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Genwen Hu, Zhong Yang, Wen Liang, Caiyong Lai, Yingjie Mei, Yufa Li, Jianmin Xu, Liangping Luo, Xianyue Quan
BACKGROUND: Renal fibrosis is a common consequence of chronic kidney disease (CKD) and is the mechanism by which various forms of CKD progress to endstage renal failure. Accurate assessment of renal fibrosis is important for treatment. PURPOSE: To measure longitudinal changes of intravoxel incoherent motion (IVIM) and arterial spin labeling (ASL) before and after reversible unilateral ureteral obstruction in an animal model. STUDY TYPE: Self-controlled animal study...
October 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
Angeline Nemeth, Bérénice Segrestin, Benjamin Leporq, Kevin Seyssel, Khuram Faraz, Valérie Sauvinet, Emmanuel Disse, Pierre-Jean Valette, Martine Laville, Hélène Ratiney, Olivier Beuf
BACKGROUND: Overweight and obesity are major worldwide health concerns characterized by an abnormal accumulation of fat in adipose tissue (AT) and liver. PURPOSE: To evaluate the volume and the fatty acid (FA) composition of the subcutaneous adipose tissue (SAT) and the visceral adipose tissue (VAT) and the fat content in the liver from 3D chemical-shift-encoded (CSE)-MRI acquisition, before and after a 31-day overfeeding protocol. STUDY TYPE: Prospective and longitudinal study...
October 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
Jiejie Zhou, Endong Chen, Huazhi Xu, Qiong Ye, Jiance Li, Shuxin Ye, Qinyuan Cheng, Liang Zhao, Min-Ying Su, Meihao Wang
BACKGROUND: Conventional diffusion-weighted imaging (DWI) with high b-values may improve lesion conspicuity, but with a low signal intensity and thus a low signal-to-noise ratio (SNR). The voxelwise computed DWI (vcDWI) may generate high-quality images with a strong lesion signal and low background. PURPOSE: To evaluate the feasibility and diagnostic performance of vcDWI. STUDY TYPE: Retrospective. POPULATION: In all, 67 patients with 72 lesions, 33 malignant and 39 benign...
October 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
Julian Emmerich, Sebastian Flassbeck, Simon Schmidt, Peter Bachert, Mark E Ladd, Sina Straub
BACKGROUND: Using lower refocusing flip angles in multi-echo turbo spin echo (ME-TSE) sequences at ultra-high magnetic field leads to non-monoexponential signal decay and overestimation of T2 values due to stimulated and secondary echoes. PURPOSE: To investigate the feasibility of a fast and accurate reconstruction of quantitative T2 values using an ME-TSE sequence with reduced refocusing flip angles at 7 Tesla, a dictionary-based reconstruction method was developed and is presented in this work...
October 17, 2018: Journal of Magnetic Resonance Imaging: JMRI
Katerina Deike-Hofmann, Franziska Koenig, Daniel Paech, Constantin Dreher, Stefan Delorme, Heinz-Peter Schlemmer, Sebastian Bickelhaupt
Oncologic imaging focused on the detection of breast cancer is of increasing importance, with over 1.7 million new cases detected each year worldwide. MRI of the breast has been described to be one of the most sensitive imaging modalities in breast cancer detection; however, clinical use is limited due to high costs. In the past, the objective and clinical routine of oncologic imaging was to provide one extended imaging protocol covering all potential needs and clinical implications regardless of the specific clinical indication or question...
October 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
Hideki Ota, Hajime Tamura, Ryo Itabashi, Yukako Yazawa, Yasuhiro Nakamura, Kenji Hisamatsu, Manabu Takamatsu, Hidenori Endo, Kuniyasu Niizuma, Yukiko Enomoto, Tatsuo Nagasaka, Kimihiro Kajita, Mika Watanabe, Shinichi Yoshimura, Chun Yuan
BACKGROUND: There is limited evidence of parametric MR mapping to characterize carotid plaques associated with cerebral ischemic events. PURPOSE: To explore the apparent diffusion coefficients (ADCs) and longitudinal relaxation rates (R1 ) of carotid plaques, including areas of hemorrhage, lipid-rich/necrotic core (LR/NC) without hemorrhage, and fibrous tissue (Fbr) STUDY TYPE: Prospective. SUBJECTS: Twelve patients who underwent carotid endarterectomy...
October 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
Niko Radovic, Gordana Ivanac, Eugen Divjak, Iva Biondic, Antonio Bulum, Boris Brkljacic
BACKGROUND: The capability of diffusion-weighted imaging (DWI) for morphological analysis of breast lesions is underexplored. PURPOSE: To evaluate the utility of DWI for assessment of morphological features of breast cancer by comparing DWI and dynamic contrast-enhanced (DCE) MRI findings to determine intermethod and interobserver agreement. STUDY TYPE: Retrospective. POPULATION: Seventy-eight women with pathohistologically proven breast cancer...
