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Behnaz Taheri, Masoud Soleimani, Sedigheh Fekri Aval, Elaheh Esmaeili, Zahra Bazi, Nosratollah Zarghami
In recent years, induced pluripotent stem cells (iPSCs) have been considered as a promising approach in the field of regenerative medicine. iPSCs can be generated from patients' somatic cells and possess the potential to differentiate, under proper conditions, into any cell type. However, the clinical application of iPS cells is restricted because of their tumorigenic potential. Recent studies have indicated that stem cells exert their therapeutic benefit via a paracrine mechanism, and extracellular vesicles have been demonstrated that play a critical role in this paracrine mechanism...
November 27, 2018: Journal of Cellular Physiology
F Heitz, P Harter, E Åvall-Lundqvist, A Reuss, P Pautier, G Cormio, N Colombo, A Reinthaller, I Vergote, A Poveda, P B Ottevanger, L C Hanker, A Leminen, J Alexandre, U Canzler, J Sehouli, J Herrstedt, B Fiane, M Merger, A du Bois
OBJECTIVE: Surgical assessment of residual tumor provides the strongest prognostic information in advanced ovarian cancer (AOC), with the best outcome observed after complete resection. Postoperative radiological assessment before initiation of chemotherapy can supplement the information obtained by surgical assessment; however, it may also reveal conflicting findings. METHODS: Patients with AOC enrolled in the AGO-OVAR 12 trial underwent baseline imaging before the first chemotherapy cycle...
November 19, 2018: Gynecologic Oncology
Simone Beretta, Anna Coppo, Elisa Bianchi, Clara Zanchi, Davide Carone, Andrea Stabile, Giada Padovano, Endrit Sulmina, Alice Grassi, Graziella Bogliun, Giuseppe Foti, Carlo Ferrarese, Antonio Pesenti, Ettore Beghi, Leonello Avalli
OBJECTIVE: To investigate neurologic outcome of patients with cardiac arrest with refractory status epilepticus (RSE) treated with a standardized aggressive protocol with antiepileptic drugs and anesthetics compared to patients with other EEG patterns. METHODS: In the prospective cohort study, 166 consecutive patients with cardiac arrest in coma were stratified according to 4 independent EEG patterns (benign, RSE, generalized periodic discharges [GPDs], malignant nonepileptiform) and multimodal prognostic indicators...
December 4, 2018: Neurology
Karin Åvall, Per-Olof Berggren, Lisa Juntti-Berggren
Serum levels of the pro-inflammatory apolipoprotein CIII (apoCIII) are increased in type-1 diabetic (T1D) patients and when β-cells are exposed to apoCIII they undergo apoptosis, which can be prevented by an antibody against apoCIII. We have previously investigated the BB rat, an animal model that develops a human-like T1D at the age of around 60 days, and found that apoCIII was also increased in sera from pre-diabetic rats and this promoted β-cell death. Lowering apoCIII with an oligonucleotide antisense during a phase of the pre-diabetic period prolonged the time to onset of T1D...
September 2018: Laboratory Animal Research
Sahar Salehi, Yvonne Brandberg, Elisabeth Åvall-Lundqvist, Chikako Suzuki, Hemming Johansson, Berit Legerstam, Henrik Falconer
PURPOSE: The health-related quality of life (HRQoL) outcomes after comprehensive surgical staging including infrarenal paraaortic lymphadenectomy in women with high-risk endometrial cancer (EC) are unknown. Our aim was to investigate the long-term HRQoL between robot-assisted laparoscopic surgery (RALS) and laparotomy (LT). PATIENTS AND METHODS: A total of 120 women with high-risk stage I-II EC were randomised to RALS or LT for hysterectomy, bilateral salpingoophorectomy, pelvic and infrarenal paraaortic lymphadenectomy in the previously reported Robot-Assisted Surgery for High-Risk Endometrial Cancer trial...
October 5, 2018: Acta Oncologica
Farzane Ordoni Aval, Shaghayegh Askarian Amiri, Abbas Azadmehr, Morteza Oladnabi, Payam Saadat, Hadi Ebrahimi, Behzad Baradaran, Behzad Mansoori, Fereshteh Pourabdolhossein, Pedram Torabian, Mahmoud Hajiahmadi
Objective: Glioblastoma (GBM) is the most malignant and aggressive type of glioma, associated with a high rate of mortality. The transforming growth factor-β receptor II (TGFβ RII) is involved in glioma initiation and progression. On the other hand, TGFβ RII silencing is critical to the inhibition of GBM. Therefore, we aimed to determine the effects of specific TGFβ RII siRNA on the survival of U-373MG cells. Methods: TGFβ RII siRNA was transfected, and qRT-PCR was performed to examine TGFβ RII mRNA expression...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Mojtaba Aghaeepoor, Ali Akbarzadeh, Sako Mirzaie, Asieh Hadian, Sanaz Jamshidi Aval, Ehsan Dehnavi
Type II l‑asparaginase (l‑ASNase) is an FDA approved enzyme drug with extensive applications for treatment of certain blood cancers. However, the therapeutic efficiency of this enzyme is hampered by its undesirable glutaminase activity. Given the pivotal role of this enzyme against cancer, designing engineered mutants with diminished glutaminase activity would be of great therapeutic interest. To this end, N248S mutation was selected as the potential mutation with beneficial effects. Various in silico analyses including MD simulation, molecular docking and QMMM studies were performed to assess the effects of N248S mutation on the activity of the enzyme...
