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JOURNAL ARTICLE
Woonghee Lee, Seokhyun Choung, Seok Kim, Jiyun Hong, Doyeon Kim, William A Tarpeh, Jeong Woo Han, Kangwoo Cho
Chlorine has been supplied by the chlor-alkali process that deploys dimensionally stable anodes (DSAs) for the electrochemical chlorine evolution reaction (ClER). The paramount bottlenecks have been ascribed to an intensive usage of precious elements and inevitable competition with the oxygen evolution reaction. Herein, a unique case of Ru2+ -O4 active motifs anchored on Magnéli Ti4 O7 (Ru-Ti4 O7 ) via a straightforward wet impregnation and mild annealing is reported. The Ru-Ti4 O7 performs radically active ClER with minimal deployment of Ru (0...
April 19, 2024: Small
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JOURNAL ARTICLE
Magne Neby, Rolf A Ims, Stefaniya Kamenova, Olivier Devineau, Eeva M Soininen
Herbivorous rodents in boreal, alpine and arctic ecosystems are renowned for their multi-annual population cycles. Researchers have hypothesised that these cycles may result from herbivore-plant interactions in various ways. For instance, if the biomass of preferred food plants is reduced after a peak phase of a cycle, rodent diets can be expected to become dominated by less preferred food plants, leading the population to a crash. It could also be expected that the taxonomic diversity of rodent diets increases from the peak to the crash phase of a cycle...
April 2024: Ecology and Evolution
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JOURNAL ARTICLE
Lucie Chastaingt, Marie Laure Toba, Carine Boulon, Loubna Dari, Joel Constans, Hela Daoud, Romain Chauvet, Caroline Adou, Julien Magne, Philippe Lacroix
<b/> Background: In the latest American Heart Association guidelines, influenza vaccination is recommended for patients with peripheral arterial disease (PAD). The vaccination coverage in this specific population is currently unknown. This study aims to determine the adherence to influenza vaccination in a PAD population and identify associated determinants. Patients and methods. Hospitalized patients and outpatients with PAD from two university departments of vascular medicine were prospectively included...
April 17, 2024: VASA. Zeitschrift Für Gefässkrankheiten
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JOURNAL ARTICLE
Kristian B Kraft, Eivor H Hoff, Magne Nylenna, Cathrine F Moe, Arnstein Mykletun, Kristian Østby
BACKGROUND: Fee-for-service is a common payment model for remunerating general practitioners (GPs) in OECD countries. In Norway, GPs earn two-thirds of their income through fee-for-service, which is determined by the number of consultations and procedures they register as fees. In general, fee-for-service incentivises many and short consultations and is associated with high service provision. GPs act as gatekeepers for various treatments and interventions, such as addictive drugs, antibiotics, referrals, and sickness certification...
April 15, 2024: BMC Health Services Research
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RANDOMIZED CONTROLLED TRIAL
Wassilios G Meissner, Philippe Remy, Caroline Giordana, David Maltête, Pascal Derkinderen, Jean-Luc Houéto, Mathieu Anheim, Isabelle Benatru, Thomas Boraud, Christine Brefel-Courbon, Nicolas Carrière, Hélène Catala, Olivier Colin, Jean-Christophe Corvol, Philippe Damier, Estelle Dellapina, David Devos, Sophie Drapier, Margherita Fabbri, Vanessa Ferrier, Alexandra Foubert-Samier, Solène Frismand-Kryloff, Aurore Georget, Christine Germain, Stéphane Grimaldi, Clémence Hardy, Lucie Hopes, Pierre Krystkowiak, Brice Laurens, Romain Lefaucheur, Louise-Laure Mariani, Ana Marques, Claire Marse, Fabienne Ory-Magne, Vincent Rigalleau, Hayet Salhi, Amandine Saubion, Simon R W Stott, Claire Thalamas, Claire Thiriez, Mélissa Tir, Richard K Wyse, Antoine Benard, Olivier Rascol
BACKGROUND: Lixisenatide, a glucagon-like peptide-1 receptor agonist used for the treatment of diabetes, has shown neuroprotective properties in a mouse model of Parkinson's disease. METHODS: In this phase 2, double-blind, randomized, placebo-controlled trial, we assessed the effect of lixisenatide on the progression of motor disability in persons with Parkinson's disease. Participants in whom Parkinson's disease was diagnosed less than 3 years earlier, who were receiving a stable dose of medications to treat symptoms, and who did not have motor complications were randomly assigned in a 1:1 ratio to daily subcutaneous lixisenatide or placebo for 12 months, followed by a 2-month washout period...
