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https://www.readbyqxmd.com/read/30091146/vitamin-a-and-beta-%C3%AE-carotene-supplementation-for-cystic-fibrosis
#1
REVIEW
Jorrit Jv de Vries, Anne B Chang, Catherine M Bonifant, Elizabeth Shevill, Julie M Marchant
BACKGROUND: People with cystic fibrosis (CF) and pancreatic insufficiency are at risk of a deficiency in fat-soluble vitamins, including vitamin A. Vitamin A deficiency predominantly causes eye and skin problems, while excessive levels of vitamin A can harm the respiratory and skeletal systems in children and interfere with the metabolism of other fat-soluble vitamins. Most CF centres administer vitamin A as supplements to reduce the frequency of vitamin A deficiency in people with CF and to improve clinical outcomes such as growth, although the recommended dose varies between different guidelines...
August 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29952422/cystic-pancreatic-neuroendocrine-tumours-a-gastroenterologist-s-point-of-view
#2
Krzysztof Dąbkowski, Beata Kos-Kudła, Elżbieta Andrysiak-Mamos, Anhelli Syrenicz, Joanna Pilch-Kowalczyk, Teresa Starzyńska
Cystic pancreatic tumors are detected with increasing frequency and remain a clinical problem. Since they have different potential of malignancy the management and decision making process is a hard task. Guidelines, concerning pancreatic cystic tumors indicate the management with mucinous, serous cystic pancreatic neoplasms and solid pseudopappilary tumor, while the management with pancreatic cystic neuroendocrine tumors is not included into these standards. This review tries to answer the question are the cystic pancreatic neuroendocrine tumors different entity from solid tumors of neuroendocrine origin...
2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29947440/pancreatic-cysts-is-the-answer-on-the-wall
#3
EDITORIAL
Yousuke Nakai, Kazuhiko Koike
Pancreatic cystic lesions (PCLs) are increasingly diagnosed with the advent of cross-sectional imaging and its incidence was as high as 13.7% on MRI in asymptomatic individuals, which increased with age or obesity [1]. Most of those asymptomatic PCLs are not malignant at the time of diagnosis but require surveillance, which can pose physical and psychological burden to those individuals under surveillance as well as the burden of medical costs. Although several guidelines for management of PCLs have been published, they are not necessarily evidence-based...
June 27, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29912020/to-resect-or-not-to-resect-a-review-of-pancreatic-cyst-disease-management
#4
Jon M Harrison, Carlos Fernandez-Del Castillo
PURPOSE OF REVIEW: With recent advances in radiographic testing, there have been increases in the incidental identification of pancreatic cysts. Determining management, specifically, which cysts can be watched versus intervened upon has significant impact on at the patient-physician level as well as globally on resource allocation and healthcare expenditures. This review focuses on the three main guidelines (Fukuoka guidelines, European consensus, and American Gastroenterological Association recommendations) for management of pancreatic cystic disease after incidental identification...
September 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29886564/managing-incidental-pancreatic-cysts
#5
REVIEW
Jennifer Phan, V Raman Muthusamy
PURPOSE OF REVIEW: The goal of this review is to critically analyze the current literature regarding the management of incidental pancreatic cysts. Given their increased rates of detection due to the frequent use of cross-sectional imaging, correctly identifying the subset of high risk lesions that are appropriate for surgical resection is critical. However, the existing consensus and societal guidelines discussed in this review lack high quality data to create evidence-based recommendations, making achieving this important aim challenging...
June 9, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29778250/surgical-management-of-intraductal-papillary-mucinous-neoplasm-with-main-duct-involvement-an-international-expert-survey-and-case-vignette-study
#6
Lianne Scholten, Nadine C M van Huijgevoort, Marco J Bruno, Carlos Fernandez-Del Castillo, Sohei Satoi, Alain Sauvanet, Christopher Wolfgang, Paul Fockens, Suresh T Chari, Marco Del Chiaro, Jeanin E van Hooft, Marc G Besselink
BACKGROUND: The risk of invasive cancer in resected intraductal papillary mucinous neoplasm with main pancreatic duct involvement is 33%-60%. Most guidelines, therefore, advise resection of main duct intraductal papillary mucinous neoplasm and mixed type intraductal papillary mucinous neoplasm in surgically fit patients, although advice on the surgical strategy (partial or total pancreatectomy) differs. We performed a survey amongst international experts to guide the design of future studies and help to prepare for a single international set of guidelines...
May 16, 2018: Surgery
https://www.readbyqxmd.com/read/29667626/eus-fna-in-cystic-pancreatic-lesions-where-are-we-now-and-where-are-we-headed-in-the-future
#7
REVIEW
Jose Lariño-Noia, Julio Iglesias-Garcia, Daniel de la Iglesia-Garcia, J Enrique Dominguez-Muñoz
EUS-FNA is often performed in the evaluation of Cystic Pancreatic Lesions (CPL) for a better preoperative characterization. The objective is to identify premalignant lesions as Mucinous Cystic Neoplasms, and/or a malignant transformation of them (adenocarcinoma). The role of cytological evaluation in this setting is discouraging and intracystic markers analysis, mainly CEA, lacks of a good specificity for the detection of mucinous neoplasms. New devices and approaches have emerged to overcome these problems as the cytology brush (Echobrush), the small mini-biopsy foceps, the cystoscopy and the needle Confocal LASER Endomicroscopy (nCLE), showing in some studies good rates of accuracy for distinguishing among mucinosus and non-mucinous neoplasms...
