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https://www.readbyqxmd.com/read/29440812/-personified-as-paragon-of-suffering-optimistic-being-of-achieving-normalcy-a-conceptual-model-derived-from-qualitative-research
#1
Shalini G Nayak, Mamatha Shivananda Pai, Linu Sara George
Background: Conceptual models developed through qualitative research are based on the unique experiences of suffering and individuals' adoptions of each participant. A wide array of problems are faced by head-and-neck cancer (HNC) patients due to disease pathology and treatment modalities which are sufficient to influence the quality of life (QOL). Men possess greater self-acceptance and are better equipped with intrapersonal strength to cope with stress and adequacy compared to women...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29428242/bu-shen-yi-sui-capsule-promotes-remyelination-correlating-with-sema3a-nrp-1-lif-lifr-and-nkx6-2-in-mice-with-experimental-autoimmune-encephalomyelitis
#2
Pei-Yuan Zhao, Yong-Qiang Wang, Xi-Hong Liu, Ying-Jun Zhu, Hui Zhao, Qiu-Xia Zhang, Fang Qi, Jun-Ling Li, Nan Zhang, Yong-Ping Fan, Kang-Ning Li, Yuan-Yuan Zhao, Jian-Feng Lei, Lei Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Bu Shen Yi Sui capsule (BSYSC), based on traditional Chinese formula Liu Wei Di Huang pill, is effective for the treatment of multiple sclerosis (MS) in clinical experience and trials. Our previous studies confirmed that BSYSC had the neuroprotective effect in MS and its animal model, experimental autoimmune encephalomyelitis (EAE); however, its mechanism of action was not clear. Thus, the effect of BSYSC on remyelination and the underlying mechanisms were investigated in the EAE mice...
February 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29424466/differential-local-tissue-permissiveness-influences-the-final-fate-of-gpr17-expressing-oligodendrocyte-precursors-in-two-distinct-models-of-demyelination
#3
Giusy T Coppolino, Davide Marangon, Camilla Negri, Gianluca Menichetti, Marta Fumagalli, Paolo Gelosa, Leda Dimou, Roberto Furlan, Davide Lecca, Maria P Abbracchio
Promoting remyelination is recognized as a novel strategy to foster repair in neurodegenerative demyelinating diseases, such as multiple sclerosis. In this respect, the receptor GPR17, recently emerged as a new target for remyelination, is expressed by early oligodendrocyte precursors (OPCs) and after a certain differentiation stage it has to be downregulated to allow progression to mature myelinating oligodendrocytes. Here, we took advantage of the first inducible GPR17 reporter mouse line (GPR17-iCreERT2 xCAG-eGFP mice) allowing to follow the final fate of GPR17+ cells by tamoxifen-induced GFP-labeling to unveil the destiny of these cells in two demyelination models: experimental autoimmune encephalomyelitis (EAE), characterized by marked immune cell activation and inflammation, and cuprizone induced demyelination, where myelin dysfunction is achieved by a toxic insult...
February 9, 2018: Glia
https://www.readbyqxmd.com/read/29423921/vitamin-c-promotes-oligodendrocytes-generation-and-remyelination
#4
Yu-E Guo, Na Suo, Xue Cui, Qianting Yuan, Xin Xie
Oligodendrocyte-formed myelin sheaths play important roles in the neuronal functions in the central nervous system. In demyelinating diseases, such as Multiple Sclerosis, the myelin sheaths are damaged and the remyelinating process is somehow hindered. Restoration of the myelin sheaths requires the differentiation of the oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs). To discover small molecule compounds that might promote the OPC to OL differentiation, a high-throughput screening system is established and L-ascorbyl-2-phosphate (As-2P), a stable form of Vitamin C (Vc), is found to greatly enhance the OPC to OL differentiation...
February 9, 2018: Glia
https://www.readbyqxmd.com/read/29419572/preconditioning-and-postconditioning-by-cardiac-glycosides-in-the-mouse-heart
#5
Qiming Duan, Yunhui Xu, Pauline V Marck, Jennifer Kalisz, Eric E Morgan, Sandrine V Pierre
Ouabain preconditioning (OPC) initiated by low concentrations of the cardiac glycoside (CG) ouabain binding to Na/K-ATPase is relayed by a unique intracellular signaling and protects cardiac myocytes against ischemia/reperfusion injury. To explore more clinically applicable protocols based on CG properties, we tested whether the FDA-approved CG digoxin could trigger cardioprotective effects comparable with those of ouabain using PC, preconditioning and PostC, postconditioning protocols in the Langendorff-perfused mouse heart subjected to global ischemia and reperfusion...