December 2018: International Journal of Biological Macromolecules
Maryam Hassanzadeh-Bashtian, Talat Khadivzadeh, Shapour Badiee-Aval, Habibollah Esmaily
Background: Women, who are in a critical situation like infertility, are more prone to depression, anxiety, and low self-esteem than other people. The aim of this study was to explore the deep experience of anxiety in infertile women who received acupressure during in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Materials and Methods: This qualitative, conventional content analysis study was performed on 14 infertile female participants in the Milad IVF Center in Mashhad, Iran, from September 2015 to August 2016...
September 2018: Iranian Journal of Nursing and Midwifery Research
Fatemeh Memari, Zeinab Joneidi, Behnaz Taheri, Sedigheh Fekri Aval, Amir Roointan, Nosratollah Zarghami
Epigenetic variations can play remarkable roles in different normal and abnormal situations. Such variations have been shown to have a direct role in the pathogenesis of various diseases either through inhibition of tumor suppressor genes or increasing the expression of oncogenes. Enzymes involving in epigenetic machinery are the main actors in tuning the epigenetic-based controls on gene expressions. Aberrant expression of these enzymes can trigger a big chaos in the cellular gene expression networks and finally lead to cancer progression...
October 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Simone Beretta, Giada Padovano, Andrea Stabile, Anna Coppo, Graziella Bogliun, Leonello Avalli, Carlo Ferrarese
Refractory nonconvulsive status epilepticus (NCSE) occurs in 10%-30% of patients following resuscitation after cardiac arrest. Both the optimal treatment and prognosis of postanoxic status epilepticus remain uncertain. We analyzed acute electroencephalographic changes, neurological outcome at 3 months, and adverse effects in consecutive postanoxic patients with super-refractory NCSE treated with add-on oral loading of perampanel. Eight postanoxic patients with super-refractory NCSE were treated with perampanel (dose range = 6-12 mg)...
October 2018: Epilepsia
Behnaz Taheri, Masoud Soleimani, Sedigheh Fekri Aval, Fatemeh Memari, Nosratollah Zarghami
The interaction between glioma cells and the surrounding microenvironment plays a key role in tumor invasion and infiltration ability. Recent studies reported the importance of glioma-derived microvesicles in the interaction of the tumor and the surrounding environment. The purpose of this study was to scrutinize the role of glioma-derived microvesicles in the interaction between tumor and normal astrocytes, which are the most abundant non-neoplastic cells in the tumor microenvironment (TME). To this end, we examined the effect of C6 tumor cell-derived microvesicles in the activation of normal rat astrocytes...
August 25, 2018: Neuroscience Letters
Maryam Hassanzadeh Bashtian, Talat Khadivzadeh, Shapour Badiee Aval, Habibollah Esmaily
CONTEXT: Infertility is one of the major stressful events in individual life, especially women. Self-efficacy means a person can perceive a potentially threatening and stressful situation as being amenable to influences of personal control. AIMS: This study was conducted to determine the acupressure effects on self-efficacy and pregnancy rate in infertile women under in vitro fertilization (IVF)/intracytoplasmic sperm injection treatment. SETTINGS AND DESIGN: This study was a randomized controlled trial in infertile women...
2018: Journal of Education and Health Promotion
Hamidreza Baghani Aval, Zeinab Ameli, Mojtaba Ameli
INTRODUCTION: Acute urinary retention is one of the most significant complications of benign prostatic hyperplasia. Until now, standard treatments include catheterization and use of α-blockers. Tadalafil has been recently seen to also play a role in the treatment of urinary symptoms caused by benign prostatic hyperplasia. The aim of this study was to survey the addition of tadalafil to tamsulosin in the treatment of acute urinary retention in patients with benign prostatic hyperplasia...
