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Gertjan Ettema, Magne Øksnes, Espen Kveli, Øyvind Sandbakk
PURPOSE: The aim of this study was to investigate the effect of exhaustive exercise on technique preference and the accompanying physiological response during classic skiing at constant workload, but with varying incline-speed combinations. METHODS: Seven male competitive cross-country skiers performed four tests, each lasting 23 min, at constant 200 W workload roller skiing on a treadmill using classic style, three in unfatigued state, and one after exhaustion...
August 13, 2018: European Journal of Applied Physiology
Magne A Flaten, Espen Bjørkedal, Peter S Lyby, Yngve Figenschau, Per M Aslaksen
Background: Associative learning has, in several studies, been modulated by the sex of the participant. Consistent with this, a recent review found that conditioned nocebo effects are stronger in females than in males. Purpose: It has been suggested that conditioned placebo responses are stronger in females, and this hypothesis was investigated in the present study. Cortisol and measures of negative emotions were taken to investigate if these processes could mediate any conditioned placebo effects. Methods: Cold pain was applied to the volar forearm...
2018: Frontiers in Psychology
Zhou Wan-Li, Tao Jun, Zhang Yu-Dong, Shuang Fei, Han Zhijian, Wu Chen-Jiang, Wang Zijie, Li Yongjun, Que Hongliang, Huang Zhengkai, Wang Zengjun, Tan Ruoyun, Gu Min
BACKGROUND: Glomerular filtration rate (GFR) is a preferred indicator of allograft renal function, but direct measurement of GFR remains complicated. PURPOSE: To prospectively compare dynamic contrast-enhanced MR renography (DCE-MRR) with 99m Tc-DTPA-based single-photon emission computed tomography (SPECT) for determination of allograft renal function. STUDY TYPE: Prospective. POPULATION: Seventy kidney-transplant recipients FIELD STRENGTH: A low-dose DCE-MRR with a 3...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Stine Hangaard, Henrik Gudbergsen, Cecilie L Daugaard, Henning Bliddal, Janus Damm Nybing, Miika T Nieminen, Victor Casula, Carl-Johan Tiderius, Mikael Boesen
BACKGROUND: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). PURPOSE: To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of menisci in obese patients with knee OA. STUDY TYPE: Cross-sectional...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Fraser M Callaghan, Paul Bannon, Edward Barin, David Celemajer, Richmond Jeremy, Gemma Figtree, Stuart M Grieve
BACKGROUND: Abnormal flow dynamics play an early and causative role in pathologic changes of the ascending aorta. PURPOSE: To identify: 1) the changes in flow, shape, and size that occur in the ascending aorta with normal human ageing and 2) the influence of these factors on aortic flow dynamics. STUDY TYPE: Retrospective. SUBJECTS: In all, 247 subjects (age range 19-86 years, mean 49 ± 17.7, 169 males) free of aortic or aortic valve pathology were included in this study...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Sigmund Ytre-Hauge, Julie A Dybvik, Arvid Lundervold, Øyvind O Salvesen, Camilla Krakstad, Kristine E Fasmer, Henrica M Werner, Balaji Ganeshan, Erling Høivik, Line Bjørge, Jone Trovik, Ingfrid S Haldorsen
BACKGROUND: Improved methods for preoperative risk stratification in endometrial cancer are highly requested by gynecologists. Texture analysis is a method for quantification of heterogeneity in images, increasingly reported as a promising diagnostic tool in various cancer types, but largely unexplored in endometrial cancer. PURPOSE: To explore whether tumor texture parameters from preoperative MRI are related to known prognostic features (deep myometrial invasion, cervical stroma invasion, lymph node metastases, and high-risk histological subtype) and to outcome in endometrial cancer patients...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Yangyang Kan, Di Dong, Yuchen Zhang, Wenyan Jiang, Nannan Zhao, Lu Han, Mengjie Fang, Yali Zang, Chaoen Hu, Jie Tian, Chunming Li, Yahong Luo
BACKGROUND: Lymph node metastasis (LNM) is the principal risk factor for poor outcomes in early-stage cervical cancer. Radiomics may offer a noninvasive way for predicting the stage of LNM. PURPOSE: To evaluate a radiomic signature of LN involvement based on sagittal T1 contrast-enhanced (CE) and T2 MRI sequences. STUDY TYPE: Retrospective. POPULATION: In all, 143 patients were randomly divided into two primary and validation cohorts with 100 patients in the primary cohort and 43 patients in the validation cohort...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Jia-Ying Zhou, Yuan-Cheng Wang, Chu-Hui Zeng, Sheng-Hong Ju