February 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29417177/stem-cells-from-human-apical-papilla-decrease-neuro-inflammation-and-stimulate-oligodendrocyte-progenitor-differentiation-via-activin-a-secretion
#6
Pauline De Berdt, Pauline Bottemanne, John Bianco, Mireille Alhouayek, Anibal Diogenes, Amy Llyod, Jose Gerardo-Nava, Gary A Brook, Véronique Miron, Giulio G Muccioli, Anne des Rieux
Secondary damage following spinal cord injury leads to non-reversible lesions and hampering of the reparative process. The local production of pro-inflammatory cytokines such as TNF-α can exacerbate these events. Oligodendrocyte death also occurs, followed by progressive demyelination leading to significant tissue degeneration. Dental stem cells from human apical papilla (SCAP) can be easily obtained at the removal of an adult immature tooth. This offers a minimally invasive approach to re-use this tissue as a source of stem cells, as compared to biopsying neural tissue from a patient with a spinal cord injury...
February 7, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29415995/plasma-hemopexin-ameliorates-murine-spinal-cord-injury-by-switching-microglia-from-the-m1-state-to-the-m2-state
#7
Dunxin Han, Zhongwang Yu, Weili Liu, Dou Yin, Yingyan Pu, Jifeng Feng, Yimin Yuan, Aijun Huang, Li Cao, Cheng He
Spinal cord injury (SCI) is a devastating type of central nervous system (CNS) trauma with limited therapeutic treatments. The polarization of microglia into the M1 or M2 state has been documented to play important roles in the pathogenesis of SCI, although the complete repertoire of underlying factors has not been identified. Interestingly, the time point at which hematomyelia (intramedullary spinal cord hemorrhage) is alleviated coincides with a decrease in the number of M2 microglia. Here the function of Hemopexin (Hpx), a hematogenous glycoprotein, was examined in the crush model of SCI...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29408919/uplc-qtof-ms-metabolomics-analysis-revealed-the-contributions-of-metabolites-to-the-pathogenesis-of-rhizoctonia-solani-strain-ag-1-ia
#8
Wenjin Hu, Xinli Pan, Fengfeng Li, Wubei Dong
To explore the pathogenesis of Rhizoctonia solani and its phytotoxin phenylacetic acid (PAA) on maize leaves and sheaths, treated leaf and sheath tissues were analyzed and interpreted by ultra-performance liquid chromatography-mass spectrometry combined with chemometrics. The PAA treatment had similar effects to those of R. solani on maize leaves regarding the metabolism of traumatin, phytosphingosine, vitexin 2'' O-beta-D-glucoside, rutin and DIBOA-glucoside, which were up-regulated, while the synthesis of OPC-8:0 and 12-OPDA, precursors for the synthesis of jasmonic acid, a plant defense signaling molecule, was down-regulated under both treatments...
2018: PloS One
https://www.readbyqxmd.com/read/29407438/thyroid-hormone-and-the-white-matter-of-the-central-nervous-system-from-development-to-repair
#9
Laura Calzà, Vito A Baldassarro, Mercedes Fernandez, Alessandro Giuliani, Luca Lorenzini, Luciana Giardino
The role of thyroid hormone (TH) on brain development, and particularly in myelination, is well known since many decades, as testified by the severe structural and functional consequences of congenital hypothyroidism. This role during development, the consideration that the early TH supplementation restores myelination capability, and the fact the cell responsible for developmental myelination and remyelination is the same, i.e., the oligodendrocyte precursor cell (OPC), claimed the attempt to improve myelin repair in the adulthood via TH supplementation...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29401846/analysis-of-the-nonlinear-kerr-effects-in-optical-transmission-systems-that-deploy-optical-phase-conjugation
#10
Mohammad A Z Al-Khateeb, Md Asif Iqbal, Mingming Tan, Abdallah Ali, Mary McCarthy, Paul Harper, Andrew D Ellis
In this work, we will derive, validate, and analyze the theoretical description of nonlinear Kerr effects resulting from various transmission systems that deploy single or multiple optical phase conjugators (OPCs). We will show that the nonlinear Kerr compensation can be achieved, with various efficiencies, in both lumped and distributed Raman transmission systems. The results show that first order distributed Raman systems are superior to the discretely amplified systems in terms of the nonlinear Kerr compensation efficiency that a mid-link OPC can achieve...
