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https://www.readbyqxmd.com/read/30326341/hypomethylation-of-line-1-elements-in-schizophrenia-and-bipolar-disorder
#1
Shufen Li, Qiong Yang, Yu Hou, Tingyun Jiang, Lu Zong, Zhongju Wang, Xia Luo, Wenquan Liang, Hu Zhao, Yuping Ning, Cunyou Zhao
Schizophrenia (SCZ) and bipolar disorder (BPD) are severe mental illnesses with evidence of significant genetic and environmental etiological elements in their complex etiologies. 5'-Methylcytosine is the main epigenetic DNA modification that mediates the interplay between genetic and environmental components. In humans, most 5'-methylcytosine modifications are observed in CpG-rich regions within the long interspersed nuclear element (LINE-1). LINE-1 is a mobile retrotransposon that comprises ∼17% of the human genome, and its methylation levels are highly correlated with global DNA methylation levels...
October 10, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/30326199/neuro-protective-role-of-nanocapsulated-curcumin-against-cerebral-ischemia-reperfusion-induced-oxidative-injury
#2
Abhishek Mukherjee, Sibani Sarkar, Sayantan Jana, Snehasikta Swarnakar, Nirmalendu Das
Cerebral ischemia-reperfusion (CIR) accelerates the progression of neurodegeneration by causing mitochondrial dysfunction to overproduce reactive oxygen species (ROS). Curcumin shows protective effects against CIR-induced oxidative damage. Free curcumin (FC) is effective at high doses due to its poor bioavailability. Also the blood-brain barrier (BBB) limits the passage of substances from circulation into the cerebral region. Thus, formulation of curcumin within polyethylene glycol (PEG)-ylated polylactide-co-glycolide (PLGA) nanoparticles (NC) was applied orally to aged rats to explore its role against CIR injury...
October 13, 2018: Brain Research
https://www.readbyqxmd.com/read/30326005/evaluation-of-interventions-intended-to-increase-colorectal-cancer-screening-rates-in-the-united-states-a-systematic-review-and-meta-analysis
#3
Michael K Dougherty, Alison T Brenner, Seth D Crockett, Shivani Gupta, Stephanie B Wheeler, Manny Coker-Schwimmer, Laura Cubillos, Teri Malo, Daniel S Reuland
Importance: Colorectal cancer screening (CRC) is recommended by all major US medical organizations but remains underused. Objective: To identify interventions associated with increasing CRC screening rates and their effect sizes. Data Sources: PubMed, Cumulative Index to Nursing and Allied Health Literature, the Cochrane Library, and ClinicalTrials.gov were searched from January 1, 1996, to August 31, 2017. Key search terms included colorectal cancer and screening...
October 15, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/30325976/impact-of-interactions-among-metabolic-syndrome-components-on-the-development-of-cardiovascular-disease-among-kazakhs-in-xinjiang
#4
Wenwen Yang, Xiang Gao, Xianghui Zhang, Yunhua Hu, Heng Guo, Kui Wang, Yizhong Yan, Jia He, Jingyu Zhang, Jiaolong Ma, Lei Mao, Lati Mu, Jiaming Liu, Shugang Li, Yusong Ding, Mei Zhang, Rulin Ma, Shuxia Guo
BACKGROUND: Few prospective studies have explored the effect of interactions among metabolic syndrome (MS) components on the development of cardiovascular disease (CVD) in the Kazakh population in Xinjiang Province of China. METHOD: As of December 2016, 2,644 participants who completed a baseline survey over a period of 5 years or more were included in the study. The multiplicative interactions among MS components were evaluated by incorporation of the product terms into a logistic regression model...
2018: PloS One
https://www.readbyqxmd.com/read/30325716/a-field-evaluation-of-a-single-sampler-for-respirable-and-inhalable-indium-and-dust-measurements-at-an-indium-tin-oxide-manufacturing-facility
#5
Brie Hawley, Jenna L Gibbs, Kristin Cummings, Aleksandr B Stefaniak, Ji Young Park, Marcia Stanton, M Abbas Virji
Indium-tin oxide production has increased greatly in the last twenty years subsequent to increased global demand for touch screens and photovoltaics. Previous studies used measurements of indium in blood as an indicator of indium exposure and observed associations with adverse respiratory outcomes. However, correlations between measurements of blood indium and airborne respirable indium are inconsistent, in part because of the long half-life of indium in blood, but also because respirable indium measurements do not incorporate inhalable indium that can contribute to the observed biological burden...
