Catherine M Alfano, Ikuyo Imayama, Marian L Neuhouser, Janice K Kiecolt-Glaser, Ashley Wilder Smith, Kathleen Meeske, Anne McTiernan, Leslie Bernstein, Kathy B Baumgartner, Cornelia M Ulrich, Rachel Ballard-Barbash
PURPOSE: Evidence suggests that inflammation may drive fatigue in cancer survivors. Research in healthy populations has shown reduced inflammation with higher dietary intake of ω-3 polyunsaturated fatty acids (PUFAs), which could potentially reduce fatigue. This study investigated fatigue, inflammation, and intake of ω-3 and ω-6 PUFAs among breast cancer survivors. METHODS: Six hundred thirty-three survivors (mean age, 56 years; stage I to IIIA) participating in the Health, Eating, Activity, and Lifestyle Study completed a food frequency/dietary supplement questionnaire and provided a blood sample assayed for C-reactive protein (CRP) and serum amyloid A (30 months after diagnosis) and completed the Piper Fatigue Scale and Short Form-36 (SF-36) vitality scale (39 months after diagnosis)...
April 20, 2012: Journal of Clinical Oncology