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Ultra High Dilution

Ayaka Wada, Naoko Nonose, Masaki Ohata, Tsutomu Miura
The analytical method of ultra-trace sulfur (S) in high-purity metal by isotope dilution inductively coupled plasma mass spectrometry (ID-ICP-MS) combined with chemical separation procedure was developed in the present study. In order to determine the ultra-trace S in high-purity metal, a chemical separation with alumina column was carried out before ICP-MS measurement. This method enabled to prevent the polyatomic ion interference arising from the metal matrix and the signal suppression derived from the space charge effect in ICP-MS...
November 1, 2018: Talanta
Zoltán Márta, Balázs Bobály, Jenő Fekete, Balázs Magda, Tímea Imre, Pál Tamás Szabó
A simple, accurate and sensitive micro UHPLC-MS/MS method was developed and validated for the simultaneous determination of 10 nonsteroidal anti-inflammatory drugs (NSAIDs) from different environmental matrices. The micro LC ‒ on-line SPE method described in this study allowed to determine the selected drugs at ultra-trace levels without the most commonly used complex off-line SPE sample preparation procedures. The presented method is capable of reaching satisfactory low LOQ values with analysing the sample directly after being diluted with water...
July 18, 2018: Journal of Pharmaceutical and Biomedical Analysis
Xueping Liu, Jiayuan Liu, Tao Jiang, Lili Zhang, Yixi Huang, Jiangfan Wan, Guoqiang Song, Haoqi Lin, Zhibin Shen, Chunping Tang
ETHNOPHARMACOLOGICAL RELEVANCE: Dryopteris fragrans (L.) Schott is a deciduous perennial herb, which has been used traditionally for treatment of ringworm infections and others skin diseases in the north of China. AIM OF THE STUDY: To characterize the chemical composition, evaluate the antifungal activity and explore possible mechanisms about action of ethanol extracts of D. fragrans. MATERIALS AND METHODS: The chemical components in the ethanol extracts of D...
July 29, 2018: Journal of Ethnopharmacology
E Jaccoulet, C Boughanem, L Auduteau, P Prognon, E Caudron
The need for high-throughput quality control of pharmaceuticals after compounding is often required before the treatment of the patients. Ultra-fast analysis using flow injection analysis coupled to UV spectroscopy and least square matching was assessed for the simultaneous quantification and identification of three therapeutic taxanes after dilution in physiological saline (cabazitaxel, docetaxel, and paclitaxel). In-depth preliminary analysis of the zero and first order UV spectra of the taxanes using principal component analysis (PCA) allowed us focusing on relevant spectral range with very low formulation influence...
July 23, 2018: European Journal of Pharmaceutical Sciences
Achim T Caspar, Markus R Meyer, Folker Westphal, Armin A Weber, Hans H Maurer
Among the emerging new psychoactive substances (NPS), compounds carrying an N-ortho-methoxybenzyl substituent, the so-called NBOMes, represented a highly potent group of new hallucinogens. Recently, 3,4-dimethoxyamphetamine (3,4-DMA)-NBOMe and 4-methylmethamphetamine (4-MMA)-NBOMe occurred, but no data on their pharmacokinetics were available. According to other NBOMes, they are expected to be extensively metabolized. For detection and identification of their phase I and II metabolites, nano liquid chromatography coupled to high resolution tandem mass spectrometry (nanoLC-HRMS/MS) was used...
October 1, 2018: Talanta
Masroor Hassan Bukhari, Salma Batool, Dr Yasir Raza, Omar Bagasra, Abbas Rizvi, Asifa Shah, Tashmeem Razzaki, Tipu Sultan
The question whether intrinsic bioelectromagnetism exists within DNA or not is an important and so far unexplored area of biology. We carried out a study of isolated genetic material, utilizing both prokaryotic and eukaryotic DNA, to measure any possible intrinsic electromagnetic effects or fields emanated within the molecules. Studies were carried out with extremely sensitive ultra-low-noise trans-impedance amplifiers and a high-precision data acquisition system to record any possible faintest electromagnetic signals from the concentrated, as well as diluted DNA, in vitro...
July 19, 2018: Electromagnetic Biology and Medicine
Cláudia Sg Gomes, Adedayo Fashina, Alfred Fernández-Castané, Timothy W Overton, Timothy J Hobley, Eirini Theodosiou, Owen Rt Thomas
BACKGROUND: The extraction of biopharmaceuticals from plasma and serum often employs overly complicated antiquated procedures that can inflict serious damage on especially prone protein targets and which afford low purification power and overall yields. This paper describes systematic development of a high-gradient magnetic fishing process for recovery of immunoglobulins from unclarified antiserum. RESULTS: Non-porous superparamagnetic particles were transformed into hydrophobic-charge induction adsorbents and then used to recover immunoglobulins from rabbit antiserum feedstocks...