October 16, 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/30323763/modified-xiaoyaosan-mxys-exerts-anti-depressive-effects-by-rectifying-the-brain-blood-oxygen-level-dependent-fmri-signals-and-improving-hippocampal-neurogenesis-in-mice
#6
Lei Gao, Peng Huang, Zhaoyang Dong, Tingting Gao, Shaohui Huang, Chuying Zhou, Yuling Lai, Guanghui Deng, Bin Liu, Ge Wen, Zhiping Lv
As the traditional Chinese herbal formula, Xiaoyaosan and its modified formula have been described in many previous studies with definite anti-depressive effects, but its underlying mechanism remains mystery. Previous work in our lab has demonstrated that depression induced by chronic stress could generate brain blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals disorder, accompanied by the impairment of hippocampal neuronal plasticity, decrease of brain-derived neurotrophic factor, and reduction of the number and complexity of adult neurons in the dentate gyrus...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30323612/total-talar-replacement-with-a-novel-3d-printed-modular-prosthesis-for-tumors
#7
Xiang Fang, Hongyuan Liu, Yan Xiong, Wenli Zhang, Yi Luo, Fan Wu, Yong Zhou, Liuhong Song, Zeping Yu, Chongqi Tu, Hong Duan
Purpose: Arthrodesis is one of the most widely accepted surgical recommended methods for tumors of the talus, but it may be associated with poor limb functions. The aim of this study was to present a novel reconstruction with ankle function preserved after en bloc talus tumor resection. Patient and method: A 43-year-old female with mesenchymal sarcoma of the talus was admitted in West China Hospital. Total talar replacement with three-dimensional (3D) printed modular prosthesis was prepared for reconstruction...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/30322947/multiplex-three-dimensional-mapping-of-macromolecular-drug-distribution-in-the-tumor-microenvironment
#8
Steve Seung-Young Lee, Vytautas P Bindokas, Stephen J Kron
Macromolecular cancer drugs such as therapeutic antibodies and nanoparticles are well known to display slow extravasation and incomplete penetration into tumors, potentially protecting cancer cells from therapeutic effects. Conventional assays to track macromolecular drug delivery are poorly matched to the heterogeneous tumor microenvironment, but recent progress on optical tissue clearing and three-dimensional (3D) tumor imaging offers a path to quantitative assays with cellular resolution. Here, we apply Transparent Tissue Tomography (T3) as a tool to track perfusion and delivery in the tumor and to evaluate target binding and vascular permeability...
October 15, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/30322872/targeting-ulcerative-colitis-by-suppressing-glucose-uptake-with-ritonavir
#9
Henrika Jodeleit, Omar Al-Amodi, Janina Caesar, Christina Villarroel Aguilera, Lesca Holdt, Roswitha Gropp, Florian Beigel, Matthias Siebeck
Glucose is the preferred source of energy in activated inflammatory cells. Glucose uptake into the cell is ensured by a family of glucose uptake transporters (GLUT) which have been identified as off target molecules of the HIV protease inhibitor ritonavir. In this study, we examined the effect of ritonavir on inflammation in vitro and in vivo Peripheral blood mononuclear cells (PBMC) were activated with anti CD3 in the presence or absence of ritonavir and analyzed by flow cytometric analysis. Frequencies of CD4+ cells were significantly affected by ritonavir (CD69+ p=3E-05; CD134 p=4E-06; CD25+ p= E-07; central memory p=0...
October 15, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/30322673/rapid-discovery-of-quality-markers-from-kaixin-san-using-chinmedomics-analysis-approach
#10
Xi-Jun Wang, Ai-Hua Zhang, Ling Kong, Jing-Bo Yu, Hong-Lei Gao, Zhi-Dong Liu, Hui Sun
BACKGROUND: Alzheimer's disease (AD), a progressive neurodegenerative disease, is more common disease of dementia among the elderly by multiple factors and presents enormous challenges in terms of diagnosis and treatment. Kaixin San (KXS), is a classic prescription for the treatment of memory decline and applied for AD nowadays. However, the quality-markers of KXS for the treatment of AD remain unclear. PURPOSE: To investigate the effects and potential quality-markers of KXS against an APP/PS1 transgenic mouse model of AD...
