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https://www.readbyqxmd.com/read/29679562/myotube-derived-factor-promotes-oligodendrocyte-precursor-cell-proliferation
#1
Akino Nakasone, Rieko Muramatsu, Yuki Kato, Yukio Kawahara, Toshihide Yamashita
Muscle cells secrete numerous molecules that function as endocrine hormones and regulate the functions of distant organs. Myelination in the central nervous system (CNS) is regulated by peripheral hormones. However, the effects of muscle-derived molecules on myelination have not been sufficiently analyzed. In this study, we show that muscle-releasing factors promote proliferation of oligodendrocyte precursor cells (OPCs), which is an element of myelination process. Supernatants of mouse myotube cultures stimulated bromodeoxyuridine (BrdU) incorporation into mouse OPCs...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29674595/developmental-and-oncogenic-programs-in-h3k27m-gliomas-dissected-by-single-cell-rna-seq
#2
Mariella G Filbin, Itay Tirosh, Volker Hovestadt, McKenzie L Shaw, Leah E Escalante, Nathan D Mathewson, Cyril Neftel, Nelli Frank, Kristine Pelton, Christine M Hebert, Christine Haberler, Keren Yizhak, Johannes Gojo, Kristof Egervari, Christopher Mount, Peter van Galen, Dennis M Bonal, Quang-De Nguyen, Alexander Beck, Claire Sinai, Thomas Czech, Christian Dorfer, Liliana Goumnerova, Cinzia Lavarino, Angel M Carcaboso, Jaume Mora, Ravindra Mylvaganam, Christina C Luo, Andreas Peyrl, Mara Popović, Amedeo Azizi, Tracy T Batchelor, Matthew P Frosch, Maria Martinez-Lage, Mark W Kieran, Pratiti Bandopadhayay, Rameen Beroukhim, Gerhard Fritsch, Gad Getz, Orit Rozenblatt-Rosen, Kai W Wucherpfennig, David N Louis, Michelle Monje, Irene Slavc, Keith L Ligon, Todd R Golub, Aviv Regev, Bradley E Bernstein, Mario L Suvà
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary H3K27M-glioma and matched models. We found that H3K27M-glioma primarily contain cells that resemble oligodendrocyte precursor cells (OPC-like), whereas more differentiated malignant cells are a minority...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29667843/standard-reference-line-combined-with-one-point-calibration-free-laser-induced-breakdown-spectroscopy-cf-libs-to-quantitatively-analyze-stainless-and-heat-resistant-steel
#3
Hongbo Fu, Huadong Wang, Junwei Jia, Zhibo Ni, Fengzhong Dong
Due to the influence of major elements' self-absorption, scarce observable spectral lines of trace elements, and relative efficiency correction of experimental system, accurate quantitative analysis with calibration-free laser-induced breakdown spectroscopy (CF-LIBS) is in fact not easy. In order to overcome these difficulties, standard reference line (SRL) combined with one-point calibration (OPC) is used to analyze six elements in three stainless-steel and five heat-resistant steel samples. The Stark broadening and Saha - Boltzmann plot of Fe are used to calculate the electron density and the plasma temperature, respectively...
January 1, 2018: Applied Spectroscopy
https://www.readbyqxmd.com/read/29664911/hpv-relatedness-definitions-for-classifying-hpv-related-oropharyngeal-cancer-patient-do-impact-on-tnm-classification-and-patients-survival
#4
Miren Taberna, Marisa Mena, Sara Tous, Miquel Angel Pavón, Marc Oliva, Xavier León, Jacinto Garcia, Marta Guix, Rafael Hijano, Teresa Bonfill, Antón Aguilà, Laia Alemany, Ricard Mesía
BACKGROUND: Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted for the 8th edition AJCC TNM (ICON-S model). However, it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. MATERIAL AND METHODS: The aim of this study was to compare different staging system models proposed for HPV-related OPC patients: 7th edition AJCC TNM, RPA stage with non-anatomic factors (Princess Margaret), RPA with N categories for nasopharyngeal cancer (MD-Anderson) and AHR-new (ICON-S), according to different HPV-relatedness definitions: HPV-DNA detection plus an additional positive marker (p16INK4a or HPV-mRNA), p16INK4a positivity alone or the combination of HPV-DNA/p16INK4a positivity as diagnostic tests...