February 5, 2018: Optics Express
https://www.readbyqxmd.com/read/29397565/myt1l-promotes-differentiation-of-oligodendrocyte-precursor-cells-and-is-necessary-for-remyelination-after-lysolecithin-induced-demyelination
#11
Yanqing Shi, Qi Shao, Zhenghao Li, Ginez A Gonzalez, Fengfeng Lu, Dan Wang, Yingyan Pu, Aijun Huang, Chao Zhao, Cheng He, Li Cao
The differentiation and maturation of oligodendrocyte precursor cells (OPCs) is essential for myelination and remyelination in the CNS. The failure of OPCs to achieve terminal differentiation in demyelinating lesions often results in unsuccessful remyelination in a variety of human demyelinating diseases. However, the molecular mechanisms controlling OPC differentiation under pathological conditions remain largely unknown. Myt1L (myelin transcription factor 1-like), mainly expressed in neurons, has been associated with intellectual disability, schizophrenia, and depression...
February 3, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29393205/microglial-activation-induces-generation-of-oligodendrocyte-progenitor-cells-from-the-subventricular-zone-after-focal-demyelination-in-the-corpus-callosum
#12
Masae Naruse, Koji Shibasaki, Hiroya Shimauchi-Ohtaki, Yasuki Ishizaki
Neuroblasts derived from neural stem cells (NSCs) in the subventricular zone (SVZ) migrate along the rostral migratory stream into the olfactory bulb to generate interneurons under normal physiological conditions. When demyelination occurs, NSCs or neural progenitor cells (NPCs) in the SVZ provide newly formed oligodendrocytes to demyelinated lesions. The plasticity of NSC/NPC lineages may tend to oligodendrogenesis under the influence of demyelinated lesions. The mechanisms, however, still remain unknown. This study revealed that focal demyelination in the corpus callosum caused activation of the microglia, not only at the site of demyelination but also in the SVZ, and dramatically increased the generation of oligodendrocyte progenitor cells (OPCs) in the SVZ...
January 25, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29392777/p53-and-nf-1-loss-plays-distinct-but-complementary-roles-in-glioma-initiation-and-progression
#13
Phillippe P Gonzalez, Jungeun Kim, Rui Pedro Galvao, Nichola Cruickshanks, Roger Abounader, Hui Zong
Malignant glioma is one of the deadliest types of cancer. Understanding how the cell of origin progressively evolves toward malignancy in greater detail could provide mechanistic insights and lead to novel concepts for tumor prevention and therapy. Previously we have identified oligodendrocyte precursor cell (OPC) as the cell of origin for glioma following the concurrent deletion of p53 and NF1 using a mouse genetic mosaic system that can reveal mutant cells prior to malignancy. In the current study, we set out to deconstruct the gliomagenic process in two aspects...
February 2, 2018: Glia
https://www.readbyqxmd.com/read/29391408/grey-matter-opcs-are-less-mature-and-less-sensitive-to-ifn%C3%AE-than-white-matter-opcs-consequences-for-remyelination
#14
Dennis H Lentferink, Jacomien M Jongsma, Inge Werkman, Wia Baron
Multiple sclerosis (MS) is a chronic inflammatory disease characterized by the formation of demyelinated lesions in the central nervous system. At later stages of the disease repair in the form of remyelination often fails, which leads to axonal degeneration and neurological disability. For the regeneration of myelin, oligodendrocyte progenitor cells (OPCs) have to migrate, proliferate and differentiate into remyelinating oligodendrocytes. Remyelination occurs faster and is more extensive in grey matter (GM) lesions than in white matter (WM) lesions...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29383653/alterations-of-hippocampal-myelin-sheath-and-axon-sprouting-by-status-convulsion-and-regulating-lingo-1-expression-with-rna-interference-in-immature-and-adult-rats
#15
Xiao-Jie Song, Wei Han, Rong He, Tian-Yi Li, Ling-Ling Xie, Li Cheng, Heng-Sheng Chen, Li Jiang
Seizure-induced brain damage is age-dependent, as evidenced by the different alterations of neural physiopathology in developing and mature brains. However, little is known about the age-dependent characteristics of myelinated fiber injury induced by seizures. Considering the critical functions of oligodendrocyte progenitor cells (OPCs) in myelination and Lingo-1 signaling in regulating OPCs' differentiation, the present study aimed to explore the effects of Lingo-1 on myelin and axon in immature and adult rats after status convulsion (SC) induced by lithium-pilocarpine, and the differences between immature and adult brains...