March 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29589102/dilemmas-for-the-pathologist-in-the-oncologic-assessment-of-pancreatoduodenectomy-specimens-an-overview-of-different-grossing-approaches-and-the-relevance-of-the-histopathological-characteristics-in-the-oncologic-assessment-of-pancreatoduodenectomy-specimens
#8
REVIEW
Eline Soer, Lodewijk Brosens, Marc van de Vijver, Frederike Dijk, Marie-Louise van Velthuysen, Arantza Farina-Sarasqueta, Hans Morreau, Johan Offerhaus, Lianne Koens, Joanne Verheij
A pancreatoduodenectomy specimen is complex, and there is much debate on how it is best approached by the pathologist. In this review, we provide an overview of topics relevant for current clinical practice in terms of gross dissection, and macro- and microscopic assessment of the pancreatoduodenectomy specimen with a suspicion of suspected pancreatic cancer. Tumor origin, tumor size, degree of differentiation, lymph node status, and resection margin status are universally accepted as prognostic for survival...
April 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29574408/european-evidence-based-guidelines-on-pancreatic-cystic-neoplasms
#9
(no author information available yet)
Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology)...
May 2018: Gut
https://www.readbyqxmd.com/read/29443760/resection-of-benign-side-branch-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-is-long-term-follow-up-indicated-a-case-report-and-review-of-the-literature
#10
Stefan Fritz, Regina Küper-Steffen, Katharina Feilhauer, Christoph M Sommer, Götz M Richter, René Hennig, Jörg Köninger
RATIONALE: Intraductal papillary mucinous neoplasms of the pancreas (IPMNs) are benign cystic tumors with a relevant risk of malignant transformation over time. Currently, follow-up after surgical resection of benign IPMNs remains controversial. PATIENT CONCERNS: This is a case report of a 68-year-old male who underwent pancreatic head resection for a multicystic side-branch IPMN with low-grade epithelial dysplasia in March 2009 at the Katharinenhospital Stuttgart, Germany...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29404638/current-concepts-in-molecular-genetics-and-management-guidelines-for-pancreatic-cystic-neoplasms-an-essential-update-for-radiologists
#11
REVIEW
Matthew Kulzer, Aatur D Singhi, Alessandro Furlan, Matthew T Heller, Venkata S Katabathina, Kevin M Mcgrath, Herbert J Zeh, Amer Zureikat, Anil K Dasyam
Cystic neoplasms in the pancreas are encountered frequently on imaging, often detected incidentally during evaluation for other conditions. They can have a variety of clinical and imaging presentations, and similarly, wide-ranging prognostic and treatment implications. In the majority, imaging helps in diagnosis of pancreatic cystic neoplasms (PCNs) and guides management decisions. But, a significant minority of the PCNs remain indeterminate. There have been multiple recent advances in biomarkers and molecular genetics which will likely prove helpful in risk stratification of PCNs...
February 5, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29358860/prevalence-and-outcomes-of-pancreatic-cystic-neoplasms-in-liver-transplant-recipients
#12
Ken Liu, Vikram Joshi, Louise van Camp, Qi-Wei Yang, Judith E Baars, Simone I Strasser, Geoffrey W McCaughan, Avik Majumdar, Payal Saxena, Arthur J Kaffes
AIM: To determine the prevalence, characteristics and clinical course of pancreatic cystic neoplasms (PCNs) in liver transplantation (LT) recipients. METHODS: We retrospectively studied consecutive patients who underwent LT between January 1998 to April 2016. Clinical and laboratory data were obtained from patient medical records. Imaging findings on computed tomography and magnetic resonance cholangiopancreatography were reviewed by two radiologists. RESULTS: During the study period, 872 patients underwent cadaveric LT...
December 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29344522/intraductal-papillary-mucinous-neoplasms-of-the-pancreas-strategic-considerations
#13
Vicente Morales-Oyarvide, Zhi Ven Fong, Carlos Fernández-Del Castillo, Andrew L Warshaw
Intraductal papillary mucinous neoplasms (IPMN) are cystic neoplasms with the potential for progression to pancreatic cancer. Recognized by the global medical community just over two decades ago, IPMN have gained great epidemiological and clinical relevance thanks to the widespread use of cross-sectional abdominal imaging, which has led to a surge in the number of incidental pancreatic cysts being diagnosed. As our understanding of this disease has improved, we now know that some IPMN have a very elevated risk of cancer and require surgical resection, while others are low-risk lesions and can be followed...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29299757/benign-tumors-of-the-pancreas-radical-surgery-versus-parenchyma-sparing-local-resection-the-challenge-facing-surgeons
#14
EDITORIAL
Hans G Beger
Pancreaticoduodenectomy and left-sided pancreatectomy are the surgical treatment standards for tumors of the pancreas. Surgeons, who are requested to treat patients with benign tumors, using standard oncological resections, face the challenge of sacrificing pancreatic and extra-pancreatic tissue. Tumor enucleation, pancreatic middle segment resection and local, duodenum-preserving pancreatic head resections are surgical procedures increasingly used as alternative treatment modalities compared to classical pancreatic resections...
