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Subcapsular cataract dexamethasone

Francesco Pichi, Paolo Nucci, Kimberly Baynes, Careen Y Lowder, Sunil K Srivastava
The purpose of this study is to review the results of treatment of juvenile idiopathic arthritis-related uveitis with the use of intravitreal dexamethasone implant. Sixteen eyes with Juvenile idiopathic arthritis (JIA)-associated uveitis received intravitreal dexamethasone implant to treat recalcitrant anterior segment inflammation (43.7 %), chronic macular edema (6.2 %), or a combination of both (50 %). One month after injection, mean visual acuity had improvement to 39.6 ± 11 ETDRS letters (p < 0...
May 24, 2016: International Ophthalmology
Ding Zhou, Yi Zhang, Lishan Wang, Yunduan Sun, Ping Liu
Prolonged glucocorticoids (GCs) treatment may lead to the formation of posterior subcapsular cataracts. The present study aimed to investigate differential gene expression in lens epithelial cells (LECs) in response to GCs using DNA microarray profiling. The gene expression profile of GSE13040 was downloaded from the Gene Expression Omnibus database, which includes 12 human LECs treated with vehicle or dexamethasone (Dex) for 4 or 16 h with six samples at each time period, of which three samples were treated with vehicle (control group) and three samples were treated with Dex (Dex group) at each time point...
June 2015: Molecular Medicine Reports
Kelly M Bui, Clement C Chow, William F Mieler
PURPOSE: Radiation maculopathy is the most common cause of severe vision loss after radiotherapy of uveal melanoma. To date, no effective therapy exists. The authors report a novel approach to the treatment of radiation maculopathy using dexamethasone (Ozurdex, Allergan Inc) intravitreal implant. METHODS: This is a retrospective case series of two patients who developed radiation maculopathy after radiotherapy for uveal melanoma and was treated with Ozurdex. Clinical outcomes included visual acuity, central foveal thickness by optical coherence tomography, intraocular pressure, and cataract formation...
2014: Retinal Cases & Brief Reports
Oren Tomkins-Netzer, Simon R J Taylor, Asaf Bar, Albert Lula, Satish Yaganti, Lazha Talat, Sue Lightman
PURPOSE: To describe the long-term outcome of eyes with uveitis after repeated treatment with dexamethasone implants (Ozurdex; Allergan, Inc., Irvine, CA). DESIGN: Retrospective, observational case series. PARTICIPANTS: Thirty-eight eyes of 27 patients with uveitis that were treated with 61 dexamethasone implants. METHODS: All eyes underwent dexamethasone pellet implantation. Anatomic and functional outcomes, as well as ocular complications, were noted...
August 2014: Ophthalmology
Bhagwat V Alapure, Mamidipudi R Praveen, Devarshi U Gajjar, Abhay R Vasavada, Trilok J Parmar, Anshul I Arora
PURPOSE: To evaluate the level of matrix metalloproteinase (MMP)-2 and MMP-9 activities in patients with steroid induced posterior subcapsular cataract (PSC). METHODS: This prospective, observational study comprised of 156 patients having either steroid induced PSC (n=50) or non-steroidal PSC (n=106) were performed to evaluate the level of MMP-2 and MMP-9 activities in the lens epithelial cells (LECs) and the serum. Anterior lens capsules harboring LECs were obtained during phacoemulsification and peripheral blood was collected from patients before administration of anesthesia...
2012: Molecular Vision
Janine A Clayton, Susan Vitale, Jonghyeon Kim, Cathy Conry-Cantilena, Phyllis Byrne, George F Reed, Frederick L Ferris, Susan F Leitman
BACKGROUND: Granulocyte donors routinely receive dexamethasone orally before donation. Steroids may increase the risk of posterior subcapsular cataract (PSC) formation. STUDY DESIGN AND METHODS: We recruited 100 granulocyte donors (four or more granulocyte donations; any number of platelet [PLT] donations) and 100 age- and sex-matched PLT donors (zero to three granulocyte donations, any number of PLT donations) to examine the risk of PSC. PSC was assessed by a masked ophthalmologist and reading center lens photograph gradings or medical record documentation of PSC as the reason for cataract extraction...