Renal function varies according to the nature and stage of diseases. Renal functional magnetic resonance imaging (fMRI), a technique considered superior to the most common method used to estimate the glomerular filtration rate, allows for noninvasive, accurate measurements of renal structures and functions in both animals and humans. It has become increasingly prevalent in research and clinical applications. In recent years, renal fMRI has developed rapidly with progress in MRI hardware and emerging postprocessing algorithms...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Trevor A McGrath, Patrick M Bossuyt, Paul Cronin, Jean-Paul Salameh, Noémie Kraaijpoel, Nicola Schieda, Matthew D F McInnes
As defined by the Cochrane Collaboration, a systematic review is a review of evidence with a clearly formulated question that uses systematic and explicit methods to identify, select, and critically appraise relevant primary research, and to extract and analyze data from the studies that are included in the review. Meta-analysis is a statistical method to combine the results from primary studies that accounts for sample size and variability to provide a summary measure of the studied outcome. Systematic reviews of diagnostic test accuracy present unique methodological and reporting challenges not present in systematic reviews of interventions...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Fengxian Wang, Chen Chu, Cheng Zhao, Yu Wei, Qinglei Zhang, Qianqian Feng, Weibo Chen, Jian He, Lingyun Sun, Zhengyang Zhou
BACKGROUND: Conventional magnetic resonance (MR) imaging is limited in providing sufficient information on microstructure or in quantitatively evaluating certain inflammation processes. Functional MR sequences such as diffusion kurtosis imaging (DKI) might help to evaluate the sacroiliac joint in ankylosing spondylitis (AS) patients. PURPOSE: To explore the application of DKI in evaluating the disease activity of AS. STUDY TYPE: Prospective...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Jeong Hee Yoon, Jeong Min Lee, Yoon Jin Lee, Kyung Bun Lee, Joon Koo Han
BACKGROUND: Small hepatocellular carcinomas (HCCs) often show atypical features at cross-sectional imaging, yet there is no preferred recommendation for the diagnosis or characterization of small observations (10-19 mm) at present. PURPOSE: To determine the added value of sequentially performed gadoxetic acid-enhanced liver MRI for contrast-enhanced computed tomography (CECT)-detected small (10-19 mm) or atypical hepatic observations ≥20 mm in the diagnosis of HCC...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Takashi Iwanaga, Yoshihiko Fukukura, Tomonori Saito, Masashi Sasaki, Yuichi Kumagae, Koji Takumi, Hiroto Hakamada, Takuro Fujisaki, Yasumasa Saigo, Takashi Yoshiura
BACKGROUND: Diffusion-weighted imaging (DWI) has been used for the detection and characterization of liver tumors because it has excellent contrast resolution. DWI using short tau inversion recovery (STIR) can improve tumor-to-liver contrast after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) administration that shortens the T1 relaxation of liver parenchyma. PURPOSE: To quantitatively and qualitatively compare the conspicuity of malignant liver tumors on DWI after Gd-EOB-DTPA administration between STIR and chemical shift selective (CHESS) sequences...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Jacob A Macdonald, Philip A Corrado, Sydney M Nguyen, Kevin M Johnson, Christopher J Francois, Ronald R Magness, Dinesh M Shah, Thaddeus G Golos, Oliver Wieben
BACKGROUND: Pregnancy complications are often associated with poor uteroplacental vascular adaptation and standard diagnostics are unable to reliably quantify flow in all uteroplacental vessels and have poor sensitivity early in gestation. PURPOSE: To investigate the feasibility of using 4D flow MRI to assess total uteroplacental blood flow in pregnant rhesus macaques as a precursor to human studies. STUDY TYPE: Retrospective feasibility study...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Hai-Hua Zou, Jing Yu, Yun Wei, Jiang-Fen Wu, Qing Xu
BACKGROUND: Tumor heterogeneity can be assessed by texture analysis (TA). TA has been applied using diffusion-weighted imaging and apparent diffusion coefficient maps to predict pathological responses to preoperative chemoradiation therapy (CRT) in patients with locally advanced rectal cancer (LARC). PURPOSE: To evaluate the texture parameters obtained from K trans maps derived from dynamic contrast-enhanced (DCE)-MRI for predicting pathological responses to preoperative CRT for LARCs...