July 2018: Journal of Chemical Technology and Biotechnology
Dharati Joshi, Meghan Hauser, Gregory Veber, Alexandra Berl, Ke Xu, Felix R Fischer
The functional integration of atomically defined graphene nanoribbons (GNRs) into single-ribbon electronic device architectures has been limited by access to nondestructive high-resolution imaging techniques that are both compatible with common supports such as Si or Si/SiO2 wafers and capable of resolving individual ribbons in dilute samples. Conventional techniques such as scanning probe (AFM, STM) or electron microscopy (SEM, TEM) have been restricted by requisite sample preparation techniques that are incompatible with lithographic device fabrication...
August 1, 2018: Journal of the American Chemical Society
Hongjian Miao, Yue Huang, Chao Ma, Jingguang Li, Yunfeng Zhao, Yongning Wu
> Background : A multitude of biomonitoring analytical methods are applied in urinary detection, but few are applicable to phthalate metabolites in human serum, and those that are invariably involve complex operation. Objective : To develop a novel method for the determination of phthalate monoesters in human serum using solid-phase extraction (SPE) and ultra-HPLC (UHPLC)-tandem mass spectrometry for multiple human serum sample determination. Method : Analytes in serum samples were extracted and purified with a novel SPE cartridge named Prime HLB and then directly injected and analyzed without eluent redissolution...
June 28, 2018: Journal of AOAC International
Bin Wang, Yumin Niu, Jing Zhang, Bing Shao, Min Zhang
OBJECTIVE: To establish a rapid and sensitive method for the analysis of eight bisphenols in breast milk using small amount of samples. METHODS: Breast milk samples were extracted by acetonitrile and the lipid substances were removed by freezing under-20 ℃ condition. Then the samples were derivatized with dansyl chloride and analyzed by ultra-performance liquid chromatography-tandem mass spectrometry( UPLCMS/MS). The seperation was performed on an ACQUITY UPLC BEH Phenyl column( 2...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Vincent Hort, Marina Nicolas, Brice Minvielle, Corentin Maleix, Caroline Desbourdes, Frédéric Hommet, Sylviane Dragacci, Gaud Dervilly-Pinel, Erwan Engel, Thierry Guérin
Consumers generally considered organic products to be healthier and safer but data regarding the contamination of organic products are scarce. This study evaluated the impact of the farming system on the levels of ochratoxin A (OTA) in the tissues of French pigs (muscle and liver) reared following three different types of production (organic, Label Rouge and conventional). Because OTA is present at trace levels in animal products, a sensitive ultra-high performance liquid chromatography-tandem mass spectrometry method using stable isotope dilution assay was developed and validated...
August 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Yannis Almirantis, Konstantinos Tsitinidis
We discuss questions related to the 'Benveniste Affair', its consequences and broader issues in an attempt to understand homeopathy. Specifically, we address the following points: 1.:  The relationship between the experiments conducted by Benveniste, Montagnier, their collaborators and groups that independently tested their results, to 'traditional' homeopathy. 2.:  Possible non-local components such as 'generalised entanglement' as the basis of the homeopathic phenomenon and experimental evidence for them...
June 5, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
Simon H Pang, Ryan P Lively, Christopher W Jones
Aminopolymer-based solid sorbents have been widely investigated for the capture of CO2 from dilute streams such as flue gas or ambient air. However, the oxidative stability of the widely studied aminopolymer, poly(ethylenimine) (PEI), is limited, causing it to lose its CO2 capture capacity after exposure to oxygen at elevated temperatures. Here, we demonstrate the use of linear poly(propylenimine) (PPI), synthesized through a simple cationic ring-opening polymerization, as a more oxidatively stable alternative to PEI with high CO2 capacity and amine efficiency...
May 29, 2018: ChemSusChem
Liwei Weng, Lili Guo, Anil Vachani, Clementina Mesaros, Ian A Blair
High mobility group box 1 (HMGB1) is a non-histone chromosomal protein, which can be secreted through a variety of pathways and bind to pattern recognition receptors to release pro-inflammatory cytokines. Previous studies have suggested that HMGB1 is upregulated in numerous inflammatory diseases and that it could be a biomarker for such diseases. However, these studies used immunoassay-based methods to analyze serum HMGB1. Autoantibodies to HMGB1 in serum are found in healthy control subjects as well as in patients with different diseases...