May 2011: Transfusion
Baichuan Wang, Chunlin Chen, Xiaolei Yin, Xiaofan Chen, Jian Ye
We investigated glucocorticoids-induced alteration of bFGF in AqH, FGFR and beta-crystallin in rat lens epithelial cells (LECs). Results. Data showed dexamethasone had no effect on bFGF in AqH, but reduced FGFR1 in LECs. After six months treatment, cells were detected under posterior capsule in 4/12 lenses. In vitro observations revealed a down-regulated FGFR1 or beta-crystallin by dexamethasone. FGFR in LECs may play an important role in formation of glucocorticoid-induced PSC.
2009: Annals of Ophthalmology
A Petersen, T Carlsson, J-O Karlsson, S Jonhede, M Zetterberg
PURPOSE: Treatment with glucocorticoids is a well known risk factor for cataract development, although the pathogenic mechanism has not been elucidated. The aim of the study was to investigate the effects of glucocorticoids in cultured human lens epithelial cells. METHODS: Human lens epithelial cells (HLECs) were exposed to dexamethasone for 24 h. The number of viable cells was determined using the 3-[4, 5-dimethylthiazolyl-2]-2, 5-diphenyltetrazolium bromide (MTT) assay, and proliferation was quantified using Ki-67...
2008: Molecular Vision
Eric R James, Victor M Fresco, Lorie L Robertson
AIMS: Clinically, steroid use is accompanied by a risk for posterior subcapsular cataracts (PSCs). PSC possibly involves perturbation of lens epithelial cell proliferation and differentiation; however, the underlying mechanism is unknown. In this study, we aimed to characterize changes in gene expression in human lens epithelial cells exposed to glucocorticoid using DNA microarray hybridization. METHODS: Human lens epithelial cells (HLE B-3) were treated with dexamethasone (1 microM) for 24 or 48 hours or with vehicle (0...
February 2005: Journal of Ocular Pharmacology and Therapeutics
Rajesh Jain, Bhushan Kumar
Dexamethasone-cyclophosphamide pulse (DCP) is the prefered mode of therapy in pemphigus in India because it is relatively free from the side effects seen with heavy doses of daily oral steroids. One hundred forty-six pemphigus patients treated with DCP were observed for side effects of this regimen. One hundred forty mg of dexamethasone was administered IV in 200 ml of 5% dextrose over a period of 60-90 minutes on 3 consecutive days. Five hundred mg of cyclophosphamide was added on first day of the pulse and 50 mg given orally daily in the intervening period...
October 2003: Journal of Dermatology
No abstract text is available yet for this article.
February 1964: Nihon Ganka Kiyo
No abstract text is available yet for this article.
1963: Acta Ophthalmologica
Jungmook Lyu, Jung-A Kim, Sung Kun Chung, Ki-San Kim, Choun-Ki Joo
PURPOSE: A side effect associated with long-term treatment of various diseases with steroids is a high incidence of posterior subcapsular cataracts (PSC). To understand the mechanism underlying steroid-induced cataract, the cultured lens model was developed, and the expression of potential candidate proteins during opacity formation was examined. METHOD: Rat lenses were carefully dissected from the surrounding ocular tissue and incubated in medium 199. Dexamethasone was then added to the medium...
May 2003: Investigative Ophthalmology & Visual Science
Rajinder S Sawhney
Cataract formation is a deleterious side effect of some hormone therapies, thus, it is important to understand how hormones regulate lens basement structure and function. We have examined the effects of dexamethasone (DEX) on the regulation of Secreted Protein Acidic and Rich in Cysteines (SPARC), fibronectin (FN), and collagen IV (CN IV). To radiolabel newly synthesized proteins, cultured monolayers of bovine anterior lens capsule epithelial (ALCE) cells were pulsed with [(3)H] proline. To identify proteins, an immunofluorescent technique, immunoprecipitation with specific antibodies, and electrophoretic separation on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) were used...