October 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
Meher R Juttukonda, Chelsea A Lee, Niral J Patel, Larry T Davis, Spencer L Waddle, Melissa C Gindville, Sumit Pruthi, Adetola A Kassim, Michael R DeBaun, Manus J Donahue, Lori C Jordan
BACKGROUND: Blood transfusions are administered to children and adults with sickle cell anemia (SCA) for secondary stroke prevention, or as treatment for recurrent pain crises or acute anemia, but transfusion effects on cerebral hemodynamics and metabolism are not well-characterized. PURPOSE: To compare blood transfusion-induced changes in hemometabolic parameters, including oxygen extraction fraction (OEF) and cerebral blood flow (CBF), within and between adults and children with SCA...
October 15, 2018: Journal of Magnetic Resonance Imaging: JMRI
Louise Ladefoged Poulsen, Magne Bisgaard, Steffen Lynge Jørgensen, Tommy Dideriksen, Jacob Roland Pedersen, Henrik Christensen
The aim of the study was to investigate cellulitis caused by Escherichia coli which has been responsible for economic and welfare problems in Danish broiler production between 2014 and 2016. The study included 13 flocks with unusually high condemnation rates due to cellulitis during a period of approximately one year. From six flocks, 126 condemned carcasses were collected at a Danish slaughterhouse. Further 272 broilers dead on their own were collected on nine broiler farms from flocks with increased mortality and cellulitis (2 farms included both birds from the rearing period and broilers subsequently condemned)...
November 2018: Veterinary Microbiology
Dina Abdallah, Najwa Skafi, Eva Hamade, Mathieu Borel, Sophie Reibel, Nicolas Vitale, Alaeddine El Jamal, Carole Bougault, Norbert Laroche, Laurence Vico, Bassam Badran, Nader Hussein, David Magne, Rene Buchet, Leyre Brizuela, Saida Mebarek
Mammalian phospholipase D (PLD) mostly hydrolyzes phosphatidylcholine producing phosphatidic acid. PLD activity was previously detected in different osteoblastic cell models, and was increased by several growth factors involved in bone homeostasis. To confirm possible actions of PLD isoforms during mineralization process, we analyzed their effects in osteoblastic cell models and during bone formation. PLD1 expression, along with PLD activity, increased during differentiation of primary osteoblasts and Saos-2 cells, and peaked at the onset of mineralization...
October 15, 2018: Journal of Cellular Biochemistry
Mustafa R Bashir, Tanya Wolfson, Anthony C Gamst, Kathryn J Fowler, Michael Ohliger, Shetal N Shah, Adina Alazraki, Andrew T Trout, Cynthia Behling, Daniela S Allende, Rohit Loomba, Arun Sanyal, Jeffrey Schwimmer, Joel E Lavine, Wei Shen, James Tonascia, Mark L Van Natta, Adrija Mamidipalli, Jonathan Hooker, Kris V Kowdley, Michael S Middleton, Claude B Sirlin
BACKGROUND: The liver R2* value is widely used as a measure of liver iron but may be confounded by the presence of hepatic steatosis and other covariates. PURPOSE: To identify the most influential covariates for liver R2* values in patients with nonalcoholic fatty liver disease (NAFLD). STUDY TYPE: Retrospective analysis of prospectively acquired data. POPULATION: Baseline data from 204 subjects enrolled in NAFLD/NASH (nonalcoholic steatohepatitis) treatment trials...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
Susanne Bensler, Tobias J Dietrich, Veronika Zubler, Christian W A Pfirrmann, Reto Sutter
BACKGROUND: In daily routine, pincer femoroacetabular impingement (FAI) findings are often seen without a clinical diagnosis of pincer FAI. PURPOSE: To assess the presence of pincer FAI MRI findings in asymptomatic volunteers with negative impingement test versus patients with clinically confirmed FAI. STUDY TYPE: Case-control study. POPULATION: Sixty-three asymptomatic volunteers and 63 matched patients with FAI were included...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
Kulam Najmudeen Magdoom, Francisco Delgado, Ana C Bohórquez, Alec C Brown, Paul R Carney, Carlos Rinaldi, Thomas H Mareci, James R Ewing, Malisa Sarntinoranont
BACKGROUND: Brainstem gliomas are aggressive and difficult to treat. Growth of these tumors may be characterized with MRI methods. PURPOSE: To visualize longitudinal changes in tumor volume, vascular leakiness, and tissue microstructure in an animal model of brainstem glioma. STUDY TYPE: Prospective animal model. ANIMAL MODEL: Male Sprague-Dawley rats (n = 9) were imaged with 9L gliosarcoma cells infused into the pontine reticular formation of the brainstem...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
Keith S Cover, Katya M Duvivier, Pim de Graaf, Rianne Wittenberg, Ruth Smit, Joost P A Kuijer, Mark B M Hofman, Ben J Slotman, Ruud M Verdaasdonk
