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M Ren, Y Y Kong, X X Shen, X Cai, J C Kong
Objective: To study the clinicopathologic features, differential diagnosis and prognosis of lentigo maligna (LM) and lentigo maligna melanoma (LMM). Methods: Histopathologic evaluation and immunohistochemical study by HRP multimer method were carried out in 24 cases of LM and LMM from 2012 to 2017 at Fudan University Shanghai Cancer Center. The clinical information and follow-up data were analyzed. Results: Of total 24 cases, there were 7 cases of LM and 17 cases of LMM; 10 males and 14 females. The age of patients ranged from 32 to 88 years (mean 67 years)...
October 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
J Rao, M Ruan, B H Yu, X Q Li, W T Yang, R H Shui
Objective: To investigate the clinicopathologic features and differential diagnosis of breast lymphoma in core needle biopsy. Methods: Seventy-two cases of breast lymphoma in core needle biopsy between 2011 and 2016 were extracted from the pathology database of Fudan University Shanghai Cancer Center. The clinicopathologic features were analyzed. The histological diagnosis of the tumors was based on the WHO classifications of tumors of hematopoietic and lymphoid tissues. Immunohistochemistry and molecular methods were performed to detect related antigens and genes...
October 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
João Santos Silva, Carolina Torres, José Alberto Teixeira, Pedro Garcia, Paulo Calvinho
Primary mediastinal tumours with chest wall involvement represent technical challenges that may offer a survival benefit. Reconstruction with osteossynthesis material, bioprosthesis and muscle flaps is indicated to re-establish the excised component function. We report a case of a 30-year-old male with a primary mediastinal seminoma operated after chemotherapy with need for en bloc resection of the residual mass and manubrium with chest wall reconstruction. This type of surgery is rare and represents a technical challenge...
January 2018: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
S Guida, P L Bencini, G Pellacani
Surgical excision can be followed by non-aesthetic scar development, despite the use of modern suture technique. Skin site involved is important since the location of scars in "aesthetic" sites, such as the face, can cause psychological problems for patients. In order to improve scar appearance, different therapeutic approaches have been employed. This article is protected by copyright. All rights reserved.
October 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
John P Berdahl, Mark J Gallardo, Mohammed K ElMallah, Blake K Williamson, Malik Y Kahook, Ahad Mahootchi, Leonard A Rappaport, Gabriel S Lazcano-Gomez, Daniela Díaz-Robles, Syril K Dorairaj
INTRODUCTION: To characterize the reduction in intraocular pressure (IOP) and IOP-lowering medication use following goniotomy via trabecular meshwork excision performed using the Kahook Dual Blade as a stand-alone procedure in adult eyes with glaucoma uncontrolled on a regimen of 1-3 topical IOP-lowering medications. METHODS: In this retrospective analysis, data from consecutive patients undergoing goniotomy with the Kahook Dual Blade by 11 surgeons were analyzed...
October 13, 2018: Advances in Therapy
Talha Ahmed Qureshi, Shabbir Akhtar, Mariam Abid
Occurrence of inflammatory pseudotumour in head and neck region or nose and paranasal sinuses is rare. However, when they do occur, they could be quite aggressive. Etiologically, they are believed to be reactive than neoplastic, and calcification may suggest end-stage. Their clinical presentation and radiologic features may resemble a malignancy. Grossly, they are not encapsulated, but multilobulated and can be circumscribed or infiltrative. Histologically, they constitute of bland spindle cells with scant cytoplasm and occasional mitotic figures...
October 2018: JPMA. the Journal of the Pakistan Medical Association
Fatima Naumeri, Muhammad Safdar Khan, Asad Rauf, Sajida Imran, Muhammad Tahir
The aim was to determine the role of needle aspiration and surgical excision in the management of suppurative Bacillus Calmette Guerin (BCG) lymphadenitis. This prospective study was done in Rafha Central Hospital, over 1.5 years. Thirty two patients were enrolled after informed consent. Needle aspiration was done if size of lymphadenitis was up to 3cm. Surgical excision was done primarily for size more than 3cm or in cases of failed aspiration. Eighteen were males and 14 were females. Median age was 3.75 months (IQR 2-7)...