2018: PloS One
https://www.readbyqxmd.com/read/29664021/a-tlr-akt-foxo3-immune-tolerance-like-pathway-disrupts-the-repair-capacity-of-oligodendrocyte-progenitors
#5
Taasin Srivastava, Parham Diba, Justin M Dean, Fatima Banine, Daniel Shaver, Matthew Hagen, Xi Gong, Weiping Su, Ben Emery, Daniel L Marks, Edward N Harris, Bruce Baggenstoss, Paul H Weigel, Larry S Sherman, Stephen A Back
Cerebral white matter injury (WMI) persistently disrupts myelin regeneration by oligodendrocyte progenitor cells (OPCs). We identified a specific bioactive hyaluronan fragment (bHAf) that downregulates myelin gene expression and chronically blocks OPC maturation and myelination via a tolerance-like mechanism that dysregulates pro-myelination signaling via AKT. Desensitization of AKT occurs via TLR4 but not TLR2 or CD44. OPC differentiation was selectively blocked by bHAf in a maturation-dependent fashion at the late OPC (preOL) stage by a noncanonical TLR4/TRIF pathway that induced persistent activation of the FoxO3 transcription factor downstream of AKT...
April 16, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29660252/encapsulated-oligodendrocyte-precursor-cell-fate-is-dependent-on-pdgf-aa-release-kinetics-in-a-3d-microparticle-hydrogel-drug-delivery-system
#6
Meghan R Pinezich, Lauren N Russell, Nicholas P Murphy, Kyle J Lampe
Biomaterial drug delivery systems (DDS) can be used to regulate growth factor release and combat the limited intrinsic regeneration capabilities of central nervous system (CNS) tissue following injury and disease. Of particular interest are systems that aid in oligodendrocyte regeneration, as oligodendrocytes generate myelin which surrounds neuronal axons and helps transmit signals throughout the CNS. Oligodendrocyte precursor cells (OPCs) are found in small numbers in the adult CNS, but are unable to effectively differentiate following CNS injury...
April 16, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29658460/-neuroprotective-effects-of-oligodendrocyte-precursor-cells-on-white-matter-damage-in-preterm-infants
#7
Yan Yue, Li Zhang, Yi Qu, De-Zhi Mu
White matter damage, characterized by demyelination due to the damage of oligodendrocyte precursor cells (OPCs), is the most common type of brain damage in preterm infants. Survivors are often subject to long-term neurodevelopmental sequelae because of the lack of effective treatment. In recent years, it has been found that cell transplantation has the potential for the treatment of white matter damage. OPCs are frequently used cells in cell transplantation therapy. With abilities of migration and myelinization, OPCs are the best seed cells for the treatment of white matter damage...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29648448/force-field-benchmark-of-amino-acids-i-hydration-and-diffusion-in-different-water-models
#8
Haiyang Zhang, Chunhua Yin, Yang Jiang, David van der Spoel
Thermodynamic and kinetic properties are of critical importance for the applicability of computational models to biomolecules such as proteins. Here we present an extensive evaluation of the Amber ff99SB-ILDN force field for modeling hydration and diffusion of amino acids with three-site (SPC, SPC/E, SPC/Eb, and TIP3P), four-site (TIP4P, TIP4P-Ew, and TIP4P/2005), and five-site (TIP5P and TIP5P-Ew) water models. Hydration free energies (HFEs) of neutral amino acid side chain analogues have little dependence on the water models with a root-mean-square error (RMSE) of ~1 kcal/mol from experimental observations...
April 12, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29627379/the-antipsychotic-drug-quetiapine-stimulates-oligodendrocyte-differentiation-by-modulating-the-cell-cycle
#9
Guiyun Mi, Yituo Wang, Enmao Ye, Yunyun Gao, Qiaowei Liu, Pinhong Chen, Yuyang Zhu, Hongju Yang, Zheng Yang
Recent studies have revealed that oligodendrocyte differentiation deficits and de-myelination occur in the brains of schizophrenic patients. Cell cycle proteins play a critical role in modulating oligodendrocyte proliferation and differentiation. In our previous studies, we found that cuprizone, a copper chelant, induces oligodendrocyte loss and demyelination, and this effect can be alleviated by using the atypical antipsychotic drug quetiapine. To explore the mechanisms of quetiapine in oligodendrocyte development, we examined the effects of quetiapine on cell cycle progression...
April 5, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29623612/the-stem-cell-factor-sox2-is-a-positive-timer-of-oligodendrocyte-development-in-the-postnatal-murine-spinal-cord
#10
Sheng Zhang, Abeer Rasai, Yan Wang, Jie Xu, Peter Bannerman, Daffcar Erol, Danayit Tsegaye, Aijun Wang, Athena Soulika, Xiangjiang Zhan, Fuzheng Guo
Myelination in the central nervous system takes place predominantly during the postnatal development of humans and rodents by myelinating oligodendrocytes (OLs), which are differentiated from oligodendrocyte progenitor cells (OPCs). We recently reported that Sox2 is essential for developmental myelination in the murine brain and spinal cord. It is still controversial regarding the role of Sox2 in oligodendroglial lineage progression in the postnatal murine spinal cord. Analyses of a series of cell- and stage-specific Sox2 mutants reveal that Sox2 plays a biphasic role in regulating oligodendroglial lineage progression in the postnatal murine spinal cord...