BACKGROUND: Each ultrafast dynamic contrast-enhanced (DCE) MRI sequence for breast cancer generates thousands of images in a 4D stack that need to be reviewed by a radiologist. PURPOSE: To assess whether color intensity projections (CIP) effectively summarizes-using only the time of arrival (ToA) and amount of signal enhancement (AoE) of the contrast agent-the thousands of ultrafast images. STUDY TYPE: Retrospective cohort clinical trial. SUBJECTS: The study included 89 patients who had been scanned with an MRI beast protocol, of which 26 had breast cancer and 63 did not...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
Octavia Bane, Steven Peti, Mathilde Wagner, Stefanie Hectors, Hadrien Dyvorne, Michael Markl, Bachir Taouli
BACKGROUND: The test-retest/interobserver repeatability and diagnostic value of 4D flow MRI in liver disease is underreported. PURPOSE: To determine the reproducibility/repeatability of flow quantification in abdominal vessels using a spiral 4D flow MRI sequence; to assess the value of 4D flow parameters in diagnosing cirrhosis and degree of portal hypertension. STUDY TYPE: Prospective. SUBJECTS: Fifty-two patients with chronic liver disease...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
Federica Pediconi, Flaminia Marzocca, Beatrice Cavallo Marincola, Alessandro Napoli
In the last decades, an increasing interest has developed towards non-invasive breast lesion treatments, which offer advantages such as the lack of surgery-related complications, better cosmetic outcomes, and less psychological distress. In addition, these treatments could be an option for patients with poor health who are not candidates for surgery. Non-surgical ablation can be performed under magnetic resonance (MR) or ultrasound (US) guidance. US is cheaper and easily available, while contrast-enhanced MR is more accurate, ensuring better safety and efficacy for the patient...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
Roberto Colotti, Patrick Omoumi, Ruud B van Heeswijk, Jessica A M Bastiaansen
BACKGROUND: Improved knee cartilage morphological delineation and T2 mapping precision necessitates isotropic 3D high-resolution and efficient fat suppression. PURPOSE: To develop and assess an isotropic 3D lipid-insensitive T2 mapping technique of the knee for improved cartilage delineation and precise measurement of T2 relaxation times. STUDY TYPE: Prospective. PHANTOM/SUBJECTS: Phantoms (n = 6) used in this study were designed to mimic the T1 and T2 relaxation times of cartilage and fat...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
Shaozhen Yan, Zhigang Qi, Yanhong An, Mo Zhang, Tianyi Qian, Jie Lu
BACKGROUND: Vascular factors contributing to cerebral hypoperfusion are implicated in the risk of developing Alzheimer's disease (AD). PURPOSE: To investigate the time-shift mapping created time-shift value of the brain by resting-state functional magnetic resonance imaging (rs-fMRI), and to determine the differences in time-shift value among AD, mild cognitive impairment (MCI), and normal control (NC) groups to better understand the disease. STUDY TYPE: Prospective...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
Bohyun Kim, So Yeon Kim, Kyoung Won Kim, Hye Young Jang, Jong Keon Jang, Gi Won Song, Sung Gyu Lee
In living donor liver transplantation (LDLT), a thorough preoperative evaluation of the donor is imperative to minimize the risk of the donors and improve the outcome of the recipients. In order to select the best candidate, knowledge of the liver volume, degree of steatosis, and anatomic variations in the vascular and biliary system in potential donors is crucial. With recent technical advances, magnetic resonance imaging (MRI) is increasingly replacing the need for computed tomography (CT) examination in essential steps of donor evaluation...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
Taiki Yamaguchi, Yuichiro Abe, Yoshio Ichino, Shigenobu Satoh, Takeshi Masuda, Shoichi Kimura, Manabu Ito, Toru Yamamoto
BACKGROUND: Radiofrequency (RF) heating during MRI theoretically increases with magnetic field strength. In addition, implanted metallic devices are reported to further increase RF heating. However, a detailed evaluation of this type of heating remains scarce in clinical practice. PURPOSE: To assess possible risks and discomfort related to RF heating during MRI examinations of patients with and without metallic implantable devices. STUDY TYPE: A retrospective study of previous questionnaire results on the heating sensation during MRI examinations of the lumbar spine...
October 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
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