves to be 'specialist centres' for the management of AIP. MATERIAL AND METHODS: Observational study of obstetric-led units in England. An anonymous survey sent to the delivery suite lead clinician in all 154 consultant-led units throughout England. The main outcome measures were whether each unit planned to manage AIP 'in-house', estimated number of AIP cases delivered in the previous five years and whether they considered themselves a 'specialist centre' for AIP management...
October 28, 2018: Acta Obstetricia et Gynecologica Scandinavica
Eliza M Berkley, Alfred Abuhamad
Placenta accreta spectrum (PAS) refers to an abnormally invasive implantation of the placenta into the uterine myometrium. The resultant risk is that of severe maternal hemorrhage and significant maternal morbidity and even mortality. The 2 strongest risk factors for the development of PAS are a history of a prior cesarean section and a placenta previa in the current pregnancy. Clinically, most patients are asymptomatic but some will present with vaginal bleeding and abdominal cramping. The goal of this article is to discuss the common clinical presentation and risk factors for placenta accreta spectrum, and to review in detail the ultrasound features/markers of PAS in each trimester...
December 2018: Clinical Obstetrics and Gynecology
Yunzhen Ye, Yao Tang, Yu Xiong, Liping Feng, Xiaotian Li
Preeclampsia leads to adverse outcomes for pregnant women. Bisphenol A (BPA) is an environmental endocrine disruptor and has been shown to be positively associated with increased risk of preeclampsia in human studies. We investigated whether BPA exposure causes preeclampsia-like features in pregnant mice and the associated underlying mechanisms. Experiments were performed in animal models and cell cultures. In pregnant mice, BPA-exposed mice exhibited preeclampsia-like features including hypertension, disruption of the circulation, and the placental angiogenesis biomarkers fms-related tyrosine kinase 1 and placenta growth factor, and glomerular atrophy; urinary protein was not affected...
October 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Eric Jauniaux, Graham J Burton
Current findings continue to support the concept of a biologically defective decidua rather than a primarily abnormally invasive trophoblast. Prior cesarean sections increase the risk of placenta previa and both adherent and invasive placenta accreta, suggesting that the endometrial/decidual defect following the iatrogenic creation of a uterine myometrium scar has an adverse effect on early implantation. Preferential attachment of the blastocyst to scar tissue facilitates abnormally deep invasion of trophoblastic cells and interactions with the radial and arcuate arteries...
December 2018: Clinical Obstetrics and Gynecology
Kristina Martimucci, Robyn Bilinski, Anisha M Perez, Theresa Kuhn, Abdulla Al-Khan, Jesus R Alvarez-Perez
INTRODUCTION: The presence of a previous uterine scar is a strong risk factor for developing abnormally invasive placentation (AIP). We sought to determine whether a short interpregnancy interval predisposes to AIP. We hypothesized that a short interpregnancy interval after a previous cesarean delivery increases the risk of AIP in comparison with a longer interpregnancy interval. MATERIAL AND METHODS: We performed a retrospective cohort study of women with a histological diagnosis of AIP and a history of a previous cesarean section...
October 4, 2018: Acta Obstetricia et Gynecologica Scandinavica
Narmada Lavu, Lauren Richardson, Elizabeth Bonney, Ramkumar Menon
INTRODUCTION: Human reproduction is a multifaceted process reliant on proper blastocyst implantation, placental and fetal membrane development, and delivery of a healthy baby. Multiple factors and pathways have been reported as critical machineries for cell differentiation and survival during pregnancy, and most of them involve glycogen synthase kinase (GSK) 3α/β for cell differentiation and survival and for maintaining cellular homeostasis. Several reports on GSK3's functional role exist; however, the specific role of GSK3 in reproductive tissues and its contribution to normal or abnormal parturition are still unclear...
October 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
Seher Basaran, Recep Has, Ibrahim Halil Kalelioglu, Birsen Karaman, Melike Kirgiz, Tahir Dehgan, Bilge Nihan Satkin, Tugba Sarac Sivrikoz, Atil Yuksel
PURPOSE:  To determine the true- and false-positive rates of cf-DNA testing in a cohort of patients from tertiary care centers and assess the impact of ultrasound examinations in pregnancy management. MATERIALS AND METHODS:  Clinical, cytogenetic and ultrasound data of 101 consecutive fetuses were collected retrospectively. Cases were classified into five groups according to the ultrasound findings. Karyotyping, interphase FISH and microarray techniques were used for follow-up studies...
September 25, 2018: Ultraschall in der Medizin
Rozi Aditya Aryananda, Aldika Akbar, Manggala Pasca Wardhana, Khanisyah Erza Gumilar, Budi Wicaksono, Ernawati Ernawati, Agus Sulistyono, Aditiawarman Aditiawarman, Hermanto Tri Joewono, Erry Gumilar Dachlan, Anupam Parange, Gustaaf Albert Dekker
OBJECTIVE: This study aimed to determine the role of three-dimensional (3D)/four-dimensional (4D) volume rendering ultrasound (VRU) in the diagnosis of abnormally invasive placenta (AIP). MATERIALS AND METHODS: Twelve consecutive patients strongly suspected of having AIP on the basis of conventional ultrasound (US) and clinical history performed between September 2016 and December 2016 in the main tertiary referral hospital in Surabaya, East Java were included in this prospective observational study...
September 23, 2018: Journal of Clinical Ultrasound: JCU
Sanaa Choufani, Andrei L Turinsky, Nir Melamed, Ellen Greenblatt, Michael Brudno, Anick Bérard, William D Fraser, Rosanna Weksberg, Jacquetta Trasler, Patricia Monnier, For The D Cohort Study Group
Children conceived using Assisted Reproductive Technologies (ART) have a higher incidence of growth and birth defects, attributable in part to epigenetic perturbations. Both ART and germline defects associated with parental infertility could interfere with epigenetic reprogramming events in germ cells or early embryos. Mouse models indicate that the placenta is more susceptible to the induction of epigenetic abnormalities than the embryo, and thus the placental methylome may provide a sensitive indicator of 'at risk' conceptuses...
September 19, 2018: Human Molecular Genetics
Arianna Laoreti, Basky Thilaganathan, Andrea Kaelin Agten, Aris Papageorghiou, Asma Khalil, James Uprichard, Edwin Chandraharan, Amarnath Bhide
No abstract text is available yet for this article.
September 15, 2018: Acta Obstetricia et Gynecologica Scandinavica
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"