April 5, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29623602/inhibition-of-astrocyte-connexin-43-channels-facilitates-the-differentiation-of-oligodendrocyte-precursor-cells-under-hypoxic-conditions-in-vitro
#11
Qiong Wang, Zhen Wang, Yeye Tian, Huaqiu Zhang, Yongkang Fang, Zhiyuan Yu, Wei Wang, Minjie Xie, Fengfei Ding
Oligodendrocyte precursor cells (OPCs) proliferation and differentiation are essential for remyelination after white matter injury. Astrocytes could promote oligodendrogenesis after white matter damage whereas the underlying mechanisms are unknown. In this study, the role of astrocytic connexin43 (Cx43) hemichannels involved in OPC proliferation and differentiation in chronic hypoxia was evaluated. In an astrocyte-OPC co-culture chronic hypoxia model, OPCs became proliferative but failed to mature into oligodendrocytes...
April 5, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29618286/neuronal-activity-dependent-control-of-postnatal-neurogenesis-and-gliogenesis
#12
Ragnihldur T Káradóttir, Chay T Kuo
The addition of new neurons and oligodendroglia in the postnatal and adult mammalian brain presents distinct forms of gray and white matter plasticity. Substantial effort has been devoted to understanding the cellular and molecular mechanisms controlling postnatal neurogenesis and gliogenesis, revealing important parallels to principles governing the embryonic stages. While during central nervous system development, scripted temporal and spatial patterns of neural and glial progenitor proliferation and differentiation are necessary to create the nervous system architecture, it remains unclear what driving forces maintain and sustain postnatal neural stem cell (NSC) and oligodendrocyte progenitor cell (OPC) production of new neurons and glia...
April 4, 2018: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/29614332/new-therapeutic-approaches-and-novel-alternatives-for-organophosphate-toxicity
#13
Francine S Katz, Stevan Pecic, Laura Schneider, Zhengxiang Zhu, Ashley Hastings, Michal Luzac, Joanne Macdonald, Donald W Landry, Milan N Stojanovic
Organophosphate compounds (OPCs) are commonly used as pesticides and were developed as nerve agents for chemical warfare. Exposure to OPCs results in toxicity due to their covalent binding and inhibition of acetylcholinesterase (AChE). Treatment for toxicity due to OPC exposure has been largely focused on the reactivation of AChE by oxime-based compounds via direct nucleophilic attack on the phosphorous center. However, due to the disadvantages to existing oxime-based reactivators for treatment of OPC poisoning, we considered non-oxime mechanisms of reactivation...
March 31, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29614310/cxcl12-gene-engineered-endothelial-progenitor-cells-further-improve-the-functions-of-oligodendrocyte-precursor-cells
#14
Fang Yuan, Shuang Chang, Longlong Luo, Yaning Li, Liping Wang, Yaying Song, Meijie Qu, Zhijun Zhang, Guo-Yuan Yang, Yongting Wang
Oligodendrocyte precursor cells (OPCs) are needed for white matter repair after various brain injury. Means that promote OPC functions could benefit white matter recovery after injury. Chemokine CXCL12 and endothelial progenitor cells (EPCs) both have been shown to promote remyelination. We hypothesize that the beneficial effects of EPCs and CXCL12 can be harnessed by genetically modifying EPCs with cxcl12 to synergistically improve the functions of OPCs. In this work, CXCL12-EPC was generated using virus-mediated gene transfer...
March 31, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29609144/a-thermodynamics-based-approach-for-examining-the-suitability-of-cementitious-formulations-for-solidifying-and-stabilizing-coal-combustion-wastes
#15
Monday Uchenna Okoronkwo, Magdalena Balonis, Lynn Katz, Maria Juenger, Gaurav Sant
Cementitious binders are often used to immobilize industrial wastes such as residues of coal combustion. Such immobilization stabilizes wastes that contain contaminants by chemical containment, i.e., by uptake of contaminants into the cementitious reaction products. Expectedly, the release ("leachability") of contaminants is linked to: (i) the stability of the matrix (i.e., its resistance to decomposition on exposure to water), and, (ii) its porosity, which offers a pathway for the intrusion of water and egress of contaminant species...