May 2018: Urologia
David Cibula, Richard Pötter, François Planchamp, Elisabeth Avall-Lundqvist, Daniela Fischerova, Christine Haie-Meder, Christhardt Köhler, Fabio Landoni, Sigurd Lax, Jacob Christian Lindegaard, Umesh Mahantshetty, Patrice Mathevet, W Glenn McCluggage, Mary McCormack, Raj Naik, Remi Nout, Sandro Pignata, Jordi Ponce, Denis Querleu, Francesco Raspagliesi, Alexandros Rodolakis, Karl Tamussino, Pauline Wimberger, Maria Rosaria Raspollini
Regrettably, the author metadata used for the previous correction (doi: ) contained an error in the tagging of W. Glenn McCluggage's name; this has been corrected. No further adjustments have been made to the Correction, or the original Guideline paper (doi: ).
July 25, 2018: Virchows Archiv: An International Journal of Pathology
Fereydoon Sargolzaei Aval, Mohammad Reza Arab, Narjes Sargolzaei, Fateme Noushadi, Abdolsamad Eteghadi, Asadollah Keykhaei, Foroug Sargolzaei Aval, Azim Hedayat Pour
Objectives: The healing of bone defects in the craniofacial region is an important clinical issue. We aimed to compare the effects of octacalcium phosphate (OCP) and the combination of OCP/gelatin (OCP/Gel) on calvarial bone regeneration in rats. Materials and Methods: In this study, 72 male Sprague Dawley rats were randomly assigned to the OCP (n=24), OCP/Gel (n=24), and control groups (n=24). Lesions with a diameter of 9 mm were created in the parietal bone and were filled with 9-mg OCP and OCP/Gel disks...
March 2018: Journal of Dentistry of Tehran University of Medical Sciences
Lukas Dostalek, Elisabeth Åvall-Lundqvist, Carien L Creutzberg, Dina Kurdiani, Jordi Ponce, Iva Dostalkova, David Cibula
OBJECTIVE: The aim of this survey was to acquire an overview of the current management of cervical cancer with an emphasis on the early disease stages. MATERIALS AND METHODS: A hyperlink to the survey was sent to the European Society of Gynaecological Oncology Office database. The survey contained 6 groups of questions regarding the characteristics of respondents, pretreatment workup, management of the early stages of cervical cancer, adjuvant treatment, fertility-sparing treatment, and surveillance...
July 2018: International Journal of Gynecological Cancer
Katrine Fuglsang, Ingfrid S Haldorsen, Elisabeth Avall-Lundqvist, Gabriel Lindahl, Henrik Roed, Kathrine Woie, Päivi Pakarinen, Asgeir Thoroddsen, Maarit Anttila, Jan Blaakaer
INTRODUCTION: Women with cervical cancer in the Nordic countries are increasingly undergoing pretreatment imaging by ultrasound, magnetic resonance imaging (MRI), positron emission tomography-computed tomography (PET-CT) or computed tomography, or sentinel lymph node procedure. The present survey reports the influence of pretreatment imaging findings on the recorded clinical International Federation of Gynecology and Obstetrics (FIGO) stage in Nordic countries and its impact on treatment planning and preferred surgical approach in cervical cancer...
October 2018: Acta Obstetricia et Gynecologica Scandinavica
David Cibula, Richard Pötter, François Planchamp, Elisabeth Avall-Lundqvist, Daniela Fischerova, Christine Haie-Meder, Christhardt Köhler, Fabio Landoni, Sigurd Lax, Jacob Christian Lindegaard, Umesh Mahantshetty, Patrice Mathevet, W Glenn McCluggage, Mary McCormack, Raj Naik, Remi Nout, Sandro Pignata, Jordi Ponce, Denis Querleu, Francesco Raspagliesi, Alexandros Rodolakis, Karl Tamussino, Pauline Wimberger, Maria Rosaria Raspollini
Two corrections were made to the above publication following its original online publication on 4th May 2018.
June 2018: Virchows Archiv: An International Journal of Pathology
Ghobad Behzadi Pour, Leila Fekri Aval, Shahnaz Eslami
Background: Hydrogen sensors are micro/nano-structure that are used to locate hydrogen leaks. They are considered to have fast response/recovery time and long lifetime as compared to conventional gas sensors. In this paper, fabrication of sensitive capacitive-type hydrogen gas sensor based on Ni thin film has been investigated. The C-V curves of the sensor in different hydrogen concentrations have been reported. Method: Dry oxidation was done in thermal chemical vapor deposition furnace (TCVD)...
April 2018: Current Nanoscience
Mohammad Vahedian-Shahroodi, Hadi Tehrani, Faeze Mohammadi, Mahdi Gholian-Aval, Nooshin Peyman
INTRODUCTION: One of the most important ways to prevent work-related diseases in occupations such as mining is to promote healthy behaviors among miners. This study aimed to predict and promote healthy behaviors among coal miners by using a health action model (HAM). METHOD: The study was conducted on 200 coal miners in Iran in two steps. In the first step, a descriptive study was implemented to determine predictive constructs and effectiveness of HAM on behavioral intention...
May 1, 2018: Global Health Promotion
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