December 18, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30322613/profiling-and-identification-of-chemical-components-of-shenshao-tablet-and-its-absorbed-components-in-rats-by-comprehensive-hplc-dad-esi-ms-n-analysis
#11
Wen-Juan Miao, Ying Hu, Li Jia, Chun-Xia Zhang, Wen-Zhi Yang, Ping Zhang, De-An Guo
Shenshao Tablet (SST), prepared from Paeoniae Radix Alba (PRA) and total ginsenoside of Ginseng Stems and Leaves (GSL), is a traditional Chinese medicine (TCM) preparation prescribed to treat coronary heart disease. However, its chemical composition and the components that can migrate into blood potentially exerting the therapeutic effects have rarely been elucidated. We developed an HPLC/DAD/ESI-MSn approach aiming to comprehensively profile and identify both the chemical components of SST and its absorbed ingredients (and metabolites) in rat plasma and urine...
October 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30322074/metagenome-analysis-as-a-tool-to-study-bacterial-infection-associated-with-acute-surgical-abdomen
#12
Shao-Chun Wu, Cheng-Shyuan Rau, Hang-Tsung Liu, Pao-Jen Kuo, Peng-Chen Chien, Ting-Min Hsieh, Ching-Hua Tsai, Jung-Fang Chuang, Chun-Ying Huang, Hsiao-Yun Hsieh, Ching-Hua Hsieh
BACKGROUND: The purpose of this study was to profile the bacterium in the ascites and blood of patients with acute surgical abdomen by metagenome analysis. METHODS: A total of 97 patients with acute surgical abdomen were included in this study. Accompanied with the standard culture procedures, ascites and blood samples were collected for metagenome analysis to measure the relative abundance of bacteria among groups of patients and between blood and ascites. RESULTS: Metagenomic analysis identified 107 bacterial taxa from the ascites of patients...
October 12, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30320398/formononetin-may-protect-aged-hearts-from-ischemia-reperfusion-damage-by-enhancing-autophagic-degradation
#13
Zhengxin Huang, Yingfeng Liu, Xianping Huang
Myocardial infarction is a leading cause of mortality worldwide, and timely blood/oxygen reperfusion may substantially improve the outcome of infarction. However, ischemia/reperfusion (I/R) may cause severe side effects through excess reactive oxygen species generation. To develop novel methods to relieve I/R induced cell damage, the present study used a component of traditional Chinese medicine. In the present study, isolated heart tissue from aged mice and H9C2 cells with chemically‑induced aging were used as experimental subjects, and it was demonstrated that formononetin was able to alleviate I/R‑induced cell or tissue apoptosis...
October 10, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30320383/-%C3%A2-epigallocatechin%C3%A2-3%C3%A2-gallate-attenuates-anesthesia%C3%A2-induced-memory-deficit-in-young-mice-via-modulation-of-nitric-oxide-expression
#14
Li Ding, Xiang Gao, Jianlei Hu, Shenghui Yu
(‑)Epigallocatechin‑3‑gallate (EGCG) is a type of polyphenol monomer and is the predominant component of catechin compounds extractable from green tea. Previous studies have demonstrated that EGCG exhibits numerous bioactivities both in vitro and in vivo, including antitumor, antioxidant and anti‑inflammatory activities, as well as lowering blood lipid levels and protecting against radiation. The present study aimed to investigate whether administration of EGCG may attenuate anesthesia‑induced memory deficit in young mice and to reveal the associated underlying mechanisms...