July 2018: JPMA. the Journal of the Pakistan Medical Association
Efstathios Kotidis, Iliana Stamatiou, Orestis Ioannidis, Manousos George Pramateftakis, Ioannis Kanellos, Konstantinos Tsalis
Lipomas are benign, usually asymptomatic, tumours and pelvic lipomas are extremely rare. We describe the case of a giant pelvic lipoma causing obstructive uropathy to a 66-year-old morbidly obese female treated in the 4th Surgical Department of the Medical School of Aristotle University of Thessaloniki in General Hospital "G. Papanikolaou" in March 2016. The patient presented with a history of nocturia and frequent daytime urination for 1 year. Her medical history included diffuse lipomatosis. Computer tomography revealed a giant pelvic mass which lead to left side hydronephrosis, hydrouterer and a pear-shaped bladder, with the differential diagnosis including pelvic lipoma or liposarcoma...
September 2018: JPMA. the Journal of the Pakistan Medical Association
Alberto S Tagliafico, Giovanna Mariscotti, Francesca Valdora, Manuela Durando, Jacopo Nori, Daniele La Forgia, Ilan Rosenberg, Francesca Caumo, Nicoletta Gandolfo, Maria Pia Sormani, Alessio Signori, Massimo Calabrese, Nehmat Houssami
BACKGROUND: Increased risk of breast cancer (BC) and increased risk of an interval BC at mammography screening are associated with high mammographic density. Adjunct imaging detects additional BCs not detected at mammography screening in women with dense breasts. AIM: The aim is to estimate the incremental cancer detection rate (CDR) and false-positive recall for each of tomosynthesis and ultrasound, as adjunct screening modalities in women with mammography-negative dense breasts...
October 11, 2018: European Journal of Cancer
Giancarlo Albo, Elisa De Lorenzis, Andrea Gallioli, Luca Boeri, Stefano P Zanetti, Fabrizio Longo, Bernardo Rocco, Emanuele Montanari
BACKGROUND: A remote interaction between a console surgeon (CS) and a bedside surgeon (BS) makes the role of the latter critical. No conclusive data are reported about the length of the learning curve of a BS. OBJECTIVE: To highlight the role of a BS during robot-assisted radical prostatectomy (RARP) and to analyze the effect of the learning curve of a BS on intra- and postoperative outcomes. DESIGN, SETTING, AND PARTICIPANTS: From June 2013 to September 2016, 129 RARPs were performed by one expert CS (>1000 RARPs) and two BSs (residents)...
October 10, 2018: European Urology Focus
Artur Ludwin, Inga Ludwin, Bala Bhagavath, Wellington P Martins, Steven R Lindheim
OBJECTIVES: To demonstrate the hymen-sparing management of a blind hemivagina in obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome with the use of transrectal ultrasound (TRUS)-guided vaginoscopic septoplasty supported by pre- and postoperative diagnostics with the use of a novel ultrasound technique: 3-dimensional saline-solution infusion contrast sonovaginocervicography (3D-SVC) with virtual speculoscopy. DESIGN: Video presentation of surgical and ultrasound techniques...
October 2018: Fertility and Sterility
Henri Azaïs, Charles-Henri Canova, Elie Vesale, Jean-Marc Simon, Geoffroy Canlorbe, Catherine Uzan
OBJECTIVE: To describe a surgical technique for laparoscopic uterine fixation (LUF) to decrease uterine radiation therapy side effects in case of rectal or anal cancer. DESIGN: This video article uses a surgical case to demonstrate the detailed technique. Institutional Review Board approval was not required for this video presentation. SETTING: University hospital. PATIENT(S): A 26-year-old nulliparous female patient diagnosed with rectal adenocarcinoma and liver metastases...
October 2018: Fertility and Sterility
Hager Aref, Georges A Abizeid
INTRODUCTION: Schwannoma is a benign encapsulated tumor of the peripheral nervous system which is mainly located in the head and neck. However, axillary Schwannoma is rare. In this article, the author presents an interesting case of a right axillary Schwannoma, where the diagnosis was preoperatively made on a Tru-cut biopsy. CASE PRESENTATION: We report a case of an enlarged right axillary swelling in a sixty-year-old male. Proper radiologic workup was performed...
September 29, 2018: International Journal of Surgery Case Reports
Vera N Merli, Sonia Dell'Oglio, Valentina Grazioli, Cristian Monterosso, Benedetta Vanini, Mauro Gori, Giovanni Quarta, Andrea M D'Armini
We report the case of a woman with pulmonary embolism due to a cardiac mass. Echocardiography, CT scan and cardiac magnetic resonance raised the suspicion of right atrial myxoma and confirmed the presence of pulmonary embolism. The patient was sent to Pavia, where the atrial myxoma was excised, and using interrupted periods of circulatory arrest, extraction of the myxoma emboli from the pulmonary arteries was performed. No adjuvant chemotherapy was required as surgical treatment is an effective therapy in cases of pulmonary embolism of a benign neoplastic mass...