April 4, 2024: New England Journal of Medicine
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JOURNAL ARTICLE
Guillermo Sanchez Rosenberg, Martin Magnéli, Niklas Barle, Michael G Kontakis, Andreas Marc Müller, Matthias Wittauer, Max Gordon, Cyrus Brodén
BACKGROUND AND PURPOSE: Large language models like ChatGPT-4 have emerged. They hold the potential to reduce the administrative burden by generating everyday clinical documents, thus allowing the physician to spend more time with the patient. We aimed to assess both the quality and efficiency of discharge documents generated by ChatGPT-4 in comparison with those produced by physicians. PATIENTS AND METHODS: To emulate real-world situations, the health records of 6 fictional orthopedic cases were created...
March 21, 2024: Acta Orthopaedica
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JOURNAL ARTICLE
Magne Stridh, Ulf Dahlstrand, Magdalena Naumovska, Karl Engelsberg, Bodil Gesslein, Rafi Sheikh, Aboma Merdasa, Malin Malmsjö
PURPOSE: The gold standard for skin cancer diagnosis is surgical excisional biopsy and histopathological examination. Several non-invasive diagnostic techniques exist, although they have not yet translated into clinical use. This is a proof-of-concept study to assess the possibility of imaging an angiosarcoma in the periocular area. METHODS: We use laser speckle, hyperspectral, and photoacoustic imaging to monitor blood perfusion and oxygen saturation, as well as the molecular composition of the tissue...
April 9, 2024: Orbit
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JOURNAL ARTICLE
Håvard Mo Fagersand, David Morin, Kjell Magne Mathisen, Jianying He, Zhiliang Zhang
Wire-arc additive manufacturing (WAAM) is a promising industrial production technique. Without optimization, inherent temperature gradients can cause powerful residual stresses and microstructural defects. There is therefore a need for data-driven methods allowing real-time process optimization for WAAM. This study focuses on machine learning (ML)-based prediction of temperature history for WAAM-produced aluminum bars with different geometries and process parameters, including bar length, number of deposition layers, and heat source movement speed...
February 3, 2024: Materials
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REVIEW
Kelly Coutant, Brice Magne, Karel Ferland, Aurélie Fuentes-Rodriguez, Olivier Chancy, Andrew Mitchell, Lucie Germain, Solange Landreville
Melanocytes are dendritic cells localized in skin, eyes, hair follicles, ears, heart and central nervous system. They are characterized by the presence of melanosomes enriched in melanin which are responsible for skin, eye and hair pigmentation. They also have different functions in photoprotection, immunity and sound perception. Melanocyte dysfunction can cause pigmentary disorders, hearing and vision impairments or increased cancer susceptibility. This review focuses on the role of melanocytes in homeostasis and disease, before discussing their potential in regenerative medicine applications, such as for disease modeling, drug testing or therapy development using stem cell technologies, tissue engineering and extracellular vesicles...
April 8, 2024: Journal of Translational Medicine
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JOURNAL ARTICLE
Erland Hermansen, Tor Åge Myklebust, Ivar Magne Austevoll, Christian Hellum, Kjersti Storheim, Hasan Banitalebi, Kari Indrekvam, Helena Brisby
PURPOSE: The aim of the present study was to investigate how canal area size changed from before surgery and up to 2 years after decompressive lumbar surgery lumbar spinal stenosis. Further, to investigate if an area change postoperatively (between 3 months to 2 years) was associated with any preoperative demographic, clinical or MRI variables or surgical method used. METHODS: The present study is analysis of data from the NORDSTEN- SST trial where 437 patients were randomized to one of three mini-invasive surgical methods for lumbar spinal stenosis...