March 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29288277/new-guidelines-for-use-of-endoscopic-ultrasound-for-evaluation-and-risk-stratification-of-pancreatic-cystic-lesions-may-be-too-conservative
#15
Nadav Sahar, Anthony Razzak, Zaheer S Kanji, David L Coy, Richard Kozarek, Andrew S Ross, Michael Gluck, Michael Larsen, Shayan Irani, S Ian Gan
BACKGROUND: The role of EUS in managing asymptomatic pancreatic cystic lesions (PCLs) remains unresolved. We retrospectively evaluated EUS in risk stratification of PCLs when adhering to the most recent AGA guidelines. METHODS: Asymptomatic PCLs that were evaluated by EUS from January 2014 to December 2014 were retrospectively reviewed including associated cytology, fluid analysis, and relevant surgical pathology. Cross-sectional imaging reports were reviewed blindly by an expert radiologist using AGA risk stratification terminology...
May 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29191271/incidental-intraductal-papillary-mucinous-neoplasm-cystic-or-premalignant-lesions-of-the-pancreas-the-case-for-aggressive-management
#16
REVIEW
Alexander T El Gammal, Jakob R Izbicki
Incidental cystic intrapancreatic lesions are daily findings in abdominal radiology. The discovery of incidental pancreatic lesions is increasingly common with technologic diagnostic advancements. This article provides a perspective and guideline on the clinical management of incidental intraductal papillary mucinous neoplasms and cystic or premalignant lesions of the pancreas.
February 2018: Surgical Clinics of North America
https://www.readbyqxmd.com/read/29167899/comparative-effectiveness-of-resection-vs-surveillance-for-pancreatic-branch-duct-intraductal-papillary-mucinous-neoplasms-with-worrisome-features
#17
Yinin Hu, Lily E. Johnston, Vanessa M. Shami, Todd W. Bauer, Reid B. Adams, George J. Stukenborg, Victor M. Zaydfudim
No abstract text is available yet for this article.
March 1, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29044541/validation-of-sendai-and-fukuoka-consensus-guidelines-in-predicting-malignancy-in-patients-with-preoperatively-diagnosed-mucinous-pancreatic-cystic-neoplasms
#18
Wentao Zhou, Yadong Xu, Yefei Rong, Wenchuan Wu, Tiantao Kuang, Baobao Xin, Hongxu Zhu, Wenhui Lou, Dansong Wang
BACKGROUND AND OBJECTIVES: The Sendai consensus guidelines (SCG) and Fukuoka consensus guidelines (FCG) have been examined for their roles in predicting advanced neoplasia (AN) in pancreatic cystic neoplasm (PCN) patients with mixed results. We aim to evaluate the utilities of both guidelines in a Chinese cohort with preoperatively diagnosed mucinous PCNs. METHODS: One hundred ninety-seven patients who underwent resections from 2008 to 2015 in Zhong Shan Hospital, Fudan University for suspected PCNs were retrospectively reviewed...
March 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28942226/intraductal-papillary-mucinous-neoplasm-of-the-pancreas-associated-with-neuroendocrine-tumor-a-case-report
#19
M Boge, B Gurses, M Vural, S Yilmaz, S Goksel, O Bilge
INTRODUCTION: Intraductal papillary mucinous neoplasm is an uncommon cystic tumor of pancreas that can be associated with ductal adenocarcinoma. Coexistence of pancreatic IPMN and neuroendocrine tumor is very rare. Here, we report the imaging features of mixed type intraductal papillary mucinous neoplasia of the pancreas with high grade dysplasia together with neuroendocrine carcinoma and perform review of the literature. PRESENTATION: A 68-year old patient has been evaluated for possible IPMN that was suspected during ultrasound...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28898198/appropriate-interval-for-imaging-follow-up-of-small-simple-pancreatic-cysts
#20
Jordan Menda, Maile E Yoon, Hyo-Chun Yoon
CONTEXT: The frequency at which patients should undergo follow-up imaging of small pancreatic cysts is problematic because different medical societies have different follow-up guidelines. OBJECTIVE: To determine whether short-term follow-up of small pancreatic cysts is necessary to detect pancreatic cancer or cystic neoplasia. DESIGN: We retrospectively reviewed all abdominal magnetic resonance imaging (MRI) studies obtained in a geographically isolated health maintenance organization between January 1, 2012, and December 31, 2014, looking for pancreatic cysts...
2017: Permanente Journal
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