March 30, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29603384/axoglial-synapses-are-formed-onto-pioneer-oligodendrocyte-precursor-cells-at-the-onset-of-spinal-cord-gliogenesis
#16
Guillaume Osterstock, Barbara Le Bras, Kalaimakan Hervé Arulkandarajah, Hervé Le Corronc, Antonny Czarnecki, Christine Mouffle, Erika Bullier, Pascal Legendre, Jean-Marie Mangin
Virtually all oligodendrocyte precursors cells (OPCs) receive glutamatergic and/or GABAergic synapses that are lost upon their differentiation into oligodendrocytes in the postnatal and adult brain. Although OPCs are generated at mid-embryonic stages, several weeks before the onset of myelination, it remains unknown when and where OPCs receive their first synapses and become susceptible to the influence of neuronal activity. In the embryonic spinal cord, neuro-epithelial precursors in the pMN domain cease generating cholinergic motor neurons (MNs) to produce OPCs when the first synapses are formed in the ventral-lateral marginal zone...
March 30, 2018: Glia
https://www.readbyqxmd.com/read/29602636/oropharyngeal-candidiasis-in-head-and-neck-cancer-patients-in-iran-species-identification-antifungal-susceptibility-and-pathogenic-characterization
#17
Z Jahanshiri, S Manifar, H Moosa, F Asghari-Paskiabi, H Mahmoodzadeh, M Shams-Ghahfarokhi, M Razzaghi-Abyaneh
OBJECTIVE: Oropharyngeal candidiasis (OPC) is the most frequent opportunistic fungal infection in head and neck cancer patients. This study was done to identify the Candida species, which cause OPC, and to evaluate their antifungal susceptibility pattern and pathogenic characteristics in Iranian head and neck cancer patients treated by radiotherapy. MATERIAL AND METHODS: The oral clinical samples were determined by culturing on CHROMagar, carbohydrate assimilation and ITS sequencing methods...
March 27, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29598954/clinical-outcomes-and-prognostic-factors-in-cisplatin-versus-cetuximab-chemoradiation-for-locally-advanced-p16-positive-oropharyngeal-carcinoma
#18
Christian L Barney, Steve Walston, Pedro Zamora, Erin H Healy, Nicole Nolan, Virginia M Diavolitsis, Anterpreet Neki, Robert Rupert, Panos Savvides, Amit Agrawal, Matthew Old, Enver Ozer, Ricardo Carrau, Stephen Kang, James Rocco, Theodoros Teknos, John C Grecula, Jessica Wobb, Darrion Mitchell, Dukagjin Blakaj, Aashish D Bhatt
OBJECTIVES: Randomized trials evaluating cisplatin versus cetuximab chemoradiation (CRT) for p16+ oropharyngeal cancer (OPC) have yet to report preliminary data. Meanwhile, as a preemptive step toward morbidity reduction, the off-trial use of cetuximab in p16+ patients is increasing, even in those who could potentially tolerate cisplatin. The purpose of this study was to compare the efficacy of cisplatin versus cetuximab CRT in the treatment of p16+ OPC and to identify prognostic factors and predictors of tumor response...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29598952/upfront-surgery-versus-definitive-chemoradiotherapy-in-patients-with-human-papillomavirus-associated-oropharyngeal-squamous-cell-cancer
#19
Jacqueline R Kelly, Henry S Park, Yi An, Wendell G Yarbrough, Joseph N Contessa, Roy Decker, Saral Mehra, Benjamin L Judson, Barbara Burtness, Zain Husain
OBJECTIVES: Currently, human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV-A OPC) is managed with either primary surgery or definitive chemoradiotherapy (CRT), despite the lack of supporting randomized prospective data. We therefore assessed the outcomes of each treatment strategy using the National Cancer Database (NCDB). METHODS: The NCDB was used to identify patients diagnosed with cT1 N2a-2b or cT2 N1-2b HPV-A OPC from 2010 to 2013 who underwent treatment with primary surgery or CRT...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29596047/oligodendrocytes-control-potassium-accumulation-in-white-matter-and-seizure-susceptibility
#20
Valerie A Larson, Yevgeniya Mironova, Kim G Vanderpool, Ari Waisman, John E Rash, Amit Agarwal, Dwight E Bergles
The inwardly rectifying K+ channel Kir 4.1 is broadly expressed by CNS glia and deficits in Kir 4.1 lead to seizures and myelin vacuolization. However, the role of oligodendrocyte Kir 4.1 channels in controlling myelination and K+ clearance in white matter has not been defined. Here we show that selective deletion of Kir 4.1 from oligodendrocyte progenitors (OPCs) or mature oligodendrocytes did not impair their development or disrupt the structure of myelin. However, mice lacking oligodendrocyte Kir 4.1 channels exhibited profound functional impairments, including slower clearance of extracellular K+ and delayed recovery of axons from repetitive stimulation in white matter, as well as spontaneous seizures, a lower seizure threshold, and activity-dependent motor deficits...
March 29, 2018: ELife
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