April 8, 2024: European Spine Journal
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JOURNAL ARTICLE
Hojjat Daniali, Mollie A Ruben, Per M Aslaksen, Charlotte Fiskum, Ted J Kaptchuk, Magne A Flaten
INTRODUCTION: Studies suggest facial expressions of caregivers may be important in placebo effects; however, this has not been systematically tested. This experiment investigated the effects of caregivers' singular positive nonverbal behaviours (NBs) on pain reports. METHODS: Fifty-one males and 53 females (total of 104) participants were randomized to four groups that were displayed positive facial expressions, tone of voice, body movement, or neutral NBs of videotaped experimenters...
2024: Journal of Pain Research
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JOURNAL ARTICLE
Kaja E Kjørholt, Nina Paulshus Sundlisæter, Anna-Birgitte Aga, Joseph Sexton, Inge C Olsen, Hallvard Fremstad, Cristina Spada, Tor Magne Madland, Christian A Høili, Gunnstein Bakland, Åse Lexberg, Inger Johanne Widding Hansen, Inger Myrnes Hansen, Hilde Haukeland, Maud-Kristine Aga Ljoså, Ellen Moholt, Till Uhlig, Tore K Kvien, Daniel H Solomon, Désirée van der Heijde, Espen A Haavardsholm, Siri Lillegraven
BACKGROUND: Tapering of disease-modifying antirheumatic drugs (DMARDs) to drug-free remission is an attractive treatment goal for patients with rheumatoid arthritis, although long-term effects of tapering and withdrawal remain unclear. We compared 3-year risks of flare between three conventional synthetic DMARD treatment strategies in patients with rheumatoid arthritis in sustained remission. METHODS: In this open-label, randomised controlled, non-inferiority trial, we enrolled patients aged 18-80 years with rheumatoid arthritis who had been in sustained remission for at least 1 year on stable conventional synthetic DMARD therapy...
April 4, 2024: Lancet Rheumatology
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JOURNAL ARTICLE
Margherita Fabbri, Vanessa Rousseau, Jean-Christophe Corvol, Agnès Sommet, Florence Tubach, Yann De Rycke, Nathalie Bertille, Yajiththa Selvarasa, Stephanie Carvalho, Véronique Chaigneau, Christine Brefel-Courbon, Fabienne Ory-Magne, Samuel Tessier, Melissa Tir, Matthieu Bereau, Wassilios G Meissner, Claire Thiriez, Ana Marques, Philippe Remy, Vincent Schneider, Elena Moro, Luc Defebvre, Jean Luc Houeto, Stephane Prange, Alexandre Eusebio, Christian Geny, Solène Frismand, Philippe Damier, Caroline Giordana Reuther, Giovanni Castelnovo, Isabelle Benatru, Anne Doe De Maindreville, Sophie Drapier, David Maltête, Ouhaid Lagha-Boukbiza, Olivier Rascol
OBJECTIVE: To assess amantadine use and associated factors in the patients with Parkinson's disease (PD). BACKGROUND: Immediate-release amantadine is approved for the treatment of PD and is largely used in clinical practice to treat "levodopa-induced dyskinesia (LIDs). Its use varies according to countries and PD stages. The prospective NS-Park cohort collects features of PD patients followed by 26 French PD Expert Centres. METHODS: Variables used for the analyses included demographics, motor and non-motor PD symptoms and motor complications [motor fluctuations (MFs), LIDs)], antiparkinsonian pharmacological classes and levodopa equivalent daily dose (LEDD)...
April 5, 2024: Journal of Neural Transmission
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Sara Calabrese, Thor Magne Jonassen, Endre Steigum, Helga Øen Åsnes, Albert Kjartan Dagbjartarson Imsland, Carolina Serra Saude, Truls Wergeland, Erik Höglund
[This corrects the article DOI: 10.3389/fvets.2024.1347062.].
2024: Frontiers in Veterinary Science
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JOURNAL ARTICLE
Håkon Magne Vegrim, Julie Werenberg Dreier, Jannicke Igland, Nils Erik Gilhus, Silje Alvestad, Mika Gissler, Maarit K Leinonen, Yuelian Sun, Helga Zoega, Jakob Christensen, Marte-Helene Bjørk, Torbjörn Tomson
OBJECTIVE: This study was undertaken to characterize the use of higher doses of folic acid (≥1 mg daily) in relation to pregnancy in Denmark, Norway, and Sweden in women with epilepsy treated with antiseizure medication (ASM). METHODS: In this observational study, we used data from national medical birth, patient, and prescription registers in Denmark, Norway, and Sweden to retrospectively identify pregnancies in women with epilepsy treated with ASM from 2006 to 2017...