January 27, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29382710/age-dependent-decline-in-fate-switch-from-ng2-cells-to-astrocytes-after-olig2-deletion
#16
Hao Zuo, William M Wood, Amin Sherafat, Robert A Hill, Q Richard Lu, Akiko Nishiyama
NG2 cells are a resident glial progenitor cell population that is uniformly distributed throughout the developing and mature mammalian central nervous system (CNS). Those in the postnatal CNS generate exclusively myelinating and non-myelinating oligodendrocytes and are hence equated with oligodendrocyte precursor cells (OPCs). Prenatally, NG2 cells in the ventral gray matter of the forebrain generate protoplasmic astrocytes as well as oligodendrocytes. The fate conversion from NG2 cells into protoplasmic astrocytes is dependent on downregulation of the key oligodendrocyte transcription factor Olig2...
January 30, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29377124/purinergic-signaling-in-oligodendrocyte-development-and-function
#17
REVIEW
Taylor G Welsh, Sarah Kucenas
Myelin, an insulating membrane that enables rapid action potential propagation, is an essential component of an efficient, functional vertebrate nervous system. Oligodendrocytes, the myelinating glia of the central nervous system (CNS), produce myelin throughout the CNS, which requires continuous proliferation, migration and differentiation of oligodendrocyte progenitor cells (OPC). Because myelination is essential for efficient neurotransmission, researchers hypothesize that neuronal signals may regulate the cascade of events necessary for this process...
January 28, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29371568/the-role-of-il-17-in-protection-against-mucosal-candida-infections
#18
REVIEW
Bemnet G Mengesha, Heather R Conti
Interleukin-17 (IL-17) is a proinflammatory cytokine produced by adaptive CD4+ T helper cells and innate lymphocytes, such as γδ-T cells and TCRβ+ "natural" Th17 cells. IL-17 activates signaling through the IL-17 receptor, which induces other proinflammatory cytokines, antimicrobial peptides and neutrophil chemokines that are important for antifungal activity. The importance of IL-17 in protective antifungal immunity is evident in mice and humans, where various genetic defects related to the IL-17-signaling pathway render them highly susceptible to forms of candidiasis such oropharyngeal candidiasis (OPC) or more broadly chronic mucocutaneous candidiasis (CMC), both caused mainly by the opportunistic fungal pathogen Candida albicans...
September 27, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29368332/head-and-neck-cancers-associated-with-exposure-to-the-september-11-2001-world-trade-center-terrorist-attacks
#19
Jonathan E Leeman, Sean M McBride, Daniel Spielsinger, Eric J Sherman, Richard Wong, Nadeem Riaz, Nancy Y Lee, Chiaojung Jillian Tsai
Exposure at the World Trade Center (WTC) terrorist collapse site on September 11, 2001 has been associated with increased cancer risk, though observational studies have identified very few cases of head and neck cancer (HNC) in exposed individuals. Eighty seven patients were identified who presented to our institution with HNC diagnosed from 2002-2017 who reported WTC exposure. The annual number and proportion of WTC-exposed HNC patients has been steadily increasing since 2002, with most cancers developing >10 years following the event...
January 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29367653/investigation-of-radiomic-signatures-for-local-recurrence-using-primary-tumor-texture-analysis-in-oropharyngeal-head-and-neck-cancer-patients
#20
(no author information available yet)
Radiomics is one such "big data" approach that applies advanced image refining/data characterization algorithms to generate imaging features that can quantitatively classify tumor phenotypes in a non-invasive manner. We hypothesize that certain textural features of oropharyngeal cancer (OPC) primary tumors will have statistically significant correlations to patient outcomes such as local control. Patients from an IRB-approved database dispositioned to (chemo)radiotherapy for locally advanced OPC were included in this retrospective series...
January 24, 2018: Scientific Reports
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