2002: Cell Biology International
A I Jobling, A Stevens, R C Augusteyn
PURPOSE: Long-term steroid therapy is a known risk factor for the development of posterior subcapsular cataract. Previous work in this laboratory has found soluble lens proteins to bind dexamethasone, but this binding is not due to a glucocorticoid receptor. This study was undertaken to identify the soluble protein or proteins involved in lens glucocorticoid binding. METHODS: Bovine lens extract was incubated with 5.2 x 10(-)(8) M [(3)H]-dexamethasone for 3 hours, and the distribution of label assessed in the soluble and insoluble fractions after centrifugation...
July 2001: Investigative Ophthalmology & Visual Science
P H Brauweiler, T Wehler, M Busin
OBJECTIVE: To assess the effectiveness and safety of implantation of a negative, silicone, posterior chamber intraocular lens (IOL) in the ciliary sulcus of phakic, highly myopic eyes. DESIGN: Noncomparative consecutive interventional series. PARTICIPANTS: Eighteen eyes of 10 patients suffering from high-degree myopia (spherical equivalent < -10 diopters) undergoing implantation of a Fyodorov 094M-1 IOL by the same surgeon (P.H.B.) were evaluated...
September 1999: Ophthalmology
T Fujiwara
Administration of glucocorticoid, one of the corticosteroid hormones, is one of the most important therapeutic strategy in ophthalmological treatment. Almost all kinds of glucocorticoid agents are commercially available for various ocular diseases, including cortisone, hydrocortisone, prednisolone, methylprednisolone, triamcinolone, dexamethasone, paramethasone, betamethasone and fluolometholone. Glucocorticoids are administrated in preparations of eye drops, ointments, injections and tablets for local and systemic use...
March 1994: Nihon Rinsho. Japanese Journal of Clinical Medicine
Y Zheng, Z Lin
13 cases (21 eyes) of patients with glucocorticoid cataract due to topical or systemical administration of dexamethasone or prednisone were reported. The patients comprised 10 men and 3 women, averaging 34 years of age (ranged from 11 to 64 years). Average time of administrating glucocorticoid was 7.1 years (ranged from 6 months to thirty years). The clinical type was posterior subcapsular cataract (PSC). After the treatment of discontinuation of the glucocorticoid drugs, cataract was not improved. 7 cases (11 eyes) of the patients underwent extracapsular cataract extraction and posterior chamber intraocular lens implantation...
June 1994: Yan Ke Xue Bao, Eye Science
P C Donshik, H D Cavanaugh, S A Boruchoff, C H Dohlman
Posterior subcapsular cataracts studied in 86 eyes of 86 patients transplanted for keratoconus were retrospectively studied. The follow-up period ranged between one and four years with a median of 18 months. Twenty-eight eyes developed posterior subcapsular cataracts. The development of posterior subcapsular cataracts was significantly related to the total cumulative steroid dose and the total time steroids were administered (p less than 0.01). Age, surgical technique, and rejection episodes could not be significantly correlated with development of a posterior cataract...
January 1981: Annals of Ophthalmology
M Miltényi, J Homoki, A K Fazekas, H Romàn, W M Teller
The side effects of corticosteroid therapy were studied in 50 children on long-term therapy for nephrotic syndrome or various collagen diseases. The treatment consisted of prednisolone given to 24 children, and Ultralan (6 alpha-fluor-16 alpha-methyl-1-dehydrocorticosterone) given to 15 patients, both in an alternate-day fashion. Both drugs as well as methylprednisolone and dexamethasone were given successively to 11 children. Duration of therapy and doses were equivalent in all patients studied. The patients on Ultralan therapy developed posterior subcapsular cataracts to a significant higher degree (10 out of 15) and more rapidly (after a cumulative dose of 5...
May 1983: Helvetica Paediatrica Acta
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