October 10, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30320108/the-ins-and-outs-of-autophagy-and-metabolism-in-hematopoietic-and-leukemic-stem-cells-food-for-thought
#15
REVIEW
Angela Ianniciello, Kevin M Rattigan, G Vignir Helgason
Discovered over fifty years ago, autophagy is a double-edged blade. On one hand, it regulates cellular energy sources by "cannibalization" of its own cellular components, feeding on proteins and other unused cytoplasmic factors. On the other, it is a recycling process that removes dangerous waste from the cytoplasm keeping the cell clean and healthy. Failure of the autophagic machinery is translated in dysfunction of the immune response, in aging, and in the progression of pathologies such as Parkinson disease, diabetes, and cancer...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/30320033/smart-diabetic-screening-and-managing-software-a-novel-decision-support-system
#16
M Ghoddusi Johari, M H Dabaghmanesh, H Zare, A R Safaeian, Gh Abdollahifard
Background: Diabetes is a serious chronic disease, and its increasing prevalence is a global concern. If diabetes mellitus is left untreated, poor control of blood glucose may cause long-term complications. A big challenge encountered by clinicians is the clinical management of diabetes. Many IT-based interventions such ad CDSS have been made to improve the adherence to the standard care for chronic diseases. Objective: The aim of this study is to establish a decision support system of diabetes management based on diabetes care guidelines in order to reduce medical errors and increase adherence to guidelines...
September 2018: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/30319917/use-of-raman-spectroscopy-to-screen-diabetes-mellitus-with-machine-learning-tools
#17
Edgar Guevara, Juan Carlos Torres-Galván, Miguel G Ramírez-Elías, Claudia Luevano-Contreras, Francisco Javier González
Type 2 diabetes mellitus (DM2) is one of the most widely prevalent diseases worldwide and is currently screened by invasive techniques based on enzymatic assays that measure plasma glucose concentration in a laboratory setting. A promising plan of action for screening DM2 is to identify molecular signatures in a non-invasive fashion. This work describes the application of portable Raman spectroscopy coupled with several supervised machine-learning techniques, to discern between diabetic patients and healthy controls (Ctrl), with a high degree of accuracy...
October 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/30319442/comparison-of-clinical-and-physiological-parameters-for-benign-prostatic-hyperplasia-in-hypertensive-and-normotensive-patients
#18
Xian-Tao Zeng, Hong Weng, Jing Xiong, Qiao Huang, Lin-Lu Ma, Ying-Hui Jin, Xing-Huan Wang
Objective: To discover the correlation of clinical and physiological measures for benign prostatic hyperplasia in hypertensive and normotensive patients. Methods: From September 2016 to October 2017, 435 patients were enrolled for further selection. The parameters evaluated for eligible patients included prostate volume, systolic blood pressure, diastolic blood pressure, international prostate symptom score, etc. Then the eligible patients were divided into two groups according to hypertension condition, and the clinical and physiological parameters were compared between two groups...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30319342/a-process-for-digitizing-and-simulating-biologically-realistic-oligocellular-networks-demonstrated-for-the-neuro-glio-vascular-ensemble
#19
Jay S Coggan, Corrado Calì, Daniel Keller, Marco Agus, Daniya Boges, Marwan Abdellah, Kalpana Kare, Heikki Lehväslaiho, Stefan Eilemann, Renaud Blaise Jolivet, Markus Hadwiger, Henry Markram, Felix Schürmann, Pierre J Magistretti
One will not understand the brain without an integrated exploration of structure and function, these attributes being two sides of the same coin: together they form the currency of biological computation. Accordingly, biologically realistic models require the re-creation of the architecture of the cellular components in which biochemical reactions are contained. We describe here a process of reconstructing a functional oligocellular assembly that is responsible for energy supply management in the brain and creating a computational model of the associated biochemical and biophysical processes...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/30318777/impact-of-hepatitis-e-virus-testing-on-the-safety-of-blood-components-in-germany-results-of-a-simulation-study
#20
Christel Kamp, Johannes Blümel, Sally A Baylis, Isabelle Bekeredjian-Ding, Michael Chudy, Margarethe Heiden, Olaf Henseler, Brigitte Keller-Stanislawski, Anneke S de Vos, Markus B Funk
Hepatitis E virus (HEV) infections may be acquired through transfusion of blood components. As transfusion-transmitted infections mostly affect vulnerable individuals, measures to ensure the supply of safe blood components are under discussion. On the basis of the epidemiological situation in Germany, different testing strategy scenarios were investigated through simulation studies. Testing for HEV RNA by nucleic acid amplification technique (NAT) assays with a pool size of 96, and a 95% LoD of 20 IU/ml will result in an 80% reduction in expected HEV transmissions as well as of consequent chronic infections with subsequent severe complications...
October 14, 2018: Vox Sanguinis
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