keyword
https://read.qxmd.com/read/38547250/extracellular-matrix-interactome-in-modulating-vascular-homeostasis-and-remodeling
#1
REVIEW
Yi Fu, Yuan Zhou, Kai Wang, Zhuofan Li, Wei Kong
The ECM (extracellular matrix) is a major component of the vascular microenvironment that modulates vascular homeostasis. ECM proteins include collagens, elastin, noncollagen glycoproteins, and proteoglycans/glycosaminoglycans. ECM proteins form complex matrix structures, such as the basal lamina and collagen and elastin fibers, through direct interactions or lysyl oxidase-mediated cross-linking. Moreover, ECM proteins directly interact with cell surface receptors or extracellular secreted molecules, exerting matricellular and matricrine modulation, respectively...
March 29, 2024: Circulation Research
https://read.qxmd.com/read/38545743/a-meta-analysis-of-risk-factors-for-acute-kidney-injury-in-pneumonia-effectiveness-of-nursing-interventions
#2
REVIEW
Liangjuan Yuan, Arshad Mehmood, Lei Meng
INTRODUCTION: The spread of coronavirus disease 2019 (COVID-19) worldwide since November 2019 is of interest to understand its impact on various organs. COVID-19 patients experience a higher incidence of acute kidney injury (AKI) compared with non-COVID-19 patients. METHODS: A systematic literature search was conducted that covered the period from November 1, 2019 to February 28, 2021. RESULTS: The analysis incorporated a comprehensive review of 19 studies of 21 362 patients...
March 28, 2024: Therapeutic Apheresis and Dialysis
https://read.qxmd.com/read/38544757/association-between-oxidative-balance-score-and-metabolic-syndrome-and-its-components-in-us-adults-a-cross-sectional-study-from-nhanes-2011-2018
#3
JOURNAL ARTICLE
Yi Lu, Meixiang Wang, Jiaxin Bao, Dashuang Chen, Hao Jiang
BACKGROUND: Metabolic syndrome (MetS) is a global health concern that threatens human well-being. The oxidative balance score (OBS) is a tool to identify the level of oxidative stress that is correlated with MetS risk. However, association between OBS and MetS and its components has not been reported. METHODS: This cross-sectional study included adult individuals with complete OBS and MetS data from National Health and Nutrition Examination Survey (NHANES) 2011-2018...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38543698/restriction-of-viral-glycoprotein-maturation-by-cellular-protease-inhibitors
#4
REVIEW
Rishikesh Lotke, Moritz Petersen, Daniel Sauter
The human genome is estimated to encode more than 500 proteases performing a wide range of important physiological functions. They digest proteins in our food, determine the activity of hormones, induce cell death and regulate blood clotting, for example. During viral infection, however, some proteases can switch sides and activate viral glycoproteins, allowing the entry of virions into new target cells and the spread of infection. To reduce unwanted effects, multiple protease inhibitors regulate the proteolytic processing of self and non-self proteins...
February 22, 2024: Viruses
https://read.qxmd.com/read/38543282/exploring-variability-in-rifampicin-plasma-exposure-and-development-of-anti-tuberculosis-drug-induced-liver-injury-among-patients-with-pulmonary-tuberculosis-from-the-pharmacogenetic-perspective
#5
JOURNAL ARTICLE
Agnija Kivrane, Viktorija Ulanova, Solveiga Grinberga, Eduards Sevostjanovs, Anda Viksna, Iveta Ozere, Ineta Bogdanova, Maksims Zolovs, Renate Ranka
Genetic polymorphisms can exert a considerable impact on drug pharmacokinetics (PK) and the development of adverse drug reactions (ADR). However, the effect of genetic polymorphisms on the anti-tuberculosis (anti-TB) drug, and particularly rifampicin (RIF), exposure or anti-TB drug-induced liver injury (DILI) remains uncertain. Here, we evaluated the relationship between single nucleotide polymorphisms (SNPs) detected in the RIF pharmacogenes ( AADAC , SLCO1B1 , SLCO1B3 , ABCB1 , and NR1I2 ) and RIF PK parameters, as well as anti-TB treatment-associated DILI...
