Read by QxMD icon Read

Subcapsular cataract

Jessica Mani Penny Tevaraj, Evelyn Tai Li Min, Raja Azmi Mohd Noor, Azhany Yaakub, Wan Hazabbah Wan Hitam
Neurofibromatosis type 2 usually presents with bilateral acoustic schwannomas. We highlight the rare presentation of neurofibromatosis initially involving third nerve. A 23-year-old Malay female presented with left eye drooping of the upper lid and limitation of upward movement for 8 years. It was associated with right-sided body weakness, change in voice, and hearing disturbance in the right ear for the past 2 years. On examination, there was mild ptosis and limitation of movement superiorly in the left eye...
2016: Case Reports in Ophthalmological Medicine
Anna Korol, Aftab Taiyab, Judith A West-Mays
Transforming growth factor (TGF)-β-induced epithelial-mesenchymal transition (EMT) leads to the formation of ocular fibrotic pathologies, such as anterior subcapsular cataract and posterior capsule opacification. Remodeling of the actin cytoskeleton, mediated by the Rho family of GTPases, plays a key role in EMT, however, how actin dynamics affect downstream markers of EMT has not been fully determined. Our previous work suggests that myocardin related transcription factor A (MRTF-A), an actin-binding protein, might be an important mediator of TGFβ-induced EMT in lens epithelial cells...
September 29, 2016: Molecular Medicine
Xianfang Rong, Xiaodi Qiu, Yongxiang Jiang, Dan Li, Jie Xu, Yinglei Zhang, Yi Lu
Histone acetylation plays key roles in gene expression, but its effects on superoxide dismutase 1 (SOD1) expression in senile cataract remains unknown. To address this problem, the study was to investigate the influence of histone acetylation on SOD1 expression and its effects in the pathogenesis of senile cataract. Senile cataract was classified into three types-nuclear cataract (NC), cortical cataract (CC), and posterior subcapsular cataract (SC)-using the Lens Opacities Classification System III. In senile cataracts, SOD1 expression decreased significantly...
October 5, 2016: Scientific Reports
Colm McAlinden, Qinmei Wang, Rongrong Gao, Weiqi Zhao, Ayong Yu, Yu Li, Yan Guo, Jinhai Huang
PURPOSE: To compare a new swept source optical coherence tomography (SS-OCT) based biometer (OA-2000) with the IOLMaster v5.4 (partial coherence interferometry) and Aladdin (optical low-coherence interferometry) biometers in terms of axial length measurement and failure rate in eyes with cataract. DESIGN: Reliability study METHODS: A total of 377 eyes of 210 patients were scanned with the three biometers in a random order. For each biometer, the number of unobtainable axial length measurements was recorded and grouped as per the type and severity of cataract based on the Lens Opacities Classification System III by the same experienced ophthalmologist...
September 21, 2016: American Journal of Ophthalmology
Stephen Tak-Lun Li, Evan Po-Fat Yiu, Angela Hiu-Yan Wong, John Chun-Ting Yeung, Lester Wang-Hon Yu
We are reporting an unusual case of haemorrhage in the Berger's space after an episode of blunt ocular trauma in an eye of a 4-year-old boy, who enjoyed premorbid normal vision. A secondary posterior subcapsular cataract developed as a complication of the haemorrhage after 6 months of observation. Surgery comprised cataract extraction, removal of a residual retrolenticular haematoma via opening of posterior continuous curvilinear capsulorhexis (CCC), anterior vitrectomy and placement of an intraocular lens...
September 8, 2016: International Ophthalmology
Lucia Grumetto, Antonio Del Prete, Giovanni Ortosecco, Antonella Borrelli, Salvatore Del Prete, Aldo Mancini
Background. We report a case of bilateral posterior subcapsular cataracts (PSCs) in a 24-year-old man with an allergic conjunctivitis history caused by a long-term therapy with glucocorticoids. Case Presentation. The patient showed a visual acuity of 9/10 for both eyes. He followed a therapy with ketotifen and bilastine for four years. During the last six months before our evaluation, he was treated with chloramphenicol and betamethasone, interrupted for onset of cataracts and increased intraocular pressure...
