Mark A Brockman, Francis Mwimanzi, Hope R Lapointe, Yurou Sang, Olga Agafitei, Peter K Cheung, Siobhan Ennis, Kurtis Ng, Simran Basra, Li Yi Lim, Fatima Yaseen, Landon Young, Gisele Umviligihozo, F Harrison Omondi, Rebecca Kalikawe, Laura Burns, Chanson J Brumme, Victor Leung, Julio S G Montaner, Daniel Holmes, Mari L DeMarco, Janet Simons, Ralph Pantophlet, Masahiro Niikura, Marc G Romney, Zabrina L Brumme
BACKGROUND: The magnitude and durability of immune responses to coronavirus disease 2019 (COVID-19) mRNA vaccines remain incompletely characterized in the elderly. METHODS: Anti-spike receptor-binding domain (RBD) antibodies, angiotensin-converting enzyme 2 (ACE2) competition, and virus neutralizing activities were assessed in plasma from 151 health care workers and older adults (range, 24-98 years of age) 1 month following the first vaccine dose, and 1 and 3 months following the second dose...
April 1, 2022: Journal of Infectious Diseases