March 12, 2024: Pharmaceutics
https://read.qxmd.com/read/38543039/enzymatic-hydrolysis-optimization-of-yak-whey-protein-concentrates-and-bioactivity-evaluation-of-the-ultrafiltered-peptide-fractions
#6
JOURNAL ARTICLE
Lingshen Hao, Xuefei Li, Baotang Zhao, Xuemei Song, Yan Zhang, Qi Liang
Yak whey protein concentrates (YWPCs) have good functional properties, but there is still a gap in the study of their peptides. In this study, peptides were obtained by enzymatic hydrolysis, and the bioactivity of each ultrafiltration fraction was evaluated using an optimal process. YWPCs were isolated and purified from yak milk as the raw material. Alkaline protease, trypsin, and papain were used to hydrolyze YWPCs. The protease with the highest degree of hydrolysis (DH) and peptide concentration was selected as the most suitable enzyme...
March 21, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542928/unraveling-light-activated-insulin-action-in-regulating-blood-glucose-new-photoactivatable-insight-as-a-novel-modality-in-diabetes-management
#7
JOURNAL ARTICLE
Fahrul Nurkolis, Rudy Kurniawan, Elvan Wiyarta, Rony Abdi Syahputra, Reggie Surya, Nurpudji Astuti Taslim, Trina Ekawati Tallei, Raymond Rubianto Tjandrawinata, Eli Y Adashi, Bonglee Kim
Diabetes, particularly type 2 diabetes (T2D), is the main component of metabolic syndrome. It is highly prevalent and has drastically increased with sedentary lifestyles, notably behaviors linked to ease of access and minimal physical activity. Central to this condition is insulin, which plays a pivotal role in regulating glucose levels in the body by aiding glucose uptake and storage in cells, and what happens to diabetes? In diabetes, there is a disruption and malfunction in insulin regulation. Despite numerous efforts, effectively addressing diabetes remains a challenge...
March 14, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542740/beyond-the-tropics-unraveling-the-complex-relationship-between-sun-exposure-dietary-intake-and-vitamin-d-deficiency-in-coastal-malaysians
#8
JOURNAL ARTICLE
Shameena Gill, Alia Maisara Adenan, Emillia Elza Thomas, Arifah Haleelur Rahman, Noor Baitee A Rahim, Noor Akmal Shareela Ismail
Despite Malaysia's year-round sunny climate, vitamin D deficiency is surprisingly common among Malaysians. However, we hypothesise that vitamin D levels among coastal populations are above average. Thus, we aim to investigate vitamin D levels and correlate them with the potential contributing factors from three selected coastal villages in Johor, Melaka, and Negeri Sembilan. Convenient sampling was employed to recruit 120 Malay male and female participants, and dried blood spots (DBS) were obtained to measure 25 (OH) vitamin D3 levels via immunoassay...
March 14, 2024: Nutrients
https://read.qxmd.com/read/38542682/the-impact-of-diet-on-mirna-regulation-and-its-implications-for-health-a-systematic-review
#9
REVIEW
María DeLucas, Juana Sánchez, Andreu Palou, Francisca Serra
The evidence suggests that diet can modulate endogenous microRNA (miRNA) expression. Changes in miRNA expression may affect metabolic processes and consequently be involved in health status and disease development. The aim of this systematic review was to summarize the evidence of the role of diet and specific food components in the regulation of miRNA expression and discuss its implications for human health and disease development. The PubMed, Embase and Web of Science databases were searched in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for relevant studies...
March 7, 2024: Nutrients
https://read.qxmd.com/read/38542511/role-of-sensory-nerves-in-pulmonary-fibrosis
#10
REVIEW
Charles E Norton
Pulmonary fibrosis results from the deposition and proliferation of extracellular matrix components in the lungs. Despite being an airway disorder, pulmonary fibrosis also has notable effects on the pulmonary vasculature, with the development and severity of pulmonary hypertension tied closely to patient mortality. Furthermore, the anatomical proximity of blood vessels, the alveolar epithelium, lymphatic tissue, and airway spaces highlights the need to identify shared pathogenic mechanisms and pleiotropic signaling across various cell types...