2016: Case Reports in Ophthalmological Medicine
H Marefat, H Abolhassani, M Ghareje Daghi, G Azizi, A Aghamohammadi
Purpose. To report early onset steroid induced posterior subcapsular cataract in a case of common variable immunodeficiency. Methods. Case report. Results. Here we report a 14-yearold male of steroid induced bilateral posterior subcapsular cataract in a common variable immunodeficiency patient with damaging mutations in Glutathione reductase gene, leading to hypersensitivity of patient to glucocorticoid (GC) products. Conclusions. In order to reduce the ocular side effects of the GCs there are some advisements, including a complete history, regular examination, GC should be prescribed in minimal dosage and minimal course, and as possible GC-sparing drugs should always be considered...
September 2016: European Annals of Allergy and Clinical Immunology
Ellen H Koo, Luis J Haddock, Namita Bhardwaj, Jorge A Fortun
BACKGROUND: Neodymium-yttrium-aluminium-garnet (Nd:YAG) laser vitreolysis has been proposed as a treatment modality for symptomatic vitreous floaters. The purpose of this paper is to report two cases of cataracts associated with posterior capsular compromise, induced by Nd:YAG laser vitreolysis for symptomatic vitreous floaters. METHOD: Case series. RESULTS: Two patients who underwent ND:YAG laser vitreolysis for symptomatic floaters, presented with decline in visual acuity in the treated eye after the laser procedure...
August 29, 2016: British Journal of Ophthalmology
Bo Ram Seol, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To determine changes of visual-field (VF) global indices after cataract surgery and the factors associated with the effect of cataracts on those indices in primary open-angle glaucoma (POAG) patients. METHODS: A retrospective chart review of 60 POAG patients who had undergone phacoemulsification and intraocular lens insertion was conducted. All of the patients were evaluated with standard automated perimetry (SAP; 30-2 Swedish interactive threshold algorithm; Carl Zeiss Meditec Inc...
August 8, 2016: Japanese Journal of Ophthalmology
Wanjun Zhang, Huiqi Li
Cataract leads to visual impairment. Among different types of cataract, posterior subcapsular cataract (PSC) can develop rapidly and surgery is usually needed. An approach to detect PSC opacities in retro-illumination images is proposed. Watershed and Markov random fields (MRF) method are employed to opacities in anterior retro-illumination images. It results in a mixture of PSC, cortical opacities and noise. Then, information in both anterior and posterior retro-illumination images is utilized. Two features are extracted to identify PSC: mean gradient comparison (MGC) between anterior and posterior retro-illumination images, and spatial location...
August 4, 2016: Medical & Biological Engineering & Computing
Jeewan S Titiyal, Esha Agarwal, Dewang Angmo, Namrata Sharma, Atul Kumar
The purpose of this study is to comparatively evaluate the morphology of cataract, intraoperative and postoperative complications (IPC), and surgical outcomes of phacoemulsification in post 23G vitrectomized eyes in silicone oil versus air/gas group. This prospective interventional clinical study took place in the Dr. RP Centre for Ophthalmic Sciences, AIIMS, New Delhi, India. Eighty-nine eyes of 89 consecutive vitrectomized patients with cataract were included. All underwent phacoemulsification and evaluated for cataract morphology, surgical difficulties, IPC, visual acuity, and specular count...
August 2, 2016: International Ophthalmology
Jongkyu Choi, Donald M Dixon, Warunee Dansithong, Walid F Abdallah, Kenneth P Roos, Maria C Jordan, Brandon Trac, Han Shin Lee, Lucio Comai, Sita Reddy
Myotonic dystrophy type I (DM1) exhibits distinctive disease specific phenotypes and the accelerated onset of a spectrum of age-associated pathologies. In DM1, dominant effects of expanded CUG repeats result in part from the inactivation of the muscleblind-like (MBNL) proteins. To test the role of MBNL3, we deleted Mbnl3 exon 2 (Mbnl3(ΔE2)) in mice and examined the onset of age-associated diseases over 4 to 13 months of age. Accelerated onset of glucose intolerance with elevated insulin levels, cardiac systole deficits, left ventricle hypertrophy, a predictor of a later onset of heart failure and the development of subcapsular and cortical cataracts is observed in Mbnl3(ΔE2) mice...
2016: Scientific Reports
Xuhua Tan, Yi Zhu, Chuan Chen, Xiaoyun Chen, Yingyan Qin, Bo Qu, Lixia Luo, Haotian Lin, Mingxing Wu, Weirong Chen, Yizhi Liu
Transforming growth factor β (TGFβ)-induced epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) plays a key role in the pathogenesis of anterior subcapsular cataract (ASC) and capsule opacification. In mouse lens, Sprouty2 (Spry2) has a negative regulatory role on TGFβ signaling. However, the regulation of Spry2 during ASC development and how Spry2 modulates TGFβ signaling pathway in human LECs have not been characterized. Here, we demonstrate that Spry2 expression level is decreased in anterior capsule LECs of ASC patients...