August 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
Yuheng Chen, Wenna Duan, Parshant Sehrawat, Vaibhav Chauhan, Freddy J Alfaro, Anna Gavrieli, Xingye Qiao, Vera Novak, Weiying Dai
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with alterations in the blood-brain barrier, neuronal damage, and arterial stiffness, thus affecting cerebral metabolism and perfusion. There is a need to implement machine-learning methodologies to identify a T2DM-related perfusion pattern and possible relationship between the pattern and cognitive performance/disease severity. PURPOSE: To develop a machine-learning pipeline to investigate the method's discriminative value between T2DM patients and normal controls, the T2DM-related network pattern, and association of the pattern with cognitive performance/disease severity...
August 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
Pia M Jungmann, Alexandra S Gersing, Klaus Woertler, Tobias J Dietrich, Thomas Baum, Frederic Baumann, Susanne Bensler
BACKGROUND: Shoulder osteoarthritis causes severe pain and functional disability. Preventive surgical procedures aiming to halt the progression of degenerative changes are increasingly applied. However, no MRI-based score exists that may be applied for scoring of osteoarthritic changes and their progression. PURPOSE: To establish a semiquantitative MRI-based shoulder osteoarthritis severity (SOAS) evaluation system and to test its reliability. STUDY TYPE: Retrospective...
August 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
Xiran Chen, Yanzi Chen, Yuan Xu, Qilu Gao, Zhiwei Shen, Wenbin Zheng
BACKGROUND: Diffuse axonal injury (DAI) is one of the devastating types of traumatic brain injury, but is difficult to detect on conventional imaging in its early stages. PURPOSE: To test the technical feasibility and diagnostic value of diffusion kurtosis imaging (DKI) and glutamate chemical exchange saturation transfer (GluCEST) imaging in the brain after DAI. STUDY TYPE: Prospective. ANIMAL MODEL: Sixty Sprague-Dawley rats...
August 6, 2018: Journal of Magnetic Resonance Imaging: JMRI
Richard Greil, Sigrun Greil-Ressler, Lukas Weiss, Charlotte Schönlieb, Teresa Magnes, Bianca Radl, Gordon T Bolger, Brigitta Vcelar, Peter P Sordillo
PURPOSE: This study was conducted to investigate the safety and tolerability of increasing doses of liposomal curcumin in patients with metastatic cancer. Investigations of anti-tumor activity and of the pharmacokinetics of curcumin were secondary objectives. METHODS: In this phase I, single-center, open-label study in patients with metastatic tumors, liposomal curcumin was administered as a weekly intravenous infusion for 8 weeks. Dose escalation was started at 100 mg/m2 over 8 h and the dose increased to 300 mg/m2 over 6 h...
August 3, 2018: Cancer Chemotherapy and Pharmacology
Pascal Magne, Mehrdad Razaghy, Marco Aurelio Carvalho, Luciana Mara Soares
PURPOSE: To evaluate in vitro the vertical seating of computer-assisted design/computer-assisted manufacturing (CAD/CAM) composite resin inlays, onlays, and overlays luted with two different composite resins. MATERIALS AND METHODS: Sixty plastic typodont molars were prepared for medium-sized MOD inlays, anatomic onlays, and flat overlays (n = 20); 3-mm thick at the central groove with similar morphology (Cerec biogeneric copy). Restorations were milled using Lava Ultimate blocks, and included standardized hemispherical occlusal concavity for seating measurements with an electromechanic system (force = 30 N)...
2018: International Journal of Esthetic Dentistry
Pralay Gayen, Jason Spataro, Sumant Avasarala, Abdul-Mehdi Ali, José M Cerrato, Brian P Chaplin
This research focused on synthesis, characterization, and application of point-of-use catalytic reactive electrochemical membranes (REMs) for electrocatalytic NO3 - reduction. Deposition of Pd-Cu and Pd-In catalysts to the REMs produced catalytic REMs (i.e., Pd-Cu/REM and Pd-In/REM) that were active for NO3 - reduction. Optimal performance was achieved with a Pd-Cu/REM and upstream counter electrode, which reduced NO3 - from 1.0 mM to below the EPAs regulatory MCL (700 μM) in a single pass through the REM (residence time ∼2 s), obtaining product selectivity of <2% toward NO2 - /NH3 ...
August 2, 2018: Environmental Science & Technology
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