March 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542503/plasma-and-platelet-brain-derived-neurotrophic-factor-bdnf-levels-in-bipolar-disorder-patients-with-post-traumatic-stress-disorder-ptsd-or-in-a-major-depressive-episode-compared-to-healthy-controls
#11
JOURNAL ARTICLE
Valerio Dell'Oste, Lionella Palego, Laura Betti, Sara Fantasia, Davide Gravina, Andrea Bordacchini, Virginia Pedrinelli, Gino Giannaccini, Claudia Carmassi
Post-traumatic stress disorder (PTSD) is a highly disabling mental disorder arising after traumatism exposure, often revealing critical and complex courses when comorbidity with bipolar disorder (BD) occurs. To search for PTSD or depression biomarkers that would help clinicians define BD presentations, this study aimed at preliminarily evaluating circulating brain-derived-neurotrophic factor (BDNF) levels in BD subjects with PTSD or experiencing a major depressive episode versus controls. Two bloodstream BDNF components were specifically investigated, the storage (intraplatelet) and the released (plasma) ones, both as adaptogenic/repair signals during neuroendocrine stress response dynamics...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542368/the-impact-of-c-3-side-chain-modifications-on-kynurenic-acid-a-behavioral-analysis-of-its-analogs-in-the-motor-domain
#12
JOURNAL ARTICLE
Diána Martos, Bálint Lőrinczi, István Szatmári, László Vécsei, Masaru Tanaka
The central nervous system (CNS) is the final frontier in drug delivery because of the blood-brain barrier (BBB), which poses significant barriers to the access of most drugs to their targets. Kynurenic acid (KYNA), a tryptophan (Trp) metabolite, plays an important role in behavioral functions, and abnormal KYNA levels have been observed in neuropsychiatric conditions. The current challenge lies in delivering KYNA to the CNS owing to its polar side chain. Recently, C-3 side chain-modified KYNA analogs have been shown to cross the BBB; however, it is unclear whether they retain the biological functions of the parent molecule...
March 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542319/unmasking-the-metabolite-signature-of-bladder-cancer-a-systematic-review
#13
REVIEW
Francisca Pereira, M Rosário Domingues, Rui Vitorino, Inês M S Guerra, Lúcio Lara Santos, José Alexandre Ferreira, Rita Ferreira
Bladder cancer (BCa) research relying on Omics approaches has increased over the last few decades, improving the understanding of BCa pathology and contributing to a better molecular classification of BCa subtypes. To gain further insight into the molecular profile underlying the development of BCa, a systematic literature search was performed in PubMed until November 2023, following the PRISMA guidelines. This search enabled the identification of 25 experimental studies using mass spectrometry or nuclear magnetic resonance-based approaches to characterize the metabolite signature associated with BCa...
March 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542123/downregulation-of-serotonergic-system-components-in-an-experimentally-induced-cryptorchidism-in-rabbits
#14
JOURNAL ARTICLE
Francisco Jiménez-Trejo, Cristian Arriaga-Canon, Luis A Herrera, Isabel Coronado-Mares, Rogelio Montiel-Manríquez, Isaac González-Santoyo, Wendy B Pérez-Báez, Miguel Tapia-Rodríguez
Cryptorchidism (CO) or undescended testes is defined as the failure of one or both testes to be positioned inside the scrotum. Typically, cryptorchidism is detected at birth or shortly thereafter, and in humans, it is considered to be part of the testicular dysgenesis syndrome (TDS), a complex pathology regarding the male reproductive system that apparently involves the interaction of both genetic and environmental harmful factors, mainly during embryonic development. Serotonin (5-HT) is an ancient molecule that participates in a broad range of body functions, and in recent years, its importance in reproduction has started to be elucidated...
March 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542110/influence-of-dna-methylation-on-vascular-smooth-muscle-cell-phenotypic-switching
#15
REVIEW
Chanthong Yorn, Hyunjung Kim, Kyuho Jeong
Vascular smooth muscle cells (VSMCs) are crucial components of the arterial wall, controlling blood flow and pressure by contracting and relaxing the artery walls. VSMCs can switch from a contractile to a synthetic state, leading to increased proliferation and migratory potential. Epigenetic pathways, including DNA methylation, play a crucial role in regulating VSMC differentiation and phenotypic flexibility. DNA methylation involves attaching a methyl group to the 5' carbon of a cytosine base, which regulates gene expression by interacting with transcription factors...