June 19, 2018: Analytical Chemistry
Quan Zhang, Ximing Wang, Zhe Li, Hangbiao Jin, Zhengbiao Lu, Chang Yu, Yu-Fang Huang, Meirong Zhao
Neonicotinoids (neonics), a class of systemic insecticides, have been frequently detected in pollen, vegetables, and fruits. Recently, an increasing concern has been aroused for human exposure to neonics. However, biological monitoring for quantifying body burden of neonics has rarely been reported. In this study, we developed an isotope-dilution ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method to simultaneously quantify nine neonics, including acetamiprid (ACE), thiamethoxam (THIAM), imidacloprid (IMIP), clothianidin (CLO), flonicamid (FLO), thiacloprid (THIAC), dinotefuran (DIN), nitenpyram (NIT), and imidaclothiz (IMIT) in urine...
September 2018: Environmental Pollution
Sofi Nöjd, Peter Holmqvist, Niels Boon, Marc Obiols-Rabasa, Priti S Mohanty, Ralf Schweins, Peter Schurtenberger
The swelling of ionic microgel particles is investigated at a wide range of concentrations using a combination of light, X-ray and neutron scattering techniques. We employ a zero-average contrast approach for small-angle neutron scattering experiments, which enables a direct determination of the form factor at high concentrations. The observed particle size initially decreases strongly with the particle concentration in the dilute regime but approaches a constant value at intermediate concentrations. This is followed by a further deswelling at high concentrations above particle overlap...
May 23, 2018: Soft Matter
Qingsong Xu, Tong Huang, Shanlong Li, Ke Li, Chuanlong Li, Yannan Liu, Yuling Wang, Chunyang Yu, Yongfeng Zhou
Hierarchical solution self-assembly has become an important biomimetic method to prepare highly complex and multifunctional supramolecular structures. However, despite great progress, it is still highly challenging to prepare hierarchical self-assemblies on a large scale because the self-assembly processes are generally performed at high dilution. Now, an emulsion-assisted polymerization-induced self-assembly (EAPISA) method with the advantages of in situ self-assembly, scalable preparation, and facile functionalization was used to prepare hierarchical multiscale sea urchin-like aggregates (SUAs)...
July 2, 2018: Angewandte Chemie
Eric Grouzmann, Catherine Centeno, Philippe J Eugster
BACKGROUND: Urinary vanillylmandelic acid (VMA) and homovanillic acid (HVA) are biomarkers for the diagnosis and follow-up of neuroblastoma, whereas urinary 5-hydroxyindoleacetic acid (5-HIAA) is used to assess a carcinoid tumor. These analytes are conventionally analyzed in a single run by chromatography (LC) coupled with electrochemical detection (LC-ECD) using commercial kits. A rapid dilute-and-shoot LC tandem mass spectrometry (LC-MS/MS) assay was validated in order to replace the LC-ECD method and therefore improve analytical specificity and throughput...
May 1, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Emiliano F Fiorentini, Leticia B Escudero, Rodolfo G Wuilloud
A simple, highly efficient, batch, and centrifuge-less dispersive liquid-liquid microextraction method based on a magnetic ionic liquid (MIL-DLLME) and electrothermal atomic absorption spectrometry (ETAAS) detection was developed for ultra-trace Cd determination in honey. Initially, Cd(II) was chelated with ammonium diethyldithiophosphate (DDTP) at pH 0.5 followed by its extraction with the MIL trihexyl(tetradecyl)phosphonium tetrachloroferrate(III) ([P6,6,6,14 ]FeCl4 ) and acetonitrile as dispersant. The MIL phase containing the analyte was separated from the aqueous phase using only a magnet...
July 2018: Analytical and Bioanalytical Chemistry
A L Garcia-Garcia, M Alvarez-Vera, L A Montoya-Santiyanes, I Dominguez-Lopez, J L Montes-Seguedo, J C Sosa-Savedra, J D O Barceinas-Sanchez
Friction is the natural response of all tribosystems. In a total knee replacement (TKR) prosthetic device, its measurement is hindered by the complex geometry of its integrating parts and that of the testing simulation rig operating under the ISO 14243-3:2014 standard. To develop prediction models of the coefficient of friction (COF) between AISI 316L steel and ultra-high molecular weight polyethylene (UHMWPE) lubricated with fetal bovine serum dilutions, the arthrokinematics and loading conditions prescribed by the ISO 142433: 2014 standard were translated to a simpler geometrical setup, via Hertz contact theory...
June 2018: Journal of the Mechanical Behavior of Biomedical Materials
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