2016: PloS One
Kyle Goerl
A clinically significant cataract is defined as an opacification of the eye lens causing a significant decrease in visual acuity or a functional visual impairment. Age-related cataracts are the leading cause of blindness in the world and one of the most common etiologies of visual impairment in the United States. Consequences can include loss of driving privileges, inability to read or watch television, inability to participate in social activities, and an increased risk of falls. In the United States, cataract surgery is the most commonly performed surgical procedure among older patients...
July 2016: FP Essentials
Ankit Shah, Marcony R Santhiago, Edgar M Espana
PURPOSE: To evaluate the surgical outcomes of cataract extraction with phacoemulsification and intraocular lens implantation in patients with severe chronic ocular graft-versus-host disease (GVHD). SETTING: University of South Florida Eye Institute, Tampa, Florida, USA. DESIGN: Retrospective case study. METHODS: A chart review was performed to identify patients with clinically severe, biopsy-proven chronic ocular GVHD who had cataract extraction...
June 2016: Journal of Cataract and Refractive Surgery
Tochi Iroku-Malize, Scott Kirsch
A clinically significant cataract is defined as an opacification of the eye lens causing a significant decrease in visual acuity or a functional visual impairment. Age-related cataracts are the leading cause of blindness in the world and one of the most common etiologies of visual impairment in the United States. Consequences can include loss of driving privileges, inability to read or watch television, inability to participate in social activities, and an increased risk of falls. In the United States, cataract surgery is the most commonly performed surgical procedure among older patients...
June 2016: FP Essentials
Teda Arunrut, Marta Sabbadini, Mahim Jain, Keren Machol, Fernando Scaglia, Anne Slavotinek
We present a 5-year-old female with a distinctive phenotype comprising global developmental delays, pre- and post-natal growth restriction, striking joint laxity with soft skin, and scoliosis. She had a triangular facies, a prominent forehead, proptosis, a small nose, and a small jaw. Her ocular findings included corneal clouding, colobomas of the iris and optic nerve, and posterior subcapsular cataracts. Exome sequencing identified homozygosity for c.970T>A, predicting p.(Cys324Ser), in the xylosylprotein 4-beta-galactosyltransferase, polypeptide 7 (B4GALT7) gene...
October 2016: American Journal of Medical Genetics. Part A
Zhale Rajavi, Sara Mokhtari, Hamideh Sabbaghi, Mehdi Yaseri
PURPOSE: To assess the long-term visual acuity (VA) outcome after congenital cataract surgery at Imam Hossein Medical Center (Tertiary Referral Center) (2004-2014). METHODS: In this descriptive study, records of 120 patients with a history of congenital cataract surgery were studied. Those with traumatic, metabolic cataract, aged <5 years at the last visit who were not able to respond VA testing accurately and follow-up < 6 months were excluded. Cases with incomplete files were recalled and reexamined...
September 2015: Journal of Current Ophthalmology
Thulasiraj D Ravilla, Sanjeev Gupta, Ravilla D Ravindran, Praveen Vashist, Tiruvengada Krishnan, Giovanni Maraini, Usha Chakravarthy, Astrid E Fletcher
BACKGROUND: Biomass cooking fuels are commonly used by Indian households especially the poorest. Cataract is highly prevalent in India and the major cause of vision loss. The evidence on biomass fuels and cataract is limited. OBJECTIVES: To examine the association of biomass cooking fuels with cataract and type of cataract. METHODS: We conducted a population-based study in north and south India using randomly sampled clusters to identify people aged 60 and over...
May 25, 2016: Environmental Health Perspectives
Francesco Pichi, Paolo Nucci, Kimberly Baynes, Careen Y Lowder, Sunil K Srivastava
The purpose of this study is to review the results of treatment of juvenile idiopathic arthritis-related uveitis with the use of intravitreal dexamethasone implant. Sixteen eyes with Juvenile idiopathic arthritis (JIA)-associated uveitis received intravitreal dexamethasone implant to treat recalcitrant anterior segment inflammation (43.7 %), chronic macular edema (6.2 %), or a combination of both (50 %). One month after injection, mean visual acuity had improvement to 39.6 ± 11 ETDRS letters (p < 0...
May 24, 2016: International Ophthalmology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"