March 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541726/breast-cancer-exposomics
#16
REVIEW
Anca-Narcisa Neagu, Taniya Jayaweera, Lilian Corrice, Kaya Johnson, Costel C Darie
We are exposed to a mixture of environmental man-made and natural xenobiotics. We experience a wide spectrum of environmental exposure in our lifetime, including the effects of xenobiotics on gametogenesis and gametes that undergo fertilization as the starting point of individual development and, moreover, in utero exposure, which can itself cause the first somatic or germline mutation necessary for breast cancer (BC) initiation. Most xenobiotics are metabolized or/and bioaccumulate and biomagnify in our tissues and cells, including breast tissues, so the xenobiotic metabolism plays an important role in BC initiation and progression...
March 18, 2024: Life
https://read.qxmd.com/read/38541661/influence-of-lemongrass-essential-oil-cymbopogon-flexuosus-supplementation-on-diabetes-in-rat-model
#17
JOURNAL ARTICLE
Ailton S S Júnior, Felipe J Aidar, Luiz A S Silva, Thais de B Silva, Sara F M de Almeida, Daiane C S Teles, Waldecy de L Junior, Dulce M Schimieguel, Daniel A de Souza, Ana C S Nascimento, Enilton A Camargo, Jymmys L Dos Santos, Ana M de O E Silva, Rogéria de S Nunes, Lysandro P Borges, Ana A M Lira
(1) Background: Species of the genus Cymbopogon and its essential oil are known for their antioxidant and hypoglycemic effects. This study aimed to investigate the impact of the essential oil of Cymbopogon flexuosus (EOCF), and its major component, citral, on glycemic, lipid, antioxidant parameters, and oxidative stress in a type 1 diabetes (DM1) rat model. (2) Methods: Initially, EOCF was analyzed by Gas chromatography-mass spectrometry (GC-MS) and the antioxidant activity of EOCF and citral was evaluated...
March 4, 2024: Life
https://read.qxmd.com/read/38541284/hiptox-hazard-identification-platform-to-assess-the-health-impacts-from-indoor-and-outdoor-air-pollutant-exposures-through-mechanistic-toxicology-a-single-centre-double-blind-human-exposure-trial-protocol
#18
JOURNAL ARTICLE
Thomas Faherty, Huda Badri, Dawei Hu, Aristeidis Voliotis, Francis D Pope, Ian Mudway, Jacky Smith, Gordon McFiggans
Over the past decade, our understanding of the impact of air pollution on short- and long-term population health has advanced considerably, focusing on adverse effects on cardiovascular and respiratory systems. There is, however, increasing evidence that air pollution exposures affect cognitive function, particularly in susceptible groups. Our study seeks to assess and hazard rank the cognitive effects of prevalent indoor and outdoor pollutants through a single-centre investigation on the cognitive functioning of healthy human volunteers aged 50 and above with a familial predisposition to dementia...
February 29, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38541105/safety-profile-of-monoclonal-antibodies-and-subsequent-drug-developments-in-the-treatment-of-paroxysmal-nocturnal-hemoglobinuria
#19
REVIEW
Vasantha Mallenahalli Neeekantappa, Ashwin Kamath, Poovizhi Bharathi Rajaduraivelpandian
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disease characterized by intravascular hemolysis due to the targeting of affected red blood cells by the complement system. Eculizumab and ravulizumab are two monoclonal antibodies that inhibit the complement system's components and have been shown to significantly improve survival and quality of life. This review describes the role of these monoclonal antibodies in the treatment of PNH with an emphasis on their safety profile. The challenges in the use of these drugs and new drugs in various stages of drug development are also described, which may be helpful in addressing some of these challenges...
February 24, 2024: Medicina
https://read.qxmd.com/read/38540938/modulatory-effects-of-lactarius-hatsudake-on-obesity-and-gut-microbiota-in-high-fat-diet-fed-c57bl-6-mice
#20
JOURNAL ARTICLE
Hanyu Zhu, Tao Hou
Lactarius hatsudake (LH), a great wild endemic fungus, contains rich nutritional components with medicinal properties. The effects of LH on body weight, liver weight, liver injury, blood lipids, and gut microbiota in C57BL/6 mice fed a high-fat diet (HFD) for 8 weeks was examined in this research. Though there was no clear impact on weight loss, the findings indicate that LH treatment effectively decreased liver damage caused by HFD, as well as lowered serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol levels...
March 20, 2024: Foods (Basel, Switzerland)
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