October 10, 2018: Annals of Thoracic Surgery
J AlexanderClark, Stuart G Campbell
KEY POINTS: Prior studies have shown variation in the functional properties of cardiomyocytes isolated from different regions of the left ventricular myocardium. We found that these region-dependent variations vanish below a tissue volume of ∼7 mm3 in the adult rat myocardium, revealing a fixed level of intrinsic relaxation rate heterogeneity that is independent of tissue volume. Within these microscopically varying cell populations, fast-relaxing cells were shown to have elevated phosphorylated troponin I compared to slow-relaxing cells...
October 13, 2018: Journal of Physiology
Roxana Kargar, Vasilis Minas, Atefeh Gorgin Karaji, Khadijeh Shadjoo, Roya Padmehr, Arash Mohazzab, Anahita Enzevaei, Saghar Samimi Sadeh, Koorosh Kamali, Shaheen Khazali
OBJECTIVE: To compare the efficiency of laparoscopically-guided transversus abdominis plane block (LTAP) versus port-site local anaesthetic infiltration (LAI) in reducing postoperative pain following laparoscopic excision of endometriosis. DESIGN: A prospective, double-blind randomized controlled trial. SETTING: A tertiary referral centre for endometriosis and minimally invasive gynaecological surgery. POPULATION: Women undergoing laparoscopic excision of endometriosis from December 2015 through July 2016...
October 13, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Youngmin Moon, Jung Hyun Han, Jang-Hee Choi, Sungho Shin, Yong-Chul Kim, Sungho Jeong
Surgical excision (Mohs micrographic surgery) is the standard procedure to treat a melanoma, in which an in situ histologic examination of sectioned skin is carried out repeatedly until no cancer cells are detected. The possibility to identify melanoma from the surrounding skin by femtosecond laser-induced breakdown spectroscopy (fs-LIBS) is investigated. For experiments, melanoma induced on a hairless mouse by injection of B16/F10 murine melanoma cell was sampled in the form of frozen tissue sections as in Mohs surgery and analyzed by fs-LIBS (λ  =  1030  nm, τ  =  550  fs)...
October 2018: Journal of Biomedical Optics
Lazar Tosic, Dominik Baschera, Bastian Jentsch, Thomas Feuerstein, Alex Alfieri
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms commonly involving visceral or parietal pleura. We present the first report of tumor-to-tumor metastasis involving a pulmonary adenocarcinoma donor and an intradural SFT recipient. The patient presented with a 1 year history of diffuse back pain. A spinal intradural contrast-enhancing mass at the T9/10 level and a tumor of the lung were diagnosed radiologically. Bronchoscopic biopsy confirmed pulmonary adenocarcinoma in the right upper lung lobe...
October 13, 2018: Acta Neurochirurgica
Sona Vodenkova, Katerina Jiraskova, Marketa Urbanova, Michal Kroupa, Jana Slyskova, Michaela Schneiderova, Miroslav Levy, Tomas Buchler, Vaclav Liska, Ludmila Vodickova, Veronika Vymetalkova, Andrew Collins, Alena Opattova, Pavel Vodicka
The DNA-damaging agent 5-fluorouracil represents the most commonly used chemotherapeutic drug for colorectal cancer patients. DNA lesions associated with 5-fluorouracil therapy are primarily repaired by base excision repair (BER) and mismatch repair (MMR) pathways. Published evidence suggests that the individual DNA repair capacity (DRC) may affect a patient's prognosis and response to chemotherapy. With this in mind, we designed a prospective study of which the main aim was to investigate BER-DRC in relation to 5-fluorouracil response as potential predictive and/or prognostic biomarker...
October 1, 2018: DNA Repair
Boštjan Luzar, Blanca Martin, Cyril Fisher, Eduardo Calonje
Glomus tumours (GTs) have traditionally been classified into benign GTs, GTs with uncertain malignant potential and malignant GTs, based on a combination of criteria such as size of the tumour, degree of nuclear atypia and the level of mitotic activity. Several of the proposed grading criteria are difficult, or even impossible to apply for GTs occurring in the skin. The aim of the study was to analyse the applicability of the currently established GT malignancy criteria for tumours occurring in the skin and to establish their prognostic significance...
October 9, 2018: Pathology
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