March 30, 2024: Epilepsia
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REVIEW
Meliha Ekinci, Tais Monteiro Magne, Luciana Magalhães Rebelo Alencar, Pierre Basilio Almeida Fechine, Ralph Santos-Oliveira, Derya Ilem-Özdemir
It is evident that radiolabeled drug delivery systems hold great promise in the field of lung cancer management. The combination of therapeutic agents with radiotracers not only allows for precise localization within lung tumors but also enables real-time monitoring of drug distribution. This approach has the potential to enhance targeted therapy and improve patient outcomes. The integration of advanced imaging modalities, such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), has played a crucial role in the non-invasive tracking of radiolabeled drugs...
March 15, 2024: Pharmaceutics
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JOURNAL ARTICLE
Hugo Ramos, Mario Altieri
El diagnóstico de Cardiomiopatía Cirrótica está basado en la presencia de cirrosis hepática avanzada con alteraciones de la función cardíaca sin cardiopatía pre-existente, pero en gran parte de su evolución natural ésta es subclínica. Por ello son imprescindibles los estudios complementarios no invasivos para confirmar el diagnóstico y su rol pronóstico en pacientes con o sin trasplante hepático. En esta segunda parte revisamos los métodos de diagnóstico desde el ECG hasta las imágenes de resonancia magnética cardíaca...
March 27, 2024: Revista de la Facultad de Ciencias Médicas
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REVIEW
Fathi Berrabah, Farouk Benaceur, Chaoyan Yin, Dawei Xin, Kévin Magne, Marie Garmier, Véronique Gruber, Pascal Ratet
Immunity and senescence play a crucial role in the functioning of the legume symbiotic nodules. The miss-regulation of one of these processes compromises the symbiosis leading to death of the endosymbiont and the arrest of the nodule functioning. The relationship between immunity and senescence is highly studied in plant organs where a synergistic response can be observed. However, the interplay between immunity and senescence in the symbiotic organ is poorly discussed in the literature and these phenomena are often mixed up...
March 25, 2024: Plant communications
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REVIEW
Linn Bernklev, Jens Aksel Nilsen, Knut Magne Augestad, Øyvind Holme, Nastazja Dagny Pilonis
Endoscopic resection techniques enable en-bloc resection of T1 colon cancers. A complete removal of T1 colon cancer can be considered curative when histologic examination of the specimens shows none of the high-risk factors for lymph nodes metastases. Criteria predicting lymph nodes metastases include deep submucosal invasion, poor differentiation, lymphovascular invasion, and high-grade tumor budding. In these cases, complete (R0), local endoscopic resection is considered sufficient as negligible risk of lymph nodes metastases does not outweigh morbidity and mortality associated with surgical resection...
February 2024: Best Practice & Research. Clinical Gastroenterology
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JOURNAL ARTICLE
Carina Lisøy, Simon-Peter Neumer, Frode Adolfsen, Jo Magne Ingul, Lene-Mari Potulski Rasmussen, Tore Wentzel-Larsen, Joshua Patras, Anne Mari Sund, Kristin Ytreland, Trine Waaktaar, Solveig Holen, Anne Liv Askeland, Ida Mari Haug, Elisabeth Valmyr Bania, Kristin Martinsen
Identifying effective components can lead to interventions that are less resource-intensive and better suited for real-world needs. In this 2×2×2 cluster-randomized factorial trial (clinicaltrials.gov NCT04263558), we investigated the effects of three components of an indicated, transdiagnostic CBT intervention for children: 1) Intervention Delivery Format (child group format versus a blended format with group sessions and automated web-based sessions), 2) Parental Involvement in the intervention (group-based versus psychoeducational brochure), and 3) a Measurement Feedback System (MFS; on versus off)...
March 18, 2024: Behaviour Research and Therapy
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